Publications:

An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.

Molecular Pharmacology

Yang, Tao T; Smith, Jarrod A JA; Leake, Brenda F BF; Sanders, Charles R CR; Meiler, Jens J; Roden, Dan M DM

Publication Date: 2013-02

Variant appearance in text: KCNQ1: L250A

PubMed Link: 23193163

Variant Present in the following documents:

• Main text

View BVdb publication page

Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.

Biophysical Journal

Ma, Li-Juan LJ; Ohmert, Iris I; Vardanyan, Vitya V

Publication Date: 2011-02-16

Variant appearance in text: KCNQ1: L250A

PubMed Link: 21320432

Variant Present in the following documents:

• Main text

View BVdb publication page

The S4-S5 linker of KCNQ1 channels forms a structural scaffold with the S6 segment controlling gate closure.

The Journal Of Biological Chemistry

Labro, Alain J AJ; Boulet, Inge R IR; Choveau, Frank S FS; Mayeur, Evy E; Bruyns, Tine T; Loussouarn, Gildas G; Raes, Adam L AL; Snyders, Dirk J DJ

Publication Date: 2011-01-07

Variant appearance in text: KCNQ1: L250A

PubMed Link: 21059661

Variant Present in the following documents:

• Main text

View BVdb publication page