Different configurations of SARS-CoV-2 spike protein delivered by integrase-defective lentiviral vectors induce persistent functional immune responses, characterized by distinct immunogenicity profiles.
Frontiers In Immunology
Borghi, Martina M; Gallinaro, Alessandra A; Pirillo, Maria Franca MF; Canitano, Andrea A; Michelini, Zuleika Z; De Angelis, Maria Laura ML; Cecchetti, Serena S; Tinari, Antonella A; Falce, Chiara C; Mariotti, Sabrina S; Capocefalo, Antonio A; Chiantore, Maria Vincenza MV; Iacobino, Angelo A; Di Virgilio, Antonio A; van Gils, Marit J MJ; Sanders, Rogier W RW; Lo Presti, Alessandra A; Nisini, Roberto R; Negri, Donatella D; Cara, Andrea A
Timeline of changes in spike conformational dynamics in emergent SARS-CoV-2 variants reveal progressive stabilization of trimer stalk with altered NTD dynamics.
Elife
Braet, Sean M SM; Buckley, Theresa S C TSC; Venkatakrishnan, Varun V; Dam, Kim-Marie A KA; Bjorkman, Pamela J PJ; Anand, Ganesh Srinivasan GS
Neuropilin-1 Mediates SARS-CoV-2 Infection of Astrocytes in Brain Organoids, Inducing Inflammation Leading to Dysfunction and Death of Neurons.
Mbio
Kong, Weili W; Montano, Mauricio M; Corley, Michael J MJ; Helmy, Ekram E; Kobayashi, Hirofumi H; Kinisu, Martin M; Suryawanshi, Rahul R; Luo, Xiaoyu X; Royer, Loic A LA; Roan, Nadia R NR; Ott, Melanie M; Ndhlovu, Lishomwa C LC; Greene, Warner C WC
Molecular epidemiology of SARS-CoV-2 in healthcare workers and identification of viral genomic correlates of transmissibility and vaccine break through infection: A retrospective observational study from a cancer hospital in eastern India.
Indian Journal Of Medical Microbiology
Bhattacharya, Sanjay S; Chatterji, Soumyadip S; Chandy, Mammen M; Mahajan, Aseem Yogishwar AY; Goel, Gaurav G; Mishra, Deepak D; Vivek, Priyanka P; Das, Parijat P; Mandal, Sudipto S; Chugani, Anup A; Mittal, Antra A; Perumal, Rajadurai Chinnasamy RC; Ramprasad, Vedam L VL; Gupta, Ravi R
SARS-CoV-2 evolution and patient immunological history shape the breadth and potency of antibody-mediated immunity.
The Journal Of Infectious Diseases
Manali, Maria M; Bissett, Laura A LA; Amat, Julien A R JAR; Logan, Nicola N; Scott, Sam S; Hughes, Ellen C EC; Harvey, William T WT; Orton, Richard R; Thomson, Emma C EC; Gunson, Rory N RN; Viana, Mafalda M; Willett, Brian B; Murcia, Pablo R PR
Shared N417-Dependent Epitope on the SARS-CoV-2 Omicron, Beta, and Delta Plus Variants.
Journal Of Virology
Moyo-Gwete, Thandeka T; Madzivhandila, Mashudu M; Mkhize, Nonhlanhla N NN; Kgagudi, Prudence P; Ayres, Frances F; Lambson, Bronwen E BE; Manamela, Nelia P NP; Richardson, Simone I SI; Makhado, Zanele Z; van der Mescht, Mieke A MA; de Beer, Zelda Z; de Villiers, Talita Roma TR; Burgers, Wendy A WA; Ntusi, Ntobeko A B NAB; Rossouw, Theresa T; Ueckermann, Veronica V; Boswell, Michael T MT; Moore, Penny L PL
Deep phylogenetic-based clustering analysis uncovers new and shared mutations in SARS-CoV-2 variants as a result of directional and convergent evolution.
Plos One
Nunes, Danilo Rosa DR; Braconi, Carla Torres CT; Ludwig-Begall, Louisa F LF; Arns, Clarice Weis CW; Durães-Carvalho, Ricardo R
SARS-CoV-2 Variants of Concern Hijack IFITM2 for Efficient Replication in Human Lung Cells.
Journal Of Virology
Nchioua, Rayhane R; Schundner, Annika A; Kmiec, Dorota D; Prelli Bozzo, Caterina C; Zech, Fabian F; Koepke, Lennart L; Graf, Alexander A; Krebs, Stefan S; Blum, Helmut H; Frick, Manfred M; Sparrer, Konstantin M J KMJ; Kirchhoff, Frank F
Towards Control and Oversight of SARS-CoV-2 Diagnosis and Monitoring through Multiplexed Quantitative Electroanalytical Immune Response Biosensors.
Angewandte Chemie (International Ed. In English)
Torrente-Rodríguez, Rebeca M RM; Montero-Calle, Ana A; San Bartolomé, Clara C; Cano, Olga O; Vázquez, Mónica M; Iglesias-Caballero, María M; Corral-Lugo, Andrés A; McConnell, Michael J MJ; Pascal, Mariona M; Mas, Vicente V; Pingarrón, José M JM; Barderas, Rodrigo R; Campuzano, Susana S
Neutralisation Hierarchy of SARS-CoV-2 Variants of Concern Using Standardised, Quantitative Neutralisation Assays Reveals a Correlation With Disease Severity; Towards Deciphering Protective Antibody Thresholds.
Frontiers In Immunology
Cantoni, Diego D; Mayora-Neto, Martin M; Nadesalingam, Angalee A; Wells, David A DA; Carnell, George W GW; Ohlendorf, Luis L; Ferrari, Matteo M; Palmer, Phil P; Chan, Andrew C Y ACY; Smith, Peter P; Bentley, Emma M EM; Einhauser, Sebastian S; Wagner, Ralf R; Page, Mark M; Raddi, Gianmarco G; Baxendale, Helen H; Castillo-Olivares, Javier J; Heeney, Jonathan J; Temperton, Nigel N
In Silico Analyses on the Comparative Potential of Therapeutic Human Monoclonal Antibodies Against Newly Emerged SARS-CoV-2 Variants Bearing Mutant Spike Protein.
Dispinseri, Stefania S; Marzinotto, Ilaria I; Brigatti, Cristina C; Pirillo, Maria Franca MF; Tolazzi, Monica M; Bazzigaluppi, Elena E; Canitano, Andrea A; Borghi, Martina M; Gallinaro, Alessandra A; Caccia, Roberta R; Vercesi, Riccardo R; McKay, Paul F PF; Ciceri, Fabio F; Piemonti, Lorenzo L; Negri, Donatella D; Cinque, Paola P; Cara, Andrea A; Scarlatti, Gabriella G; Lampasona, Vito V
Temporal-Geographical Dispersion of SARS-CoV-2 Spike Glycoprotein Variant Lineages and Their Functional Prediction Using in Silico Approach.
Mbio
Boon, Siaw Shi SS; Xia, Chichao C; Wang, Maggie Haitian MH; Yip, Ka Lai KL; Luk, Ho Yin HY; Li, Sile S; Ng, Rita W Y RWY; Lai, Christopher K C CKC; Chan, Paul Kay Sheung PKS; Chen, Zigui Z
mRNA Vaccination Induces Durable Immune Memory to SARS-CoV-2 with Continued Evolution to Variants of Concern.
Biorxiv : The Preprint Server For Biology
Goel, Rishi R RR; Painter, Mark M MM; Apostolidis, Sokratis A SA; Mathew, Divij D; Meng, Wenzhao W; Rosenfeld, Aaron M AM; Lundgreen, Kendall A KA; Reynaldi, Arnold A; Khoury, David S DS; Pattekar, Ajinkya A; Gouma, Sigrid S; Kuri-Cervantes, Leticia L; Hicks, Philip P; Dysinger, Sarah S; Hicks, Amanda A; Sharma, Harsh H; Herring, Sarah S; Korte, Scott S; Baxter, Amy E AE; Oldridge, Derek A DA; Giles, Josephine R JR; Weirick, Madison E ME; McAllister, Christopher M CM; Awofolaju, Moses M; Tanenbaum, Nicole N; Drapeau, Elizabeth M EM; Dougherty, Jeanette J; Long, Sherea S; D'Andrea, Kurt K; Hamilton, Jacob T JT; McLaughlin, Maura M; Williams, Justine C JC; Adamski, Sharon S; Kuthuru, Oliva O; , ; Frank, Ian I; Betts, Michael R MR; Vella, Laura A LA; Grifoni, Alba A; Weiskopf, Daniela D; Sette, Alessandro A; Hensley, Scott E SE; Davenport, Miles P MP; Bates, Paul P; Luning Prak, Eline T ET; Greenplate, Allison R AR; Wherry, E John EJ
Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants.
Science (New York, N.Y.)
Wang, Lingshu L; Zhou, Tongqing T; Zhang, Yi Y; Yang, Eun Sung ES; Schramm, Chaim A CA; Shi, Wei W; Pegu, Amarendra A; Oloniniyi, Olamide K OK; Henry, Amy R AR; Darko, Samuel S; Narpala, Sandeep R SR; Hatcher, Christian C; Martinez, David R DR; Tsybovsky, Yaroslav Y; Phung, Emily E; Abiona, Olubukola M OM; Antia, Avan A; Cale, Evan M EM; Chang, Lauren A LA; Choe, Misook M; Corbett, Kizzmekia S KS; Davis, Rachel L RL; DiPiazza, Anthony T AT; Gordon, Ingelise J IJ; Hait, Sabrina Helmold SH; Hermanus, Tandile T; Kgagudi, Prudence P; Laboune, Farida F; Leung, Kwanyee K; Liu, Tracy T; Mason, Rosemarie D RD; Nazzari, Alexandra F AF; Novik, Laura L; O'Connell, Sarah S; O'Dell, Sijy S; Olia, Adam S AS; Schmidt, Stephen D SD; Stephens, Tyler T; Stringham, Christopher D CD; Talana, Chloe Adrienna CA; Teng, I-Ting IT; Wagner, Danielle A DA; Widge, Alicia T AT; Zhang, Baoshan B; Roederer, Mario M; Ledgerwood, Julie E JE; Ruckwardt, Tracy J TJ; Gaudinski, Martin R MR; Moore, Penny L PL; Doria-Rose, Nicole A NA; Baric, Ralph S RS; Graham, Barney S BS; McDermott, Adrian B AB; Douek, Daniel C DC; Kwong, Peter D PD; Mascola, John R JR; Sullivan, Nancy J NJ; Misasi, John J