POLE c.890C>T ;(p.S297F)

Variant ID: 12-133253151-G-A

NM_006231.2(POLE):c.890C>T;(p.S297F)

This variant was identified in 83 publications

View GRCh38 version.




Publications:


Single-strand mismatch and damage patterns revealed by single-molecule DNA sequencing.

Biorxiv : The Preprint Server For Biology
Liu, Mei Hong MH; Costa, Benjamin B; Choi, Una U; Bandler, Rachel C RC; Lassen, Emilie E; Grońska-Pęski, Marta M; Schwing, Adam A; Murphy, Zachary R ZR; Rosenkjær, Daniel D; Picciotto, Shany S; Bianchi, Vanessa V; Stengs, Lucie L; Edwards, Melissa M; Loh, Caitlin A CA; Truong, Tina K TK; Brand, Randall E RE; Pastinen, Tomi T; Wagner, J Richard JR; Skytte, Anne-Bine AB; Tabori, Uri U; Shoag, Jonathan E JE; Evrony, Gilad D GD
Publication Date: 2023-02-19

Variant appearance in text: POLE: S297F
PubMed Link: 36824744
Variant Present in the following documents:
  • media-3.xlsx, sheet 2
  • media-3.xlsx, sheet 1
  • media-1.pdf
  • media-3.xlsx, sheet 3
  • media-3.xlsx, sheet 4
View BVdb publication page



Utility of molecular subtypes and genetic alterations for evaluating clinical outcomes in 1029 patients with endometrial cancer.

British Journal Of Cancer
Asami, Yuka Y; Kobayashi Kato, Mayumi M; Hiranuma, Kengo K; Matsuda, Maiko M; Shimada, Yoko Y; Ishikawa, Mitsuya M; Koyama, Takafumi T; Komatsu, Masaaki M; Hamamoto, Ryuji R; Nagashima, Minoru M; Terao, Yasuhisa Y; Itakura, Atsuo A; Kohno, Takashi T; Sekizawa, Akihiko A; Matsumoto, Koji K; Kato, Tomoyasu T; Shiraishi, Kouya K; Yoshida, Hiroshi H
Publication Date: 2023-02-16

Variant appearance in text: POLE: S297F
PubMed Link: 36797358
Variant Present in the following documents:
  • Main text
  • 41416_2023_Article_2203.pdf
  • 41416_2023_2203_MOESM1_ESM.pdf
View BVdb publication page



Pan-Asian adapted ESMO Clinical Practice Guidelines for the diagnosis, treatment and follow-up of patients with endometrial cancer.

Esmo Open
Koppikar, S S; Oaknin, A A; Babu, K Govind KG; Lorusso, D D; Gupta, S S; Wu, L-Y LY; Rajabto, W W; Harano, K K; Hong, S-H SH; Malik, R A RA; Strebel, H H; Aggarwal, I M IM; Lai, C-H CH; Dejthevaporn, T T; Tangjitgamol, S S; Cheng, W F WF; Chay, W Y WY; Benavides, D D; Hashim, N M NM; Moon, Y W YW; Yunokawa, M M; Anggraeni, T D TD; Wei, W W; Curigliano, G G; Maheshwari, A A; Mahantshetty, U U; Sheshadri, S S; Peters, S S; Yoshino, T T; Pentheroudakis, G G
Publication Date: 2023-01-23

Variant appearance in text: POLE: Ser297Phe
PubMed Link: 36696825
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Immunologic Signatures across Molecular Subtypes and Potential Biomarkers for Sub-Stratification in Endometrial Cancer.

International Journal Of Molecular Sciences
Jiang, Fang F; Jiang, Shiyang S; Cao, Dongyan D; Mao, Mingyi M; Xiang, Yang Y
Publication Date: 2023-01-16

Variant appearance in text: POLE: S297F
PubMed Link: 36675305
Variant Present in the following documents:
  • Main text
  • ijms-24-01791.pdf
View BVdb publication page



Molecular profile-based recommendations for postoperative adjuvant therapy in early endometrial cancer with high-intermediate or intermediate risk: a Chinese randomized phase III trial (PROBEAT).

Journal Of Gynecologic Oncology
Li, Yang Y; Zhu, Changkun C; Xie, Hongyu H; Chen, Yaxia Y; Lv, Weiguo W; Xie, Xing X; Wang, Xinyu X
Publication Date: 2023-01-10

Variant appearance in text: POLE: S297F
PubMed Link: 36659832
Variant Present in the following documents:
  • jgo-34-e37.pdf
View BVdb publication page



Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe.

Plos One
Pai, Chen-Chun CC; Heitzer, Ellen E; Bertrand, Sibyl S; Toumazou, Sophia S; Humphrey, Timothy C TC; Kearsey, Stephen E SE
Publication Date: 2023

Variant appearance in text: POLE: S297F
PubMed Link: 36626373
Variant Present in the following documents:
  • Main text
  • pone.0271016.pdf
View BVdb publication page



Refining adjuvant treatment in endometrial cancer based on molecular features: the RAINBO clinical trial program.

International Journal Of Gynecological Cancer : Official Journal Of The International Gynecological Cancer Society
,
Publication Date: 2022-12-20

Variant appearance in text: POLE: 890C>T; S297F
PubMed Link: 36600534
Variant Present in the following documents:
  • ijgc-2022-004039supp001.pdf
View BVdb publication page



Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics
Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q
Publication Date: 2022-11-04

Variant appearance in text: POLE: 890C>T; Ser297Phe
PubMed Link: 36333792
Variant Present in the following documents:
  • 12920_2022_1376_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer.

Frontiers In Oncology
Tian, Wenjuan W; Ji, Zhaodong Z; Wang, Jingshu J; Meng, Jiao J; Bi, Rui R; Ren, Yulan Y; Shan, Boer B; Yang, Gong G; Wang, Huaying H
Publication Date: 2022

Variant appearance in text: POLE: S297F
PubMed Link: 36313640
Variant Present in the following documents:
  • Main text
  • fonc-12-1018034.pdf
View BVdb publication page



Pathologic complete response to immune checkpoint inhibitor in a stage IIIB ovarian clear cell carcinoma patient with POLE mutation resistant to platinum-based chemotherapy: a case report.

Gland Surgery
Li, Shuzhan S; Zhang, Jiali J; Du, Weijiao W; Ren, Xiubao X; Zhang, Xinwei X
Publication Date: 2022-09

Variant appearance in text: POLE: S297F
PubMed Link: 36221285
Variant Present in the following documents:
  • Main text
  • gs-11-09-1562.pdf
View BVdb publication page



A new strategy in molecular typing: the accuracy of an NGS panel for the molecular classification of endometrial cancers.

Annals Of Translational Medicine
Li, Yang Y; Feng, Junnan J; Zhao, Chengzhi C; Meng, Lin L; Shi, Shanshan S; Liu, Kangdong K; Ma, Jie J
Publication Date: 2022-08

Variant appearance in text: POLE: 890C>T
PubMed Link: 36111057
Variant Present in the following documents:
  • Main text
  • atm-10-16-870.pdf
View BVdb publication page



POLE/POLD1 mutation and tumor immunotherapy.

Journal Of Experimental & Clinical Cancer Research : Cr
Ma, Xiaoting X; Dong, Lin L; Liu, Xiu X; Ou, Kai K; Yang, Lin L
Publication Date: 2022-07-02

Variant appearance in text: POLE: S297F
PubMed Link: 35780178
Variant Present in the following documents:
  • Main text
  • 13046_2022_Article_2422.pdf
View BVdb publication page



Biomarker characterization in endometrial cancer in Italy: first survey data analysis.

Pathologica
Zannoni, Gian Franco GF; Santoro, Angela A; D'Alessandris, Nicoletta N; Scaglione, Giulia G; Inzani, Frediano F; Angelico, Giuseppe G; Bragantini, Emma E; Piermattei, Alessia A; Cianfrini, Federica F; Bisaro, Brigitte B; Fassan, Matteo M; ,
Publication Date: 2022-06

Variant appearance in text: POLE: S297F
PubMed Link: 35775705
Variant Present in the following documents:
  • Main text
  • pathol-2022-03-189.pdf
View BVdb publication page



Preparation of Duplex Sequencing Libraries for Archival Paraffin-Embedded Tissue Samples Using Single-Strand-Specific Nuclease P1.

International Journal Of Molecular Sciences
Mitiushkina, Natalia V NV; Yanus, Grigory A GA; Kuligina, Ekatherina Sh ES; Laidus, Tatiana A TA; Romanko, Alexandr A AA; Kholmatov, Maksim M MM; Ivantsov, Alexandr O AO; Aleksakhina, Svetlana N SN; Imyanitov, Evgeny N EN
Publication Date: 2022-04-21

Variant appearance in text: POLE: S297F
PubMed Link: 35562977
Variant Present in the following documents:
  • ijms-23-04586.pdf
View BVdb publication page



Current Prognostic and Predictive Biomarkers for Endometrial Cancer in Clinical Practice: Recommendations/Proposal from the Italian Study Group.

Frontiers In Oncology
Zannoni, Gian Franco GF; Bragantini, Emma E; Castiglione, Francesca F; Fassan, Matteo M; Troncone, Giancarlo G; Inzani, Frediano F; Pesci, Anna A; Santoro, Angela A; Fraggetta, Filippo F
Publication Date: 2022

Variant appearance in text: POLE: S297F
PubMed Link: 35463299
Variant Present in the following documents:
  • Main text
  • fonc-12-805613.pdf
View BVdb publication page



Clinical impact of genetic alterations of CTNNB1 in patients with grade 3 endometrial endometrioid carcinoma.

Cancer Science
Kobayashi Kato, Mayumi M; Asami, Yuka Y; Takayanagi, Daisuke D; Matsuda, Maiko M; Shimada, Yoko Y; Hiranuma, Kengo K; Kuno, Ikumi I; Komatsu, Masaaki M; Hamamoto, Ryuji R; Matsumoto, Koji K; Ishikawa, Mitsuya M; Kohno, Takashi T; Kato, Tomoyasu T; Shiraishi, Kouya K; Yoshida, Hiroshi H
Publication Date: 2022-05

Variant appearance in text: POLE: S297F
PubMed Link: 35278272
Variant Present in the following documents:
  • Main text
  • CAS-113-1712.pdf
View BVdb publication page



Collision of germline POLE and PMS2 variants in a young patient treated with immune checkpoint inhibitors.

Npj Precision Oncology
Berrino, Enrico E; Filippi, Roberto R; Visintin, Clara C; Peirone, Serena S; Fenocchio, Elisabetta E; Farinea, Giovanni G; Veglio, Franco F; Aglietta, Massimo M; Sapino, Anna A; Cereda, Matteo M; Visintin, Rosella R; Pasini, Barbara B; Marchiò, Caterina C
Publication Date: 2022-03-08

Variant appearance in text: POLE: S297F
PubMed Link: 35260767
Variant Present in the following documents:
  • 41698_2022_Article_258.pdf
View BVdb publication page



Clinical and Molecular Characterization of POLE Mutations as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Cancers.

Jco Precision Oncology
Garmezy, Benjamin B; Gheeya, Jinesh J; Lin, Heather Y HY; Huang, Yuefan Y; Kim, Taebeom T; Jiang, Xianli X; Thein, Kyaw Z KZ; Pilié, Patrick G PG; Zeineddine, Fadl F; Wang, Wanlin W; Shaw, Kenna R KR; Rodon, Jordi J; Shen, John Paul JP; Yuan, Ying Y; Meric-Bernstam, Funda F; Chen, Ken K; Yap, Timothy A TA
Publication Date: 2022-02

Variant appearance in text: POLE: S297F
PubMed Link: 35108036
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical and Molecular Characterization of POLE Mutations as Predictive Biomarkers of Response to Immune Checkpoint Inhibitors in Advanced Cancers.

Jco Precision Oncology
Garmezy, Benjamin B; Gheeya, Jinesh J; Lin, Heather Y HY; Huang, Yuefan Y; Kim, Taebeom T; Jiang, Xianli X; Thein, Kyaw Z KZ; Pilié, Patrick G PG; Zeineddine, Fadl F; Wang, Wanlin W; Shaw, Kenna R KR; Rodon, Jordi J; Shen, John Paul JP; Yuan, Ying Y; Meric-Bernstam, Funda F; Chen, Ken K; Yap, Timothy A TA
Publication Date: 2022-02

Variant appearance in text: POLE: S297F
PubMed Link: 35108036
Variant Present in the following documents:
  • Main text
View BVdb publication page



A framework for mutational signature analysis based on DNA shape parameters.

Plos One
Karolak, Aleksandra A; Levatić, Jurica J; Supek, Fran F
Publication Date: 2022

Variant appearance in text: POLE: S297F
PubMed Link: 35015788
Variant Present in the following documents:
  • Main text
  • pone.0262495.s010.pdf
  • pone.0262495.pdf
View BVdb publication page



A framework for mutational signature analysis based on DNA shape parameters.

Plos One
Karolak, Aleksandra A; Levatić, Jurica J; Supek, Fran F
Publication Date: 2022

Variant appearance in text: POLE: S297F
PubMed Link: 35015788
Variant Present in the following documents:
  • Main text
  • pone.0262495.s010.pdf
  • pone.0262495.pdf
View BVdb publication page



Clinical evaluation of a droplet digital PCR assay for detecting POLE mutations and molecular classification of endometrial cancer.

Journal Of Gynecologic Oncology
Kim, Gilhyang G; Lee, Song Kook SK; Suh, Dong Hoon DH; Kim, Kidong K; No, Jae Hong JH; Kim, Yong Beom YB; Kim, Hyojin H
Publication Date: 2022-03

Variant appearance in text: POLE: S297F
PubMed Link: 34910396
Variant Present in the following documents:
  • jgo-33-e15.pdf
View BVdb publication page



Identification of Immune-Related Gene Signatures in Lung Adenocarcinoma and Lung Squamous Cell Carcinoma.

Frontiers In Immunology
Li, Na N; Wang, Jiahong J; Zhan, Xianquan X
Publication Date: 2021

Variant appearance in text: POLE: 890C>T; S297F
PubMed Link: 34887858
Variant Present in the following documents:
  • Table_4.xlsx, sheet 1
View BVdb publication page



A radiogenomics application for prognostic profiling of endometrial cancer.

Communications Biology
Hoivik, Erling A EA; Hodneland, Erlend E; Dybvik, Julie A JA; Wagner-Larsen, Kari S KS; Fasmer, Kristine E KE; Berg, Hege F HF; Halle, Mari K MK; Haldorsen, Ingfrid S IS; Krakstad, Camilla C
Publication Date: 2021-12-06

Variant appearance in text: POLE: S297F
PubMed Link: 34873276
Variant Present in the following documents:
  • Main text
  • 42003_2021_Article_2894.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: POLE: S297F
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Distinct mutational profile and immune microenvironment in microsatellite-unstable and POLE-mutated tumors.

Journal For Immunotherapy Of Cancer
Hwang, Hee Sang HS; Kim, Deokhoon D; Choi, Jene J
Publication Date: 2021-10

Variant appearance in text: POLE: S297F
PubMed Link: 34607897
Variant Present in the following documents:
  • Main text
  • jitc-2021-002797.pdf
View BVdb publication page



POLE/POLD1 mutation in non-exonuclease domain matters for predicting efficacy of immune-checkpoint-inhibitor therapy.

Clinical And Translational Medicine
Chen, Yan-Xing YX; Wang, Zi-Xian ZX; Yuan, Shu-Qiang SQ; Jiang, Teng-Jia TJ; Huang, You-Sheng YS; Xu, Rui-Hua RH; Wang, Feng F; Zhao, Qi Q
Publication Date: 2021-09

Variant appearance in text: POLE: S297F
PubMed Link: 34586735
Variant Present in the following documents:
  • CTM2-11-e524-s001.xlsx, sheet 2
  • CTM2-11-e524-s001.xlsx, sheet 6
View BVdb publication page



Tumor BRCA testing can reveal a high tumor mutational burden related to POLE pathogenic variants.

Gynecologic Oncology Reports
Villy, M-C MC; Masliah-Planchon, J J; Melaabi, S S; Trabelsi Grati, O O; Girard, E E; Bataillon, G G; Vincent-Salomon, A A; Le Gall, J J; Golmard, L L; Stoppa-Lyonnet, D D; Bieche, I I; Colas, C C
Publication Date: 2021-08

Variant appearance in text: POLE: 890C>T; Ser297Phe
PubMed Link: 34541275
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Adjuvant Treatment Recommendations in Early-Stage Endometrial Cancer: What Changes With the Introduction of The Integrated Molecular-Based Risk Assessment.

Frontiers In Oncology
Nero, Camilla C; Ciccarone, Francesca F; Pietragalla, Antonella A; Duranti, Simona S; Daniele, Gennaro G; Scambia, Giovanni G; Lorusso, Domenica D
Publication Date: 2021

Variant appearance in text: POLE: S297F
PubMed Link: 34540651
Variant Present in the following documents:
  • Main text
View BVdb publication page



Towards Personalized Medicine: Non-Coding RNAs and Endometrial Cancer.

Healthcare (Basel, Switzerland)
Cavaliere, Anna Franca AF; Perelli, Federica F; Zaami, Simona S; Piergentili, Roberto R; Mattei, Alberto A; Vizzielli, Giuseppe G; Scambia, Giovanni G; Straface, Gianluca G; Restaino, Stefano S; Signore, Fabrizio F
Publication Date: 2021-07-30

Variant appearance in text: POLE: S297F
PubMed Link: 34442102
Variant Present in the following documents:
  • Main text
  • healthcare-09-00965.pdf
View BVdb publication page



A computational and structural analysis of germline and somatic variants affecting the DDR mechanism, and their impact on human diseases.

Scientific Reports
Magraner-Pardo, Lorena L; Laskowski, Roman A RA; Pons, Tirso T; Thornton, Janet M JM
Publication Date: 2021-07-12

Variant appearance in text: POLE: 890C>T; S297F
PubMed Link: 34253785
Variant Present in the following documents:
  • 41598_2021_93715_MOESM2_ESM.xlsx, sheet 10
View BVdb publication page



Frequent POLE-driven hypermutation in ovarian endometrioid cancer revealed by mutational signatures in RNA sequencing.

Bmc Medical Genomics
Davila, Jaime I JI; Chanana, Pritha P; Sarangi, Vivekananda V; Fogarty, Zachary C ZC; Weroha, S John SJ; Guo, Ruifeng R; Goode, Ellen L EL; Huang, Yajue Y; Wang, Chen C
Publication Date: 2021-06-22

Variant appearance in text: POLE: S297F
PubMed Link: 34158040
Variant Present in the following documents:
  • Main text
  • 12920_2021_Article_1017.pdf
View BVdb publication page



Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer.

Journal Of Hematology & Oncology
Chen, Gong G; Peng, Junjie J; Xiao, Qian Q; Wu, Hao-Xiang HX; Wu, Xiaojun X; Wang, Fulong F; Li, Liren L; Ding, Peirong P; Zhao, Qi Q; Li, Yaqi Y; Wang, Da D; Shao, Yang Y; Bao, Hua H; Pan, Zhizhong Z; Ding, Ke-Feng KF; Cai, Sanjun S; Wang, Feng F; Xu, Rui-Hua RH
Publication Date: 2021-05-17

Variant appearance in text: POLE: S297F
PubMed Link: 34001194
Variant Present in the following documents:
  • 13045_2021_1089_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Genotyping data of routinely processed matched primary/metastatic tumor samples.

Data In Brief
Kotoula, Vassiliki V; Chatzopoulos, Kyriakos K; Papadopoulou, Kyriaki K; Giannoulatou, Eleni E; Koliou, Georgia-Angeliki GA; Karavasilis, Vasilios V; Pazarli, Elissavet E; Pervana, Stavroula S; Kafiri, Georgia G; Tsoulfas, Georgios G; Chrisafi, Sofia S; Sgouramali, Helen H; Papakostas, Pavlos P; Pectasides, Dimitrios D; Hytiroglou, Prodromos P; Pentheroudakis, George G; Fountzilas, George G
Publication Date: 2021-02

Variant appearance in text: POLE: 890C>T; Ser297Phe
PubMed Link: 33365374
Variant Present in the following documents:
  • mmc1.xlsx, sheet 3
View BVdb publication page



Combination of Proactive Molecular Risk Classifier for Endometrial cancer (ProMisE) with sonographic and demographic characteristics in preoperative prediction of recurrence or progression of endometrial cancer.

Ultrasound In Obstetrics & Gynecology : The Official Journal Of The International Society Of Ultrasound In Obstetrics And Gynecology
Eriksson, L S E LSE; Nastic, D D; Lindqvist, P G PG; Imboden, S S; Järnbert-Pettersson, H H; Carlson, J W JW; Epstein, E E
Publication Date: 2021-09

Variant appearance in text: POLE: S297F
PubMed Link: 33314410
Variant Present in the following documents:
  • Main text
  • UOG-58-457.pdf
View BVdb publication page



Clinical factors as prognostic variables among molecular subgroups of endometrial cancer.

Plos One
Kolehmainen, Anne A; Pasanen, Annukka A; Tuomi, Taru T; Koivisto-Korander, Riitta R; Bützow, Ralf R; Loukovaara, Mikko M
Publication Date: 2020

Variant appearance in text: POLE: 890C>T; S297F
PubMed Link: 33232359
Variant Present in the following documents:
  • Main text
View BVdb publication page



Ultra-mutated colorectal cancer patients with POLE driver mutations exhibit distinct clinical patterns.

Cancer Medicine
Hu, Hanguang H; Cai, Wen W; Wu, Dehao D; Hu, Wangxiong W; Dong Wang, Li L; Mao, Jianshan J; Zheng, Shu S; Ge, Weiting W
Publication Date: 2021-01

Variant appearance in text: POLE: S297F
PubMed Link: 33125191
Variant Present in the following documents:
  • Main text
  • CAM4-10-135.pdf
View BVdb publication page



Molecular stratification of endometrioid ovarian carcinoma predicts clinical outcome.

Nature Communications
Hollis, Robert L RL; Thomson, John P JP; Stanley, Barbara B; Churchman, Michael M; Meynert, Alison M AM; Rye, Tzyvia T; Bartos, Clare C; Iida, Yasushi Y; Croy, Ian I; Mackean, Melanie M; Nussey, Fiona F; Okamoto, Aikou A; Semple, Colin A CA; Gourley, Charlie C; Herrington, C Simon CS
Publication Date: 2020-10-05

Variant appearance in text: POLE: S297F
PubMed Link: 33020491
Variant Present in the following documents:
  • 41467_2020_Article_18819.pdf
View BVdb publication page