Publications:

---

Hyperphosphorylated PTEN exerts oncogenic properties.

Nature Communications

van Ree, Janine H JH; Jeganathan, Karthik B KB; Fierro Velasco, Raul O RO; Zhang, Cheng C; Can, Ismail I; Hamada, Masakazu M; Li, Hu H; Baker, Darren J DJ; van Deursen, Jan M JM

Publication Date: 2023-05-24

Variant appearance in text: PTEN: S380A

PubMed Link: 37225693

Variant Present in the following documents:

• Main text
• 41467_2023_38740_MOESM1_ESM.pdf
• 41467_2023_38740_MOESM3_ESM.pdf
• 41467_2023_Article_38740.pdf

View BVdb publication page

---

Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase.

Nature Cell Biology

Walpole, Glenn F W GFW; Pacheco, Jonathan J; Chauhan, Neha N; Clark, Jonathan J; Anderson, Karen E KE; Abbas, Yazan M YM; Brabant-Kirwan, Danielle D; Montaño-Rendón, Fernando F; Liu, Zetao Z; Zhu, Hongxian H; Brumell, John H JH; Deiters, Alexander A; Stephens, Len R LR; Hawkins, Phillip T PT; Hammond, Gerald R V GRV; Grinstein, Sergio S; Fairn, Gregory D GD

Publication Date: 2022-05

Variant appearance in text: PTEN: S380A

PubMed Link: 35484249

Variant Present in the following documents:

• NIHMS1787486-supplement-Supplementary_Tables_1_-_4.xlsx, sheet 1

View BVdb publication page

---

Pten Regulates Cardiomyocyte Differentiation by Modulating Non-CG Methylation via Dnmt3.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)

Wang, Wuming W; Lu, Gang G; Liu, Hong-Bin HB; Xiong, Zhiqiang Z; Leung, Ho-Duen HD; Cao, Ruican R; Pang, Alan Lap-Yin AL; Su, Xianwei X; Law, Patrick Wai Nok PWN; Zhao, Zhiju Z; Chen, Zi-Jiang ZJ; Chan, Wai-Yee WY

Publication Date: 2021-09

Variant appearance in text: PTEN: S380A

PubMed Link: 34247447

Variant Present in the following documents:

• Main text
• ADVS-8-2100849.pdf

View BVdb publication page

---

The Loss of Nuclear PTEN Increases Tumorigenesis in a Preclinical Mouse Model for Hepatocellular Carcinoma.

Iscience

Kato, Takashi T; Yamada, Tatsuya T; Nakamura, Hideki H; Igarashi, Atsushi A; Anders, Robert A RA; Sesaki, Hiromi H; Iijima, Miho M

Publication Date: 2020-10-23

Variant appearance in text: PTEN: S380A

PubMed Link: 33083717

Variant Present in the following documents:

• Main text
• main.pdf
• mmc1.pdf

View BVdb publication page

---

Pten-mediated Gsk3β modulates the naïve pluripotency maintenance in embryonic stem cells.

Cell Death & Disease

Wang, Wuming W; Lu, Gang G; Su, Xianwei X; Tang, Chengcheng C; Li, Hongjian H; Xiong, Zhiqiang Z; Leung, Chi-Kwan CK; Wong, Man-Sze MS; Liu, Hongbin H; Ma, Jin-Long JL; Cheung, Hoi-Hung HH; Kung, Hsiang-Fu HF; Chen, Zi-Jiang ZJ; Chan, Wai-Yee WY

Publication Date: 2020-02-07

Variant appearance in text: PTEN: S380A

PubMed Link: 32034125

Variant Present in the following documents:

• Main text
• 41419_2020_Article_2271.pdf

View BVdb publication page

---

The Impact of Genetic Variants on PTEN Molecular Functions and Cellular Phenotypes.

Cold Spring Harbor Perspectives In Medicine

Hasle, Nicholas N; Matreyek, Kenneth A KA; Fowler, Douglas M DM

Publication Date: 2019-11-01

Variant appearance in text: PTEN: S380A

PubMed Link: 31451538

Variant Present in the following documents:

• Main text

View BVdb publication page

---

PTEN is a protein phosphatase that targets active PTK6 and inhibits PTK6 oncogenic signaling in prostate cancer.

Nature Communications

Wozniak, Darren J DJ; Kajdacsy-Balla, Andre A; Macias, Virgilia V; Ball-Kell, Susan S; Zenner, Morgan L ML; Bie, Wenjun W; Tyner, Angela L AL

Publication Date: 2017-11-15

Variant appearance in text: PTEN: S380A

PubMed Link: 29142193

Variant Present in the following documents:

• 41467_2017_Article_1574.pdf

View BVdb publication page

---

A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.

Elife

Ciarlo, Christie C; Kaufman, Charles K CK; Kinikoglu, Beste B; Michael, Jonathan J; Yang, Song S; D Amato, Christopher C; Blokzijl-Franke, Sasja S; den Hertog, Jeroen J; Schlaeger, Thorsten M TM; Zhou, Yi Y; Liao, Eric E; Zon, Leonard I LI

Publication Date: 2017-08-23

Variant appearance in text: PTEN: S380A

PubMed Link: 28832322

Variant Present in the following documents:

• Main text

View BVdb publication page

---

PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex.

Elife

Javadi, Arman A; Deevi, Ravi K RK; Evergren, Emma E; Blondel-Tepaz, Elodie E; Baillie, George S GS; Scott, Mark Gh MG; Campbell, Frederick C FC

Publication Date: 2017-07-27

Variant appearance in text: PTEN: S380A

PubMed Link: 28749339

Variant Present in the following documents:

• Main text
• elife-24578.pdf

View BVdb publication page

---

Contribution of classical end-joining to PTEN inactivation in p53-mediated glioblastoma formation and drug-resistant survival.

Nature Communications

Kang, Youn-Jung YJ; Balter, Barbara B; Csizmadia, Eva E; Haas, Brian B; Sharma, Himanshu H; Bronson, Roderick R; Yan, Catherine T CT

Publication Date: 2017-01-17

Variant appearance in text: PTEN: S380A

PubMed Link: 28094268

Variant Present in the following documents:

• Main text
• ncomms14013.pdf

View BVdb publication page

---

Controlling PTEN (Phosphatase and Tensin Homolog) Stability: A DOMINANT ROLE FOR LYSINE 66.

The Journal Of Biological Chemistry

Gupta, Amit A; Leslie, Nicholas R NR

Publication Date: 2016-08-26

Variant appearance in text: PTEN: S380A

PubMed Link: 27405757

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes.

Nature Cell Biology

van Ree, Janine H JH; Nam, Hyun-Ja HJ; Jeganathan, Karthik B KB; Kanakkanthara, Arun A; van Deursen, Jan M JM

Publication Date: 2016-07

Variant appearance in text: PTEN: S380A

PubMed Link: 27240320

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Fine-Tuning of Pten Localization and Phosphatase Activity Is Essential for Zebrafish Angiogenesis.

Plos One

Stumpf, Miriam M; Blokzijl-Franke, Sasja S; den Hertog, Jeroen J

Publication Date: 2016

Variant appearance in text: PTEN: S380A

PubMed Link: 27138341

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Hypoxia-induced modulation of PTEN activity and EMT phenotypes in lung cancers.

Cancer Cell International

Kohnoh, Takashi T; Hashimoto, Naozumi N; Ando, Akira A; Sakamoto, Koji K; Miyazaki, Shinichi S; Aoyama, Daisuke D; Kusunose, Masaaki M; Kimura, Motohiro M; Omote, Norihito N; Imaizumi, Kazuyoshi K; Kawabe, Tsutomu T; Hasegawa, Yoshinori Y

Publication Date: 2016

Variant appearance in text: PTEN: S380A

PubMed Link: 27095949

Variant Present in the following documents:

• Main text
• 12935_2016_Article_308.pdf

View BVdb publication page

---

Inorganic Phosphate Activates the AKT/mTORC1 Pathway and Shortens the Life Span of an α‑Klotho-Deficient Model.

Journal Of The American Society Of Nephrology : Jasn

Kawai, Masanobu M; Kinoshita, Saori S; Ozono, Keiichi K; Michigami, Toshimi T

Publication Date: 2016-09

Variant appearance in text: PTEN: S380A

PubMed Link: 26872488

Variant Present in the following documents:

• Main text

View BVdb publication page

---

The intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activity.

The Biochemical Journal

Masson, Glenn R GR; Perisic, Olga O; Burke, John E JE; Williams, Roger L RL

Publication Date: 2016-01-15

Variant appearance in text: PTEN: S380A

PubMed Link: 26527737

Variant Present in the following documents:

• Main text
• bj4730135.pdf

View BVdb publication page

---

Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.

Cancer Science

Kusunose, Masaaki M; Hashimoto, Naozumi N; Kimura, Motohiro M; Ogata, Ryo R; Aoyama, Daisuke D; Sakamoto, Koji K; Miyazaki, Shinichi S; Ando, Akira A; Omote, Norihito N; Imaizumi, Kazuyoshi K; Kawabe, Tsutomu T; Hasegawa, Yoshinori Y

Publication Date: 2015-12

Variant appearance in text: PTEN: S380A

PubMed Link: 26450531

Variant Present in the following documents:

• Main text

View BVdb publication page

---

BCR-ABL inactivates cytosolic PTEN through Casein Kinase II mediated tail phosphorylation.

Cell Cycle (Georgetown, Tex.)

Morotti, Alessandro A; Panuzzo, Cristina C; Crivellaro, Sabrina S; Carrà, Giovanna G; Fava, Carmen C; Guerrasio, Angelo A; Pandolfi, Pier Paolo PP; Saglio, Giuseppe G

Publication Date: 2015

Variant appearance in text: PTEN: S380A

PubMed Link: 25608112

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Exosome-mediated delivery of the intrinsic C-terminus domain of PTEN protects it from proteasomal degradation and ablates tumorigenesis.

Molecular Therapy : The Journal Of The American Society Of Gene Therapy

Ahmed, Syed Feroj SF; Das, Nilanjana N; Sarkar, Moumita M; Chatterjee, Uttara U; Chatterjee, Sandip S; Ghosh, Mrinal Kanti MK

Publication Date: 2015-02

Variant appearance in text: PTEN: S380A

PubMed Link: 25327178

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Plk1 phosphorylation of PTEN causes a tumor-promoting metabolic state.

Molecular And Cellular Biology

Li, Zhiguo Z; Li, Jie J; Bi, Pengpeng P; Lu, Ying Y; Burcham, Grant G; Elzey, Bennett D BD; Ratliff, Timothy T; Konieczny, Stephen F SF; Ahmad, Nihal N; Kuang, Shihuan S; Liu, Xiaoqi X

Publication Date: 2014-10-01

Variant appearance in text: PTEN: S380A

PubMed Link: 25047839

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin.

The Journal Of Biological Chemistry

Choi, Byeong Hyeok BH; Pagano, Michele M; Huang, Chaunshu C; Dai, Wei W

Publication Date: 2014-06-20

Variant appearance in text: PTEN: S380A

PubMed Link: 24811168

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.

Cell

Papa, Antonella A; Wan, Lixin L; Bonora, Massimo M; Salmena, Leonardo L; Song, Min Sup MS; Hobbs, Robin M RM; Lunardi, Andrea A; Webster, Kaitlyn K; Ng, Christopher C; Newton, Ryan H RH; Knoblauch, Nicholas N; Guarnerio, Jlenia J; Ito, Keisuke K; Turka, Laurence A LA; Beck, Andy H AH; Pinton, Paolo P; Bronson, Roderick T RT; Wei, Wenyi W; Pandolfi, Pier Paolo PP

Publication Date: 2014-04-24

Variant appearance in text: PTEN: S380A

PubMed Link: 24766807

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Plk1 protein phosphorylates phosphatase and tensin homolog (PTEN) and regulates its mitotic activity during the cell cycle.

The Journal Of Biological Chemistry

Choi, Byeong Hyeok BH; Pagano, Michele M; Dai, Wei W

Publication Date: 2014-05-16

Variant appearance in text: PTEN: S380A

PubMed Link: 24706748

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers.

Nature Communications

Nakahata, Shingo S; Ichikawa, Tomonaga T; Maneesaay, Phudit P; Saito, Yusuke Y; Nagai, Kentaro K; Tamura, Tomohiro T; Manachai, Nawin N; Yamakawa, Norio N; Hamasaki, Makoto M; Kitabayashi, Issay I; Arai, Yasuhito Y; Kanai, Yae Y; Taki, Tomohiko T; Abe, Takaya T; Kiyonari, Hiroshi H; Shimoda, Kazuya K; Ohshima, Koichi K; Horii, Akira A; Shima, Hiroshi H; Taniwaki, Masafumi M; Yamaguchi, Ryoji R; Morishita, Kazuhiro K

Publication Date: 2014-02-26

Variant appearance in text: PTEN: S380A

PubMed Link: 24569712

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Involvement of TGFβ-induced phosphorylation of the PTEN C-terminus on TGFβ-induced acquisition of malignant phenotypes in lung cancer cells.

Plos One

Aoyama, Daisuke D; Hashimoto, Naozumi N; Sakamoto, Koji K; Kohnoh, Takashi T; Kusunose, Masaaki M; Kimura, Motohiro M; Ogata, Ryo R; Imaizumi, Kazuyoshi K; Kawabe, Tsutomu T; Hasegawa, Yoshinori Y

Publication Date: 2013

Variant appearance in text: PTEN: S380A

PubMed Link: 24278390

Variant Present in the following documents:

• Main text
• pone.0081133.pdf

View BVdb publication page

---

Acid ceramidase promotes nuclear export of PTEN through sphingosine 1-phosphate mediated Akt signaling.

Plos One

Beckham, Thomas H TH; Cheng, Joseph C JC; Lu, Ping P; Marrison, S Tucker ST; Norris, James S JS; Liu, Xiang X

Publication Date: 2013

Variant appearance in text: PTEN: S380A

PubMed Link: 24098536

Variant Present in the following documents:

• Main text
• pone.0076593.pdf

View BVdb publication page

---

PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress.

Antioxidants & Redox Signaling

Wu, Yong Y; Zhou, Hillary H; Wu, Ke K; Lee, Sangkyu S; Li, Ruijin R; Liu, Xuan X

Publication Date: 2014-03-20

Variant appearance in text: PTEN: S380A

PubMed Link: 24063548

Variant Present in the following documents:

• Main text

View BVdb publication page

---

TOPK and PTEN participate in CHFR mediated mitotic checkpoint.

Cellular Signalling

Shinde, Swapnil R SR; Gangula, Narmadha Reddy NR; Kavela, Sridhar S; Pandey, Vimal V; Maddika, Subbareddy S

Publication Date: 2013-12

Variant appearance in text: PTEN: S380A

PubMed Link: 24012691

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Multiple host kinases contribute to Akt activation during Salmonella infection.

Plos One

Roppenser, Bernhard B; Kwon, Hyunwoo H; Canadien, Veronica V; Xu, Risheng R; Devreotes, Peter N PN; Grinstein, Sergio S; Brumell, John H JH

Publication Date: 2013

Variant appearance in text: PTEN: S380A

PubMed Link: 23990921

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia.

The Journal Of Cell Biology

Howitt, Jason J; Lackovic, Jenny J; Low, Ley-Hian LH; Naguib, Adam A; Macintyre, Alison A; Goh, Choo-Peng CP; Callaway, Jennifer K JK; Hammond, Vicki V; Thomas, Tim T; Dixon, Matthew M; Putz, Ulrich U; Silke, John J; Bartlett, Perry P; Yang, Baoli B; Kumar, Sharad S; Trotman, Lloyd C LC; Tan, Seong-Seng SS

Publication Date: 2012-01-09

Variant appearance in text: PTEN: S380A

PubMed Link: 22213801

Variant Present in the following documents:

• Main text
• JCB_201105009.pdf

View BVdb publication page

---

PTEN-Associated Complexes: An Overview.

Current Topics In Biochemical Research

Mosessian, Sherly S; Wu, Hong H

Publication Date: 2010

Variant appearance in text: PTEN: S380A

PubMed Link: 22081748

Variant Present in the following documents:

• Main text

View BVdb publication page

---

A mutant form of PTEN linked to autism.

Protein Science : A Publication Of The Protein Society

Redfern, Roberta E RE; Daou, Marie-Claire MC; Li, Li L; Munson, Mary M; Gericke, Arne A; Ross, Alonzo H AH

Publication Date: 2010-10

Variant appearance in text: PTEN: S380A

PubMed Link: 20718038

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Semaphorin 4D/Plexin-B1 stimulates PTEN activity through R-Ras GTPase-activating protein activity, inducing growth cone collapse in hippocampal neurons.

The Journal Of Biological Chemistry

Oinuma, Izumi I; Ito, Yuri Y; Katoh, Hironori H; Negishi, Manabu M

Publication Date: 2010-09-03

Variant appearance in text: PTEN: S380A

PubMed Link: 20610402

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Ubiquitination of PTEN (phosphatase and tensin homolog) inhibits phosphatase activity and is enhanced by membrane targeting and hyperosmotic stress.

The Journal Of Biological Chemistry

Maccario, Helene H; Perera, Nevin M NM; Gray, Alexander A; Downes, C Peter CP; Leslie, Nick R NR

Publication Date: 2010-04-23

Variant appearance in text: PTEN: S380A

PubMed Link: 20177066

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex.

The Journal Of Biological Chemistry

Mosessian, Sherly S; Avliyakulov, Nuraly K NK; Mulholland, David J DJ; Boontheung, Pinmanee P; Loo, Joseph A JA; Wu, Hong H

Publication Date: 2009-10-30

Variant appearance in text: PTEN: S380A

PubMed Link: 19740742

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Phosphorylation keeps PTEN phosphatase closed for business.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Ross, Alonzo H AH; Gericke, Arne A

Publication Date: 2009-02-03

Variant appearance in text: PTEN: S380A

PubMed Link: 19174524

Variant Present in the following documents:

• Main text

View BVdb publication page

---

A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Rahdar, Meghdad M; Inoue, Takanari T; Meyer, Tobias T; Zhang, Jin J; Vazquez, Francisca F; Devreotes, Peter N PN

Publication Date: 2009-01-13

Variant appearance in text: PTEN: S380A

PubMed Link: 19114656

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Cellular commitment to reentry into the cell cycle after stalled DNA is determined by site-specific phosphorylation of Chk1 and PTEN.

Molecular Cancer Therapeutics

Martin, Sarah A SA; Ouchi, Toru T

Publication Date: 2008-08

Variant appearance in text: PTEN: S380A

PubMed Link: 18723495

Variant Present in the following documents:

• Main text

View BVdb publication page

---

PTEN is destabilized by phosphorylation on Thr366.

The Biochemical Journal

Maccario, Helene H; Perera, Nevin M NM; Davidson, Lindsay L; Downes, C Peter CP; Leslie, Nick R NR

Publication Date: 2007-08-01

Variant appearance in text: PTEN: S380A

PubMed Link: 17444818

Variant Present in the following documents:

• Main text

View BVdb publication page

---

PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration.

Current Biology : Cb

Leslie, Nick R NR; Yang, Xuesong X; Downes, C Peter CP; Weijer, Cornelis J CJ

Publication Date: 2007-01-23

Variant appearance in text: PTEN: S380A

PubMed Link: 17240336

Variant Present in the following documents:

• mmc1.pdf

View BVdb publication page

---

Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.

Molecular Biology Of The Cell

Gil, Anabel A; Andrés-Pons, Amparo A; Fernández, Elena E; Valiente, Miguel M; Torres, Josema J; Cervera, Javier J; Pulido, Rafael R

Publication Date: 2006-09

Variant appearance in text: PTEN: S380A

PubMed Link: 16807353

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Okumura, Koichi K; Zhao, Mujun M; Depinho, Ronald A RA; Furnari, Frank B FB; Cavenee, Webster K WK

Publication Date: 2005-02-22

Variant appearance in text: PTEN: S380A

PubMed Link: 15659546

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Membrane-binding and activation mechanism of PTEN.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Das, Sudipto S; Dixon, Jack E JE; Cho, Wonhwa W

Publication Date: 2003-06-24

Variant appearance in text: PTEN: S380A

PubMed Link: 12808147

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Phosphorylation of the PTEN tail regulates protein stability and function.

Molecular And Cellular Biology

Vazquez, F F; Ramaswamy, S S; Nakamura, N N; Sellers, W R WR

Publication Date: 2000-07

Variant appearance in text: PTEN: S380A

PubMed Link: 10866658

Variant Present in the following documents:

• Main text

View BVdb publication page

---