HRAS c.175G>A ;(p.A59T)

Variant ID: 11-533881-C-T

NM_005343.2(HRAS):c.175G>A;(p.A59T)

This variant was identified in 47 publications

View GRCh38 version.




Publications:


Alteration in molecular properties during establishment and passaging of endometrial carcinoma patient-derived xenografts.

Scientific Reports
Imai, Toshio T; Yoshida, Hiroshi H; Machida, Yukino Y; Kuramochi, Mizuki M; Ichikawa, Hitoshi H; Kubo, Takashi T; Takahashi, Mami M; Kato, Tomoyasu T
Publication Date: 2023-05-25

Variant appearance in text: HRAS: A59T
PubMed Link: 37231035
Variant Present in the following documents:
  • 41598_2023_35703_MOESM1_ESM.pdf
View BVdb publication page



Spatial transcriptomics reveal topological immune landscapes of Asian head and neck angiosarcoma.

Communications Biology
Loh, Jui Wan JW; Lee, Jing Yi JY; Lim, Abner Herbert AH; Guan, Peiyong P; Lim, Boon Yee BY; Kannan, Bavani B; Lee, Elizabeth Chun Yong ECY; Gu, Ning Xin NX; Ko, Tun Kiat TK; Ng, Cedric Chuan-Young CC; Lim, Jeffrey Chun Tatt JCT; Yeong, Joe J; Lim, Jing Quan JQ; Ong, Choon Kiat CK; Teh, Bin Tean BT; Chan, Jason Yongsheng JY
Publication Date: 2023-04-27

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 37106027
Variant Present in the following documents:
  • 42003_2023_4856_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: HRAS: 175G>A; Ala59Thr
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: HRAS: A59T
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
View BVdb publication page



IntegralVac: A Machine Learning-Based Comprehensive Multivalent Epitope Vaccine Design Method.

Vaccines
Suri, Sadhana S; Dakshanamurthy, Sivanesan S
Publication Date: 2022-10-08

Variant appearance in text: HRAS: A59T
PubMed Link: 36298543
Variant Present in the following documents:
  • Main text
  • vaccines-10-01678.pdf
View BVdb publication page



The mutational landscape of cancer's vulnerability to ionizing radiation.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Gopal, Priyanka P; Yard, Brian D BD; Petty, Aaron A; Lal, Jessica C JC; Bera, Titas K TK; Hoang, Trung Q TQ; Buhimschi, Alexandru B AB; Abazeed, Mohamed E ME
Publication Date: 2022-10-12

Variant appearance in text: HRAS: A59T
PubMed Link: 36222846
Variant Present in the following documents:
  • ccr-22-1914_supplementary_data_3_suppds3.xlsx, sheet 1
  • ccr-22-1914_supplementary_data_2_suppds2.xlsx, sheet 1
View BVdb publication page



Clinical genomic profiling in the management of patients with soft tissue and bone sarcoma.

Nature Communications
Gounder, Mrinal M MM; Agaram, Narasimhan P NP; Trabucco, Sally E SE; Robinson, Victoria V; Ferraro, Richard A RA; Millis, Sherri Z SZ; Krishnan, Anita A; Lee, Jessica J; Attia, Steven S; Abida, Wassim W; Drilon, Alexander A; Chi, Ping P; Angelo, Sandra P D' SP; Dickson, Mark A MA; Keohan, Mary Lou ML; Kelly, Ciara M CM; Agulnik, Mark M; Chawla, Sant P SP; Choy, Edwin E; Chugh, Rashmi R; Meyer, Christian F CF; Myer, Parvathi A PA; Moore, Jessica L JL; Okimoto, Ross A RA; Pollock, Raphael E RE; Ravi, Vinod V; Singh, Arun S AS; Somaiah, Neeta N; Wagner, Andrew J AJ; Healey, John H JH; Frampton, Garrett M GM; Venstrom, Jeffrey M JM; Ross, Jeffrey S JS; Ladanyi, Marc M; Singer, Samuel S; Brennan, Murray F MF; Schwartz, Gary K GK; Lazar, Alexander J AJ; Thomas, David M DM; Maki, Robert G RG; Tap, William D WD; Ali, Siraj M SM; Jin, Dexter X DX
Publication Date: 2022-06-15

Variant appearance in text: HRAS: A59T
PubMed Link: 35705558
Variant Present in the following documents:
  • 41467_2022_30496_MOESM2_ESM.xls, sheet 1
View BVdb publication page



Molecular landscape and therapeutic alterations in Asian soft-tissue sarcoma patients.

Cancer Medicine
Gan, Meifu M; Zhang, Chen C; Qiu, Liqing L; Wang, Yue Y; Bao, Hua H; Yu, Ruoying R; Liu, Rui R; Wu, Xue X; Shao, Yang Y; Hou, Peifeng P; Fei, Zhenglei Z
Publication Date: 2022-11

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 35586877
Variant Present in the following documents:
  • CAM4-11-4070-s004.xlsx, sheet 1
View BVdb publication page



Recurrent Alterations in the MAPK pathway in Sporadic Pyogenic Granuloma of Childhood.

Acta Dermato-Venereologica
Strobel, Katharina K; Maurus, Katja K; Hamm, Henning H; Roth, Sabine S; Goebeler, Matthias M; Rosenwald, Andreas A; Wobser, Marion M
Publication Date: 2022-05-19

Variant appearance in text: HRAS: 175G>A; Ala59Thr
PubMed Link: 35393626
Variant Present in the following documents:
  • Main text
  • ActaDV-102-1119.pdf
View BVdb publication page



Base editing sensor libraries for high-throughput engineering and functional analysis of cancer-associated single nucleotide variants.

Nature Biotechnology
Sánchez-Rivera, Francisco J FJ; Diaz, Bianca J BJ; Kastenhuber, Edward R ER; Schmidt, Henri H; Katti, Alyna A; Kennedy, Margaret M; Tem, Vincent V; Ho, Yu-Jui YJ; Leibold, Josef J; Paffenholz, Stella V SV; Barriga, Francisco M FM; Chu, Kevan K; Goswami, Sukanya S; Wuest, Alexandra N AN; Simon, Janelle M JM; Tsanov, Kaloyan M KM; Chakravarty, Debyani D; Zhang, Hongxin H; Leslie, Christina S CS; Lowe, Scott W SW; Dow, Lukas E LE
Publication Date: 2022-06

Variant appearance in text: HRAS: A59T
PubMed Link: 35165384
Variant Present in the following documents:
  • NIHMS1760571-supplement-Supplementary_Table_S2.xlsx, sheet 4
  • NIHMS1760571-supplement-Supplementary_Table_S7.xlsx, sheet 5
  • NIHMS1760571-supplement-Supplementary_Table_S2.xlsx, sheet 6
View BVdb publication page



A New Epitope Selection Method: Application to Design a Multi-Valent Epitope Vaccine Targeting HRAS Oncogene in Squamous Cell Carcinoma.

Vaccines
Savsani, Kush K; Jabbour, Gabriel G; Dakshanamurthy, Sivanesan S
Publication Date: 2021-12-31

Variant appearance in text: HRAS: A59T
PubMed Link: 35062725
Variant Present in the following documents:
  • Main text
  • vaccines-10-00063.pdf
View BVdb publication page



A New Epitope Selection Method: Application to Design a Multi-Valent Epitope Vaccine Targeting HRAS Oncogene in Squamous Cell Carcinoma.

Vaccines
Savsani, Kush K; Jabbour, Gabriel G; Dakshanamurthy, Sivanesan S
Publication Date: 2021-12-31

Variant appearance in text: HRAS: A59T
PubMed Link: 35062725
Variant Present in the following documents:
  • Main text
  • vaccines-10-00063.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: HRAS: A59T
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Mitogen-activated protein kinase activity drives cell trajectories in colorectal cancer.

Embo Molecular Medicine
Uhlitz, Florian F; Bischoff, Philip P; Peidli, Stefan S; Sieber, Anja A; Trinks, Alexandra A; Lüthen, Mareen M; Obermayer, Benedikt B; Blanc, Eric E; Ruchiy, Yana Y; Sell, Thomas T; Mamlouk, Soulafa S; Arsie, Roberto R; Wei, Tzu-Ting TT; Klotz-Noack, Kathleen K; Schwarz, Roland F RF; Sawitzki, Birgit B; Kamphues, Carsten C; Beule, Dieter D; Landthaler, Markus M; Sers, Christine C; Horst, David D; Blüthgen, Nils N; Morkel, Markus M
Publication Date: 2021-10-07

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 34409732
Variant Present in the following documents:
  • EMMM-13-e14123-s009.xls, sheet 1
View BVdb publication page



The landscape of driver mutations in cutaneous squamous cell carcinoma.

Npj Genomic Medicine
Chang, Darwin D; Shain, A Hunter AH
Publication Date: 2021-07-16

Variant appearance in text: HRAS: A59T
PubMed Link: 34272401
Variant Present in the following documents:
  • 41525_2021_226_MOESM5_ESM.xlsx, sheet 1
View BVdb publication page



Improvement of Neoantigen Identification Through Convolution Neural Network.

Frontiers In Immunology
Hao, Qing Q; Wei, Ping P; Shu, Yang Y; Zhang, Yi-Guan YG; Xu, Heng H; Zhao, Jun-Ning JN
Publication Date: 2021

Variant appearance in text: HRAS: A59T
PubMed Link: 34113354
Variant Present in the following documents:
  • Table_1.xlsx, sheet 31
View BVdb publication page



Spatially interacting phosphorylation sites and mutations in cancer.

Nature Communications
Huang, Kuan-Lin KL; Scott, Adam D AD; Zhou, Daniel Cui DC; Wang, Liang-Bo LB; Weerasinghe, Amila A; Elmas, Abdulkadir A; Liu, Ruiyang R; Wu, Yige Y; Wendl, Michael C MC; Wyczalkowski, Matthew A MA; Baral, Jessika J; Sengupta, Sohini S; Lai, Chin-Wen CW; Ruggles, Kelly K; Payne, Samuel H SH; Raphael, Benjamin B; Fenyö, David D; Chen, Ken K; Mills, Gordon G; Ding, Li L
Publication Date: 2021-04-19

Variant appearance in text: HRAS: A59T
PubMed Link: 33875650
Variant Present in the following documents:
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 1
  • 41467_2021_22481_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications
Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q
Publication Date: 2021-01-04

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 33397889
Variant Present in the following documents:
  • 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports
Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA
Publication Date: 2020-09-21

Variant appearance in text: HRAS: A59T
PubMed Link: 32958805
Variant Present in the following documents:
  • 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



Clinical Application of Targeted Deep Sequencing in Metastatic Colorectal Cancer Patients: Actionable Genomic Alteration in K-MASTER Project.

Cancer Research And Treatment
Lee, Youngwoo Y; Lee, Soohyeon S; Sung, Jae Sook JS; Chung, Hee-Joon HJ; Lim, Ah-Reum AR; Kim, Ju Won JW; Choi, Yoon Ji YJ; Park, Kyong Hwa KH; Kim, Yeul Hong YH
Publication Date: 2021-01

Variant appearance in text: HRAS: A59T
PubMed Link: 32810930
Variant Present in the following documents:
  • crt-2020-559-suppl3.pdf
View BVdb publication page



The effects of mutant Ras proteins on the cell signalome.

Cancer Metastasis Reviews
Takács, Tamás T; Kudlik, Gyöngyi G; Kurilla, Anita A; Szeder, Bálint B; Buday, László L; Vas, Virag V
Publication Date: 2020-12

Variant appearance in text: HRAS: A59T
PubMed Link: 32648136
Variant Present in the following documents:
  • 10555_2020_Article_9912.pdf
View BVdb publication page



Angiosarcoma heterogeneity and potential therapeutic vulnerability to immune checkpoint blockade: insights from genomic sequencing.

Genome Medicine
Boichard, Amélie A; Wagner, Michael J MJ; Kurzrock, Razelle R
Publication Date: 2020-07-09

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 32646514
Variant Present in the following documents:
  • 13073_2020_753_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: HRAS: A59T
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Genetic Profiling of Advanced Melanoma: Candidate Mutations for Predicting Sensitivity and Resistance to Targeted Therapy.

Targeted Oncology
Olbryt, Magdalena M; Pigłowski, Wojciech W; Rajczykowski, Marcin M; Pfeifer, Aleksandra A; Student, Sebastian S; Fiszer-Kierzkowska, Anna A
Publication Date: 2020-02

Variant appearance in text: HRAS: 175G>A; Ala59Thr
PubMed Link: 31980996
Variant Present in the following documents:
  • 11523_2020_Article_695.pdf
  • 11523_2020_695_MOESM1_ESM.pdf
View BVdb publication page



Diversity spectrum analysis identifies mutation-specific effects of cancer driver genes.

Communications Biology
Dong, Xiaobao X; Huang, Dandan D; Yi, Xianfu X; Zhang, Shijie S; Wang, Zhao Z; Yan, Bin B; Chung Sham, Pak P; Chen, Kexin K; Jun Li, Mulin M
Publication Date: 2020-01-07

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 31925297
Variant Present in the following documents:
  • 42003_2019_736_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Comparative analysis of functional assay evidence use by ClinGen Variant Curation Expert Panels.

Genome Medicine
Kanavy, Dona M DM; McNulty, Shannon M SM; Jairath, Meera K MK; Brnich, Sarah E SE; Bizon, Chris C; Powell, Bradford C BC; Berg, Jonathan S JS
Publication Date: 2019-11-29

Variant appearance in text: HRAS: 175G>A; Ala59Thr
PubMed Link: 31783775
Variant Present in the following documents:
  • 13073_2019_683_MOESM2_ESM.xlsx, sheet 12
View BVdb publication page



Development and validation of a targeted gene sequencing panel for application to disparate cancers.

Scientific Reports
McCabe, Mark J MJ; Gauthier, Marie-Emilie A MA; Chan, Chia-Ling CL; Thompson, Tanya J TJ; De Sousa, Sunita M C SMC; Puttick, Clare C; Grady, John P JP; Gayevskiy, Velimir V; Tao, Jiang J; Ying, Kevin K; Cipponi, Arcadi A; Deng, Niantao N; Swarbrick, Alex A; Thomas, Melissa L ML; Lord, Reginald V RV; Johns, Amber L AL; Kohonen-Corish, Maija M; O'Toole, Sandra A SA; Clark, Jonathan J; Mueller, Simon A SA; Gupta, Ruta R; McCormack, Ann I AI; Dinger, Marcel E ME; Cowley, Mark J MJ; ,
Publication Date: 2019-11-19

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 31745186
Variant Present in the following documents:
  • 41598_2019_52000_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology
Muñoz-Maldonado, Carmen C; Zimmer, Yitzhak Y; Medová, Michaela M
Publication Date: 2019

Variant appearance in text: HRAS: A59T
PubMed Link: 31681616
Variant Present in the following documents:
  • Main text
  • fonc-09-01088.pdf
View BVdb publication page



Activating Mutations of RRAS2 Are a Rare Cause of Noonan Syndrome.

American Journal Of Human Genetics
Capri, Yline Y; Flex, Elisabetta E; Krumbach, Oliver H F OHF; Carpentieri, Giovanna G; Cecchetti, Serena S; Lißewski, Christina C; Rezaei Adariani, Soheila S; Schanze, Denny D; Brinkmann, Julia J; Piard, Juliette J; Pantaleoni, Francesca F; Lepri, Francesca R FR; Goh, Elaine Suk-Ying ES; Chong, Karen K; Stieglitz, Elliot E; Meyer, Julia J; Kuechler, Alma A; Bramswig, Nuria C NC; Sacharow, Stephanie S; Strullu, Marion M; Vial, Yoann Y; Vignal, Cédric C; Kensah, George G; Cuturilo, Goran G; Kazemein Jasemi, Neda S NS; Dvorsky, Radovan R; Monaghan, Kristin G KG; Vincent, Lisa M LM; Cavé, Hélène H; Verloes, Alain A; Ahmadian, Mohammad R MR; Tartaglia, Marco M; Zenker, Martin M
Publication Date: 2019-06-06

Variant appearance in text: HRAS: Ala59Thr
PubMed Link: 31130282
Variant Present in the following documents:
  • Main text
View BVdb publication page



Validation of the Oncomine™ focus panel for next-generation sequencing of clinical tumour samples.

Virchows Archiv : An International Journal Of Pathology
Williams, Hannah L HL; Walsh, Kathy K; Diamond, Austin A; Oniscu, Anca A; Deans, Zandra C ZC
Publication Date: 2018-10

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 30105577
Variant Present in the following documents:
  • 428_2018_2411_MOESM3_ESM.xlsx, sheet 1
  • 428_2018_2411_MOESM1_ESM.xlsx, sheet 1
  • 428_2018_2411_MOESM1_ESM.xlsx, sheet 4
  • 428_2018_2411_MOESM2_ESM.xlsx, sheet 1
  • 428_2018_2411_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine
Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L
Publication Date: 2018-07-27

Variant appearance in text: HRAS: A59T
PubMed Link: 30053901
Variant Present in the following documents:
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 19
  • 13073_2018_564_MOESM2_ESM.xlsx, sheet 13
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: HRAS: A59T
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 1
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Predictive and Prognostic Implications of Mutation Profiling and Microsatellite Instability Status in Patients with Metastatic Colorectal Carcinoma.

Gastroenterology Research And Practice
Liu, Jianhua J; Zeng, Weiqiang W; Huang, Chengzhi C; Wang, Junjiang J; Yang, Dongyang D; Ma, Dong D
Publication Date: 2018

Variant appearance in text: HRAS: A59T
PubMed Link: 29643917
Variant Present in the following documents:
  • GRP2018-4585802.pdf
View BVdb publication page



NetSig: network-based discovery from cancer genomes.

Nature Methods
Horn, Heiko H; Lawrence, Michael S MS; Chouinard, Candace R CR; Shrestha, Yashaswi Y; Hu, Jessica Xin JX; Worstell, Elizabeth E; Shea, Emily E; Ilic, Nina N; Kim, Eejung E; Kamburov, Atanas A; Kashani, Alireza A; Hahn, William C WC; Campbell, Joshua D JD; Boehm, Jesse S JS; Getz, Gad G; Lage, Kasper K
Publication Date: 2018-01

Variant appearance in text: HRAS: A59T
PubMed Link: 29200198
Variant Present in the following documents:
  • NIHMS918089-supplement-ST5.xlsx, sheet 1
View BVdb publication page



Comprehensive genomic analysis of Oesophageal Squamous Cell Carcinoma reveals clinical relevance.

Scientific Reports
Du, Peina P; Huang, Peide P; Huang, Xuanlin X; Li, Xiangchun X; Feng, Zhimin Z; Li, Fengyu F; Liang, Shaoguang S; Song, Yongmei Y; Stenvang, Jan J; Brünner, Nils N; Yang, Huanming H; Ou, Yunwei Y; Gao, Qiang Q; Li, Lin L
Publication Date: 2017-11-10

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 29127303
Variant Present in the following documents:
  • 41598_2017_14909_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



Genomic characterization of tobacco/nut chewing HPV-negative early stage tongue tumors identify MMP10 asa candidate to predict metastases.

Oral Oncology
Upadhyay, Pawan P; Gardi, Nilesh N; Desai, Sanket S; Chandrani, Pratik P; Joshi, Asim A; Dharavath, Bhaskar B; Arora, Priyanca P; Bal, Munita M; Nair, Sudhir S; Dutt, Amit A
Publication Date: 2017-10

Variant appearance in text: HRAS: A59T; rs727503093
PubMed Link: 28939077
Variant Present in the following documents:
  • mmc3.xlsx, sheet 5
View BVdb publication page



Sources of discordance among germ-line variant classifications in ClinVar.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics
Yang, Shan S; Lincoln, Stephen E SE; Kobayashi, Yuya Y; Nykamp, Keith K; Nussbaum, Robert L RL; Topper, Scott S
Publication Date: 2017-10

Variant appearance in text: HRAS: 175G>A; Ala59Thr
PubMed Link: 28569743
Variant Present in the following documents:
  • gim201760x7.xlsx, sheet 2
View BVdb publication page



Muscle RAS oncogene homolog (MRAS) recurrent mutation in Borrmann type IV gastric cancer.

Cancer Medicine
Yasumoto, Makiko M; Sakamoto, Etsuko E; Ogasawara, Sachiko S; Isobe, Taro T; Kizaki, Junya J; Sumi, Akiko A; Kusano, Hironori H; Akiba, Jun J; Torimura, Takuji T; Akagi, Yoshito Y; Itadani, Hiraku H; Kobayashi, Tsutomu T; Hasako, Shinichi S; Kumazaki, Masafumi M; Mizuarai, Shinji S; Oie, Shinji S; Yano, Hirohisa H
Publication Date: 2017-01

Variant appearance in text: HRAS: A59T
PubMed Link: 27891760
Variant Present in the following documents:
  • Main text
  • CAM4-6-235.pdf
View BVdb publication page



LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Bmc Bioinformatics
Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L
Publication Date: 2016-02-09

Variant appearance in text: HRAS: A59T
PubMed Link: 26860319
Variant Present in the following documents:
  • 12859_2016_935_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Genomic analyses reveal FAM84B and the NOTCH pathway are associated with the progression of esophageal squamous cell carcinoma.

Gigascience
Cheng, Caixia C; Cui, Heyang H; Zhang, Ling L; Jia, Zhiwu Z; Song, Bin B; Wang, Fang F; Li, Yaoping Y; Liu, Jing J; Kong, Pengzhou P; Shi, Ruyi R; Bi, Yanghui Y; Yang, Bin B; Wang, Juan J; Zhao, Zhenxiang Z; Zhang, Yanyan Y; Hu, Xiaoling X; Yang, Jie J; He, Chanting C; Zhao, Zhiping Z; Wang, Jinfen J; Xi, Yanfeng Y; Xu, Enwei E; Li, Guodong G; Guo, Shiping S; Chen, Yunqing Y; Yang, Xiaofeng X; Chen, Xing X; Liang, Jianfang J; Guo, Jiansheng J; Cheng, Xiaolong X; Wang, Chuangui C; Zhan, Qimin Q; Cui, Yongping Y
Publication Date: 2016

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 26759717
Variant Present in the following documents:
  • 13742_2015_107_MOESM11_ESM.xlsx, sheet 1
View BVdb publication page



Overexpression of wildtype EGFR is tumorigenic and denotes a therapeutic target in non-small cell lung cancer.

Oncotarget
Xu, Naiqing N; Fang, Wenfeng W; Mu, Libing L; Tang, Yanna Y; Gao, Lei L; Ren, Shengxiang S; Cao, Dengfeng D; Zhou, Lixin L; Zhang, Aiqun A; Liu, Deruo D; Zhou, Caicun C; Wong, Kwok-Kin KK; Yu, Lei L; Zhang, Li L; Chen, Liang L
Publication Date: 2016-01-26

Variant appearance in text: HRAS: A59T
PubMed Link: 26646697
Variant Present in the following documents:
  • oncotarget-07-3884-s001.pdf
View BVdb publication page



Recurrent inactivating RASA2 mutations in melanoma.

Nature Genetics
Arafeh, Rand R; Qutob, Nouar N; Emmanuel, Rafi R; Keren-Paz, Alona A; Madore, Jason J; Elkahloun, Abdel A; Wilmott, James S JS; Gartner, Jared J JJ; Di Pizio, Antonella A; Winograd-Katz, Sabina S; Sindiri, Sivasish S; Rotkopf, Ron R; Dutton-Regester, Ken K; Johansson, Peter P; Pritchard, Antonia L AL; Waddell, Nicola N; Hill, Victoria K VK; Lin, Jimmy C JC; Hevroni, Yael Y; Rosenberg, Steven A SA; Khan, Javed J; Ben-Dor, Shifra S; Niv, Masha Y MY; Ulitsky, Igor I; Mann, Graham J GJ; Scolyer, Richard A RA; Hayward, Nicholas K NK; Samuels, Yardena Y
Publication Date: 2015-12

Variant appearance in text: HRAS: A59T
PubMed Link: 26502337
Variant Present in the following documents:
  • NIHMS65345-supplement-Supplementary_table_3.xlsx, sheet 2
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Targeted massively parallel sequencing of angiosarcomas reveals frequent activation of the mitogen activated protein kinase pathway.

Oncotarget
Murali, Rajmohan R; Chandramohan, Raghu R; Möller, Inga I; Scholz, Simone L SL; Berger, Michael M; Huberman, Kety K; Viale, Agnes A; Pirun, Mono M; Socci, Nicholas D ND; Bouvier, Nancy N; Bauer, Sebastian S; Artl, Monika M; Schilling, Bastian B; Schimming, Tobias T; Sucker, Antje A; Schwindenhammer, Benjamin B; Grabellus, Florian F; Speicher, Michael R MR; Schaller, Jörg J; Hillen, Uwe U; Schadendorf, Dirk D; Mentzel, Thomas T; Cheng, Donavan T DT; Wiesner, Thomas T; Griewank, Klaus G KG
Publication Date: 2015-11-03

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 26440310
Variant Present in the following documents:
  • Main text
  • oncotarget-06-36041.pdf
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Genomic analyses reveal mutational signatures and frequently altered genes in esophageal squamous cell carcinoma.

American Journal Of Human Genetics
Zhang, Ling L; Zhou, Yong Y; Cheng, Caixia C; Cui, Heyang H; Cheng, Le L; Kong, Pengzhou P; Wang, Jiaqian J; Li, Yin Y; Chen, Wenliang W; Song, Bin B; Wang, Fang F; Jia, Zhiwu Z; Li, Lin L; Li, Yaoping Y; Yang, Bin B; Liu, Jing J; Shi, Ruyi R; Bi, Yanghui Y; Zhang, Yanyan Y; Wang, Juan J; Zhao, Zhenxiang Z; Hu, Xiaoling X; Yang, Jie J; Li, Hongyi H; Gao, Zhibo Z; Chen, Gang G; Huang, Xuanlin X; Yang, Xukui X; Wan, Shengqing S; Chen, Chao C; Li, Bin B; Tan, Yongkai Y; Chen, Longyun L; He, Minghui M; Xie, Sha S; Li, Xiangchun X; Zhuang, Xuehan X; Wang, Mengyao M; Xia, Zhi Z; Luo, Longhai L; Ma, Jie J; Dong, Bing B; Zhao, Jiuzhou J; Song, Yongmei Y; Ou, Yunwei Y; Li, Enming E; Xu, Liyan L; Wang, Jinfen J; Xi, Yanfeng Y; Li, Guodong G; Xu, Enwei E; Liang, Jianfang J; Yang, Xiaofeng X; Guo, Jiansheng J; Chen, Xing X; Zhang, Yanbo Y; Li, Qingshan Q; Liu, Lixin L; Li, Yingrui Y; Zhang, Xiuqing X; Yang, Huanming H; Lin, Dongxin D; Cheng, Xiaolong X; Guo, Yongjun Y; Wang, Jun J; Zhan, Qimin Q; Cui, Yongping Y
Publication Date: 2015-04-02

Variant appearance in text: HRAS: 175G>A; A59T
PubMed Link: 25839328
Variant Present in the following documents:
  • mmc4.xlsx, sheet 1
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Functional consequences of somatic mutations in cancer using protein pocket-based prioritization approach.

Genome Medicine
Vuong, Huy H; Cheng, Feixiong F; Lin, Chen-Ching CC; Zhao, Zhongming Z
Publication Date: 2014

Variant appearance in text: HRAS: A59T
PubMed Link: 25360158
Variant Present in the following documents:
  • 13073_2014_81_MOESM1_ESM.xlsx, sheet 1
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Age-related mutations associated with clonal hematopoietic expansion and malignancies.

Nature Medicine
Xie, Mingchao M; Lu, Charles C; Wang, Jiayin J; McLellan, Michael D MD; Johnson, Kimberly J KJ; Wendl, Michael C MC; McMichael, Joshua F JF; Schmidt, Heather K HK; Yellapantula, Venkata V; Miller, Christopher A CA; Ozenberger, Bradley A BA; Welch, John S JS; Link, Daniel C DC; Walter, Matthew J MJ; Mardis, Elaine R ER; Dipersio, John F JF; Chen, Feng F; Wilson, Richard K RK; Ley, Timothy J TJ; Ding, Li L
Publication Date: 2014-12

Variant appearance in text: HRAS: A59T
PubMed Link: 25326804
Variant Present in the following documents:
  • NIHMS630249-supplement-5.xlsx, sheet 1
  • NIHMS630249-supplement-6.xlsx, sheet 1
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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research
Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C
Publication Date: 2011-09-01

Variant appearance in text: HRAS: A59T
PubMed Link: 21727090
Variant Present in the following documents:
  • supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1
View BVdb publication page