Deuterated buprenorphine retains pharmacodynamic properties of buprenorphine and resists metabolism to the active metabolite norbuprenorphine in rats.
Frontiers In Pharmacology
Janganati, Venumadhav V; Salazar, Paloma P; Parks, Brian J BJ; Gorman, Gregory S GS; Prather, Paul L PL; Peterson, Eric C EC; Alund, Alexander W AW; Moran, Jeffery H JH; Crooks, Peter A PA; Brents, Lisa K LK