Insulin receptor activation by proinsulin preserves synapses and vision in retinitis pigmentosa.
Cell Death & Disease
Sánchez-Cruz, Alonso A; Hernández-Pinto, Alberto A; Lillo, Concepción C; Isiegas, Carolina C; Marchena, Miguel M; Lizasoain, Ignacio I; Bosch, Fátima F; de la Villa, Pedro P; Hernández-Sánchez, Catalina C; de la Rosa, Enrique J EJ
New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations.
Cellular And Molecular Life Sciences : Cmls
Herrera-Hernández, María Guadalupe MG; Razzaghi, Neda N; Fernandez-Gonzalez, Pol P; Bosch-Presegué, Laia L; Vila-Julià, Guillem G; Pérez, Juan Jesús JJ; Garriga, Pere P
New insights into the molecular mechanism of rhodopsin retinitis pigmentosa from the biochemical and functional characterization of G90V, Y102H and I307N mutations.
Cellular And Molecular Life Sciences : Cmls
Herrera-Hernández, María Guadalupe MG; Razzaghi, Neda N; Fernandez-Gonzalez, Pol P; Bosch-Presegué, Laia L; Vila-Julià, Guillem G; Pérez, Juan Jesús JJ; Garriga, Pere P
Nrf2 overexpression rescues the RPE in mouse models of retinitis pigmentosa.
Jci Insight
Wu, David M DM; Ji, Xuke X; Ivanchenko, Maryna V MV; Chung, Michelle M; Piper, Mary M; Rana, Parimal P; Wang, Sean K SK; Xue, Yunlu Y; West, Emma E; Zhao, Sophia R SR; Xu, Hongbin H; Cicconet, Marcelo M; Xiong, Wenjun W; Cepko, Constance L CL
ALDH2 protects naturally aged mouse retina via inhibiting oxidative stress-related apoptosis and enhancing unfolded protein response in endoplasmic reticulum.
Aging
Long, Pan P; He, Mengshan M; Yan, Weiming W; Chen, Wei W; Wei, Dongyu D; Wang, Siwang S; Zhang, Zuoming Z; Ge, Wei W; Chen, Tao T
Targeted Knockout of the Vegfa Gene in the Retina by Subretinal Injection of RNP Complexes Containing Cas9 Protein and Modified sgRNAs.
Molecular Therapy : The Journal Of The American Society Of Gene Therapy
Holmgaard, Andreas Braae AB; Askou, Anne Louise AL; Jensen, Emilie Grarup EG; Alsing, Sidsel S; Bak, Rasmus O RO; Mikkelsen, Jacob Giehm JG; Corydon, Thomas J TJ
Pharmacological Chaperones: A Therapeutic Approach for Diseases Caused by Destabilizing Missense Mutations.
International Journal Of Molecular Sciences
Liguori, Ludovica L; Monticelli, Maria M; Allocca, Mariateresa M; Hay Mele, Bruno B; Lukas, Jan J; Cubellis, Maria Vittoria MV; Andreotti, Giuseppina G
Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction.
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Lobanova, Ekaterina S ES; Schuhmann, Kai K; Finkelstein, Stella S; Lewis, Tylor R TR; Cady, Martha A MA; Hao, Ying Y; Keuthan, Casey C; Ash, John D JD; Burns, Marie E ME; Shevchenko, Andrej A; Arshavsky, Vadim Y VY
Metabolic Deregulation of the Blood-Outer Retinal Barrier in Retinitis Pigmentosa.
Cell Reports
Wang, Wei W; Kini, Ashwini A; Wang, Yekai Y; Liu, Tingting T; Chen, Yao Y; Vukmanic, Eric E; Emery, Douglas D; Liu, Yongqing Y; Lu, Xiaoqin X; Jin, Lei L; Lee, San Joon SJ; Scott, Patrick P; Liu, Xiao X; Dean, Kevin K; Lu, Qingxian Q; Fortuny, Enzo E; James, Robert R; Kaplan, Henry J HJ; Du, Jianhai J; Dean, Douglas C DC
Organoids as a new model for improving regenerative medicine and cancer personalized therapy in renal diseases.
Cell Death & Disease
Grassi, Ludovica L; Alfonsi, Romina R; Francescangeli, Federica F; Signore, Michele M; De Angelis, Maria Laura ML; Addario, Antonio A; Costantini, Manuela M; Flex, Elisabetta E; Ciolfi, Andrea A; Pizzi, Simone S; Bruselles, Alessandro A; Pallocca, Matteo M; Simone, Giuseppe G; Haoui, Mustapha M; Falchi, Mario M; Milella, Michele M; Sentinelli, Steno S; Di Matteo, Paola P; Stellacci, Emilia E; Gallucci, Michele M; Muto, Giovanni G; Tartaglia, Marco M; De Maria, Ruggero R; Bonci, Désirée D
Modulation of GSK-3 provides cellular and functional neuroprotection in the rd10 mouse model of retinitis pigmentosa.
Molecular Neurodegeneration
Sánchez-Cruz, Alonso A; Villarejo-Zori, Beatriz B; Marchena, Miguel M; Zaldivar-Díez, Josefa J; Palomo, Valle V; Gil, Carmen C; Lizasoain, Ignacio I; de la Villa, Pedro P; Martínez, Ana A; de la Rosa, Enrique J EJ; Hernández-Sánchez, Catalina C
Ligand channel in pharmacologically stabilized rhodopsin.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Mattle, Daniel D; Kuhn, Bernd B; Aebi, Johannes J; Bedoucha, Marc M; Kekilli, Demet D; Grozinger, Nathalie N; Alker, Andre A; Rudolph, Markus G MG; Schmid, Georg G; Schertler, Gebhard F X GFX; Hennig, Michael M; Standfuss, Jörg J; Dawson, Roger J P RJP
In vivo effect of mutant ELOVL4 on the expression and function of wild-type ELOVL4.
Investigative Ophthalmology & Visual Science
Mandal, Nawajes A NA; Tran, Julie-Thu A JT; Zheng, Lixin L; Wilkerson, Joseph L JL; Brush, Richard S RS; McRae, Joel J; Agbaga, Martin-Paul MP; Zhang, Kang K; Petrukhin, Konstantin K; Ayyagari, Radha R; Anderson, Robert E RE