Publications:

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Discovering Synergistic Compounds with BYL-719 in PI3K Overactivated Basal-like PDXs.

Cancers

Boyd, David C DC; Zboril, Emily K EK; Olex, Amy L AL; Leftwich, Tess J TJ; Hairr, Nicole S NS; Byers, Holly A HA; Valentine, Aaron D AD; Altman, Julia E JE; Alzubi, Mohammad A MA; Grible, Jacqueline M JM; Turner, Scott A SA; Ferreira-Gonzalez, Andrea A; Dozmorov, Mikhail G MG; Harrell, J Chuck JC

Publication Date: 2023-03-03

Variant appearance in text: PTEN: 919G>A

PubMed Link: 36900375

Variant Present in the following documents:

• cancers-15-01582.pdf

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A bipartite graph-based expected networks approach identifies DDR genes not associated with TMB yet predictive of immune checkpoint blockade response.

Cell Reports. Medicine

Weir, William H WH; Mucha, Peter J PJ; Kim, William Y WY

Publication Date: 2022-05-17

Variant appearance in text: PTEN: 919G>A; Glu307Lys

PubMed Link: 35584624

Variant Present in the following documents:

• mmc2.xlsx, sheet 4

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Blocking Y-Box Binding Protein-1 through Simultaneous Targeting of PI3K and MAPK in Triple Negative Breast Cancers.

Cancers

Tiwari, Aadhya A; Iida, Mari M; Kosnopfel, Corinna C; Abbariki, Mahyar M; Menegakis, Apostolos A; Fehrenbacher, Birgit B; Maier, Julia J; Schaller, Martin M; Brucker, Sara Y SY; Wheeler, Deric L DL; Harari, Paul M PM; Rothbauer, Ulrich U; Schittek, Birgit B; Zips, Daniel D; Toulany, Mahmoud M

Publication Date: 2020-09-29

Variant appearance in text: PTEN: E307K

PubMed Link: 33003386

Variant Present in the following documents:

• Main text
• cancers-12-02795.pdf

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Proliferative Classification of Intracranially Injected HER2-positive Breast Cancer Cell Lines.

Cancers

Kuroiwa, Yuka Y; Nakayama, Jun J; Adachi, Chihiro C; Inoue, Takafumi T; Watanabe, Shinya S; Semba, Kentaro K

Publication Date: 2020-07-06

Variant appearance in text: PTEN: E307K

PubMed Link: 32640677

Variant Present in the following documents:

• Main text
• cancers-12-01811.pdf

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Combined p53- and PTEN-deficiency activates expression of mesenchyme homeobox 1 (MEOX1) required for growth of triple-negative breast cancer.

The Journal Of Biological Chemistry

Gasparyan, Mari M; Lo, Miao-Chia MC; Jiang, Hui H; Lin, Chang-Ching CC; Sun, Duxin D

Publication Date: 2020-08-21

Variant appearance in text: PTEN: 919G>A; E307K

PubMed Link: 32467227

Variant Present in the following documents:

• Main text

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What turns CREB on? And off? And why does it matter?

Cellular And Molecular Life Sciences : Cmls

Steven, André A; Friedrich, Michael M; Jank, Paul P; Heimer, Nadine N; Budczies, Jan J; Denkert, Carsten C; Seliger, Barbara B

Publication Date: 2020-10

Variant appearance in text: PTEN: E307K

PubMed Link: 32347317

Variant Present in the following documents:

• 18_2020_3525_MOESM1_ESM.pdf

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Genetic and transcriptional evolution alters cancer cell line drug response.

Nature

Ben-David, Uri U; Siranosian, Benjamin B; Ha, Gavin G; Tang, Helen H; Oren, Yaara Y; Hinohara, Kunihiko K; Strathdee, Craig A CA; Dempster, Joshua J; Lyons, Nicholas J NJ; Burns, Robert R; Nag, Anwesha A; Kugener, Guillaume G; Cimini, Beth B; Tsvetkov, Peter P; Maruvka, Yosef E YE; O'Rourke, Ryan R; Garrity, Anthony A; Tubelli, Andrew A AA; Bandopadhayay, Pratiti P; Tsherniak, Aviad A; Vazquez, Francisca F; Wong, Bang B; Birger, Chet C; Ghandi, Mahmoud M; Thorner, Aaron R AR; Bittker, Joshua A JA; Meyerson, Matthew M; Getz, Gad G; Beroukhim, Rameen R; Golub, Todd R TR

Publication Date: 2018-08

Variant appearance in text: PTEN: 919G>A; E307K

PubMed Link: 30089904

Variant Present in the following documents:

• NIHMS977514-supplement-Sup_Table_23.xlsx, sheet 1

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Molecular characterization of breast cancer cell lines through multiple omic approaches.

Breast Cancer Research : Bcr

Smith, Shari E SE; Mellor, Paul P; Ward, Alison K AK; Kendall, Stephanie S; McDonald, Megan M; Vizeacoumar, Frederick S FS; Vizeacoumar, Franco J FJ; Napper, Scott S; Anderson, Deborah H DH

Publication Date: 2017-06-05

Variant appearance in text: PTEN: E307K

PubMed Link: 28583138

Variant Present in the following documents:

• 13058_2017_855_MOESM4_ESM.xlsx, sheet 1

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Generation, characterization, and maintenance of trastuzumab-resistant HER2+ breast cancer cell lines.

American Journal Of Cancer Research

Zazo, Sandra S; González-Alonso, Paula P; Martín-Aparicio, Ester E; Chamizo, Cristina C; Cristóbal, Ion I; Arpí, Oriol O; Rovira, Ana A; Albanell, Joan J; Eroles, Pilar P; Lluch, Ana A; Madoz-Gúrpide, Juan J; Rojo, Federico F

Publication Date: 2016

Variant appearance in text: PTEN: E307K

PubMed Link: 27904779

Variant Present in the following documents:

• Main text

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Heregulin-expressing HER2-positive breast and gastric cancer exhibited heterogeneous susceptibility to the anti-HER2 agents lapatinib, trastuzumab and T-DM1.

Oncotarget

Nonagase, Yoshikane Y; Yonesaka, Kimio K; Kawakami, Hisato H; Watanabe, Satomi S; Haratani, Koji K; Takahama, Takayuki T; Takegawa, Naoki N; Ueda, Hiroto H; Tanizaki, Junko J; Hayashi, Hidetoshi H; Yoshida, Takeshi T; Takeda, Masayuki M; Chiba, Yasutaka Y; Tamura, Takao T; Nakagawa, Kazuhiko K; Tsurutani, Junji J

Publication Date: 2016-12-20

Variant appearance in text: PTEN: E307K

PubMed Link: 27768588

Variant Present in the following documents:

• Main text
• oncotarget-07-84860.pdf

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: PTEN: 919G>A; E307K

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 3

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A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities.

Molecular Systems Biology

Vizeacoumar, Franco J FJ; Arnold, Roland R; Vizeacoumar, Frederick S FS; Chandrashekhar, Megha M; Buzina, Alla A; Young, Jordan T F JT; Kwan, Julian H M JH; Sayad, Azin A; Mero, Patricia P; Lawo, Steffen S; Tanaka, Hiromasa H; Brown, Kevin R KR; Baryshnikova, Anastasia A; Mak, Anthony B AB; Fedyshyn, Yaroslav Y; Wang, Yadong Y; Brito, Glauber C GC; Kasimer, Dahlia D; Makhnevych, Taras T; Ketela, Troy T; Datti, Alessandro A; Babu, Mohan M; Emili, Andrew A; Pelletier, Laurence L; Wrana, Jeff J; Wainberg, Zev Z; Kim, Philip M PM; Rottapel, Robert R; O'Brien, Catherine A CA; Andrews, Brenda B; Boone, Charles C; Moffat, Jason J

Publication Date: 2013-10-08

Variant appearance in text: PTEN: E307K

PubMed Link: 24104479

Variant Present in the following documents:

• msb201354-s13.xlsx, sheet 1

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Assessment of computational methods for predicting the effects of missense mutations in human cancers.

Bmc Genomics

Gnad, Florian F; Baucom, Albion A; Mukhyala, Kiran K; Manning, Gerard G; Zhang, Zemin Z

Publication Date: 2013

Variant appearance in text: PTEN: E307K

PubMed Link: 23819521

Variant Present in the following documents:

• 1471-2164-14-S3-S7-S1.xlsx, sheet 1

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PtdIns(4,5)P2-mediated cell signaling: emerging principles and PTEN as a paradigm for regulatory mechanism.

Advances In Experimental Medicine And Biology

Gericke, Arne A; Leslie, Nicholas R NR; Lösche, Mathias M; Ross, Alonzo H AH

Publication Date: 2013

Variant appearance in text: PTEN: E307K

PubMed Link: 23775692

Variant Present in the following documents:

• Main text

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Characterization of a novel PTEN mutation in MDA-MB-453 breast carcinoma cell line.

Bmc Cancer

Singh, Gobind G; Odriozola, Leticia L; Guan, Hong H; Kennedy, Colin R CR; Chan, Andrew M AM

Publication Date: 2011-11-21

Variant appearance in text: PTEN: E307K

PubMed Link: 22103913

Variant Present in the following documents:

• Main text
• 1471-2407-11-490.pdf

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Molecular apocrine differentiation is a common feature of breast cancer in patients with germline PTEN mutations.

Breast Cancer Research : Bcr

Banneau, Guillaume G; Guedj, Mickaël M; MacGrogan, Gaëtan G; de Mascarel, Isabelle I; Velasco, Valerie V; Schiappa, Renaud R; Bonadona, Valerie V; David, Albert A; Dugast, Catherine C; Gilbert-Dussardier, Brigitte B; Ingster, Olivier O; Vabres, Pierre P; Caux, Frederic F; de Reynies, Aurelien A; Iggo, Richard R; Sevenet, Nicolas N; Bonnet, Françoise F; Longy, Michel M

Publication Date: 2010

Variant appearance in text: PTEN: 919G>A; Glu307Lys

PubMed Link: 20712882

Variant Present in the following documents:

• Main text
• bcr2626.pdf

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Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.

Nature Genetics

Saal, Lao H LH; Gruvberger-Saal, Sofia K SK; Persson, Camilla C; Lövgren, Kristina K; Jumppanen, Mervi M; Staaf, Johan J; Jönsson, Göran G; Pires, Maira M MM; Maurer, Matthew M; Holm, Karolina K; Koujak, Susan S; Subramaniyam, Shivakumar S; Vallon-Christersson, Johan J; Olsson, Håkan H; Su, Tao T; Memeo, Lorenzo L; Ludwig, Thomas T; Ethier, Stephen P SP; Krogh, Morten M; Szabolcs, Matthias M; Murty, Vundavalli V V S VV; Isola, Jorma J; Hibshoosh, Hanina H; Parsons, Ramon R; Borg, Ake A

Publication Date: 2008-01

Variant appearance in text: PTEN: E307K

PubMed Link: 18066063

Variant Present in the following documents:

• Main text

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