Publications:

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The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.

Iscience

Kato, Takashi T; Yamada, Tatsuya T; Nakamura, Hideki H; Igarashi, Atsushi A; Anders, Robert A RA; Sesaki, Hiromi H; Iijima, Miho M

Publication Date: 2020-10-23

Variant appearance in text: PTEN: S370A

PubMed Link: 33083717

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A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.

Elife

Ciarlo, Christie C; Kaufman, Charles K CK; Kinikoglu, Beste B; Michael, Jonathan J; Yang, Song S; D Amato, Christopher C; Blokzijl-Franke, Sasja S; den Hertog, Jeroen J; Schlaeger, Thorsten M TM; Zhou, Yi Y; Liao, Eric E; Zon, Leonard I LI

Publication Date: 2017-08-23

Variant appearance in text: PTEN: S370A

PubMed Link: 28832322

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Characterization of PTEN mutations in brain cancer reveals that pten mono-ubiquitination promotes protein stability and nuclear localization.

Oncogene

Yang, Jr-M JM; Schiapparelli, P P; Nguyen, H-N HN; Igarashi, A A; Zhang, Q Q; Abbadi, S S; Amzel, L M LM; Sesaki, H H; Quiñones-Hinojosa, A A; Iijima, M M

Publication Date: 2017-06-29

Variant appearance in text: PTEN: S370A

PubMed Link: 28263967

Variant Present in the following documents:

• Main text
• onc2016493a.pdf

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Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis.

Plos One

Stumpf, Miriam M; Blokzijl-Franke, Sasja S; den Hertog, Jeroen J

Publication Date: 2016

Variant appearance in text: PTEN: S370A

PubMed Link: 27138341

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The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.

The Biochemical Journal

Masson, Glenn R GR; Perisic, Olga O; Burke, John E JE; Williams, Roger L RL

Publication Date: 2016-01-15

Variant appearance in text: PTEN: S370A

PubMed Link: 26527737

Variant Present in the following documents:

• Main text
• bj4730135.pdf

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BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation.

Cell Cycle (Georgetown, Tex.)

Morotti, Alessandro A; Panuzzo, Cristina C; Crivellaro, Sabrina S; Carrà, Giovanna G; Fava, Carmen C; Guerrasio, Angelo A; Pandolfi, Pier Paolo PP; Saglio, Giuseppe G

Publication Date: 2015

Variant appearance in text: PTEN: S370A

PubMed Link: 25608112

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Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.

Molecular And Cellular Biology

Li, Zhiguo Z; Li, Jie J; Bi, Pengpeng P; Lu, Ying Y; Burcham, Grant G; Elzey, Bennett D BD; Ratliff, Timothy T; Konieczny, Stephen F SF; Ahmad, Nihal N; Kuang, Shihuan S; Liu, Xiaoqi X

Publication Date: 2014-10-01

Variant appearance in text: PTEN: S370A

PubMed Link: 25047839

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Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin.

The Journal Of Biological Chemistry

Choi, Byeong Hyeok BH; Pagano, Michele M; Huang, Chaunshu C; Dai, Wei W

Publication Date: 2014-06-20

Variant appearance in text: PTEN: S370A

PubMed Link: 24811168

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Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle.

The Journal Of Biological Chemistry

Choi, Byeong Hyeok BH; Pagano, Michele M; Dai, Wei W

Publication Date: 2014-05-16

Variant appearance in text: PTEN: S370A

PubMed Link: 24706748

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Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.

Nature Communications

Nakahata, Shingo S; Ichikawa, Tomonaga T; Maneesaay, Phudit P; Saito, Yusuke Y; Nagai, Kentaro K; Tamura, Tomohiro T; Manachai, Nawin N; Yamakawa, Norio N; Hamasaki, Makoto M; Kitabayashi, Issay I; Arai, Yasuhito Y; Kanai, Yae Y; Taki, Tomohiko T; Abe, Takaya T; Kiyonari, Hiroshi H; Shimoda, Kazuya K; Ohshima, Koichi K; Horii, Akira A; Shima, Hiroshi H; Taniwaki, Masafumi M; Yamaguchi, Ryoji R; Morishita, Kazuhiro K

Publication Date: 2014-02-26

Variant appearance in text: PTEN: S370A

PubMed Link: 24569712

Variant Present in the following documents:

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• ncomms4393-s1.pdf
• ncomms4393.pdf

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Glycogen Synthase Kinase 3 influences cell motility and chemotaxis by regulating PI3K membrane localization in Dictyostelium.

Development, Growth & Differentiation

Sun, Tong T; Kim, Bohye B; Kim, Lou W LW

Publication Date: 2013-10

Variant appearance in text: PTEN: S370A

PubMed Link: 24102085

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Regulation of PTEN stability and activity by Plk3.

The Journal Of Biological Chemistry

Xu, Dazhong D; Yao, Yixin Y; Jiang, Xuejun X; Lu, Luo L; Dai, Wei W

Publication Date: 2010-12-17

Variant appearance in text: PTEN: S370A

PubMed Link: 20940307

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Leptin-dependent phosphorylation of PTEN mediates actin restructuring and activation of ATP-sensitive K+ channels.

The Journal Of Biological Chemistry

Ning, Ke K; Miller, Lisa C LC; Laidlaw, Hilary A HA; Watterson, Kenneth R KR; Gallagher, Jennifer J; Sutherland, Calum C; Ashford, Michael L J ML

Publication Date: 2009-04-03

Variant appearance in text: PTEN: S370A

PubMed Link: 19208634

Variant Present in the following documents:

• Main text
• 9331.pdf

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PTEN is destabilized by phosphorylation on Thr366.

The Biochemical Journal

Maccario, Helene H; Perera, Nevin M NM; Davidson, Lindsay L; Downes, C Peter CP; Leslie, Nick R NR

Publication Date: 2007-08-01

Variant appearance in text: PTEN: S370A

PubMed Link: 17444818

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Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.

Molecular Biology Of The Cell

Gil, Anabel A; Andrés-Pons, Amparo A; Fernández, Elena E; Valiente, Miguel M; Torres, Josema J; Cervera, Javier J; Pulido, Rafael R

Publication Date: 2006-09

Variant appearance in text: PTEN: S370A

PubMed Link: 16807353

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Phosphorylation of the PTEN tail regulates protein stability and function.

Molecular And Cellular Biology

Vazquez, F F; Ramaswamy, S S; Nakamura, N N; Sellers, W R WR

Publication Date: 2000-07

Variant appearance in text: PTEN: S370A

PubMed Link: 10866658

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