Publications:

---

Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.

Nature Communications

Willegems, Katrien K; Eldstrom, Jodene J; Kyriakis, Efthimios E; Ataei, Fariba F; Sahakyan, Harutyun H; Dou, Ying Y; Russo, Sophia S; Van Petegem, Filip F; Fedida, David D

Publication Date: 2022-06-29

Variant appearance in text: KCNQ1: F332A

PubMed Link: 35768468

Variant Present in the following documents:

• Main text
• 41467_2022_Article_31526.pdf

View BVdb publication page

---

ML277 regulates KCNQ1 single-channel amplitudes and kinetics, modified by voltage sensor state.

The Journal Of General Physiology

Eldstrom, Jodene J; McAfee, Donald A DA; Dou, Ying Y; Wang, Yundi Y; Fedida, David D

Publication Date: 2021-12-06

Variant appearance in text: KCNQ1: F332A

PubMed Link: 34636894

Variant Present in the following documents:

• Main text
• JGP_202112969.pdf

View BVdb publication page

---

Probing binding sites and mechanisms of action of an I(Ks) activator by computations and experiments.

Biophysical Journal

Xu, Yu Y; Wang, Yuhong Y; Zhang, Mei M; Jiang, Min M; Rosenhouse-Dantsker, Avia A; Wassenaar, Tsjerk T; Tseng, Gea-Ny GN

Publication Date: 2015-01-06

Variant appearance in text: KCNQ1: F332A

PubMed Link: 25564853

Variant Present in the following documents:

• Main text

View BVdb publication page

---

An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.

Molecular Pharmacology

Yang, Tao T; Smith, Jarrod A JA; Leake, Brenda F BF; Sanders, Charles R CR; Meiler, Jens J; Roden, Dan M DM

Publication Date: 2013-02

Variant appearance in text: KCNQ1: F332A

PubMed Link: 23193163

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.

Biophysical Journal

Ma, Li-Juan LJ; Ohmert, Iris I; Vardanyan, Vitya V

Publication Date: 2011-02-16

Variant appearance in text: KCNQ1: F332A

PubMed Link: 21320432

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Ginsenoside Rg3 enhances large conductance Ca2+-activated potassium channel currents: a role of Tyr360 residue.

Molecules And Cells

Choi, Sun-Hye SH; Shin, Tae-Joon TJ; Lee, Byung-Hwan BH; Hwang, Sung Hee SH; Lee, Sang-Mok SM; Lee, Byung-Cheol BC; Park, Cheol-Seung CS; Ha, Tal Soo TS; Nah, Seung-Yeol SY

Publication Date: 2011-02

Variant appearance in text: KCNQ1: F332A

PubMed Link: 21191818

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Mutation of colocalized residues of the pore helix and transmembrane segments S5 and S6 disrupt deactivation and modify inactivation of KCNQ1 K+ channels.

The Journal Of Physiology

Seebohm, Guiscard G; Westenskow, Peter P; Lang, Florian F; Sanguinetti, Michael C MC

Publication Date: 2005-03-01

Variant appearance in text: KCNQ1: F332A

PubMed Link: 15649981

Variant Present in the following documents:

• Main text

View BVdb publication page

---

Tight coupling of rubidium conductance and inactivation in human KCNQ1 potassium channels.

The Journal Of Physiology

Seebohm, Guiscard G; Sanguinetti, Michael C MC; Pusch, Michael M

Publication Date: 2003-10-15

Variant appearance in text: KCNQ1: F332A

PubMed Link: 14561821

Variant Present in the following documents:

• Main text

View BVdb publication page

---