Publications:

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Ancient medicinal plant rosemary contains a highly efficacious and isoform-selective KCNQ potassium channel opener.

Communications Biology

Manville, Rían W RW; Hogenkamp, Derk D; Abbott, Geoffrey W GW

Publication Date: 2023-06-15

Variant appearance in text: KCNQ1: R243A

PubMed Link: 37322081

Variant Present in the following documents:

• 42003_2023_5021_MOESM2_ESM.pdf

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A PIP2 substitute mediates voltage sensor-pore coupling in KCNQ activation.

Communications Biology

Liu, Yongfeng Y; Xu, Xianjin X; Gao, Junyuan J; Naffaa, Moawiah M MM; Liang, Hongwu H; Shi, Jingyi J; Wang, Hong Zhan HZ; Yang, Nien-Du ND; Hou, Panpan P; Zhao, Wenshan W; White, Kelli McFarland KM; Kong, Wenjuan W; Dou, Alex A; Cui, Amy A; Zhang, Guohui G; Cohen, Ira S IS; Zou, Xiaoqin X; Cui, Jianmin J

Publication Date: 2020-07-16

Variant appearance in text: KCNQ1: R243A

PubMed Link: 32678288

Variant Present in the following documents:

• 42003_2020_1104_MOESM2_ESM.xlsx, sheet 1

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The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator.

Communications Biology

Redford, Kaitlyn E KE; Abbott, Geoffrey W GW

Publication Date: 2020-07-08

Variant appearance in text: KCNQ1: R243A

PubMed Link: 32641720

Variant Present in the following documents:

• Main text
• 42003_2020_1089_MOESM1_ESM.pdf
• 42003_2020_Article_1089.pdf

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Cilantro leaf harbors a potent potassium channel-activating anticonvulsant.

Faseb Journal : Official Publication Of The Federation Of American Societies For Experimental Biology

Manville, Rían W RW; Abbott, Geoffrey W GW

Publication Date: 2019-10

Variant appearance in text: KCNQ1: R243A

PubMed Link: 31311306

Variant Present in the following documents:

• Main text

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Deconstruction of an African folk medicine uncovers a novel molecular strategy for therapeutic potassium channel activation.

Science Advances

De Silva, Angele M AM; Manville, Rían W RW; Abbott, Geoffrey W GW

Publication Date: 2018-11

Variant appearance in text: KCNQ1: R243A

PubMed Link: 30443601

Variant Present in the following documents:

• Main text
• aav0824.pdf
• aav0824_SM.pdf

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KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Osteen, Jeremiah D JD; Gonzalez, Carlos C; Sampson, Kevin J KJ; Iyer, Vivek V; Rebolledo, Santiago S; Larsson, H Peter HP; Kass, Robert S RS

Publication Date: 2010-12-28

Variant appearance in text: KCNQ1: R243A

PubMed Link: 21149716

Variant Present in the following documents:

• Main text

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Voltage-dependent C-type inactivation in a constitutively open K+ channel.

Biophysical Journal

Panaghie, Gianina G; Purtell, Kerry K; Tai, Kwok-Keung KK; Abbott, Geoffrey W GW

Publication Date: 2008-09-15

Variant appearance in text: KCNQ1: R243A

PubMed Link: 18567635

Variant Present in the following documents:

• Main text

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The role of S4 charges in voltage-dependent and voltage-independent KCNQ1 potassium channel complexes.

The Journal Of General Physiology

Panaghie, Gianina G; Abbott, Geoffrey W GW

Publication Date: 2007-02

Variant appearance in text: KCNQ1: R243A

PubMed Link: 17227916

Variant Present in the following documents:

• Main text
• jgp1290121.pdf

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