KRAS c.458A>T ;(p.D153V)

Variant ID: 12-25362838-T-A

NM_004985.3(KRAS):c.458A>T;(p.D153V)

This variant was identified in 47 publications

View GRCh38 version.




Publications:


Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.

Cancer Research Communications
White, Jason A JA; Kaninjing, Ernest T ET; Adeniji, Kayode A KA; Jibrin, Paul P; Obafunwa, John O JO; Ogo, Chidiebere N CN; Mohammed, Faruk F; Popoola, Ademola A; Fatiregun, Omolara A OA; Oluwole, Olabode P OP; Karanam, Balasubramanyam B; Elhussin, Isra I; Ambs, Stefan S; Tang, Wei W; Davis, Melissa M; Polak, Paz P; Campbell, Moray J MJ; Brignole, Kathryn R KR; Rotimi, Solomon O SO; Dean-Colomb, Windy W; Odedina, Folake T FT; Martin, Damali N DN; Yates, Clayton C
Publication Date: 2022-09

Variant appearance in text: KRAS: 458A>T; D153V; rs104894360
PubMed Link: 36922933
Variant Present in the following documents:
  • crc-22-0136-s01.xlsx, sheet 1
View BVdb publication page



Network expansion of genetic associations defines a pleiotropy map of human cell biology.

Nature Genetics
Barrio-Hernandez, Inigo I; Schwartzentruber, Jeremy J; Shrivastava, Anjali A; Del-Toro, Noemi N; Gonzalez, Asier A; Zhang, Qian Q; Mountjoy, Edward E; Suveges, Daniel D; Ochoa, David D; Ghoussaini, Maya M; Bradley, Glyn G; Hermjakob, Henning H; Orchard, Sandra S; Dunham, Ian I; Anderson, Carl A CA; Porras, Pablo P; Beltrao, Pedro P
Publication Date: 2023-02-23

Variant appearance in text: KRAS: 458A>T; Glu153Val
PubMed Link: 36823319
Variant Present in the following documents:
  • 41588_2023_1327_MOESM4_ESM.xlsx, sheet 6
View BVdb publication page



Infantile epileptic spasms syndrome in children with cardiofaciocutanous syndrome: Clinical presentation and associations with genotype.

American Journal Of Medical Genetics. Part C, Seminars In Medical Genetics
Kenney-Jung, Daniel L DL; Rogers, Dante J DJ; Kroening, Samuel J SJ; Zatkalik, Abigail L AL; Whitmarsh, Ashley E AE; Roberts, Amy E AE; Zenker, Martin M; Gambardella, Maria Luigia ML; Contaldo, Ilaria I; Leoni, Chiara C; Onesimo, Roberta R; Zampino, Giuseppe G; Tartaglia, Marco M; Battaglia, Domenica I DI; Pierpont, Elizabeth I EI
Publication Date: 2022-11-29

Variant appearance in text: KRAS: D153V
PubMed Link: 36448195
Variant Present in the following documents:
  • Main text
  • AJMG-190-501.pdf
View BVdb publication page



Effects of Noonan Syndrome-Germline Mutations on Mitochondria and Energy Metabolism.

Cells
Bajia, Donald D; Bottani, Emanuela E; Derwich, Katarzyna K
Publication Date: 2022-10-01

Variant appearance in text: KRAS: D153V
PubMed Link: 36231062
Variant Present in the following documents:
  • cells-11-03099.pdf
View BVdb publication page



Inside the Noonan "universe": Literature review on growth, GH/IGF axis and rhGH treatment: Facts and concerns.

Frontiers In Endocrinology
Stagi, Stefano S; Ferrari, Vittorio V; Ferrari, Marta M; Priolo, Manuela M; Tartaglia, Marco M
Publication Date: 2022

Variant appearance in text: KRAS: Asp153Val
PubMed Link: 36060964
Variant Present in the following documents:
  • Main text
  • fendo-13-951331.pdf
View BVdb publication page



Whole-exome analysis of 177 pediatric patients with undiagnosed diseases.

Scientific Reports
Narita, Kotaro K; Muramatsu, Hideki H; Narumi, Satoshi S; Nakamura, Yuji Y; Okuno, Yusuke Y; Suzuki, Kyogo K; Hamada, Motoharu M; Yamaguchi, Naoya N; Suzuki, Atsushi A; Nishio, Yosuke Y; Shiraki, Anna A; Yamamori, Ayako A; Tsumura, Yusuke Y; Sawamura, Fumi F; Kawaguchi, Masahiro M; Wakamatsu, Manabu M; Kataoka, Shinsuke S; Kato, Kohji K; Asada, Hideyuki H; Kubota, Tetsuo T; Muramatsu, Yukako Y; Kidokoro, Hiroyuki H; Natsume, Jun J; Mizuno, Seiji S; Nakata, Tomohiko T; Inagaki, Hidehito H; Ishihara, Naoko N; Yonekawa, Takahiro T; Okumura, Akihisa A; Ogi, Tomoo T; Kojima, Seiji S; Kaname, Tadashi T; Hasegawa, Tomonobu T; Saitoh, Shinji S; Takahashi, Yoshiyuki Y
Publication Date: 2022-08-26

Variant appearance in text: KRAS: D153V
PubMed Link: 36028527
Variant Present in the following documents:
  • 41598_2022_14161_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Clinical characteristics and survival of children with hypertrophic cardiomyopathy in China: A multicentre retrospective cohort study.

Eclinicalmedicine
Chan, Wenxiu W; Yang, Shiwei S; Wang, Jian J; Tong, Shilu S; Lin, Minyin M; Lu, Pengtao P; Yao, Ruen R; Wu, Lanping L; Chen, Lijun L; Guo, Ying Y; Shen, Jie J; Liu, Tingliang T; Li, Fen F; Chen, Huiwen H; Zhang, Hao H; Wang, Shushui S; Fu, Lijun L
Publication Date: 2022-07

Variant appearance in text: KRAS: 458A>T; Asp153Val
PubMed Link: 35747179
Variant Present in the following documents:
  • mmc1.pdf
View BVdb publication page



Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology
Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C
Publication Date: 2021

Variant appearance in text: KRAS: D153V
PubMed Link: 34630336
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Effect of Whole-Genome Sequencing on the Clinical Management of Acutely Ill Infants With Suspected Genetic Disease: A Randomized Clinical Trial.

Jama Pediatrics
, ; Krantz, Ian D ID; Medne, Livija L; Weatherly, Jamila M JM; Wild, K Taylor KT; Biswas, Sawona S; Devkota, Batsal B; Hartman, Tiffiney T; Brunelli, Luca L; Fishler, Kristen P KP; Abdul-Rahman, Omar O; Euteneuer, Joshua C JC; Hoover, Denise D; Dimmock, David D; Cleary, John J; Farnaes, Lauge L; Knight, Jason J; Schwarz, Adam J AJ; Vargas-Shiraishi, Ofelia M OM; Wigby, Kristin K; Zadeh, Neda N; Shinawi, Marwan M; Wambach, Jennifer A JA; Baldridge, Dustin D; Cole, F Sessions FS; Wegner, Daniel J DJ; Urraca, Nora N; Holtrop, Shannon S; Mostafavi, Roya R; Mroczkowski, Henry J HJ; Pivnick, Eniko K EK; Ward, Jewell C JC; Talati, Ajay A; Brown, Chester W CW; Belmont, John W JW; Ortega, Julia L JL; Robinson, Keisha D KD; Brocklehurst, W Tyler WT; Perry, Denise L DL; Ajay, Subramanian S SS; Hagelstrom, R Tanner RT; Bennett, Maren M; Rajan, Vani V; Taft, Ryan J RJ
Publication Date: 2021-12-01

Variant appearance in text: KRAS: 458A>T; Asp153Val
PubMed Link: 34570182
Variant Present in the following documents:
  • jamapediatr-e213496-s003.xlsx, sheet 1
View BVdb publication page



Embryonic Expression of NrasG 12 D Leads to Embryonic Lethality and Cardiac Defects.

Frontiers In Cell And Developmental Biology
You, Xiaona X; Ryu, Myung-Jeom MJ; Cho, Eunjin E; Sang, Yanzhi Y; Damnernsawad, Alisa A; Zhou, Yun Y; Liu, Yangang Y; Zhang, Jing J; Lee, Youngsook Y
Publication Date: 2021

Variant appearance in text: KRAS: D153V
PubMed Link: 33681212
Variant Present in the following documents:
  • Main text
  • fcell-09-633661.pdf
View BVdb publication page



Mechanisms of Ras Membrane Organization and Signaling: Ras Rocks Again.

Biomolecules
Abankwa, Daniel D; Gorfe, Alemayehu A AA
Publication Date: 2020-11-06

Variant appearance in text: K-Ras4B: D153V
PubMed Link: 33172116
Variant Present in the following documents:
  • Main text
  • biomolecules-10-01522.pdf
View BVdb publication page



Induction of Noonan syndrome-specific human-induced pluripotent stem cells under serum-, feeder-, and integration-free conditions.

In Vitro Cellular & Developmental Biology. Animal
Hamada, Atsuko A; Akagi, Eri E; Obayashi, Fumitaka F; Yamasaki, Sachiko S; Koizumi, Koichi K; Ohtaka, Manami M; Nishimura, Ken K; Nakanishi, Mahito M; Toratani, Shigeaki S; Okamoto, Tetsuji T
Publication Date: 2020-12

Variant appearance in text: KRAS: D153V
PubMed Link: 33140329
Variant Present in the following documents:
  • Main text
View BVdb publication page



Clinical advantage of targeted sequencing for unbiased tumor mutational burden estimation in samples with low tumor purity.

Journal For Immunotherapy Of Cancer
Hong, Tae Hee TH; Cha, Hongui H; Shim, Joon Ho JH; Lee, Boram B; Chung, Jongsuk J; Lee, Chung C; Kim, Nayoung K D NKD; Choi, Yoon-La YL; Hwang, Soohyun S; Lee, Yoomi Y; Park, Sehhoon S; Jung, Hyun Ae HA; Kim, Ji-Yeon JY; Park, Yeon Hee YH; Sun, Jong-Mu JM; Ahn, Jin Seok JS; Ahn, Myung-Ju MJ; Park, Keunchil K; Lee, Se-Hoon SH; Park, Woong-Yang WY
Publication Date: 2020-10

Variant appearance in text: KRAS: D153V
PubMed Link: 33077514
Variant Present in the following documents:
  • jitc-2020-001199supp002.pdf
View BVdb publication page



Identification of pathogenic missense mutations using protein stability predictors.

Scientific Reports
Gerasimavicius, Lukas L; Liu, Xin X; Marsh, Joseph A JA
Publication Date: 2020-09-21

Variant appearance in text: KRAS: D153V
PubMed Link: 32958805
Variant Present in the following documents:
  • 41598_2020_72404_MOESM2_ESM.xlsx, sheet 2
View BVdb publication page



The duality of human oncoproteins: drivers of cancer and congenital disorders.

Nature Reviews. Cancer
Castel, Pau P; Rauen, Katherine A KA; McCormick, Frank F
Publication Date: 2020-07

Variant appearance in text: KRAS: D153V
PubMed Link: 32341551
Variant Present in the following documents:
  • Main text
View BVdb publication page



Germline and sporadic cancers driven by the RAS pathway: parallels and contrasts.

Annals Of Oncology : Official Journal Of The European Society For Medical Oncology
Dunnett-Kane, V V; Burkitt-Wright, E E; Blackhall, F H FH; Malliri, A A; Evans, D G DG; Lindsay, C R CR
Publication Date: 2020-07

Variant appearance in text: KRAS: D153V
PubMed Link: 32240795
Variant Present in the following documents:
  • Main text
View BVdb publication page



Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association
Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H
Publication Date: 2020-07

Variant appearance in text: KRAS: D153V
PubMed Link: 32107691
Variant Present in the following documents:
  • 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12
View BVdb publication page



Comparative analysis of functional assay evidence use by ClinGen Variant Curation Expert Panels.

Genome Medicine
Kanavy, Dona M DM; McNulty, Shannon M SM; Jairath, Meera K MK; Brnich, Sarah E SE; Bizon, Chris C; Powell, Bradford C BC; Berg, Jonathan S JS
Publication Date: 2019-11-29

Variant appearance in text: KRAS: 458A>T; Asp153Val
PubMed Link: 31783775
Variant Present in the following documents:
  • 13073_2019_683_MOESM2_ESM.xlsx, sheet 12
  • 13073_2019_683_MOESM2_ESM.xlsx, sheet 13
View BVdb publication page



Finding driver mutations in cancer: Elucidating the role of background mutational processes.

Plos Computational Biology
Brown, Anna-Leigh AL; Li, Minghui M; Goncearenco, Alexander A; Panchenko, Anna R AR
Publication Date: 2019-04

Variant appearance in text: KRAS: D153V
PubMed Link: 31034466
Variant Present in the following documents:
  • pcbi.1006981.s010.xlsx, sheet 1
View BVdb publication page



Clinical and mutation profile of pediatric patients with RASopathy-associated hypertrophic cardiomyopathy: results from a Chinese cohort.

Orphanet Journal Of Rare Diseases
Chen, Hao H; Li, Xin X; Liu, Xiaoliang X; Wang, Jian J; Zhang, Zhen Z; Wu, Jinjin J; Huang, Meirong M; Guo, Ying Y; Li, Fen F; Wang, Xiumin X; Fu, Lijun L
Publication Date: 2019-02-07

Variant appearance in text: KRAS: 458A>T; D153V
PubMed Link: 30732632
Variant Present in the following documents:
  • Main text
  • 13023_2019_Article_1010.pdf
View BVdb publication page



Co-occurrence of Noonan and Cardiofaciocutaneous Syndrome Features in a Patient with KRAS Variant.

Journal Of Pediatric Genetics
Rodríguez, Fernando F; Vallejos, Carla C; Bolanos-Garcia, Víctor M VM; Ponce, Diana D; Unanue, Nancy N; Garay, Francisco F; Cassorla, Fernando F; Aracena, Mariana M
Publication Date: 2018-12

Variant appearance in text: KRAS: D153V
PubMed Link: 30430033
Variant Present in the following documents:
  • Main text
View BVdb publication page



Epileptic spasms in PPP1CB-associated Noonan-like syndrome: a case report with clinical and therapeutic implications.

Bmc Neurology
Lin, Chien-Heng CH; Lin, Wei-De WD; Chou, I-Ching IC; Lee, Inn-Chi IC; Fan, Hueng-Chuen HC; Hong, Syuan-Yu SY
Publication Date: 2018-09-20

Variant appearance in text: KRAS: D153V
PubMed Link: 30236064
Variant Present in the following documents:
  • Main text
  • 12883_2018_Article_1157.pdf
View BVdb publication page



Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies.

Scientific Reports
Leung, Gordon K C GKC; Luk, H M HM; Tang, Vincent H M VHM; Gao, W W WW; Mak, Christopher C Y CCY; Yu, Mullin H C MHC; Wong, W L WL; Chu, Yoyo W Y YWY; Yang, W L WL; Wong, Wilfred H S WHS; Ma, Alvin C H ACH; Leung, Anskar Y H AYH; Jin, D Y DY; Chan, Kelvin Y K KYK; Allanson, Judith J; Lo, Ivan F M IFM; Chung, Brian H Y BHY
Publication Date: 2018-02-05

Variant appearance in text: KRAS: D153V
PubMed Link: 29402968
Variant Present in the following documents:
  • Main text
  • 41598_2018_Article_20894.pdf
View BVdb publication page



Comparative analysis of primary versus relapse/refractory DLBCL identifies shifts in mutation spectrum.

Oncotarget
Greenawalt, Danielle M DM; Liang, Winnie S WS; Saif, Sakina S; Johnson, Justin J; Todorov, Petar P; Dulak, Austin A; Enriquez, Daniel D; Halperin, Rebecca R; Ahmed, Ambar A; Saveliev, Vladislav V; Carpten, John J; Craig, David D; Barrett, J Carl JC; Dougherty, Brian B; Zinda, Michael M; Fawell, Stephen S; Dry, Jonathan R JR; Byth, Kate K
Publication Date: 2017-11-21

Variant appearance in text: KRAS: 458A>T
PubMed Link: 29245897
Variant Present in the following documents:
  • oncotarget-08-99237-s002.xlsx, sheet 1
View BVdb publication page



An atypical case of Noonan syndrome with KRAS mutation diagnosed by targeted exome sequencing.

Annals Of Pediatric Endocrinology & Metabolism
Kim, Jinsup J; Cho, Sung Yoon SY; Yang, Aram A; Jang, Ja-Hyun JH; Choi, Youngbin Y; Lee, Ji-Eun JE; Jin, Dong-Kyu DK
Publication Date: 2017-09

Variant appearance in text: KRAS: 458A>T; D153V
PubMed Link: 29025208
Variant Present in the following documents:
  • Main text
  • apem-2017-22-3-203.pdf
View BVdb publication page



KRAS Alleles: The Devil Is in the Detail.

Trends In Cancer
Haigis, Kevin M KM
Publication Date: 2017-10

Variant appearance in text: KRAS: D153V
PubMed Link: 28958387
Variant Present in the following documents:
  • Main text
View BVdb publication page



Detecting protein variants by mass spectrometry: a comprehensive study in cancer cell-lines.

Genome Medicine
Alfaro, Javier A JA; Ignatchenko, Alexandr A; Ignatchenko, Vladimir V; Sinha, Ankit A; Boutros, Paul C PC; Kislinger, Thomas T
Publication Date: 2017-07-18

Variant appearance in text: KRAS: D153V; rs104894360
PubMed Link: 28716134
Variant Present in the following documents:
  • 13073_2017_454_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



The landscape of genetic diseases in Saudi Arabia based on the first 1000 diagnostic panels and exomes.

Human Genetics
Monies, Dorota D; Abouelhoda, Mohamed M; AlSayed, Moeenaldeen M; Alhassnan, Zuhair Z; Alotaibi, Maha M; Kayyali, Husam H; Al-Owain, Mohammed M; Shah, Ayaz A; Rahbeeni, Zuhair Z; Al-Muhaizea, Mohammad A MA; Alzaidan, Hamad I HI; Cupler, Edward E; Bohlega, Saeed S; Faqeih, Eissa E; Faden, Maha M; Alyounes, Banan B; Jaroudi, Dyala D; Goljan, Ewa E; Elbardisy, Hadeel H; Akilan, Asma A; Albar, Renad R; Aldhalaan, Hesham H; Gulab, Shamshad S; Chedrawi, Aziza A; Al Saud, Bandar K BK; Kurdi, Wesam W; Makhseed, Nawal N; Alqasim, Tahani T; El Khashab, Heba Y HY; Al-Mousa, Hamoud H; Alhashem, Amal A; Kanaan, Imaduddin I; Algoufi, Talal T; Alsaleem, Khalid K; Basha, Talal A TA; Al-Murshedi, Fathiya F; Khan, Sameena S; Al-Kindy, Adila A; Alnemer, Maha M; Al-Hajjar, Sami S; Alyamani, Suad S; Aldhekri, Hasan H; Al-Mehaidib, Ali A; Arnaout, Rand R; Dabbagh, Omar O; Shagrani, Mohammad M; Broering, Dieter D; Tulbah, Maha M; Alqassmi, Amal A; Almugbel, Maisoon M; AlQuaiz, Mohammed M; Alsaman, Abdulaziz A; Al-Thihli, Khalid K; Sulaiman, Raashda A RA; Al-Dekhail, Wajeeh W; Alsaegh, Abeer A; Bashiri, Fahad A FA; Qari, Alya A; Alhomadi, Suzan S; Alkuraya, Hisham H; Alsebayel, Mohammed M; Hamad, Muddathir H MH; Szonyi, Laszlo L; Abaalkhail, Faisal F; Al-Mayouf, Sulaiman M SM; Almojalli, Hamad H; Alqadi, Khalid S KS; Elsiesy, Hussien H; Shuaib, Taghreed M TM; Seidahmed, Mohammed Zain MZ; Abosoudah, Ibraheem I; Akleh, Hana H; AlGhonaium, Abdulaziz A; Alkharfy, Turki M TM; Al Mutairi, Fuad F; Eyaid, Wafa W; Alshanbary, Abdullah A; Sheikh, Farrukh R FR; Alsohaibani, Fahad I FI; Alsonbul, Abdullah A; Al Tala, Saeed S; Balkhy, Soher S; Bassiouni, Randa R; Alenizi, Ahmed S AS; Hussein, Maged H MH; Hassan, Saeed S; Khalil, Mohamed M; Tabarki, Brahim B; Alshahwan, Saad S; Oshi, Amira A; Sabr, Yasser Y; Alsaadoun, Saad S; Salih, Mustafa A MA; Mohamed, Sarar S; Sultana, Habiba H; Tamim, Abdullah A; El-Haj, Moayad M; Alshahrani, Saif S; Bubshait, Dalal K DK; Alfadhel, Majid M; Faquih, Tariq T; El-Kalioby, Mohamed M; Subhani, Shazia S; Shah, Zeeshan Z; Moghrabi, Nabil N; Meyer, Brian F BF; Alkuraya, Fowzan S FS
Publication Date: 2017-08

Variant appearance in text: KRAS: 458A>T; D153V; rs104894360
PubMed Link: 28600779
Variant Present in the following documents:
  • 439_2017_1821_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



Sources of discordance among germ-line variant classifications in ClinVar.

Genetics In Medicine : Official Journal Of The American College Of Medical Genetics
Yang, Shan S; Lincoln, Stephen E SE; Kobayashi, Yuya Y; Nykamp, Keith K; Nussbaum, Robert L RL; Topper, Scott S
Publication Date: 2017-10

Variant appearance in text: KRAS: 458A>T; Asp153Val
PubMed Link: 28569743
Variant Present in the following documents:
  • gim201760x7.xlsx, sheet 2
View BVdb publication page



Proteome-wide Structural Analysis of PTM Hotspots Reveals Regulatory Elements Predicted to Impact Biological Function and Disease.

Molecular & Cellular Proteomics : Mcp
Torres, Matthew P MP; Dewhurst, Henry H; Sundararaman, Niveda N
Publication Date: 2016-11

Variant appearance in text: KRAS: 458A>T
PubMed Link: 27697855
Variant Present in the following documents:
  • 10.1074_M116.062331_mcp.M116.062331-3.xlsx, sheet 5
View BVdb publication page



A Landscape of Pharmacogenomic Interactions in Cancer.

Cell
Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ
Publication Date: 2016-07-28

Variant appearance in text: KRAS: 458A>T; D153V
PubMed Link: 27397505
Variant Present in the following documents:
  • mmc3.xlsx, sheet 3
View BVdb publication page



Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.

Chemical Society Reviews
Lu, Shaoyong S; Jang, Hyunbum H; Gu, Shuo S; Zhang, Jian J; Nussinov, Ruth R
Publication Date: 2016-09-21

Variant appearance in text: K-Ras4B: D153V
PubMed Link: 27396271
Variant Present in the following documents:
  • Main text
View BVdb publication page



Oncogenic K-Ras Binds to an Anionic Membrane in Two Distinct Orientations: A Molecular Dynamics Analysis.

Biophysical Journal
Prakash, Priyanka P; Zhou, Yong Y; Liang, Hong H; Hancock, John F JF; Gorfe, Alemayehu A AA
Publication Date: 2016-03-08

Variant appearance in text: K-Ras4B: D153V
PubMed Link: 26958889
Variant Present in the following documents:
  • Main text
View BVdb publication page



The disordered hypervariable region and the folded catalytic domain of oncogenic K-Ras4B partner in phospholipid binding.

Current Opinion In Structural Biology
Banerjee, Avik A; Jang, Hyunbum H; Nussinov, Ruth R; Gaponenko, Vadim V
Publication Date: 2016-02

Variant appearance in text: K-Ras4B: D153V
PubMed Link: 26709496
Variant Present in the following documents:
  • Main text
View BVdb publication page



Oncogenic and RASopathy-associated K-RAS mutations relieve membrane-dependent occlusion of the effector-binding site.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Mazhab-Jafari, Mohammad T MT; Marshall, Christopher B CB; Smith, Matthew J MJ; Gasmi-Seabrook, Geneviève M C GM; Stathopulos, Peter B PB; Inagaki, Fuyuhiko F; Kay, Lewis E LE; Neel, Benjamin G BG; Ikura, Mitsuhiko M
Publication Date: 2015-05-26

Variant appearance in text: KRAS: D153V
PubMed Link: 25941399
Variant Present in the following documents:
  • Main text
View BVdb publication page



Cancer spectrum and frequency among children with Noonan, Costello, and cardio-facio-cutaneous syndromes.

British Journal Of Cancer
Kratz, C P CP; Franke, L L; Peters, H H; Kohlschmidt, N N; Kazmierczak, B B; Finckh, U U; Bier, A A; Eichhorn, B B; Blank, C C; Kraus, C C; Kohlhase, J J; Pauli, S S; Wildhardt, G G; Kutsche, K K; Auber, B B; Christmann, A A; Bachmann, N N; Mitter, D D; Cremer, F W FW; Mayer, K K; Daumer-Haas, C C; Nevinny-Stickel-Hinzpeter, C C; Oeffner, F F; Schlüter, G G; Gencik, M M; Überlacker, B B; Lissewski, C C; Schanze, I I; Greene, M H MH; Spix, C C; Zenker, M M
Publication Date: 2015-04-14

Variant appearance in text: KRAS: D153V
PubMed Link: 25742478
Variant Present in the following documents:
  • Main text
  • bjc201575a.pdf
View BVdb publication page



Benchmarking mutation effect prediction algorithms using functionally validated cancer-related missense mutations.

Genome Biology
Martelotto, Luciano G LG; Ng, Charlotte Ky CK; De Filippo, Maria R MR; Zhang, Yan Y; Piscuoglio, Salvatore S; Lim, Raymond S RS; Shen, Ronglai R; Norton, Larry L; Reis-Filho, Jorge S JS; Weigelt, Britta B
Publication Date: 2014-10-28

Variant appearance in text: KRAS: D153V
PubMed Link: 25348012
Variant Present in the following documents:
  • 13059_2014_484_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Molecular Systems Biology
Kiel, Christina C; Serrano, Luis L
Publication Date: 2014-05-06

Variant appearance in text: KRAS: D153V
PubMed Link: 24803665
Variant Present in the following documents:
  • MSB-10-5-727-s13.xls, sheet 1
View BVdb publication page



A lethal course of hypertrophic cardiomyopathy in Noonan syndrome due to a novel germline mutation in the KRAS gene: case study.

Croatian Medical Journal
Nosan, Gregor G; Bertok, Sara S; Vesel, Samo S; Yntema, Helger G HG; Paro-Panjan, Darja D
Publication Date: 2013-12

Variant appearance in text: KRAS: Asp153Val
PubMed Link: 24382853
Variant Present in the following documents:
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  • CroatMedJ_54_0574.pdf
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Functional specificity of ras isoforms: so similar but so different.

Genes & Cancer
Castellano, Esther E; Santos, Eugenio E
Publication Date: 2011-03

Variant appearance in text: K-Ras4B: D153V
PubMed Link: 21779495
Variant Present in the following documents:
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Dermatological findings in 61 mutation-positive individuals with cardiofaciocutaneous syndrome.

The British Journal Of Dermatology
Siegel, D H DH; McKenzie, J J; Frieden, I J IJ; Rauen, K A KA
Publication Date: 2011-03

Variant appearance in text: KRAS: D153V
PubMed Link: 21062266
Variant Present in the following documents:
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Germline KRAS mutations cause aberrant biochemical and physical properties leading to developmental disorders.

Human Mutation
Gremer, Lothar L; Merbitz-Zahradnik, Torsten T; Dvorsky, Radovan R; Cirstea, Ion C IC; Kratz, Christian Peter CP; Zenker, Martin M; Wittinghofer, Alfred A; Ahmadian, Mohammad Reza MR
Publication Date: 2011-01

Variant appearance in text: KRAS: D153V
PubMed Link: 20949621
Variant Present in the following documents:
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Noonan syndrome: clinical aspects and molecular pathogenesis.

Molecular Syndromology
Tartaglia, M M; Zampino, G G; Gelb, B D BD
Publication Date: 2010-02

Variant appearance in text: KRAS: Asp153Val
PubMed Link: 20648242
Variant Present in the following documents:
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High-throughput sequencing screen reveals novel, transforming RAS mutations in myeloid leukemia patients.

Blood
Tyner, Jeffrey W JW; Erickson, Heidi H; Deininger, Michael W N MW; Willis, Stephanie G SG; Eide, Christopher A CA; Levine, Ross L RL; Heinrich, Michael C MC; Gattermann, Norbert N; Gilliland, D Gary DG; Druker, Brian J BJ; Loriaux, Marc M MM
Publication Date: 2009-02-19

Variant appearance in text: KRAS: D153V
PubMed Link: 19075190
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An unexpected new role of mutant Ras: perturbation of human embryonic development.

Journal Of Molecular Medicine (Berlin, Germany)
Kratz, Christian P CP; Niemeyer, Charlotte M CM; Zenker, Martin M
Publication Date: 2007-03

Variant appearance in text: KRAS: D153V
PubMed Link: 17211612
Variant Present in the following documents:
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  • 109_2006_Article_135.pdf
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Expansion of the genotypic and phenotypic spectrum in patients with KRAS germline mutations.

Journal Of Medical Genetics
Zenker, Martin M; Lehmann, Katarina K; Schulz, Anna Leana AL; Barth, Helmut H; Hansmann, Dagmar D; Koenig, Rainer R; Korinthenberg, Rudolf R; Kreiss-Nachtsheim, Martina M; Meinecke, Peter P; Morlot, Susanne S; Mundlos, Stefan S; Quante, Anne S AS; Raskin, Salmo S; Schnabel, Dirk D; Wehner, Lars-Erik LE; Kratz, Christian P CP; Horn, Denise D; Kutsche, Kerstin K
Publication Date: 2007-02

Variant appearance in text: KRAS: D153V
PubMed Link: 17056636
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Germline missense mutations affecting KRAS Isoform B are associated with a severe Noonan syndrome phenotype.

American Journal Of Human Genetics
Carta, Claudio C; Pantaleoni, Francesca F; Bocchinfuso, Gianfranco G; Stella, Lorenzo L; Vasta, Isabella I; Sarkozy, Anna A; Digilio, Cristina C; Palleschi, Antonio A; Pizzuti, Antonio A; Grammatico, Paola P; Zampino, Giuseppe G; Dallapiccola, Bruno B; Gelb, Bruce D BD; Tartaglia, Marco M
Publication Date: 2006-07

Variant appearance in text: KRAS: Asp153Val
PubMed Link: 16773572
Variant Present in the following documents:
  • Main text
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