Publications:

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PROTACs in the Management of Prostate Cancer.

Molecules (Basel, Switzerland)

Yedla, Poornachandra P; Babalghith, Ahmed O AO; Andra, Vindhya Vasini VV; Syed, Riyaz R

Publication Date: 2023-04-25

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PubMed Link: 37175108

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• molecules-28-03698.pdf

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Androgen Receptor Signaling Inhibition in Advanced Castration Resistance Prostate Cancer: What Is Expected for the Near Future?

Cancers

Pozas, Javier J; Álvarez Rodríguez, Sara S; Fernández, Víctor Albarrán VA; Burgos, Javier J; Santoni, Matteo M; Manneh Kopp, Ray R; Molina-Cerrillo, Javier J; Alonso-Gordoa, Teresa T

Publication Date: 2022-12-09

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PubMed Link: 36551557

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• cancers-14-06071.pdf

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A novel inhibitor of ARfl and ARv7 induces protein degradation to overcome enzalutamide resistance in advanced prostate cancer.

Acta Pharmaceutica Sinica. B

Li, Yan Y; Chu, Ya Y; Shi, Guangjiang G; Wang, Xiaobin X; Ye, Wanli W; Shan, Chun C; Wang, Dajia D; Zhang, Di D; He, Wei W; Jiang, Jingwei J; Ma, Shuqian S; Han, Yuhong Y; Zhao, Zhili Z; Du, Shijia S; Chen, Zhen Z; Li, Zhiyu Z; Yang, Yong Y; Wang, Chen C; Xu, Xi X; Wu, Hongxi H

Publication Date: 2022-11

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PubMed Link: 36386477

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Prostate Cancer Review: Genetics, Diagnosis, Treatment Options, and Alternative Approaches.

Molecules (Basel, Switzerland)

Sekhoacha, Mamello M; Riet, Keamogetswe K; Motloung, Paballo P; Gumenku, Lemohang L; Adegoke, Ayodeji A; Mashele, Samson S

Publication Date: 2022-09-05

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PubMed Link: 36080493

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• molecules-27-05730.pdf

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Second generation androgen receptor antagonists and challenges in prostate cancer treatment.

Cell Death & Disease

Chen, Yanhua Y; Zhou, Qianqian Q; Hankey, William W; Fang, Xiaosheng X; Yuan, Fuwen F

Publication Date: 2022-07-21

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PubMed Link: 35864113

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• 41419_2022_Article_5084.pdf

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Overcoming the mechanisms of primary and acquired resistance to new generation hormonal therapies in advanced prostate cancer: focus on androgen receptor independent pathways.

Cancer Drug Resistance (Alhambra, Calif.)

Bungaro, Maristella M; Buttigliero, Consuelo C; Tucci, Marcello M

Publication Date: 2020

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PubMed Link: 35582226

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• cdr-3-726.pdf

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Overcoming Cancer Drug Resistance Utilizing PROTAC Technology.

Frontiers In Cell And Developmental Biology

Burke, Matthew R MR; Smith, Alexis R AR; Zheng, Guangrong G

Publication Date: 2022

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PubMed Link: 35547806

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• fcell-10-872729.pdf

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The natural compound atraric acid suppresses androgen-regulated neo-angiogenesis of castration-resistant prostate cancer through angiopoietin 2.

Oncogene

Ehsani, Marzieh M; Bartsch, Sophie S; Rasa, Seyed Mohammad Mahdi SMM; Dittmann, Jessica J; Pungsrinont, Thanakorn T; Neubert, Laura L; Huettner, Soeren S SS; Kotolloshi, Roland R; Schindler, Katrin K; Ahmad, Aya A; Mosig, Alexander S AS; Adam, Lisa L; Ori, Alessandro A; Neri, Francesco F; Berndt, Alexander A; Grimm, Marc-Oliver MO; Baniahmad, Aria A

Publication Date: 2022-06

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PubMed Link: 35513564

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• 41388_2022_Article_2333.pdf

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Apalutamide, Darolutamide and Enzalutamide for Nonmetastatic Castration-Resistant Prostate Cancer (nmCRPC): A Critical Review.

Cancers

Cattrini, Carlo C; Caffo, Orazio O; De Giorgi, Ugo U; Mennitto, Alessia A; Gennari, Alessandra A; Olmos, David D; Castro, Elena E

Publication Date: 2022-03-31

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PubMed Link: 35406564

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• cancers-14-01792.pdf

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Targeting Oncoproteins for Degradation by Small Molecule-Based Proteolysis-Targeting Chimeras (PROTACs) in Sex Hormone-Dependent Cancers.

Frontiers In Endocrinology

Liu, Li L; Shi, Lihong L; Wang, Zhaodi Z; Zeng, Jun J; Wang, Yue Y; Xiao, Hongtao H; Zhu, Yongxia Y

Publication Date: 2022

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PubMed Link: 35370971

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• fendo-13-839857.pdf

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Non-Invasive Profiling of Advanced Prostate Cancer via Multi-Parametric Liquid Biopsy and Radiomic Analysis.

International Journal Of Molecular Sciences

Morrison, Gareth G; Buckley, Jonathan J; Ostrow, Dejerianne D; Varghese, Bino B; Cen, Steven Y SY; Werbin, Jeffrey J; Ericson, Nolan N; Cunha, Alexander A; Lu, Yi-Tsung YT; George, Thaddeus T; Smith, Jeffrey J; Quinn, David D; Duddalwar, Vinay V; Triche, Timothy T; Goldkorn, Amir A

Publication Date: 2022-02-25

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PubMed Link: 35269713

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• ijms-23-02571.pdf

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Endocrine Disruptors and Prostate Cancer.

International Journal Of Molecular Sciences

Corti, Margherita M; Lorenzetti, Stefano S; Ubaldi, Alessandro A; Zilli, Romano R; Marcoccia, Daniele D

Publication Date: 2022-01-21

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PubMed Link: 35163140

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Endocrine Disruptors and Prostate Cancer.

International Journal Of Molecular Sciences

Corti, Margherita M; Lorenzetti, Stefano S; Ubaldi, Alessandro A; Zilli, Romano R; Marcoccia, Daniele D

Publication Date: 2022-01-21

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PubMed Link: 35163140

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Biomarkers of Castrate Resistance in Prostate Cancer: Androgen Receptor Amplification and T877A Mutation Detection by Multiplex Droplet Digital PCR.

Journal Of Clinical Medicine

Young, Francis P FP; Becker, Therese M TM; Nimir, Mohammed M; Opperman, Thomas T; Chua, Wei W; Balakrishnar, Bavanthi B; de Souza, Paul P; Ma, Yafeng Y

Publication Date: 2022-01-04

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PubMed Link: 35011998

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• Main text
• jcm-11-00257.pdf

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Biomarkers of Castrate Resistance in Prostate Cancer: Androgen Receptor Amplification and T877A Mutation Detection by Multiplex Droplet Digital PCR.

Journal Of Clinical Medicine

Young, Francis P FP; Becker, Therese M TM; Nimir, Mohammed M; Opperman, Thomas T; Chua, Wei W; Balakrishnar, Bavanthi B; de Souza, Paul P; Ma, Yafeng Y

Publication Date: 2022-01-04

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PubMed Link: 35011998

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• Main text
• jcm-11-00257.pdf

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The metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer.

The Journal Of Biological Chemistry

Lim, Syer C SC; Geleta, Bekesho B; Maleki, Sanaz S; Richardson, Des R DR; Kovačević, Žaklina Ž

Publication Date: 2021-11-14

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PubMed Link: 34785213

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• main.pdf

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The metastasis suppressor NDRG1 directly regulates androgen receptor signaling in prostate cancer.

The Journal Of Biological Chemistry

Lim, Syer C SC; Geleta, Bekesho B; Maleki, Sanaz S; Richardson, Des R DR; Kovačević, Žaklina Ž

Publication Date: 2021-12

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PubMed Link: 34785213

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• main.pdf

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Second-Generation Jak2 Inhibitors for Advanced Prostate Cancer: Are We Ready for Clinical Development?

Cancers

Beinhoff, Paul P; Sabharwal, Lavannya L; Udhane, Vindhya V; Maranto, Cristina C; LaViolette, Peter S PS; Jacobsohn, Kenneth M KM; Tsai, Susan S; Iczkowski, Kenneth A KA; Wang, Liang L; Hall, William A WA; Dehm, Scott M SM; Kilari, Deepak D; Nevalainen, Marja T MT

Publication Date: 2021-10-17

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PubMed Link: 34680353

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• Main text
• cancers-13-05204.pdf

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Non-apoptotic function of caspase-8 confers prostate cancer enzalutamide resistance via NF-κB activation.

Cell Death & Disease

Xia, Jia J; Zhang, Jiahui J; Wang, Liangzhe L; Liu, Hailong H; Wang, Jie J; Liu, Junyan J; Liu, Zhaoqian Z; Zhu, Yingjian Y; Xu, Yingjie Y; Yang, Wen W; Yu, Yongjiang Y

Publication Date: 2021-09-04

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PubMed Link: 34482382

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• 41419_2021_Article_4126.pdf

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Conformational dynamics of androgen receptors bound to agonists and antagonists.

Scientific Reports

Gim, Hyo Jin HJ; Park, Jiyong J; Jung, Michael E ME; Houk, K N KN

Publication Date: 2021-08-05

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PubMed Link: 34354111

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• Main text
• 41598_2021_Article_94707.pdf

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Exploration and Biological Evaluation of Basic Heteromonocyclic Propanamide Derivatives as SARDs for the Treatment of Enzalutamide-Resistant Prostate Cancer.

Journal Of Medicinal Chemistry

He, Yali Y; Hwang, Dong-Jin DJ; Ponnusamy, Suriyan S; Thiyagarajan, Thirumagal T; Mohler, Michael L ML; Narayanan, Ramesh R; Miller, Duane D DD

Publication Date: 2021-08-12

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PubMed Link: 34269581

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A Review of the Pathophysiological Mechanisms Underlying Castration-resistant Prostate Cancer.

Research And Reports In Urology

Crowley, Fionnuala F; Sterpi, Michelle M; Buckley, Conor C; Margetich, Lauren L; Handa, Shivani S; Dovey, Zach Z

Publication Date: 2021

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PubMed Link: 34235102

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• Main text
• rru-13-457.pdf

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Undesirable Status of Prostate Cancer Cells after Intensive Inhibition of AR Signaling: Post-AR Era of CRPC Treatment.

Biomedicines

Makino, Tomoyuki T; Izumi, Kouji K; Mizokami, Atsushi A

Publication Date: 2021-04-12

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PubMed Link: 33921329

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Design, synthesis and evaluation of novel enzalutamide analogues as potential anticancer agents.

Heliyon

Bhole, Ritesh P RP; Chikhale, Rupesh V RV; Wavhale, Ravindra D RD; Asmary, Fatmah Ali FA; Almutairi, Tahani Mazyad TM; Alhajri, Hassna Mohammed HM; Bonde, Chandrakant G CG

Publication Date: 2021-03

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PubMed Link: 33869816

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• main.pdf

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A narrative review of proteolytic targeting chimeras (PROTACs): future perspective for prostate cancer therapy.

Translational Andrology And Urology

Chen, Xuanrong X; Shen, Haishan H; Shao, Yi Y; Ma, Qianwang Q; Niu, Yuanjie Y; Shang, Zhiqun Z

Publication Date: 2021-02

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PubMed Link: 33718095

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• tau-10-02-954.pdf

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New Prognostic Biomarkers in Metastatic Castration-Resistant Prostate Cancer.

Cells

Conteduca, Vincenza V; Mosca, Alessandra A; Brighi, Nicole N; de Giorgi, Ugo U; Rescigno, Pasquale P

Publication Date: 2021-01-19

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PubMed Link: 33478015

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• Main text
• cells-10-00193.pdf

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Pyrazol-1-yl-propanamides as SARD and Pan-Antagonists for the Treatment of Enzalutamide-Resistant Prostate Cancer.

Journal Of Medicinal Chemistry

He, Yali Y; Hwang, Dong-Jin DJ; Ponnusamy, Suriyan S; Thiyagarajan, Thirumagal T; Mohler, Michael L ML; Narayanan, Ramesh R; Miller, Duane D DD

Publication Date: 2020-11-12

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PubMed Link: 33095584

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Assessment of STAT5 as a potential therapy target in enzalutamide-resistant prostate cancer.

Plos One

Erb, Holger H H HHH; Bodenbender, Julia J; Handle, Florian F; Diehl, Tamara T; Donix, Lukas L; Tsaur, Igor I; Gleave, Martin M; Haferkamp, Axel A; Huber, Johannes J; Fuessel, Susanne S; Juengel, Eva E; Culig, Zoran Z; Thomas, Christian C

Publication Date: 2020

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PubMed Link: 32790723

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• pone.0237248.pdf

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Quantitative Evaluation of the Transcriptional Activity of Steroid Hormone Receptor Mutants and Variants Using a Single Vector With Two Reporters and a Receptor Expression Cassette.

Frontiers In Endocrinology

Ji, Huimin H; Li, Ying Y; Liu, Zhao Z; Tang, Min M; Zou, Lihui L; Su, Fei F; Zhang, Yaqun Y; Zhang, Junhua J; Li, Hexin H; Li, Lin L; Ai, Bin B; Ma, Jie J; Wang, Lunan L; Liu, Ming M; Xiao, Fei F

Publication Date: 2020

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PubMed Link: 32296391

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• Main text
• fendo-11-00167.pdf

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Androgen receptor variant-driven prostate cancer II: advances in laboratory investigations.

Prostate Cancer And Prostatic Diseases

Lu, Changxue C; Brown, Landon C LC; Antonarakis, Emmanuel S ES; Armstrong, Andrew J AJ; Luo, Jun J

Publication Date: 2020-09

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PubMed Link: 32139878

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• Main text
• nihms-1564248.pdf

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Second-Generation Antiandrogens: From Discovery to Standard of Care in Castration Resistant Prostate Cancer.

Frontiers In Oncology

Rice, Meghan A MA; Malhotra, Sanjay V SV; Stoyanova, Tanya T

Publication Date: 2019

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PubMed Link: 31555580

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• Main text
• fonc-09-00801.pdf

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Enzalutamide-Induced Feed-Forward Signaling Loop Promotes Therapy-Resistant Prostate Cancer Growth Providing an Exploitable Molecular Target for Jak2 Inhibitors.

Molecular Cancer Therapeutics

Udhane, Vindhya V; Maranto, Cristina C; Hoang, David T DT; Gu, Lei L; Erickson, Andrew A; Devi, Savita S; Talati, Pooja G PG; Banerjee, Anjishnu A; Iczkowski, Kenneth A KA; Jacobsohn, Kenneth K; See, William A WA; Mirtti, Tuomas T; Kilari, Deepak D; Nevalainen, Marja T MT

Publication Date: 2020-01

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PubMed Link: 31548294

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A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer.

Cancer Chemotherapy And Pharmacology

Peer, Cody J CJ; Schmidt, Keith T KT; Kindrick, Jessica D JD; Eisner, Joel R JR; Brown, Victoria V VV; Baskin-Bey, Edwina E; Madan, Ravi R; Figg, William D WD

Publication Date: 2019-10

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PubMed Link: 31367790

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Cellular and Molecular Mechanisms Underlying Prostate Cancer Development: Therapeutic Implications.

Medicines (Basel, Switzerland)

Testa, Ugo U; Castelli, Germana G; Pelosi, Elvira E

Publication Date: 2019-07-30

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PubMed Link: 31366128

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• Main text
• medicines-06-00082.pdf

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Androgen Receptor-Directed Molecular Conjugates for Targeting Prostate Cancer.

Frontiers In Chemistry

Beretta, Giovanni L GL; Zaffaroni, Nadia N

Publication Date: 2019

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PubMed Link: 31192191

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• Main text
• fchem-07-00369.pdf

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Metastatic prostate cancer remains incurable, why?

Asian Journal Of Urology

Dong, Liang L; Zieren, Richard C RC; Xue, Wei W; de Reijke, Theo M TM; Pienta, Kenneth J KJ

Publication Date: 2019-01

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PubMed Link: 30775246

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• main.pdf

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Enzalutamide-resistant castration-resistant prostate cancer: challenges and solutions.

Oncotargets And Therapy

Tucci, Marcello M; Zichi, Clizia C; Buttigliero, Consuelo C; Vignani, Francesca F; Scagliotti, Giorgio V GV; Di Maio, Massimo M

Publication Date: 2018

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PubMed Link: 30425524

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• Main text
• ott-11-7353.pdf

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Castration-Resistant Prostate Cancer Refractory to Second-Generation Androgen Receptor Axis-Targeted Agents: Opportunities and Challenges.

Cancers

Kita, Yuki Y; Goto, Takayuki T; Akamatsu, Shusuke S; Yamasaki, Toshinari T; Inoue, Takahiro T; Ogawa, Osamu O; Kobayashi, Takashi T

Publication Date: 2018-09-21

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PubMed Link: 30248934

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Strategy for Tumor-Selective Disruption of Androgen Receptor Function in the Spectrum of Prostate Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Rosati, Rayna R; Polin, Lisa L; Ducker, Charles C; Li, Jing J; Bao, Xun X; Selvakumar, Dakshnamurthy D; Kim, Seongho S; Xhabija, Besa B; Larsen, Martha M; McFall, Thomas T; Huang, Yanfang Y; Kidder, Benjamin L BL; Fribley, Andrew A; Saxton, Janice J; Kakuta, Hiroki H; Shaw, Peter P; Ratnam, Manohar M

Publication Date: 2018-12-15

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PubMed Link: 30185422

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Rational design and synthesis of novel phenylsulfonyl-benzamides as anti-prostate cancer agents.

Medchemcomm

Bassetto, Marcella M; Ferla, Salvatore S; Giancotti, Gilda G; Pertusati, Fabrizio F; Westwell, Andrew D AD; Brancale, Andrea A; McGuigan, Christopher C

Publication Date: 2017-07-01

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PubMed Link: 30108852

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• Main text
• MD-008-C7MD00164A.pdf

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Precision medicine applications in prostate cancer.

Therapeutic Advances In Medical Oncology

McCrea, Edel M EM; Lee, Daniel K DK; Sissung, Tristan M TM; Figg, William D WD

Publication Date: 2018

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PubMed Link: 29977347

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• 10.1177_1758835918776920.pdf

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Liquid biopsy approach in the management of prostate cancer.

Translational Research : The Journal Of Laboratory And Clinical Medicine

Riaz, Irbaz Bin IB; Wang, Liang L; Kohli, Manish M

Publication Date: 2018-11

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PubMed Link: 29936077

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Recent advances on the progressive mechanism and therapy in castration-resistant prostate cancer.

Oncotargets And Therapy

Wang, Keshan K; Ruan, Hailong H; Xu, Tianbo T; Liu, Lei L; Liu, Di D; Yang, Hongmei H; Zhang, Xiaoping X; Chen, Ke K

Publication Date: 2018

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PubMed Link: 29881290

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• ott-11-3167.pdf

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Development of Neuroendocrine Prostate Cancers by the Ser/Arg Repetitive Matrix 4-Mediated RNA Splicing Network.

Frontiers In Oncology

Lee, Ahn R AR; Che, Nicole N; Lovnicki, Jessica M JM; Dong, Xuesen X

Publication Date: 2018

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PubMed Link: 29666783

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• fonc-08-00093.pdf

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