KRAS c.436G>A ;(p.A146T)

Variant ID: 12-25378562-C-T

NM_004985.3(KRAS):c.436G>A;(p.A146T)

This variant was identified in 587 publications

View GRCh38 version.




Publications:


PD-1 inhibitor combined with radiotherapy and GM-CSF in MSS/pMMR metastatic colon cancer: a case report.

Frontiers In Oncology
Yang, Jiabao J; Xing, Pengfei P; Kong, Yuehong Y; Xu, Meiling M; Zhang, Liyuan L
Publication Date: 2023

Variant appearance in text: KRAS: A146T
PubMed Link: 37188188
Variant Present in the following documents:
  • Main text
  • fonc-13-1078915.pdf
View BVdb publication page



Alisertib exerts KRAS allele‑specific anticancer effects on colorectal cancer cell lines.

Experimental And Therapeutic Medicine
Ren, Baojun B; Geng, Yan Y; Chen, Shuxiang S; Gao, Zhuowei Z; Zheng, Kehong K; Yang, Yong Y; Luo, Qimei Q; Feng, Jing J; Luo, Zhentao Z; Ju, Yongle Y; Huang, Zonghai Z
Publication Date: 2023-06

Variant appearance in text: KRAS: A146T
PubMed Link: 37153900
Variant Present in the following documents:
  • Main text
  • etm-25-06-11942.pdf
View BVdb publication page



An integrated model for predicting KRAS dependency.

Plos Computational Biology
Tsai, Yihsuan S YS; Chareddy, Yogitha S YS; Price, Brandon A BA; Parker, Joel S JS; Pecot, Chad V CV
Publication Date: 2023-05-04

Variant appearance in text: KRAS: A146T
PubMed Link: 37141389
Variant Present in the following documents:
  • Main text
  • pcbi.1011095.pdf
View BVdb publication page



Genomic Landscape of Primary Resistance to Osimertinib Among Hispanic Patients with EGFR-Mutant Non-Small Cell Lung Cancer (NSCLC): Results of an Observational Longitudinal Cohort Study.

Targeted Oncology
Chamorro, Diego F DF; Cardona, Andrés F AF; Rodríguez, July J; Ruiz-Patiño, Alejandro A; Arrieta, Oscar O; Moreno-Pérez, Darwin A DA; Rojas, Leonardo L; Zatarain-Barrón, Zyanya Lucia ZL; Ardila, Dora V DV; Viola, Lucia L; Recondo, Gonzalo G; Blaquier, Juan B JB; Martín, Claudio C; Raez, Luis L; Samtani, Suraj S; Ordóñez-Reyes, Camila C; Garcia-Robledo, Juan Esteban JE; Corrales, Luis L; Sotelo, Carolina C; Ricaurte, Luisa L; Cuello, Mauricio M; Mejía, Sergio S; Jaller, Elvira E; Vargas, Carlos C; Carranza, Hernán H; Otero, Jorge J; Archila, Pilar P; Bermudez, Maritza M; Gamez, Tatiana T; Russo, Alessandro A; Malapelle, Umberto U; de Miguel Perez, Diego D; de Lima, Vladmir C Cordeiro VCC; Freitas, Helano H; Saldahna, Erick E; Rolfo, Christian C; Rosell, Rafael R; ,
Publication Date: 2023-04-05

Variant appearance in text: KRAS: A146T
PubMed Link: 37017806
Variant Present in the following documents:
  • 11523_2023_955_MOESM1_ESM.pdf
View BVdb publication page



Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.

Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA
Publication Date: 2023-04-03

Variant appearance in text: KRAS: A146T
PubMed Link: 37012232
Variant Present in the following documents:
  • 41467_2023_37547_MOESM10_ESM.xlsx, sheet 3
  • 41467_2023_37547_MOESM12_ESM.xlsx, sheet 2
View BVdb publication page



Plasma ctDNA increases tissue NGS-based detection of therapeutically targetable mutations in lung cancers.

Bmc Cancer
Xie, Jianjiang J; Yao, Weishen W; Chen, Lingxiu L; Zhu, Wenjun W; Liu, Qiang Q; Geng, Geng G; Fang, Jing J; Zhao, Yang Y; Xiao, Li L; Huang, Zhenhua Z; Zhao, Jing J
Publication Date: 2023-03-31

Variant appearance in text: KRAS: Ala146Thr
PubMed Link: 37004022
Variant Present in the following documents:
  • Main text
View BVdb publication page



Relapse timing is associated with distinct evolutionary dynamics in DLBCL.

Medrxiv : The Preprint Server For Health Sciences
Hilton, Laura K LK; Ngu, Henry S HS; Collinge, Brett B; Dreval, Kostiantyn K; Ben-Neriah, Susana S; Rushton, Christopher K CK; Wong, Jasper C H JCH; Cruz, Manuela M; Roth, Andrew A; Boyle, Merrill M; Meissner, Barbara B; Slack, Graham W GW; Farinha, Pedro P; Craig, Jeffrey W JW; Gerrie, Alina S AS; Freeman, Ciara L CL; Villa, Diego D; Crump, Michael M; Shepherd, Lois L; Hay, Annette E AE; Kuruvilla, John J; Savage, Kerry J KJ; Kridel, Robert R; Karsan, Aly A; Marra, Marco A MA; Sehn, Laurie H LH; Steidl, Christian C; Morin, Ryan D RD; Scott, David W DW
Publication Date: 2023-03-08

Variant appearance in text: KRAS: 436G>A; A146T; rs121913527
PubMed Link: 36945587
Variant Present in the following documents:
  • media-1.xlsx, sheet 14
View BVdb publication page



KRAS, NRAS, BRAF, and PIK3CA mutation rates, clinicopathological association, and their prognostic value in Iranian colorectal cancer patients.

Journal Of Clinical Laboratory Analysis
Mirzapoor Abbasabadi, Zohreh Z; Hamedi Asl, Dariush D; Rahmani, Babak B; Shahbadori, Rozhin R; Karami, Sara S; Peymani, Amir A; Taghizadeh, Sara S; Samiee Rad, Fatemeh F
Publication Date: 2023-03-17

Variant appearance in text: KRAS: A146T
PubMed Link: 36930789
Variant Present in the following documents:
  • Main text
View BVdb publication page



The EGFR C797S Mutation Confers Resistance to a Novel EGFR Inhibitor CLN-081 to EGFR Exon 20 Insertion Mutations.

Jto Clinical And Research Reports
Kagawa, Yosuke Y; Hayashida, Takuma T; Liu, Jie J; Mori, Shunta S; Izumi, Hiroki H; Kumagai, Shogo S; Udagawa, Hibiki H; Hattori, Noboru N; Goto, Koichi K; Kobayashi, Susumu S SS
Publication Date: 2023-03

Variant appearance in text: KRAS: A146T
PubMed Link: 36915628
Variant Present in the following documents:
  • mmc1.xlsx, sheet 1
View BVdb publication page



Predictive and Prognostic Value of Oncogene Mutations and Microsatellite Instability in Locally-Advanced Rectal Cancer Treated with Neoadjuvant Radiation-Based Therapy: A Systematic Review and Meta-Analysis.

Cancers
De Mattia, Elena E; Polesel, Jerry J; Mezzalira, Silvia S; Palazzari, Elisa E; Pollesel, Sara S; Toffoli, Giuseppe G; Cecchin, Erika E
Publication Date: 2023-02-25

Variant appearance in text: KRAS: A146T
PubMed Link: 36900260
Variant Present in the following documents:
  • Main text
  • cancers-15-01469.pdf
View BVdb publication page



Mimicking tumor cell heterogeneity of colorectal cancer in a patient-derived organoid-fibroblast model.

Cellular And Molecular Gastroenterology And Hepatology
Atanasova, Velina S VS; de Jesus Cardona, Crhistian C; Hejret, Václav V; Tiefenbacher, Andreas A; Mair, Theresia T; Tran, Loan L; Pfneissl, Janette J; Draganić, Kristina K; Binder, Carina C; Kabiljo, Julijan J; Clement, Janik J; Woeran, Katharina K; Neudert, Barbara B; Wohlhaupter, Sabrina S; Haase, Astrid A; Domazet, Sandra S; Hengstschläger, Markus M; Mitterhauser, Markus M; Müllauer, Leonhard L; Tichý, Boris B; Bergmann, Michael M; Schweikert, Gabriele G; Hartl, Markus M; Dolznig, Helmut H; Egger, Gerda G
Publication Date: 2023-03-01

Variant appearance in text: KRAS: Ala146Thr
PubMed Link: 36868311
Variant Present in the following documents:
  • Main text
  • main.pdf
View BVdb publication page



Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancer.

Cancer Discovery
Pradat, Yoann Y; Viot, Julien J; Yurchenko, Andrey A AA; Gunbin, Konstantin K; Cerbone, Luigi L; Deloger, Marc M; Grisay, Guillaume G; Verlingue, Loic L; Scott, Veronique V; Padioleau, Ismael I; Panunzi, Leonardo L; Michiels, Stefan S; Hollebecque, Antoine A; Jules-Clement, Gerome G; Mezquita, Laura L; Laine, Antoine A; Loriot, Yohann Y; Besse, Benjamin B; Friboulet, Luc L; Andre, Fabrice F; Cournede, Paul-Henry PH; Gautheret, Daniel D; Nikolaev, Sergey I SI
Publication Date: 2023-03-02

Variant appearance in text: KRAS: 436G>A; A146T; rs121913527
PubMed Link: 36862804
Variant Present in the following documents:
  • cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 10
  • cd-22-0966_supplementary_tables_s1-s11_suppst1.xlsx, sheet 6
View BVdb publication page



In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders.

Journal Of Chemical Information And Modeling
Leini, Renne R; Pantsar, Tatu T
Publication Date: 2023-02-28

Variant appearance in text: KRAS: A146T
PubMed Link: 36854010
Variant Present in the following documents:
  • ci2c01479_si_002.xlsx, sheet 1
View BVdb publication page



Candidate mechanisms of acquired resistance to first-line osimertinib in EGFR-mutated advanced non-small cell lung cancer.

Nature Communications
Chmielecki, Juliann J; Gray, Jhanelle E JE; Cheng, Ying Y; Ohe, Yuichiro Y; Imamura, Fumio F; Cho, Byoung Chul BC; Lin, Meng-Chih MC; Majem, Margarita M; Shah, Riyaz R; Rukazenkov, Yuri Y; Todd, Alexander A; Markovets, Aleksandra A; Barrett, J Carl JC; Hartmaier, Ryan J RJ; Ramalingam, Suresh S SS
Publication Date: 2023-02-27

Variant appearance in text: KRAS: A146T
PubMed Link: 36849494
Variant Present in the following documents:
  • Main text
  • 41467_2023_Article_35961.pdf
  • 41467_2023_35961_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



High-risk multiple myeloma predicted by circulating plasma cells and its genetic characteristics.

Frontiers In Oncology
Xia, Yuan Y; Shen, Na N; Zhang, Run R; Wu, Yujie Y; Shi, Qinglin Q; Li, Jianyong J; Chen, Lijuan L; Xu, Min M; Jin, Yuanyuan Y
Publication Date: 2023

Variant appearance in text: rs121913527
PubMed Link: 36845679
Variant Present in the following documents:
  • Table_1.xlsx, sheet 2
View BVdb publication page



Circulating tumour DNA analysis predicts relapse and improves risk stratification in primary refractory multiple myeloma.

Blood Cancer Journal
Mithraprabhu, Sridurga S; Reynolds, John J; Turner, Rose R; Quach, Hang H; Horvath, Noemi N; Kerridge, Ian I; Kalff, Anna A; Bergin, Krystal K; Hocking, Jay J; Yuen, Flora F; Khong, Tiffany T; Durie, Brian M BM; Spencer, Andrew A
Publication Date: 2023-02-13

Variant appearance in text: KRAS: 436G>A; A146T
PubMed Link: 36781844
Variant Present in the following documents:
  • 41408_2023_796_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Tumor-informed or tumor-agnostic circulating tumor DNA as a biomarker for risk of recurrence in resected colorectal cancer patients.

Frontiers In Oncology
Chan, Hiu Ting HT; Nagayama, Satoshi S; Otaki, Masumi M; Chin, Yoon Ming YM; Fukunaga, Yosuke Y; Ueno, Masashi M; Nakamura, Yusuke Y; Low, Siew-Kee SK
Publication Date: 2022

Variant appearance in text: KRAS: 436G>A; A146T
PubMed Link: 36776372
Variant Present in the following documents:
  • DataSheet_1.xlsx, sheet 5
  • DataSheet_1.xlsx, sheet 10
  • DataSheet_1.xlsx, sheet 9
View BVdb publication page



Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.

Nature Communications
Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI
Publication Date: 2023-02-08

Variant appearance in text: KRAS: A146T
PubMed Link: 36755027
Variant Present in the following documents:
  • 41467_2023_36328_MOESM6_ESM.xlsx, sheet 1
View BVdb publication page



Dynamics of age- versus therapy-related clonal hematopoiesis in long-term survivors of pediatric cancer.

Cancer Discovery
Hagiwara, Kohei K; Natarajan, Sivaraman S; Wang, Zhaoming Z; Zubair, Haseeb H; Mulder, Heather L HL; Dong, Li L; Plyler, Emily M EM; Thimmaiah, Padma P; Ma, Xiaotu X; Ness, Kirsten K KK; Li, Zhenghong Z; Mulrooney, Daniel A DA; Wilson, Carmen L CL; Yasui, Yutaka Y; Hudson, Melissa M MM; Easton, John J; Robison, Leslie L LL; Zhang, Jinghui J
Publication Date: 2023-02-08

Variant appearance in text: KRAS: A146T
PubMed Link: 36751942
Variant Present in the following documents:
  • cd-22-0956_tables_s2_s7_s8_s9_suppst1.xlsx, sheet 4
  • cd-22-0956_tables_s2_s7_s8_s9_suppst1.xlsx, sheet 1
View BVdb publication page



Significance of logistic regression scoring model based on natural killer cell-mediated cytotoxic pathway in the diagnosis of colon cancer.

Frontiers In Immunology
Ye, Zhen Z; Zhang, Huanhuan H; Liang, Jianwei J; Yi, Shuying S; Zhan, Xianquan X
Publication Date: 2023

Variant appearance in text: KRAS: A146T; rs121913527
PubMed Link: 36742322
Variant Present in the following documents:
  • Table_7.xlsx, sheet 1
  • Table_8.xlsx, sheet 1
View BVdb publication page



Spectrum and clinical features of gene mutations in Chinese pediatric acute lymphoblastic leukemia.

Bmc Pediatrics
Shen, Diying D; Liu, Lixia L; Xu, Xiaojun X; Song, Hua H; Zhang, Jingying J; Xu, Weiqun W; Zhao, Fenying F; Liang, Juan J; Liao, Chan C; Wang, Yan Y; Xia, Tian T; Wang, Chengcheng C; Lou, Feng F; Cao, Shanbo S; Qin, Jiayue J; Tang, Yongmin Y
Publication Date: 2023-02-04

Variant appearance in text: KRAS: 436G>A; A146T
PubMed Link: 36739388
Variant Present in the following documents:
  • 12887_2023_3856_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Selective Eradication of Colon Cancer Cells Harboring PI3K and/or MAPK Pathway Mutations in 3D Culture by Combined PI3K/AKT/mTOR Pathway and MEK Inhibition.

International Journal Of Molecular Sciences
Atanasova, Velina S VS; Riedl, Angelika A; Strobl, Marcus M; Flandorfer, Julia J; Unterleuthner, Daniela D; Weindorfer, Claudia C; Neuhold, Patrick P; Stang, Simone S; Hengstschläger, Markus M; Bergmann, Michael M; Dolznig, Helmut H
Publication Date: 2023-01-14

Variant appearance in text: KRAS: Ala146Thr
PubMed Link: 36675180
Variant Present in the following documents:
  • Main text
  • ijms-24-01668.pdf
View BVdb publication page



Clinical sequencing identifies potential actionable alterations in a high rate of urachal and primary bladder adenocarcinomas.

Cancer Medicine
Varadi, Melinda M; Nagy, Nikolett N; Reis, Henning H; Hadaschik, Boris B; Niedworok, Christian C; Modos, Orsolya O; Szendroi, Attila A; Ablat, Jason J; Black, Peter C PC; Keresztes, David D; Csizmarik, Anita A; Olah, Csilla C; Gaisa, Nadine T NT; Kiss, Andras A; Timar, Jozsef J; Toth, Erika E; Csernak, Erzsebet E; Gerstner, Arpad A; Mittal, Vinay V; Karkampouna, Sofia S; Kruithof de Julio, Marianna M; Gyorffy, Balazs B; Bedics, Gabor G; Rink, Michael M; Fisch, Margit M; Nyirady, Peter P; Szarvas, Tibor T
Publication Date: 2023-01-20

Variant appearance in text: KRAS: Ala146Thr
PubMed Link: 36670542
Variant Present in the following documents:
  • CAM4-12-9041-s001.xlsx, sheet 2
  • CAM4-12-9041-s001.xlsx, sheet 1
View BVdb publication page



Unexplained mismatch repair deficiency: Case closed.

Hgg Advances
Eikenboom, Ellis L EL; Moen, Sarah S; van Leeuwen, Lotte L; Geurts-Giele, Willemina R R WRR; Tops, Carli M J CMJ; van Ham, Tjakko J TJ; Dinjens, Winand N M WNM; Dubbink, Hendrikus J HJ; Spaander, Manon C W MCW; Wagner, Anja A
Publication Date: 2023-01-12

Variant appearance in text: KRAS: A146T
PubMed Link: 36624813
Variant Present in the following documents:
  • mmc1.pdf
  • mmc2.pdf
View BVdb publication page



The Prevalence of BRAF, PIK3CA, and RAS Mutations in Indian Patients with Colorectal Cancer.

South Asian Journal Of Cancer
Shetty, Omshree O; Vengurlekar, Vaibhavi V; Kapoor, Akhil A; Kamble, Vishakha V; Gurav, Mamta M; Bhargava, Prabhat P; Srinivas, Sujay S; Ramaswamy, Anant A; Ramadwar, Mukta M; Saklani, Avanish P AP; Desouza, Ashwin A; Ostwal, Vikas V
Publication Date: 2022-07

Variant appearance in text: KRAS: A146T
PubMed Link: 36620501
Variant Present in the following documents:
  • Main text
View BVdb publication page



Tumor genomic profiling and personalized tracking of circulating tumor DNA in Vietnamese colorectal cancer patients.

Frontiers In Oncology
Nguyen, Huu Thinh HT; Nguyen, Trieu Vu TV; Nguyen Hoang, Van-Anh VA; Tran, Duc Huy DH; Le Trinh, Ngoc An NA; Le, Minh Triet MT; Nguyen Tran, Tuan-Anh TA; Pham, Thanh Huyen TH; Dinh, Thi Cuc TC; Nguyen, Tien Sy TS; Nguyen The, Ky Cuong KC; Mai, Hoa H; Chu, Minh Tuan MT; Pham, Dinh Hoang DH; Nguyen, Xuan Chi XC; Ngo Ha, Thien My TM; Nguyen, Duy Sinh DS; Nguyen, Du Quyen DQ; Lu, Y-Thanh YT; Do Thi, Thanh Thuy TT; Truong, Dinh Kiet DK; Nguyen, Quynh Tho QT; Nguyen, Hoai-Nghia HN; Giang, Hoa H; Tu, Lan N LN
Publication Date: 2022

Variant appearance in text: KRAS: A146T
PubMed Link: 36578946
Variant Present in the following documents:
  • DataSheet_2.xlsx, sheet 2
  • DataSheet_2.xlsx, sheet 1
View BVdb publication page



Evolution of RAS Mutations in Cell-Free DNA of Patients with Tissue RAS Wild-Type Metastatic Colorectal Cancer Receiving First-Line Treatment: The PERSEIDA Study.

Cancers
Valladares-Ayerbes, Manuel M; Garcia-Alfonso, Pilar P; Muñoz Luengo, Jorge J; Pimentel Caceres, Paola Patricia PP; Castillo Trujillo, Oscar Alfredo OA; Vidal-Tocino, Rosario R; Llanos, Marta M; Llorente Ayala, Beatriz B; Limon Miron, Maria Luisa ML; Salud, Antonieta A; Cirera Nogueras, Luis L; Garcia-Carbonero, Rocio R; Safont, Maria Jose MJ; Falco Ferrer, Esther E; Aparicio, Jorge J; Vicente Conesa, Maria Angeles MA; Guillén-Ponce, Carmen C; Garcia-Teijido, Paula P; Medina Magan, Maria Begoña MB; Busquier, Isabel I; Salgado, Mercedes M; Lloansí Vila, Ariadna A; ,
Publication Date: 2022-12-09

Variant appearance in text: KRAS: 436G>A
PubMed Link: 36551560
Variant Present in the following documents:
  • Main text
  • cancers-14-06075.pdf
View BVdb publication page



Mutations matter: An observational study of the prognostic and predictive value of KRAS mutations in metastatic colorectal cancer.

Frontiers In Oncology
Lavacchi, Daniele D; Fancelli, Sara S; Roviello, Giandomenico G; Castiglione, Francesca F; Caliman, Enrico E; Rossi, Gemma G; Venturini, Jacopo J; Pellegrini, Elisa E; Brugia, Marco M; Vannini, Agnese A; Bartoli, Caterina C; Cianchi, Fabio F; Pillozzi, Serena S; Antonuzzo, Lorenzo L
Publication Date: 2022

Variant appearance in text: KRAS: A146T
PubMed Link: 36523988
Variant Present in the following documents:
  • Main text
  • fonc-12-1055019.pdf
View BVdb publication page



An EGFR L858R mutation identified in 1862 Chinese NSCLC patients can be a promising neoantigen vaccine therapeutic strategy.

Frontiers In Immunology
Lin, Jing J; Liu, Jun J; Hao, Shi-Guang SG; Lan, Bin B; Zheng, Xiao-Bin XB; Xiong, Jia-Ni JN; Zhang, Ying-Qian YQ; Gao, Xuan X; Chen, Chuan-Ben CB; Chen, Ling L; Huang, Yu-Fang YF; Luo, Hong H; Yi, Yu-Ting YT; Yi, Xin X; Lu, Jian-Ping JP; Zheng, Xiong-Wei XW; Chen, Gang G; Wang, Xue-Feng XF; Chen, Yu Y
Publication Date: 2022

Variant appearance in text: KRAS: 436G>A; A146T
PubMed Link: 36505399
Variant Present in the following documents:
  • Table_2.xlsx, sheet 2
View BVdb publication page



Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors.

Npj Precision Oncology
Lee, Jessica K JK; Sivakumar, Smruthy S; Schrock, Alexa B AB; Madison, Russell R; Fabrizio, David D; Gjoerup, Ole O; Ross, Jeffrey S JS; Frampton, Garrett M GM; Napalkov, Pavel P; Montesion, Meagan M; Schutzman, Jennifer L JL; Ye, Xin X; Hegde, Priti S PS; Nagasaka, Misako M; Oxnard, Geoffrey R GR; Sokol, Ethan S ES; Ou, Sai-Hong Ignatius SI; Shi, Zhen Z
Publication Date: 2022-12-09

Variant appearance in text: KRAS: A146T
PubMed Link: 36494601
Variant Present in the following documents:
  • 41698_2022_334_MOESM1_ESM.pdf
  • 41698_2022_334_MOESM2_ESM.xlsx, sheet 3
  • 41698_2022_Article_334.pdf
View BVdb publication page



Epithelial TGFβ engages growth-factor signalling to circumvent apoptosis and drive intestinal tumourigenesis with aggressive features.

Nature Communications
Flanagan, Dustin J DJ; Amirkhah, Raheleh R; Vincent, David F DF; Gundaz, Nuray N; Gentaz, Pauline P; Cammareri, Patrizia P; McCooey, Aoife J AJ; McCorry, Amy M B AMB; Fisher, Natalie C NC; Davis, Hayley L HL; Ridgway, Rachel A RA; Lohuis, Jeroen J; Leach, Joshua D G JDG; Jackstadt, Rene R; Gilroy, Kathryn K; Mariella, Elisa E; Nixon, Colin C; Clark, William W; Hedley, Ann A; Markert, Elke K EK; Strathdee, Douglas D; Bartholin, Laurent L; Redmond, Keara L KL; Kerr, Emma M EM; Longley, Daniel B DB; Ginty, Fiona F; Cho, Sanghee S; Coleman, Helen G HG; Loughrey, Maurice B MB; Bardelli, Alberto A; Maughan, Timothy S TS; Campbell, Andrew D AD; Lawler, Mark M; Leedham, Simon J SJ; Barry, Simon T ST; Inman, Gareth J GJ; van Rheenen, Jacco J; Dunne, Philip D PD; Sansom, Owen J OJ
Publication Date: 2022-12-07

Variant appearance in text: KRAS: A146T
PubMed Link: 36477656
Variant Present in the following documents:
  • 41467_2022_35134_MOESM4_ESM.xlsx, sheet 3
View BVdb publication page



Transcriptome-based molecular subtypes and differentiation hierarchies improve the classification framework of acute myeloid leukemia.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Cheng, Wen-Yan WY; Li, Jian-Feng JF; Zhu, Yong-Mei YM; Lin, Xiang-Jie XJ; Wen, Li-Jun LJ; Zhang, Fan F; Zhang, Yu-Liang YL; Zhao, Ming M; Fang, Hai H; Wang, Sheng-Yue SY; Lin, Xiao-Jing XJ; Qiao, Niu N; Yin, Wei W; Zhang, Jia-Nan JN; Dai, Yu-Ting YT; Jiang, Lu L; Sun, Xiao-Jian XJ; Xu, Yi Y; Zhang, Tong-Tong TT; Chen, Su-Ning SN; Zhu, Hong-Hu HH; Chen, Zhu Z; Jin, Jie J; Wu, De-Pei DP; Shen, Yang Y; Chen, Sai-Juan SJ
Publication Date: 2022-12-06

Variant appearance in text: KRAS: A146T
PubMed Link: 36442087
Variant Present in the following documents:
  • pnas.2211429119.sd02.xlsx, sheet 1
View BVdb publication page



A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study.

The Lancet. Haematology
,
Publication Date: 2022-11-24

Variant appearance in text: KRAS: 436G>A; A146T
PubMed Link: 36436542
Variant Present in the following documents:
  • mmc2.xlsx, sheet 1
View BVdb publication page



Systematic assessment and optimizing algorithm of tumor mutational burden calculation and their implications in clinical decision-making.

Frontiers In Oncology
Sun, Daqiang D; Xu, Meilin M; Pan, Chaohu C; Tang, Hongzhen H; Wang, Peng P; Wu, Dongfang D; Luo, Haitao H
Publication Date: 2022

Variant appearance in text: KRAS: 436G>A; Ala146Thr
PubMed Link: 36425562
Variant Present in the following documents:
  • Table_3.xlsx, sheet 1
  • Table_5.xlsx, sheet 1
  • Table_4.xlsx, sheet 1
View BVdb publication page



Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications
Boström, Martin M; Larsson, Erik E
Publication Date: 2022-11-17

Variant appearance in text: KRAS: A146T
PubMed Link: 36396655
Variant Present in the following documents:
  • 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1
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Prevalence and patterns of mutations in RAS/RAF/MEK/ERK/MAPK signaling pathway in colorectal cancer in North Africa.

Bmc Cancer
Jafari, Meryem M; Laraqui, Abdelilah A; Baba, Walid W; Benmokhtar, Soukaina S; Zaitouni, Sara El SE; Ali, Abdelmounaim Ait AA; Bounaim, Ahmed A; Moujahid, Mountassir M; Tanz, Rachid R; Mahfoud, Tarik T; Sbitti, Yassir Y; Annaz, Hicham El HE; Abi, Rachid R; Tagajdid, Mohamed Rida MR; Kochri, Safae El SE; Lahlou, Idriss Amine IA; Hsaini, Houda El HE; Belayachi, Lamiae L; Benjouad, Abdelaziz A; Ichou, Mohammed M; En-Nya, Amina A; Ennibi, Khalid K
Publication Date: 2022-11-07

Variant appearance in text: KRAS: 436G>A; Ala146Thr
PubMed Link: 36344948
Variant Present in the following documents:
  • Main text
  • 12885_2022_Article_10235.pdf
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Genomic landscape, immune characteristics and prognostic mutation signature of cervical cancer in China.

Bmc Medical Genomics
Liu, Jing J; Li, Zirong Z; Lu, Ting T; Pan, Junping J; Li, Li L; Song, Yanwen Y; Hu, Dan D; Zhuo, Yanhong Y; Chen, Ying Y; Xu, Qin Q
Publication Date: 2022-11-04

Variant appearance in text: N/A
PubMed Link: 36333792
Variant Present in the following documents:
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Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing.

Life Science Alliance
Chow, Signy S; Kis, Olena O; Mulder, David T DT; Danesh, Arnavaz A; Bruce, Jeff J; Wang, Ting Ting TT; Reece, Donna D; Bhalis, Nizar N; Neri, Paola P; Sabatini, Peter Jb PJ; Keats, Jonathan J; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2023-01

Variant appearance in text: KRAS: A146T
PubMed Link: 36328595
Variant Present in the following documents:
  • Main text
  • LSA-2022-01543.pdf
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ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer.

Bmc Cancer
Davis, S Lindsey SL; Hartman, Sarah J SJ; Bagby, Stacey M SM; Schlaepfer, Marina M; Yacob, Betelehem W BW; Tse, Tonia T; Simmons, Dennis M DM; Diamond, Jennifer R JR; Lieu, Christopher H CH; Leal, Alexis D AD; Cadogan, Elaine B EB; Hughes, Gareth D GD; Durant, Stephen T ST; Messersmith, Wells A WA; Pitts, Todd M TM
Publication Date: 2022-10-29

Variant appearance in text: KRAS: A146T
PubMed Link: 36309653
Variant Present in the following documents:
  • 12885_2022_10084_MOESM1_ESM.pdf
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Phenotypic plasticity and genetic control in colorectal cancer evolution.

Nature
Househam, Jacob J; Heide, Timon T; Cresswell, George D GD; Spiteri, Inmaculada I; Kimberley, Chris C; Zapata, Luis L; Lynn, Claire C; James, Chela C; Mossner, Maximilian M; Fernandez-Mateos, Javier J; Vinceti, Alessandro A; Baker, Ann-Marie AM; Gabbutt, Calum C; Berner, Alison A; Schmidt, Melissa M; Chen, Bingjie B; Lakatos, Eszter E; Gunasri, Vinaya V; Nichol, Daniel D; Costa, Helena H; Mitchinson, Miriam M; Ramazzotti, Daniele D; Werner, Benjamin B; Iorio, Francesco F; Jansen, Marnix M; Caravagna, Giulio G; Barnes, Chris P CP; Shibata, Darryl D; Bridgewater, John J; Rodriguez-Justo, Manuel M; Magnani, Luca L; Sottoriva, Andrea A; Graham, Trevor A TA
Publication Date: 2022-11

Variant appearance in text: KRAS: A146T
PubMed Link: 36289336
Variant Present in the following documents:
  • 41586_2022_5311_MOESM10_ESM.xlsx, sheet 1
  • 41586_2022_Article_5311.pdf
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Drugging KRAS: current perspectives and state-of-art review.

Journal Of Hematology & Oncology
Parikh, Kaushal K; Banna, Giuseppe G; Liu, Stephen V SV; Friedlaender, Alex A; Desai, Aakash A; Subbiah, Vivek V; Addeo, Alfredo A
Publication Date: 2022-10-25

Variant appearance in text: KRAS: A146T
PubMed Link: 36284306
Variant Present in the following documents:
  • Main text
  • 13045_2022_Article_1375.pdf
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EV-ADD, a database for EV-associated DNA in human liquid biopsy samples.

Journal Of Extracellular Vesicles
Tsering, Thupten T; Li, Mingyang M; Chen, Yunxi Y; Nadeau, Amélie A; Laskaris, Alexander A; Abdouh, Mohamed M; Bustamante, Prisca P; Burnier, Julia V JV
Publication Date: 2022-10

Variant appearance in text: KRAS: A146T
PubMed Link: 36271888
Variant Present in the following documents:
  • JEV2-11-e12270-s002.xlsx, sheet 1
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Predictive mutation signature of immunotherapy benefits in NSCLC based on machine learning algorithms.

Frontiers In Immunology
Liu, Zhichao Z; Lin, Guo G; Yan, Zeping Z; Li, Linduo L; Wu, Xingchen X; Shi, Jingrong J; He, Jianxing J; Zhao, Lei L; Liang, Hengrui H; Wang, Wei W
Publication Date: 2022

Variant appearance in text: KRAS: 436G>A; A146T
PubMed Link: 36238300
Variant Present in the following documents:
  • Table_1.xlsx, sheet 4
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Whole-genome analysis identifies novel drivers and high-risk double-hit events in relapsed/refractory myeloma.

Blood
Ansari-Pour, Naser N; Samur, Mehmet K MK; Flynt, Erin E; Gooding, Sarah S; Towfic, Fadi F; Stong, Nicholas N; Ortiz Estevez, Maria M; Mavrommatis, Konstantinos K; Walker, Brian A BA; Morgan, Gareth J GJ; Munshi, Nikhil C NC; Avet Loiseau, Herve H; Thakurta, Anjan A
Publication Date: 2022-10-12

Variant appearance in text: KRAS: A146T
PubMed Link: 36223594
Variant Present in the following documents:
  • BLOOD_BLD-2022-017010-mmc2.xlsx, sheet 1
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A comprehensive next generation sequencing tissue assay for Asian-prevalent cancers-Analytical validation and performance evaluation with clinical samples.

Frontiers In Molecular Biosciences
Ng, Cedric Chuan-Young CC; Lim, Sandy S; Lim, Abner Herbert AH; Md Nasir, Nur Diyana ND; Zhang, Jingxian J; Rajasegaran, Vikneswari V; Lee, Jing Yi JY; Kok, Jessica Sook Ting JST; Thike, Aye Aye AA; Lim, Johnathan Xiande JX; Weng, Ruifen R; Yee, Sidney S; Choudhury, Yukti Y; Chan, Jason Yongsheng JY; Tan, Puay Hoon PH; Tan, Min-Han MH; Teh, Bin Tean BT
Publication Date: 2022

Variant appearance in text: KRAS: A146T
PubMed Link: 36213130
Variant Present in the following documents:
  • DataSheet1.xlsx, sheet 11
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Duplex Sequencing Uncovers Recurrent Low-frequency Cancer-associated Mutations in Infant and Childhood KMT2A-rearranged Acute Leukemia.

Hemasphere
Pilheden, Mattias M; Ahlgren, Louise L; Hyrenius-Wittsten, Axel A; Gonzalez-Pena, Veronica V; Sturesson, Helena H; Hansen Marquart, Hanne Vibeke HV; Lausen, Birgitte B; Castor, Anders A; Pronk, Cornelis Jan CJ; Barbany, Gisela G; Pokrovskaja Tamm, Katja K; Fogelstrand, Linda L; Lohi, Olli O; Norén-Nyström, Ulrika U; Asklin, Johanna J; Chen, Yilun Y; Song, Guangchun G; Walsh, Michael M; Ma, Jing J; Zhang, Jinghui J; Saal, Lao H LH; Gawad, Charles C; Hagström-Andersson, Anna K AK
Publication Date: 2022-10

Variant appearance in text: KRAS: A146T
PubMed Link: 36204688
Variant Present in the following documents:
  • hs9-6-e785-s001.xlsx, sheet 6
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EPHA5 mutation was associated with adverse outcome of atezolizumab treatment in late-stage non-small cell lung cancers.

Bmc Pulmonary Medicine
Li, Zhenxiang Z; Zhou, Qing Q; Wang, Qi Q; Wang, Haiyong H; Yue, Weiming W
Publication Date: 2022-09-19

Variant appearance in text: KRAS: 436G>A; A146T
PubMed Link: 36123678
Variant Present in the following documents:
  • 12890_2022_2161_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page