Publications:

Structural and electrophysiological basis for the modulation of KCNQ1 channel currents by ML277.

Nature Communications

Willegems, Katrien K; Eldstrom, Jodene J; Kyriakis, Efthimios E; Ataei, Fariba F; Sahakyan, Harutyun H; Dou, Ying Y; Russo, Sophia S; Van Petegem, Filip F; Fedida, David D

Publication Date: 2022-06-29

Variant appearance in text: KCNQ1: S338A

PubMed Link: 35768468

Variant Present in the following documents:

• Main text
• 41467_2022_Article_31526.pdf
• 41467_2022_31526_MOESM1_ESM.pdf
• 41467_2022_31526_MOESM2_ESM.pdf

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An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.

Molecular Pharmacology

Yang, Tao T; Smith, Jarrod A JA; Leake, Brenda F BF; Sanders, Charles R CR; Meiler, Jens J; Roden, Dan M DM

Publication Date: 2013-02

Variant appearance in text: KCNQ1: S338A

PubMed Link: 23193163

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Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.

Biophysical Journal

Ma, Li-Juan LJ; Ohmert, Iris I; Vardanyan, Vitya V

Publication Date: 2011-02-16

Variant appearance in text: KCNQ1: S338A

PubMed Link: 21320432

Variant Present in the following documents:

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AMP-activated protein kinase inhibits KCNQ1 channels through regulation of the ubiquitin ligase Nedd4-2 in renal epithelial cells.

American Journal Of Physiology. Renal Physiology

Alzamora, Rodrigo R; Gong, Fan F; Rondanino, Christine C; Lee, Jeffrey K JK; Smolak, Christy C; Pastor-Soler, Núria M NM; Hallows, Kenneth R KR

Publication Date: 2010-12

Variant appearance in text: KCNQ1: S338A

PubMed Link: 20861072

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Desensitization of chemical activation by auxiliary subunits: convergence of molecular determinants critical for augmenting KCNQ1 potassium channels.

The Journal Of Biological Chemistry

Gao, Zhaobing Z; Xiong, Qiaojie Q; Sun, Haiyan H; Li, Min M

Publication Date: 2008-08-15

Variant appearance in text: KCNQ1: S338A

PubMed Link: 18490447

Variant Present in the following documents:

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