Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming.
Genes & Development
Geter, Phillip A PA; Ernlund, Amanda W AW; Bakogianni, Sofia S; Alard, Amandine A; Arju, Rezina R; Giashuddin, Shah S; Gadi, Abhilash A; Bromberg, Jacqueline J; Schneider, Robert J RJ
MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL.
Nature Communications
Landon, Ari L AL; Muniandy, Parameswary A PA; Shetty, Amol C AC; Lehrmann, Elin E; Volpon, Laurent L; Houng, Simone S; Zhang, Yongqing Y; Dai, Bojie B; Peroutka, Raymond R; Mazan-Mamczarz, Krystyna K; Steinhardt, James J; Mahurkar, Anup A; Becker, Kevin G KG; Borden, Katherine L KL; Gartenhaus, Ronald B RB