KRAS c.469_470delinsGC ;(p.Y157A)

Variant ID: 12-25362826-TA-GC

NM_004985.3(KRAS):c.469_470delinsGC;(p.Y157A)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.

Nature Communications
Tran, Timothy H TH; Chan, Albert H AH; Young, Lucy C LC; Bindu, Lakshman L; Neale, Chris C; Messing, Simon S; Dharmaiah, Srisathiyanarayanan S; Taylor, Troy T; Denson, John-Paul JP; Esposito, Dominic D; Nissley, Dwight V DV; Stephen, Andrew G AG; McCormick, Frank F; Simanshu, Dhirendra K DK
Publication Date: 2021-02-19

Variant appearance in text: KRAS: Y157A
PubMed Link: 33608534
Variant Present in the following documents:
  • Main text
  • 41467_2021_21422_MOESM4_ESM.xlsx, sheet 4
  • 41467_2021_Article_21422.pdf
  • 41467_2021_21422_MOESM1_ESM.pdf
  • 41467_2021_21422_MOESM4_ESM.xlsx, sheet 7
View BVdb publication page



DIRAS3 (ARHI) Blocks RAS/MAPK Signaling by Binding Directly to RAS and Disrupting RAS Clusters.

Cell Reports
Sutton, Margie N MN; Lu, Zhen Z; Li, Yao-Cheng YC; Zhou, Yong Y; Huang, Tao T; Reger, Albert S AS; Hurwitz, Amy M AM; Palzkill, Timothy T; Logsdon, Craig C; Liang, Xiaowen X; Gray, Joe W JW; Nan, Xiaolin X; Hancock, John J; Wahl, Geoffrey M GM; Bast, Robert C RC
Publication Date: 2019-12-10

Variant appearance in text: K-Ras4B: Y157A
PubMed Link: 31825828
Variant Present in the following documents:
  • Main text
View BVdb publication page



Deconstruction of the Ras switching cycle through saturation mutagenesis.

Elife
Bandaru, Pradeep P; Shah, Neel H NH; Bhattacharyya, Moitrayee M; Barton, John P JP; Kondo, Yasushi Y; Cofsky, Joshua C JC; Gee, Christine L CL; Chakraborty, Arup K AK; Kortemme, Tanja T; Ranganathan, Rama R; Kuriyan, John J
Publication Date: 2017-07-07

Variant appearance in text: KRAS: Y157A
PubMed Link: 28686159
Variant Present in the following documents:
  • Main text
  • elife-27810.pdf
View BVdb publication page