Patients with sporadic FTLD exhibit similar increases in lysosomal proteins and storage material as patients with FTD due to GRN mutations.
Acta Neuropathologica Communications
Davis, Skylar E SE; Cook, Anna K AK; Hall, Justin A JA; Voskobiynyk, Yuliya Y; Carullo, Nancy V NV; Boyle, Nicholas R NR; Hakim, Ahmad R AR; Anderson, Kristian M KM; Hobdy, Kierra P KP; Pugh, Derian A DA; Murchison, Charles F CF; McMeekin, Laura J LJ; Simmons, Micah M; Margolies, Katherine A KA; Cowell, Rita M RM; Nana, Alissa L AL; Spina, Salvatore S; Grinberg, Lea T LT; Miller, Bruce L BL; Seeley, William W WW; Arrant, Andrew E AE
Long non-coding RNA SNHG8 drives stress granule formation in tauopathies.
Medrxiv : The Preprint Server For Health Sciences
Bhagat, Reshma R; Minaya, Miguel A MA; Renganathan, Arun A; Mehra, Muneshwar M; Marsh, Jacob J; Martinez, Rita R; Nana, Alissa L AL; Spina, Salvatore S; Seeley, William W WW; Grinberg, Lea T LT; Karch, Celeste M CM
Exploring discordant low amyloid beta and high neocortical tau positron emission tomography cases.
Alzheimer'S & Dementia (Amsterdam, Netherlands)
Krishnadas, Natasha N; Doré, Vincent V; Laws, Simon M SM; Porter, Tenielle T; Lamb, Fiona F; Bozinovski, Svetlana S; Villemagne, Victor L VL; Rowe, Christopher C CC
Single-molecule imaging reveals Tau trapping at nanometer-sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion.
The Embo Journal
Padmanabhan, Pranesh P; Kneynsberg, Andrew A; Cruz, Esteban E; Amor, Rumelo R; Sibarita, Jean-Baptiste JB; Götz, Jürgen J
Quantitative transportomics identifies Kif5a as a major regulator of neurodegeneration.
Elife
Shah, Sahil H SH; Schiapparelli, Lucio M LM; Ma, Yuanhui Y; Yokota, Satoshi S; Atkins, Melissa M; Xia, Xin X; Cameron, Evan G EG; Huang, Thanh T; Saturday, Sarah S; Sun, Catalina B CB; Knasel, Cara C; Blackshaw, Seth S; Yates, John R JR; Cline, Hollis T HT; Goldberg, Jeffrey L JL
Long-Term Hydromethylthionine Treatment Is Associated with Delayed Clinical Onset and Slowing of Cerebral Atrophy in a Pre-Symptomatic P301S MAPT Mutation Carrier.
Journal Of Alzheimer'S Disease : Jad
Bentham, Peter P; Staff, Roger T RT; Schelter, Bjoern O BO; Shiells, Helen H; Harrington, Charles R CR; Wischik, Claude M CM
Tau Filament Self-Assembly and Structure: Tau as a Therapeutic Target.
Frontiers In Neurology
Oakley, Sebastian S SS; Maina, Mahmoud B MB; Marshall, Karen E KE; Al-Hilaly, Youssra K YK; Harrington, Charlie R CR; Wischik, Claude M CM; Serpell, Louise C LC
Mid to late-life scores of depression in the cognitively healthy are associated with cognitive status and Alzheimer's disease pathology at death.
International Journal Of Geriatric Psychiatry
Robinson, Andrew C AC; Roncaroli, Federico F; Davidson, Yvonne S YS; Minshull, James J; Heal, Calvin C; Montaldi, Daniela D; Payton, Antony A; Horan, Michael A MA; Pendleton, Neil N; Mann, David M A DMA
Pre-clinical characterisation of E2814, a high-affinity antibody targeting the microtubule-binding repeat domain of tau for passive immunotherapy in Alzheimer's disease.
Acta Neuropathologica Communications
Roberts, Malcolm M; Sevastou, Ioanna I; Imaizumi, Yoichi Y; Mistry, Kavita K; Talma, Sonia S; Dey, Madhurima M; Gartlon, Jane J; Ochiai, Hiroshi H; Zhou, Zhi Z; Akasofu, Shigeru S; Tokuhara, Naoki N; Ogo, Makoto M; Aoyama, Muneo M; Aoyagi, Hirofumi H; Strand, Kate K; Sajedi, Ezat E; Agarwala, Kishan Lal KL; Spidel, Jared J; Albone, Earl E; Horie, Kanta K; Staddon, James M JM; de Silva, Rohan R
Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study.
The Lancet. Neurology
Moore, Katrina M KM; Nicholas, Jennifer J; Grossman, Murray M; McMillan, Corey T CT; Irwin, David J DJ; Massimo, Lauren L; Van Deerlin, Vivianna M VM; Warren, Jason D JD; Fox, Nick C NC; Rossor, Martin N MN; Mead, Simon S; Bocchetta, Martina M; Boeve, Bradley F BF; Knopman, David S DS; Graff-Radford, Neill R NR; Forsberg, Leah K LK; Rademakers, Rosa R; Wszolek, Zbigniew K ZK; van Swieten, John C JC; Jiskoot, Lize C LC; Meeter, Lieke H LH; Dopper, Elise Gp EG; Papma, Janne M JM; Snowden, Julie S JS; Saxon, Jennifer J; Jones, Matthew M; Pickering-Brown, Stuart S; Le Ber, Isabelle I; Camuzat, Agnès A; Brice, Alexis A; Caroppo, Paola P; Ghidoni, Roberta R; Pievani, Michela M; Benussi, Luisa L; Binetti, Giuliano G; Dickerson, Bradford C BC; Lucente, Diane D; Krivensky, Samantha S; Graff, Caroline C; Öijerstedt, Linn L; Fallström, Marie M; Thonberg, Håkan H; Ghoshal, Nupur N; Morris, John C JC; Borroni, Barbara B; Benussi, Alberto A; Padovani, Alessandro A; Galimberti, Daniela D; Scarpini, Elio E; Fumagalli, Giorgio G GG; Mackenzie, Ian R IR; Hsiung, Ging-Yuek R GR; Sengdy, Pheth P; Boxer, Adam L AL; Rosen, Howie H; Taylor, Joanne B JB; Synofzik, Matthis M; Wilke, Carlo C; Sulzer, Patricia P; Hodges, John R JR; Halliday, Glenda G; Kwok, John J; Sanchez-Valle, Raquel R; Lladó, Albert A; Borrego-Ecija, Sergi S; Santana, Isabel I; Almeida, Maria Rosário MR; Tábuas-Pereira, Miguel M; Moreno, Fermin F; Barandiaran, Myriam M; Indakoetxea, Begoña B; Levin, Johannes J; Danek, Adrian A; Rowe, James B JB; Cope, Thomas E TE; Otto, Markus M; Anderl-Straub, Sarah S; de Mendonça, Alexandre A; Maruta, Carolina C; Masellis, Mario M; Black, Sandra E SE; Couratier, Philippe P; Lautrette, Geraldine G; Huey, Edward D ED; Sorbi, Sandro S; Nacmias, Benedetta B; Laforce, Robert R; Tremblay, Marie-Pier L ML; Vandenberghe, Rik R; Damme, Philip Van PV; Rogalski, Emily J EJ; Weintraub, Sandra S; Gerhard, Alexander A; Onyike, Chiadi U CU; Ducharme, Simon S; Papageorgiou, Sokratis G SG; Ng, Adeline Su Lyn ASL; Brodtmann, Amy A; Finger, Elizabeth E; Guerreiro, Rita R; Bras, Jose J; Rohrer, Jonathan D JD; ,
18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes.
Alzheimer'S Research & Therapy
Tsai, Richard M RM; Bejanin, Alexandre A; Lesman-Segev, Orit O; LaJoie, Renaud R; Visani, Adrienne A; Bourakova, Viktoriya V; O'Neil, James P JP; Janabi, Mustafa M; Baker, Suzanne S; Lee, Suzee E SE; Perry, David C DC; Bajorek, Lynn L; Karydas, Anna A; Spina, Salvatore S; Grinberg, Lea T LT; Seeley, William W WW; Ramos, Eliana M EM; Coppola, Giovanni G; Gorno-Tempini, Maria Luisa ML; Miller, Bruce L BL; Rosen, Howard J HJ; Jagust, William W; Boxer, Adam L AL; Rabinovici, Gil D GD
Exome Sequencing of Extended Families with Alzheimer's Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function.
Journal Of Alzheimer'S Disease & Parkinsonism
Cukier, H N HN; Kunkle, B K BK; Hamilton, K L KL; Rolati, S S; Kohli, M A MA; Whitehead, P L PL; Jaworski, J J; Vance, J M JM; Cuccaro, M L ML; Carney, R M RM; Gilbert, J R JR; Farrer, L A LA; Martin, E R ER; Beecham, G W GW; Haines, J L JL; Pericak-Vance, M A MA
Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease.
Plos Genetics
Fernández, Maria Victoria MV; Kim, Jong Hun JH; Budde, John P JP; Black, Kathleen K; Medvedeva, Alexandra A; Saef, Ben B; Deming, Yuetiva Y; Del-Aguila, Jorge J; Ibañez, Laura L; Dube, Umber U; Harari, Oscar O; Norton, Joanne J; Chasse, Rachel R; Morris, John C JC; Goate, Alison A; , ; , ; Cruchaga, Carlos C
Presence of a carboxy-terminal pseudorepeat and disease-like pseudohyperphosphorylation critically influence tau's interaction with microtubules in axon-like processes.
Molecular Biology Of The Cell
Niewidok, Benedikt B; Igaev, Maxim M; Sündermann, Frederik F; Janning, Dennis D; Bakota, Lidia L; Brandt, Roland R
An autoradiographic evaluation of AV-1451 Tau PET in dementia.
Acta Neuropathologica Communications
Lowe, Val J VJ; Curran, Geoffry G; Fang, Ping P; Liesinger, Amanda M AM; Josephs, Keith A KA; Parisi, Joseph E JE; Kantarci, Kejal K; Boeve, Bradley F BF; Pandey, Mukesh K MK; Bruinsma, Tyler T; Knopman, David S DS; Jones, David T DT; Petrucelli, Leonard L; Cook, Casey N CN; Graff-Radford, Neill R NR; Dickson, Dennis W DW; Petersen, Ronald C RC; Jack, Clifford R CR; Murray, Melissa E ME
Invited review: Frontotemporal dementia caused by microtubule-associated protein tau gene (MAPT) mutations: a chameleon for neuropathology and neuroimaging.
Neuropathology And Applied Neurobiology
Ghetti, B B; Oblak, A L AL; Boeve, B F BF; Johnson, K A KA; Dickerson, B C BC; Goedert, M M
Usp14 deficiency increases tau phosphorylation without altering tau degradation or causing tau-dependent deficits.
Plos One
Jin, Youngnam N YN; Chen, Ping-Chung PC; Watson, Jennifer A JA; Walters, Brandon J BJ; Phillips, Scott E SE; Green, Karen K; Schmidt, Robert R; Wilson, Julie A JA; Johnson, Gail V GV; Roberson, Erik D ED; Dobrunz, Lynn E LE; Wilson, Scott M SM