Publications:

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A Proteomic Approach Identifies Isoform-Specific and Nucleotide-Dependent RAS Interactions.

Molecular & Cellular Proteomics : Mcp

Miller, Seth P SP; Maio, George G; Zhang, Xiaoyu X; Badillo Soto, Felix S FS; Zhu, Julia J; Ramirez, Stephen Z SZ; Lin, Hening H

Publication Date: 2022-08

Variant appearance in text: KRAS: C185S

PubMed Link: 35839996

Variant Present in the following documents:

• mmc1.pdf

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KRAS is vulnerable to reversible switch-II pocket engagement in cells.

Nature Chemical Biology

Vasta, James D JD; Peacock, D Matthew DM; Zheng, Qinheng Q; Walker, Joel A JA; Zhang, Ziyang Z; Zimprich, Chad A CA; Thomas, Morgan R MR; Beck, Michael T MT; Binkowski, Brock F BF; Corona, Cesear R CR; Robers, Matthew B MB; Shokat, Kevan M KM

Publication Date: 2022-06

Variant appearance in text: KRAS: C185S

PubMed Link: 35314814

Variant Present in the following documents:

• 41589_2022_985_MOESM3_ESM.xlsx, sheet 8
• 41589_2022_985_MOESM4_ESM.xlsx, sheet 1
• 41589_2022_985_MOESM3_ESM.xlsx, sheet 10

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Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.

Journal Of Medicinal Chemistry

Yelland, Tamas T; Garcia, Esther E; Parry, Charles C; Kowalczyk, Dominika D; Wojnowska, Marta M; Gohlke, Andrea A; Zalar, Matja M; Cameron, Kenneth K; Goodwin, Gillian G; Yu, Qing Q; Zhu, Peng-Cheng PC; ElMaghloob, Yasmin Y; Pugliese, Angelo A; Archibald, Lewis L; Jamieson, Andrew A; Chen, Yong Xiang YX; McArthur, Duncan D; Bower, Justin J; Ismail, Shehab S

Publication Date: 2022-02-01

Variant appearance in text: KRAS: C185S

PubMed Link: 35104933

Variant Present in the following documents:

• jm1c01265_si_001.pdf

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Stabilization of the RAS:PDE6D Complex Is a Novel Strategy to Inhibit RAS Signaling.

Journal Of Medicinal Chemistry

Yelland, Tamas T; Garcia, Esther E; Parry, Charles C; Kowalczyk, Dominika D; Wojnowska, Marta M; Gohlke, Andrea A; Zalar, Matja M; Cameron, Kenneth K; Goodwin, Gillian G; Yu, Qing Q; Zhu, Peng-Cheng PC; ElMaghloob, Yasmin Y; Pugliese, Angelo A; Archibald, Lewis L; Jamieson, Andrew A; Chen, Yong Xiang YX; McArthur, Duncan D; Bower, Justin J; Ismail, Shehab S

Publication Date: 2022-02-10

Variant appearance in text: KRAS: C185S

PubMed Link: 35104933

Variant Present in the following documents:

• jm1c01265_si_001.pdf

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A structural model of a Ras-Raf signalosome.

Nature Structural & Molecular Biology

Mysore, Venkatesh P VP; Zhou, Zhi-Wei ZW; Ambrogio, Chiara C; Li, Lianbo L; Kapp, Jonas N JN; Lu, Chunya C; Wang, Qi Q; Tucker, Maxwell R MR; Okoro, Jeffrey J JJ; Nagy-Davidescu, Gabriela G; Bai, Xiaochen X; Plückthun, Andreas A; Jänne, Pasi A PA; Westover, Kenneth D KD; Shan, Yibing Y; Shaw, David E DE

Publication Date: 2021-10

Variant appearance in text: KRAS: C185S

PubMed Link: 34625747

Variant Present in the following documents:

• Main text

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Oncogenic KRAS engages an RSK1/NF1 pathway to inhibit wild-type RAS signaling in pancreatic cancer.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Cheng, Derek K DK; Oni, Tobiloba E TE; Thalappillil, Jennifer S JS; Park, Youngkyu Y; Ting, Hsiu-Chi HC; Alagesan, Brinda B; Prasad, Nadia V NV; Addison, Kenneth K; Rivera, Keith D KD; Pappin, Darryl J DJ; Van Aelst, Linda L; Tuveson, David A DA

Publication Date: 2021-05-25

Variant appearance in text: KRAS: C185S

PubMed Link: 34021083

Variant Present in the following documents:

• Main text
• pnas.202016904.pdf
• pnas.2016904118.sapp.pdf

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Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules.

Cell

Tulpule, Asmin A; Guan, Juan J; Neel, Dana S DS; Allegakoen, Hannah R HR; Lin, Yone Phar YP; Brown, David D; Chou, Yu-Ting YT; Heslin, Ann A; Chatterjee, Nilanjana N; Perati, Shriya S; Menon, Shruti S; Nguyen, Tan A TA; Debnath, Jayanta J; Ramirez, Alejandro D AD; Shi, Xiaoyu X; Yang, Bin B; Feng, Siyu S; Makhija, Suraj S; Huang, Bo B; Bivona, Trever G TG

Publication Date: 2021-05-13

Variant appearance in text: KRAS: C185S

PubMed Link: 33848463

Variant Present in the following documents:

• Main text

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The Ins and Outs of RAS Effector Complexes.

Biomolecules

Kiel, Christina C; Matallanas, David D; Kolch, Walter W

Publication Date: 2021-02-07

Variant appearance in text: KRAS: C185S

PubMed Link: 33562401

Variant Present in the following documents:

• Main text
• biomolecules-11-00236.pdf

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Discernment between candidate mechanisms for KRAS G13D colorectal cancer sensitivity to EGFR inhibitors.

Cell Communication And Signaling : Ccs

McFall, Thomas T; Schomburg, Noah K NK; Rossman, Kent L KL; Stites, Edward C EC

Publication Date: 2020-11-05

Variant appearance in text: KRAS: C185S

PubMed Link: 33153459

Variant Present in the following documents:

• Main text
• 12964_2020_Article_645.pdf

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Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy.

Oncology Letters

Hu, Kongwang K; Yu, Weiqiang W; Ajayi, Olugbenga Emmanuel OE; Li, Longlong L; Huang, Zhiguo Z; Rong, Qiqi Q; Wang, Shuaili S; Wu, Qing-Fa QF

Publication Date: 2020-10

Variant appearance in text: KRAS: C185S

PubMed Link: 32863928

Variant Present in the following documents:

• ol-20-04-11976.pdf

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Analysis of RAS protein interactions in living cells reveals a mechanism for pan-RAS depletion by membrane-targeted RAS binders.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Li, Yao-Cheng YC; Lytle, Nikki K NK; Gammon, Seth T ST; Wang, Luke L; Hayes, Tikvah K TK; Sutton, Margie N MN; Bast, Robert C RC; Der, Channing J CJ; Piwnica-Worms, David D; McCormick, Frank F; Wahl, Geoffrey M GM

Publication Date: 2020-06-02

Variant appearance in text: KRAS: C185S

PubMed Link: 32424096

Variant Present in the following documents:

• Main text

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Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior.

Elife

Goswami, Debanjan D; Chen, De ; Yang, Yue Y; Gudla, Prabhakar R PR; Columbus, John J; Worthy, Karen K; Rigby, Megan M; Wheeler, Madeline M; Mukhopadhyay, Suman S; Powell, Katie K; Burgan, William W; Wall, Vanessa V; Esposito, Dominic D; Simanshu, Dhirendra K DK; Lightstone, Felice C FC; Nissley, Dwight V DV; McCormick, Frank F; Turbyville, Thomas T

Publication Date: 2020-01-20

Variant appearance in text: KRAS: C185S

PubMed Link: 31958057

Variant Present in the following documents:

• Main text
• elife-47654.pdf

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Galectin-8 binds to the Farnesylated C-terminus of K-Ras4B and Modifies Ras/ERK Signaling and Migration in Pancreatic and Lung Carcinoma Cells.

Cancers

Meinohl, Christopher C; Barnard, Sarah J SJ; Fritz-Wolf, Karin K; Unger, Monika M; Porr, Andreea A; Heipel, Marisa M; Wirth, Stefanie S; Madlung, Johannes J; Nordheim, Alfred A; Menke, Andre A; Becker, Katja K; Giehl, Klaudia K

Publication Date: 2019-12-20

Variant appearance in text: K-Ras4B: C185S

PubMed Link: 31861875

Variant Present in the following documents:

• Main text
• cancers-12-00030.pdf

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DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.

Cell Reports

Sutton, Margie N MN; Lu, Zhen Z; Li, Yao-Cheng YC; Zhou, Yong Y; Huang, Tao T; Reger, Albert S AS; Hurwitz, Amy M AM; Palzkill, Timothy T; Logsdon, Craig C; Liang, Xiaowen X; Gray, Joe W JW; Nan, Xiaolin X; Hancock, John J; Wahl, Geoffrey M GM; Bast, Robert C RC

Publication Date: 2019-12-10

Variant appearance in text: K-Ras4B: C185S

PubMed Link: 31825828

Variant Present in the following documents:

• Main text

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New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics.

Seminars In Cancer Biology

Esposito, Dominic D; Stephen, Andrew G AG; Turbyville, Thomas J TJ; Holderfield, Matthew M

Publication Date: 2019-02

Variant appearance in text: KRAS: C185S

PubMed Link: 29432816

Variant Present in the following documents:

• Main text

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The G protein-coupled receptor GPR31 promotes membrane association of KRAS.

The Journal Of Cell Biology

Fehrenbacher, Nicole N; Tojal da Silva, Israel I; Ramirez, Craig C; Zhou, Yong Y; Cho, Kwang-Jin KJ; Kuchay, Shafi S; Shi, Jie J; Thomas, Susan S; Pagano, Michele M; Hancock, John F JF; Bar-Sagi, Dafna D; Philips, Mark R MR

Publication Date: 2017-08-07

Variant appearance in text: KRAS: C185S

PubMed Link: 28619714

Variant Present in the following documents:

• Main text
• JCB_201609096.pdf
• JCB_201609096_sm.pdf

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Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission.

Molecular And Cellular Biology

van der Hoeven, Dharini D; Cho, Kwang-jin KJ; Ma, Xiaoping X; Chigurupati, Sravanthi S; Parton, Robert G RG; Hancock, John F JF

Publication Date: 2013-01

Variant appearance in text: K-Ras4B: C185S

PubMed Link: 23129805

Variant Present in the following documents:

• Main text

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