ATM c.5959T>G ;(p.S1987A)

Variant ID: 11-108183178-T-G

NM_000051.3(ATM):c.5959T>G;(p.S1987A)

This variant was identified in 12 publications

View GRCh38 version.




Publications:


The Cancer-Associated ATM R3008H Mutation Reveals the Link between ATM Activation and Its Exchange.

Cancer Research
Milanovic, Maja M; Houghton, Lisa M LM; Menolfi, Demis D; Lee, Ji-Hoon JH; Yamamoto, Kenta K; Li, Yang Y; Lee, Brian J BJ; Xu, Jun J; Estes, Verna M VM; Wang, Dong D; Mckinnon, Peter J PJ; Paull, Tanya T TT; Zha, Shan S
Publication Date: 2021-01-15

Variant appearance in text: ATM: S1987A
PubMed Link: 33239428
Variant Present in the following documents:
  • Main text
View BVdb publication page



ATM, ATR and DNA-PKcs kinases-the lessons from the mouse models: inhibition ≠ deletion.

Cell & Bioscience
Menolfi, Demis D; Zha, Shan S
Publication Date: 2020

Variant appearance in text: ATM: S1987A
PubMed Link: 32015826
Variant Present in the following documents:
  • Main text
  • 13578_2020_Article_376.pdf
View BVdb publication page



Breaking up with ATM.

Journal Of Immunological Sciences
Adamowicz, Marek M
Publication Date: 2018-01

Variant appearance in text: ATM: S1987A
PubMed Link: 29652413
Variant Present in the following documents:
  • Main text
  • emss-76340.pdf
View BVdb publication page



Regulation of the DNA Damage Response by DNA-PKcs Inhibitory Phosphorylation of ATM.

Molecular Cell
Zhou, Yi Y; Lee, Ji-Hoon JH; Jiang, Wenxia W; Crowe, Jennie L JL; Zha, Shan S; Paull, Tanya T TT
Publication Date: 2017-01-05

Variant appearance in text: ATM: S1987A
PubMed Link: 27939942
Variant Present in the following documents:
  • Main text
View BVdb publication page



Multifunctional role of ATM/Tel1 kinase in genome stability: from the DNA damage response to telomere maintenance.

Biomed Research International
Di Domenico, Enea Gino EG; Romano, Elena E; Del Porto, Paola P; Ascenzioni, Fiorentina F
Publication Date: 2014

Variant appearance in text: ATM: S1987A
PubMed Link: 25247188
Variant Present in the following documents:
  • Main text
View BVdb publication page



Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice.

The Journal Of Cell Biology
Yamamoto, Kenta K; Wang, Yunyue Y; Jiang, Wenxia W; Liu, Xiangyu X; Dubois, Richard L RL; Lin, Chyuan-Sheng CS; Ludwig, Thomas T; Bakkenist, Christopher J CJ; Zha, Shan S
Publication Date: 2012-08-06

Variant appearance in text: ATM: S1987A
PubMed Link: 22869596
Variant Present in the following documents:
  • Main text
  • JCB_201204098.pdf
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Autophosphorylation and ATM activation: additional sites add to the complexity.

The Journal Of Biological Chemistry
Kozlov, Sergei V SV; Graham, Mark E ME; Jakob, Burkhard B; Tobias, Frank F; Kijas, Amanda W AW; Tanuji, Marcel M; Chen, Philip P; Robinson, Phillip J PJ; Taucher-Scholz, Gisela G; Suzuki, Keiji K; So, Sairai S; Chen, David D; Lavin, Martin F MF
Publication Date: 2011-03-18

Variant appearance in text: ATM: S1987A
PubMed Link: 21149446
Variant Present in the following documents:
  • Main text
View BVdb publication page



Multiple roles of ATM in monitoring and maintaining DNA integrity.

Febs Letters
Derheimer, Frederick A FA; Kastan, Michael B MB
Publication Date: 2010-09-10

Variant appearance in text: ATM: S1987A
PubMed Link: 20580718
Variant Present in the following documents:
  • Main text
View BVdb publication page



Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks.

Cell Cycle (Georgetown, Tex.)
Davis, Anthony J AJ; So, Sairei S; Chen, David J DJ
Publication Date: 2010-07-01

Variant appearance in text: ATM: S1987A
PubMed Link: 20543558
Variant Present in the following documents:
  • Main text
View BVdb publication page



Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.

The Journal Of Cell Biology
So, Sairei S; Davis, Anthony J AJ; Chen, David J DJ
Publication Date: 2009-12-28

Variant appearance in text: ATM: S1987A
PubMed Link: 20026654
Variant Present in the following documents:
  • Main text
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Activation of ATM depends on chromatin interactions occurring before induction of DNA damage.

Nature Cell Biology
Kim, Yong-Chul YC; Gerlitz, Gabi G; Furusawa, Takashi T; Catez, Frédéric F; Nussenzweig, Andre A; Oh, Kyu-Seon KS; Kraemer, Kenneth H KH; Shiloh, Yosef Y; Bustin, Michael M
Publication Date: 2009-01

Variant appearance in text: ATM: S1987A
PubMed Link: 19079244
Variant Present in the following documents:
  • Main text
  • nihms75763.pdf
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Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.

The Journal Of Cell Biology
Daniel, Jeremy A JA; Pellegrini, Manuela M; Lee, Ji-Hoon JH; Paull, Tanya T TT; Feigenbaum, Lionel L; Nussenzweig, André A
Publication Date: 2008-12-01

Variant appearance in text: ATM: S1987A
PubMed Link: 19047460
Variant Present in the following documents:
  • Main text
View BVdb publication page