Murine models of HRAS-mediated cutaneous skeletal hypophosphatemia syndrome suggest bone as the FGF23 excess source.
The Journal Of Clinical Investigation
Ovejero, Diana D; Michel, Zachary Z; Cataisson, Christophe C; Saikali, Amanda A; Galisteo, Rebeca R; Yuspa, Stuart H SH; Collins, Michael T MT; de Castro, Luis F LF
Network expansion of genetic associations defines a pleiotropy map of human cell biology.
Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Targeted and explorative profiling of kallikrein proteases and global proteome biology of pancreatic ductal adenocarcinoma, chronic pancreatitis, and normal pancreas highlights disease-specific proteome remodelling.
Neoplasia (New York, N.Y.)
Werner, Janina J; Bernhard, Patrick P; Cosenza-Contreras, Miguel M; Pinter, Niko N; Fahrner, Matthias M; Pallavi, Prama P; Eberhard, Johannes J; Bronsert, Peter P; Rückert, Felix F; Schilling, Oliver O
The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations.
Nature Cancer
Villani, Anita A; Davidson, Scott S; Kanwar, Nisha N; Lo, Winnie W WW; Li, Yisu Y; Cohen-Gogo, Sarah S; Fuligni, Fabio F; Edward, Lisa-Monique LM; Light, Nicholas N; Layeghifard, Mehdi M; Harripaul, Ricardo R; Waldman, Larissa L; Gallinger, Bailey B; Comitani, Federico F; Brunga, Ledia L; Hayes, Reid R; Anderson, Nathaniel D ND; Ramani, Arun K AK; Yuki, Kyoko E KE; Blay, Sasha S; Johnstone, Brittney B; Inglese, Cara C; Hammad, Rawan R; Goudie, Catherine C; Shuen, Andrew A; Wasserman, Jonathan D JD; Venier, Rosemarie E RE; Eliou, Marianne M; Lorenti, Miranda M; Ryan, Carol Ann CA; Braga, Michael M; Gloven-Brown, Meagan M; Han, Jianan J; Montero, Maria M; Spatare, Famida F; Whitlock, James A JA; Scherer, Stephen W SW; Chun, Kathy K; Somerville, Martin J MJ; Hawkins, Cynthia C; Abdelhaleem, Mohamed M; Ramaswamy, Vijay V; Somers, Gino R GR; Kyriakopoulou, Lianna L; Hitzler, Johann J; Shago, Mary M; Morgenstern, Daniel A DA; Tabori, Uri U; Meyn, Stephen S; Irwin, Meredith S MS; Malkin, David D; Shlien, Adam A
Ras drives malignancy through stem cell crosstalk with the microenvironment.
Nature
Yuan, Shaopeng S; Stewart, Katherine S KS; Yang, Yihao Y; Abdusselamoglu, Merve Deniz MD; Parigi, S Martina SM; Feinberg, Tamar Y TY; Tumaneng, Karen K; Yang, Hanseul H; Levorse, John M JM; Polak, Lisa L; Ng, David D; Fuchs, Elaine E
Molecular Basis and Rationale for the Use of Targeted Agents and Immunotherapy in Sinonasal Cancers.
Journal Of Clinical Medicine
Esposito, Andrea A; Stucchi, Erika E; Baronchelli, Maria M; Di Mauro, Pierluigi P; Ferrari, Marco M; Lorini, Luigi L; Gurizzan, Cristina C; London, Nyall Robert Jr NRJ; Hermsen, Mario M; Lechner, Matt M; Bossi, Paolo P
Predicting Deleterious Non-Synonymous Single Nucleotide Polymorphisms (nsSNPs) of HRAS Gene and In Silico Evaluation of Their Structural and Functional Consequences towards Diagnosis and Prognosis of Cancer.
Increased osteoclastogenesis contributes to bone loss in the Costello syndrome Hras G12V mouse model.
Frontiers In Cell And Developmental Biology
Nandi, Sayantan S; Chennappan, Saravanakkumar S; Andrasch, Yannik Y; Fidan, Miray M; Engler, Melanie M; Ahmad, Mubashir M; Tuckermann, Jan P JP; Zenker, Martin M; Cirstea, Ion Cristian IC
The mutational landscape of cancer's vulnerability to ionizing radiation.
Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research
Gopal, Priyanka P; Yard, Brian D BD; Petty, Aaron A; Lal, Jessica C JC; Bera, Titas K TK; Hoang, Trung Q TQ; Buhimschi, Alexandru B AB; Abazeed, Mohamed E ME
Proceedings Of The National Academy Of Sciences Of The United States Of America
Herman, Jacob A JA; Romain, Romario R RR; Hoellerbauer, Pia P; Shirnekhi, Hazheen K HK; King, David C DC; DeLuca, Keith F KF; Osborne Nishimura, Erin E; Paddison, Patrick J PJ; DeLuca, Jennifer G JG
Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery.
Nature Communications
Havugimana, Pierre C PC; Goel, Raghuveera Kumar RK; Phanse, Sadhna S; Youssef, Ahmed A; Padhorny, Dzmitry D; Kotelnikov, Sergei S; Kozakov, Dima D; Emili, Andrew A
Purine Synthesis Inhibitor L-Alanosine Impairs Mitochondrial Function and Stemness of Brain Tumor Initiating Cells.
Biomedicines
Singh, Simranjit X SX; Yang, Rui R; Roso, Kristen K; Hansen, Landon J LJ; Du, Changzheng C; Chen, Lee H LH; Greer, Paula K PK; Pirozzi, Christopher J CJ; He, Yiping Y
KRAS is vulnerable to reversible switch-II pocket engagement in cells.
Nature Chemical Biology
Vasta, James D JD; Peacock, D Matthew DM; Zheng, Qinheng Q; Walker, Joel A JA; Zhang, Ziyang Z; Zimprich, Chad A CA; Thomas, Morgan R MR; Beck, Michael T MT; Binkowski, Brock F BF; Corona, Cesear R CR; Robers, Matthew B MB; Shokat, Kevan M KM
Lentiviral-Induced Spinal Cord Gliomas in Rat Model.
International Journal Of Molecular Sciences
Nagarajan, Purva P PP; Tora, Muhibullah S MS; Neill, Stewart G SG; Federici, Thais T; Texakalidis, Pavlos P; Donsante, Anthony A; Canoll, Peter P; Lei, Kecheng K; Boulis, Nicholas M NM
Dickkopf-1 promotes angiogenesis by upregulating VEGF receptor 2-mediated mTOR/p70S6K signaling in hepatocellular carcinoma.
American Journal Of Cancer Research
Seo, Sang Hyun SH; Cho, Kyung Joo KJ; Park, Hye Jung HJ; Kim, Hyemi H; Lee, Hye Won HW; Kim, Beom Kyung BK; Park, Jun Yong JY; Kim, Do Young DY; Ahn, Sang Hoon SH; Kim, Seung Up SU
Senescence-Associated Secretory Phenotype as a Hinge Between Cardiovascular Diseases and Cancer.
Frontiers In Cardiovascular Medicine
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