Publications:

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Functional and structural insights into the MRX/MRN complex, a key player in recognition and repair of DNA double-strand breaks.

Computational And Structural Biotechnology Journal

Tisi, Renata R; Vertemara, Jacopo J; Zampella, Giuseppe G; Longhese, Maria Pia MP

Publication Date: 2020

Variant appearance in text: ATM: R805E

PubMed Link: 32489527

Variant Present in the following documents:

• mmc1.pdf

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Adjacent mutations in the archaeal Rad50 ABC ATPase D-loop disrupt allosteric regulation of ATP hydrolysis through different mechanisms.

Nucleic Acids Research

Boswell, Zachary K ZK; Canny, Marella D MD; Buschmann, Tanner A TA; Sang, Julie J; Latham, Michael P MP

Publication Date: 2020-03-18

Variant appearance in text: ATM: R805E

PubMed Link: 31889185

Variant Present in the following documents:

• Main text
• gkz1228.pdf

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The ATP-bound conformation of the Mre11-Rad50 complex is essential for Tel1/ATM activation.

Nucleic Acids Research

Cassani, Corinne C; Vertemara, Jacopo J; Bassani, Matteo M; Marsella, Antonio A; Tisi, Renata R; Zampella, Giuseppe G; Longhese, Maria Pia MP

Publication Date: 2019-04-23

Variant appearance in text: ATM: R805E

PubMed Link: 30698745

Variant Present in the following documents:

• Main text
• gkz038.pdf

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A dynamic allosteric pathway underlies Rad50 ABC ATPase function in DNA repair.

Scientific Reports

Boswell, Zachary K ZK; Rahman, Samiur S; Canny, Marella D MD; Latham, Michael P MP

Publication Date: 2018-01-26

Variant appearance in text: ATM: R805E

PubMed Link: 29374232

Variant Present in the following documents:

• 41598_2018_Article_19908.pdf

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Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair.

Progress In Biophysics And Molecular Biology

Lafrance-Vanasse, Julien J; Williams, Gareth J GJ; Tainer, John A JA

Publication Date: 2015-03

Variant appearance in text: ATM: R805E

PubMed Link: 25576492

Variant Present in the following documents:

• Main text

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ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.

The Embo Journal

Deshpande, Rajashree A RA; Williams, Gareth J GJ; Limbo, Oliver O; Williams, R Scott RS; Kuhnlein, Jeff J; Lee, Ji-Hoon JH; Classen, Scott S; Guenther, Grant G; Russell, Paul P; Tainer, John A JA; Paull, Tanya T TT

Publication Date: 2014-03-03

Variant appearance in text: ATM: R805E

PubMed Link: 24493214

Variant Present in the following documents:

• Main text

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