Publications:

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Data-Driven Computational Modeling Identifies Determinants of Glioblastoma Response to SHP2 Inhibition.

Cancer Research

Day, Evan K EK; Zhong, Qing Q; Purow, Benjamin B; Lazzara, Matthew J MJ

Publication Date: 2021-04-15

Variant appearance in text: PTEN: Y240F

PubMed Link: 33574084

Variant Present in the following documents:

• Main text

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Regulating tumor suppressor genes: post-translational modifications.

Signal Transduction And Targeted Therapy

Chen, Ling L; Liu, Shuang S; Tao, Yongguang Y

Publication Date: 2020-06-10

Variant appearance in text: PTEN: Y240F

PubMed Link: 32532965

Variant Present in the following documents:

• Main text
• 41392_2020_Article_196.pdf

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The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.

Cold Spring Harbor Perspectives In Medicine

Hasle, Nicholas N; Matreyek, Kenneth A KA; Fowler, Douglas M DM

Publication Date: 2019-11-01

Variant appearance in text: PTEN: Y240F

PubMed Link: 31451538

Variant Present in the following documents:

• Main text

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Cancer Cell

Ma, Jianhui J; Benitez, Jorge A JA; Li, Jie J; Miki, Shunichiro S; Ponte de Albuquerque, Claudio C; Galatro, Thais T; Orellana, Laura L; Zanca, Ciro C; Reed, Rachel R; Boyer, Antonia A; Koga, Tomoyuki T; Varki, Nissi M NM; Fenton, Tim R TR; Nagahashi Marie, Suely Kazue SK; Lindahl, Erik E; Gahman, Timothy C TC; Shiau, Andrew K AK; Zhou, Huilin H; DeGroot, John J; Sulman, Erik P EP; Cavenee, Webster K WK; Kolodner, Richard D RD; Chen, Clark C CC; Furnari, Frank B FB

Publication Date: 2019-05-13

Variant appearance in text: PTEN: Y240F

PubMed Link: 31085179

Variant Present in the following documents:

• Main text

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Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair.

Cancer Cell

Ma, Jianhui J; Benitez, Jorge A JA; Li, Jie J; Miki, Shunichiro S; Ponte de Albuquerque, Claudio C; Galatro, Thais T; Orellana, Laura L; Zanca, Ciro C; Reed, Rachel R; Boyer, Antonia A; Koga, Tomoyuki T; Varki, Nissi M NM; Fenton, Tim R TR; Nagahashi Marie, Suely Kazue SK; Lindahl, Erik E; Gahman, Timothy C TC; Shiau, Andrew K AK; Zhou, Huilin H; DeGroot, John J; Sulman, Erik P EP; Cavenee, Webster K WK; Kolodner, Richard D RD; Chen, Clark C CC; Furnari, Frank B FB

Publication Date: 2019-03-18

Variant appearance in text: PTEN: Y240F

PubMed Link: 30827889

Variant Present in the following documents:

• Main text

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Therapeutic targeting of cancers with loss of PTEN function.

Current Drug Targets

Dillon, Lloye M LM; Miller, Todd W TW

Publication Date: 2014-01

Variant appearance in text: PTEN: Tyr240Phe

PubMed Link: 24387334

Variant Present in the following documents:

• Main text

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Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Fenton, Tim R TR; Nathanson, David D; Ponte de Albuquerque, Claudio C; Kuga, Daisuke D; Iwanami, Akio A; Dang, Julie J; Yang, Huijun H; Tanaka, Kazuhiro K; Oba-Shinjo, Sueli Mieko SM; Uno, Miyuki M; Inda, Maria del Mar MM; Wykosky, Jill J; Bachoo, Robert M RM; James, C David CD; DePinho, Ronald A RA; Vandenberg, Scott R SR; Zhou, Huilin H; Marie, Suely K N SK; Mischel, Paul S PS; Cavenee, Webster K WK; Furnari, Frank B FB

Publication Date: 2012-08-28

Variant appearance in text: PTEN: Y240F

PubMed Link: 22891331

Variant Present in the following documents:

• Main text

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Rak functions as a tumor suppressor by regulating PTEN protein stability and function.

Cancer Cell

Yim, Eun-Kyoung EK; Peng, Guang G; Dai, Hui H; Hu, Ruozhen R; Li, Kaiyi K; Lu, Yiling Y; Mills, Gordon B GB; Meric-Bernstam, Funda F; Hennessy, Bryan T BT; Craven, Rolf J RJ; Lin, Shiaw-Yih SY

Publication Date: 2009-04-07

Variant appearance in text: PTEN: Y240F

PubMed Link: 19345329

Variant Present in the following documents:

• Main text

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