Reactive metabolites of acetaminophen activate and sensitize the capsaicin receptor TRPV1.
Scientific Reports
Eberhardt, Mirjam J MJ; Schillers, Florian F; Eberhardt, Esther M EM; Risser, Linus L; de la Roche, Jeanne J; Herzog, Christine C; Echtermeyer, Frank F; Leffler, Andreas A
The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons.
The Journal Of Clinical Investigation
Leffler, Andreas A; Fischer, Michael J MJ; Rehner, Dietlinde D; Kienel, Stephanie S; Kistner, Katrin K; Sauer, Susanne K SK; Gavva, Narender R NR; Reeh, Peter W PW; Nau, Carla C