Publications:

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Small-molecule IKKβ activation modulator (IKAM) targets MAP3K1 and inhibits pancreatic tumor growth.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Napoleon, John Victor JV; Sagar, Satish S; Kubica, Sydney P SP; Boghean, Lidia L; Kour, Smit S; King, Hannah M HM; Sonawane, Yogesh A YA; Crawford, Ayrianne J AJ; Gautam, Nagsen N; Kizhake, Smitha S; Bialk, Pawel A PA; Kmiec, Eric E; Mallareddy, Jayapal Reddy JR; Patil, Prathamesh P PP; Rana, Sandeep S; Singh, Sarbjit S; Prahlad, Janani J; Grandgenett, Paul M PM; Borgstahl, Gloria E O GEO; Ghosal, Gargi G; Alnouti, Yazen Y; Hollingsworth, Michael A MA; Radhakrishnan, Prakash P; Natarajan, Amarnath A

Publication Date: 2022-05-03

Variant appearance in text: KRAS: S181E

PubMed Link: 35476515

Variant Present in the following documents:

• pnas.202115071.pdf

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Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane.

The Journal Of Biological Chemistry

Lakshman, Bindu B; Messing, Simon S; Schmid, Eva M EM; Clogston, Jeffrey D JD; Gillette, William K WK; Esposito, Dominic D; Kessing, Bailey B; Fletcher, Daniel A DA; Nissley, Dwight V DV; McCormick, Frank F; Stephen, Andrew G AG; Jean-Francois, Frantz L FL

Publication Date: 2019-02-08

Variant appearance in text: KRAS: S181E

PubMed Link: 30559287

Variant Present in the following documents:

• Main text

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Mouse Pancreatic Tumor Model Independent of Tumor Suppressor Gene Inactivation.

Pancreas

Naramura, Mayumi M; Natarajan, Amarnath A

Publication Date: 2018

Variant appearance in text: KRAS: S181E

PubMed Link: 29702533

Variant Present in the following documents:

• Main text

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Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Dharmaiah, Srisathiyanarayanan S; Bindu, Lakshman L; Tran, Timothy H TH; Gillette, William K WK; Frank, Peter H PH; Ghirlando, Rodolfo R; Nissley, Dwight V DV; Esposito, Dominic D; McCormick, Frank F; Stephen, Andrew G AG; Simanshu, Dhirendra K DK

Publication Date: 2016-11-01

Variant appearance in text: KRAS: S181E

PubMed Link: 27791178

Variant Present in the following documents:

• Main text

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Narrowing the focus: a toolkit to systematically connect oncogenic signaling pathways with cancer phenotypes.

Genes & Cancer

Singleton, Katherine R KR; Wood, Kris C KC

Publication Date: 2016-07

Variant appearance in text: KRAS: S181E

PubMed Link: 27738492

Variant Present in the following documents:

• Main text

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Targeting protein prenylation for cancer therapy.

Nature Reviews. Cancer

Berndt, Norbert N; Hamilton, Andrew D AD; Sebti, Saïd M SM

Publication Date: 2011-10-24

Variant appearance in text: KRAS: S181E

PubMed Link: 22020205

Variant Present in the following documents:

• Main text

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