Publications:

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Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements.

Frontiers In Physiology

Chen, Lei L; Peng, Gary G; Comollo, Thomas W TW; Zou, Xinle X; Sampson, Kevin J KJ; Larsson, H Peter HP; Kass, Robert S RS

Publication Date: 2022

Variant appearance in text: KCNQ1: F340A

PubMed Link: 35957984

Variant Present in the following documents:

• Main text
• fphys-13-903050.pdf

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Two-stage electro-mechanical coupling of a KV channel in voltage-dependent activation.

Nature Communications

Hou, Panpan P; Kang, Po Wei PW; Kongmeneck, Audrey Deyawe AD; Yang, Nien-Du ND; Liu, Yongfeng Y; Shi, Jingyi J; Xu, Xianjin X; White, Kelli McFarland KM; Zaydman, Mark A MA; Kasimova, Marina A MA; Seebohm, Guiscard G; Zhong, Ling L; Zou, Xiaoqin X; Tarek, Mounir M; Cui, Jianmin J

Publication Date: 2020-02-03

Variant appearance in text: Kv7.1: F340A

PubMed Link: 32015334

Variant Present in the following documents:

• 41467_2020_Article_14406.pdf

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Effects of protein-protein interactions and ligand binding on the ion permeation in KCNQ1 potassium channel.

Plos One

Jalily Hasani, Horia H; Ganesan, Aravindhan A; Ahmed, Marawan M; Barakat, Khaled H KH

Publication Date: 2018

Variant appearance in text: KCNQ1: Phe340Ala

PubMed Link: 29444113

Variant Present in the following documents:

• Main text
• pone.0191905.pdf

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KCNE1 and KCNE3 modulate KCNQ1 channels by affecting different gating transitions.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Barro-Soria, Rene R; Ramentol, Rosamary R; Liin, Sara I SI; Perez, Marta E ME; Kass, Robert S RS; Larsson, H Peter HP

Publication Date: 2017-08-29

Variant appearance in text: KCNQ1: F340A

PubMed Link: 28808020

Variant Present in the following documents:

• Main text

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Enhanced effects of isoflurane on the long QT syndrome 1-associated A341V mutant.

Anesthesiology

Mikuni, Ikuomi I; Torres, Carlos G CG; Bakshi, Tania T; Tampo, Akihito A; Carlson, Brian E BE; Bienengraeber, Martin W MW; Kwok, Wai-Meng WM

Publication Date: 2015-04

Variant appearance in text: KCNQ1: F340A

PubMed Link: 25585005

Variant Present in the following documents:

• Main text

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An allosteric mechanism for drug block of the human cardiac potassium channel KCNQ1.

Molecular Pharmacology

Yang, Tao T; Smith, Jarrod A JA; Leake, Brenda F BF; Sanders, Charles R CR; Meiler, Jens J; Roden, Dan M DM

Publication Date: 2013-02

Variant appearance in text: KCNQ1: F340A

PubMed Link: 23193163

Variant Present in the following documents:

• Main text

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Allosteric features of KCNQ1 gating revealed by alanine scanning mutagenesis.

Biophysical Journal

Ma, Li-Juan LJ; Ohmert, Iris I; Vardanyan, Vitya V

Publication Date: 2011-02-16

Variant appearance in text: KCNQ1: F340A

PubMed Link: 21320432

Variant Present in the following documents:

• Main text

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