van Ree, Janine H JH; Jeganathan, Karthik B KB; Fierro Velasco, Raul O RO; Zhang, Cheng C; Can, Ismail I; Hamada, Masakazu M; Li, Hu H; Baker, Darren J DJ; van Deursen, Jan M JM
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase.
Nature Cell Biology
Walpole, Glenn F W GFW; Pacheco, Jonathan J; Chauhan, Neha N; Clark, Jonathan J; Anderson, Karen E KE; Abbas, Yazan M YM; Brabant-Kirwan, Danielle D; Montaño-Rendón, Fernando F; Liu, Zetao Z; Zhu, Hongxian H; Brumell, John H JH; Deiters, Alexander A; Stephens, Len R LR; Hawkins, Phillip T PT; Hammond, Gerald R V GRV; Grinstein, Sergio S; Fairn, Gregory D GD
A chemical screen in zebrafish embryonic cells establishes that Akt activation is required for neural crest development.
Elife
Ciarlo, Christie C; Kaufman, Charles K CK; Kinikoglu, Beste B; Michael, Jonathan J; Yang, Song S; D Amato, Christopher C; Blokzijl-Franke, Sasja S; den Hertog, Jeroen J; Schlaeger, Thorsten M TM; Zhou, Yi Y; Liao, Eric E; Zon, Leonard I LI
Direct regulation of transforming growth factor β-induced epithelial-mesenchymal transition by the protein phosphatase activity of unphosphorylated PTEN in lung cancer cells.
Cancer Science
Kusunose, Masaaki M; Hashimoto, Naozumi N; Kimura, Motohiro M; Ogata, Ryo R; Aoyama, Daisuke D; Sakamoto, Koji K; Miyazaki, Shinichi S; Ando, Akira A; Omote, Norihito N; Imaizumi, Kazuyoshi K; Kawabe, Tsutomu T; Hasegawa, Yoshinori Y
Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin.
The Journal Of Biological Chemistry
Choi, Byeong Hyeok BH; Pagano, Michele M; Huang, Chaunshu C; Dai, Wei W
Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function.
Cell
Papa, Antonella A; Wan, Lixin L; Bonora, Massimo M; Salmena, Leonardo L; Song, Min Sup MS; Hobbs, Robin M RM; Lunardi, Andrea A; Webster, Kaitlyn K; Ng, Christopher C; Newton, Ryan H RH; Knoblauch, Nicholas N; Guarnerio, Jlenia J; Ito, Keisuke K; Turka, Laurence A LA; Beck, Andy H AH; Pinton, Paolo P; Bronson, Roderick T RT; Wei, Wenyi W; Pandolfi, Pier Paolo PP
Ndfip1 regulates nuclear Pten import in vivo to promote neuronal survival following cerebral ischemia.
The Journal Of Cell Biology
Howitt, Jason J; Lackovic, Jenny J; Low, Ley-Hian LH; Naguib, Adam A; Macintyre, Alison A; Goh, Choo-Peng CP; Callaway, Jennifer K JK; Hammond, Vicki V; Thomas, Tim T; Dixon, Matthew M; Putz, Ulrich U; Silke, John J; Bartlett, Perry P; Yang, Baoli B; Kumar, Sharad S; Trotman, Lloyd C LC; Tan, Seong-Seng SS
Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs.
Molecular Biology Of The Cell
Gil, Anabel A; Andrés-Pons, Amparo A; Fernández, Elena E; Valiente, Miguel M; Torres, Josema J; Cervera, Javier J; Pulido, Rafael R