Publications:

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Direct GDP-KRASG12C inhibitors and mechanisms of resistance: the tip of the iceberg.

Therapeutic Advances In Medical Oncology

Rosen, Joshua C JC; Sacher, Adrian A; Tsao, Ming-Sound MS

Publication Date: 2023

Variant appearance in text: KRAS: F156L

PubMed Link: 36950276

Variant Present in the following documents:

• Main text
• 10.1177_17588359231160141.pdf

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Tissue and liquid biopsy profiling reveal convergent tumor evolution and therapy evasion in breast cancer.

Nature Communications

Sivakumar, Smruthy S; Jin, Dexter X DX; Tukachinsky, Hanna H; Murugesan, Karthikeyan K; McGregor, Kimberly K; Danziger, Natalie N; Pavlick, Dean D; Gjoerup, Ole O; Ross, Jeffrey S JS; Harmon, Robert R; Chung, Jon J; Decker, Brennan B; Dennis, Lucas L; Frampton, Garrett M GM; Molinero, Luciana L; Oesterreich, Steffi S; Venstrom, Jeffrey M JM; Oxnard, Geoffrey R GR; Hegde, Priti S PS; Sokol, Ethan S ES

Publication Date: 2022-12-05

Variant appearance in text: KRAS: F156L

PubMed Link: 36470901

Variant Present in the following documents:

• 41467_2022_35245_MOESM4_ESM.xlsx, sheet 17

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: KRAS: F156L

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

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Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.

Blood

Ansari-Pour, Naser N; Samur, Mehmet K MK; Flynt, Erin E; Gooding, Sarah S; Towfic, Fadi F; Stong, Nicholas N; Ortiz Estevez, Maria M; Mavrommatis, Konstantinos K; Walker, Brian A BA; Morgan, Gareth J GJ; Munshi, Nikhil C NC; Avet Loiseau, Herve H; Thakurta, Anjan A

Publication Date: 2022-10-12

Variant appearance in text: KRAS: F156L

PubMed Link: 36223594

Variant Present in the following documents:

• BLOOD_BLD-2022-017010-mmc2.xlsx, sheet 1

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A bipartite graph-based expected networks approach identifies DDR genes not associated with TMB yet predictive of immune checkpoint blockade response.

Cell Reports. Medicine

Weir, William H WH; Mucha, Peter J PJ; Kim, William Y WY

Publication Date: 2022-05-17

Variant appearance in text: KRAS: Phe156Leu

PubMed Link: 35584624

Variant Present in the following documents:

• mmc2.xlsx, sheet 4

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Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.

Blood Advances

Tran, Thai Hoa TH; Langlois, Sylvie S; Meloche, Caroline C; Caron, Maxime M; Saint-Onge, Pascal P; Rouette, Alexandre A; Bataille, Alain R AR; Jimenez-Cortes, Camille C; Sontag, Thomas T; Bittencourt, Henrique H; Laverdière, Caroline C; Lavallée, Vincent-Philippe VP; Leclerc, Jean-Marie JM; Cole, Peter D PD; Gennarini, Lisa M LM; Kahn, Justine M JM; Kelly, Kara M KM; Michon, Bruno B; Santiago, Raoul R; Stevenson, Kristen E KE; Welch, Jennifer J G JJG; Schroeder, Kaitlin M KM; Koch, Victoria V; Cellot, Sonia S; Silverman, Lewis B LB; Sinnett, Daniel D

Publication Date: 2022-02-22

Variant appearance in text: KRAS: F156L

PubMed Link: 34933343

Variant Present in the following documents:

• advancesADV2021005634-suppl1.xlsx, sheet 1
• advancesADV2021005634-suppl1.xlsx, sheet 3

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: KRAS: F156L

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

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Embryonic Expression of NrasG 12 D Leads to Embryonic Lethality and Cardiac Defects.

Frontiers In Cell And Developmental Biology

You, Xiaona X; Ryu, Myung-Jeom MJ; Cho, Eunjin E; Sang, Yanzhi Y; Damnernsawad, Alisa A; Zhou, Yun Y; Liu, Yangang Y; Zhang, Jing J; Lee, Youngsook Y

Publication Date: 2021

Variant appearance in text: KRAS: F156L

PubMed Link: 33681212

Variant Present in the following documents:

• Main text
• fcell-09-633661.pdf

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Comprehensive next-generation profiling of clonal hematopoiesis in cancer patients using paired tumor-blood sequencing for guiding personalized therapies.

Clinical And Translational Medicine

Li, Ziyang Z; Huang, Wensou W; Yin, Jiani C JC; Na, Chenglong C; Wu, Xue X; Shao, Yang Y; Ding, Huaxin H; Li, Jinming J

Publication Date: 2020-11

Variant appearance in text: KRAS: F156L

PubMed Link: 33252848

Variant Present in the following documents:

• Main text
• CTM2-10-e222-s004.xlsx, sheet 1
• CTM2-10-e222.pdf
• CTM2-10-e222-s003.xlsx, sheet 1

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Integrated molecular drivers coordinate biological and clinical states in melanoma.

Nature Genetics

Conway, Jake R JR; Dietlein, Felix F; Taylor-Weiner, Amaro A; AlDubayan, Saud S; Vokes, Natalie N; Keenan, Tanya T; Reardon, Brendan B; He, Meng Xiao MX; Margolis, Claire A CA; Weirather, Jason L JL; Haq, Rizwan R; Schilling, Bastian B; Stephen Hodi, F F; Schadendorf, Dirk D; Liu, David D; Van Allen, Eliezer M EM

Publication Date: 2020-12

Variant appearance in text: N/A

PubMed Link: 33230298

Variant Present in the following documents:

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KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples.

Translational Lung Cancer Research

Loong, Herbert Ho-Fung HH; Du, Nan N; Cheng, Chunyan C; Lin, Hanqing H; Guo, Jian J; Lin, Gen G; Li, Mingjiang M; Jiang, Tao T; Shi, Zhihua Z; Cui, Yanzhi Y; Jin, Xianfeng X; Yao, Jicheng J; Xing, Yutong Y; Yao, Ming M; Wang, Kai K; Mok, Tony S K TSK; Liu, Lunxu L

Publication Date: 2020-10

Variant appearance in text: KRAS: F156L

PubMed Link: 33209599

Variant Present in the following documents:

• Main text
• tlcr-09-05-1759.pdf

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Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity.

Journal For Immunotherapy Of Cancer

Hong, Tae Hee TH; Cha, Hongui H; Shim, Joon Ho JH; Lee, Boram B; Chung, Jongsuk J; Lee, Chung C; Kim, Nayoung K D NKD; Choi, Yoon-La YL; Hwang, Soohyun S; Lee, Yoomi Y; Park, Sehhoon S; Jung, Hyun Ae HA; Kim, Ji-Yeon JY; Park, Yeon Hee YH; Sun, Jong-Mu JM; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Lee, Se-Hoon SH; Park, Woong-Yang WY

Publication Date: 2020-10

Variant appearance in text: KRAS: F156L

PubMed Link: 33077514

Variant Present in the following documents:

• jitc-2020-001199supp002.pdf

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Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports

Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA

Publication Date: 2020-09-21

Variant appearance in text: KRAS: F156L

PubMed Link: 32958805

Variant Present in the following documents:

• 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2

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Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology

Dunnett-Kane, V V; Burkitt-Wright, E E; Blackhall, F H FH; Malliri, A A; Evans, D G DG; Lindsay, C R CR

Publication Date: 2020-07

Variant appearance in text: KRAS: F156L

PubMed Link: 32240795

Variant Present in the following documents:

• Main text
• main.pdf

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GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.

Birth Defects Research

Bera, Asim K AK; Lu, Jia J; Lu, Chunya C; Li, Lianbo L; Gondi, Sudershan S; Yan, Wei W; Nelson, Andrew A; Zhang, Goujun G; Westover, Kenneth D KD

Publication Date: 2020-06

Variant appearance in text: KRAS: F156L

PubMed Link: 32187889

Variant Present in the following documents:

• Main text

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: KRAS: F156L

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

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Therapy-induced mutations drive the genomic landscape of relapsed acute lymphoblastic leukemia.

Blood

Li, Benshang B; Brady, Samuel W SW; Ma, Xiaotu X; Shen, Shuhong S; Zhang, Yingchi Y; Li, Yongjin Y; Szlachta, Karol K; Dong, Li L; Liu, Yu Y; Yang, Fan F; Wang, Ningling N; Flasch, Diane A DA; Myers, Matthew A MA; Mulder, Heather L HL; Ding, Lixia L; Liu, Yanling Y; Tian, Liqing L; Hagiwara, Kohei K; Xu, Ke K; Zhou, Xin X; Sioson, Edgar E; Wang, Tianyi T; Yang, Liu L; Zhao, Jie J; Zhang, Hui H; Shao, Ying Y; Sun, Hongye H; Sun, Lele L; Cai, Jiaoyang J; Sun, Hui-Ying HY; Lin, Ting-Nien TN; Du, Lijuan L; Li, Hui H; Rusch, Michael M; Edmonson, Michael N MN; Easton, John J; Zhu, Xiaofan X; Zhang, Jingliao J; Cheng, Cheng C; Raphael, Benjamin J BJ; Tang, Jingyan J; Downing, James R JR; Alexandrov, Ludmil B LB; Zhou, Bin-Bing S BS; Pui, Ching-Hon CH; Yang, Jun J JJ; Zhang, Jinghui J

Publication Date: 2020-01-02

Variant appearance in text: KRAS: F156L

PubMed Link: 31697823

Variant Present in the following documents:

• Main text

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Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology

Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR

Publication Date: 2019-04

Variant appearance in text: KRAS: F156L

PubMed Link: 31034466

Variant Present in the following documents:

• pcbi.1006981.s010.xlsx, sheet 1

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From mutations to mechanisms and dysfunction via computation and mining of protein energy landscapes.

Bmc Genomics

Qiao, Wanli W; Akhter, Nasrin N; Fang, Xiaowen X; Maximova, Tatiana T; Plaku, Erion E; Shehu, Amarda A

Publication Date: 2018-09-24

Variant appearance in text: KRAS: F156L

PubMed Link: 30255791

Variant Present in the following documents:

• 12864_2018_Article_5024.pdf

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Correlation between MEK signature and Ras gene alteration in advanced gastric cancer.

Oncotarget

Ahn, Soomin S; Brant, Roz R; Sharpe, Alan A; Dry, Jonathan R JR; Hodgson, Darren R DR; Kilgour, Elaine E; Kim, Kyung K; Kim, Seung Tae ST; Park, Se Hoon SH; Kang, Won Ki WK; Kim, Kyoung-Mee KM; Lee, Jeeyun J

Publication Date: 2017-12-08

Variant appearance in text: KRAS: F156L

PubMed Link: 29296181

Variant Present in the following documents:

• Main text
• oncotarget-08-107492.pdf

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Identification of an oncogenic RAB protein.

Science (New York, N.Y.)

Wheeler, Douglas B DB; Zoncu, Roberto R; Root, David E DE; Sabatini, David M DM; Sawyers, Charles L CL

Publication Date: 2015-10-09

Variant appearance in text: N/A

PubMed Link: 26338797

Variant Present in the following documents:

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RASopathies: unraveling mechanisms with animal models.

Disease Models & Mechanisms

Jindal, Granton A GA; Goyal, Yogesh Y; Burdine, Rebecca D RD; Rauen, Katherine A KA; Shvartsman, Stanislav Y SY

Publication Date: 2015-08-01

Variant appearance in text: KRAS: F156L

PubMed Link: 26203125

Variant Present in the following documents:

• supp_8.8.769_DMM020339supp.pdf

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Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Molecular Systems Biology

Kiel, Christina C; Serrano, Luis L

Publication Date: 2014-05-06

Variant appearance in text: KRAS: F156L

PubMed Link: 24803665

Variant Present in the following documents:

• Main text
• MSB-10-5-727-s13.xls, sheet 1
• MSB-10-5-727.pdf
• MSB-10-5-727-s14.xlsx, sheet 1

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A lethal course of hypertrophic cardiomyopathy in Noonan syndrome due to a novel germline mutation in the KRAS gene: case study.

Croatian Medical Journal

Nosan, Gregor G; Bertok, Sara S; Vesel, Samo S; Yntema, Helger G HG; Paro-Panjan, Darja D

Publication Date: 2013-12

Variant appearance in text: KRAS: Phe156Leu

PubMed Link: 24382853

Variant Present in the following documents:

• Main text
• CroatMedJ_54_0574.pdf

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Negative regulation of Shh levels by Kras and Fgfr2 during hair follicle development.

Developmental Biology

Mukhopadhyay, Anandaroop A; Krishnaswami, Suguna Rani SR; Cowing-Zitron, Christopher C; Hung, Nai-Jung NJ; Reilly-Rhoten, Heather H; Burns, Julianne J; Yu, Benjamin D BD

Publication Date: 2013-01-15

Variant appearance in text: N/A

PubMed Link: 23123965

Variant Present in the following documents:

View BVdb publication page

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BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors.

Cancer Discovery

Dahlman, Kimberly Brown KB; Xia, Junfeng J; Hutchinson, Katherine K; Ng, Charles C; Hucks, Donald D; Jia, Peilin P; Atefi, Mohammad M; Su, Zengliu Z; Branch, Suzanne S; Lyle, Pamela L PL; Hicks, Donna J DJ; Bozon, Viviana V; Glaspy, John A JA; Rosen, Neal N; Solit, David B DB; Netterville, James L JL; Vnencak-Jones, Cindy L CL; Sosman, Jeffrey A JA; Ribas, Antoni A; Zhao, Zhongming Z; Pao, William W

Publication Date: 2012-09

Variant appearance in text: KRAS: 466T>C

PubMed Link: 22798288

Variant Present in the following documents:

• Main text

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Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.

Human Mutation

Gremer, Lothar L; Merbitz-Zahradnik, Torsten T; Dvorsky, Radovan R; Cirstea, Ion C IC; Kratz, Christian Peter CP; Zenker, Martin M; Wittinghofer, Alfred A; Ahmadian, Mohammad Reza MR

Publication Date: 2011-01

Variant appearance in text: N/A

PubMed Link: 20949621

Variant Present in the following documents:

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Noonan syndrome: clinical aspects and molecular pathogenesis.

Molecular Syndromology

Tartaglia, M M; Zampino, G G; Gelb, B D BD

Publication Date: 2010-02

Variant appearance in text: N/A

PubMed Link: 20648242

Variant Present in the following documents:

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Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back.

American Journal Of Medical Genetics. Part A

Rauen, Katherine A KA; Schoyer, Lisa L; McCormick, Frank F; Lin, Angela E AE; Allanson, Judith E JE; Stevenson, David A DA; Gripp, Karen W KW; Neri, Giovanni G; Carey, John C JC; Legius, Eric E; Tartaglia, Marco M; Schubbert, Suzanne S; Roberts, Amy E AE; Gelb, Bruce D BD; Shannon, Kevin K; Gutmann, David H DH; McMahon, Martin M; Guerra, Carmen C; Fagin, James A JA; Yu, Benjamin B; Aoki, Yoko Y; Neel, Benjamin G BG; Balmain, Allan A; Drake, Richard R RR; Nolan, Garry P GP; Zenker, Martin M; Bollag, Gideon G; Sebolt-Leopold, Judith J; Gibbs, Jackson B JB; Silva, Alcino J AJ; Patton, E Elizabeth EE; Viskochil, David H DH; Kieran, Mark W MW; Korf, Bruce R BR; Hagerman, Randi J RJ; Packer, Roger J RJ; Melese, Teri T

Publication Date: 2010-01

Variant appearance in text: KRAS: F156L

PubMed Link: 20014119

Variant Present in the following documents:

• Main text

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High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.

Blood

Tyner, Jeffrey W JW; Erickson, Heidi H; Deininger, Michael W N MW; Willis, Stephanie G SG; Eide, Christopher A CA; Levine, Ross L RL; Heinrich, Michael C MC; Gattermann, Norbert N; Gilliland, D Gary DG; Druker, Brian J BJ; Loriaux, Marc M MM

Publication Date: 2009-02-19

Variant appearance in text: N/A

PubMed Link: 19075190

Variant Present in the following documents:

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Biochemical and functional characterization of germ line KRAS mutations.

Molecular And Cellular Biology

Schubbert, Suzanne S; Bollag, Gideon G; Lyubynska, Natalya N; Nguyen, Hoa H; Kratz, Christian P CP; Zenker, Martin M; Niemeyer, Charlotte M CM; Molven, Anders A; Shannon, Kevin K

Publication Date: 2007-11

Variant appearance in text: N/A

PubMed Link: 17875937

Variant Present in the following documents:

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