KRAS c.403_404delinsGC ;(p.R135A)

Variant ID: 12-25378594-CT-GC

NM_004985.3(KRAS):c.403_404delinsGC;(p.R135A)

This variant was identified in 4 publications

View GRCh38 version.




Publications:


A structural model of a Ras-Raf signalosome.

Nature Structural & Molecular Biology
Mysore, Venkatesh P VP; Zhou, Zhi-Wei ZW; Ambrogio, Chiara C; Li, Lianbo L; Kapp, Jonas N JN; Lu, Chunya C; Wang, Qi Q; Tucker, Maxwell R MR; Okoro, Jeffrey J JJ; Nagy-Davidescu, Gabriela G; Bai, Xiaochen X; Plückthun, Andreas A; Jänne, Pasi A PA; Westover, Kenneth D KD; Shan, Yibing Y; Shaw, David E DE
Publication Date: 2021-10

Variant appearance in text: KRAS: R135A
PubMed Link: 34625747
Variant Present in the following documents:
  • Main text
View BVdb publication page



Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery.

Cancer Metastasis Reviews
Pálfy, Gyula G; Menyhárd, Dóra K DK; Perczel, András A
Publication Date: 2020-12

Variant appearance in text: K-Ras4B: Arg135Ala
PubMed Link: 32815102
Variant Present in the following documents:
  • Main text
  • 10555_2020_Article_9917.pdf
View BVdb publication page



K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and function.

The Journal Of Biological Chemistry
Cao, Shufen S; Chung, Stacey S; Kim, SoonJeung S; Li, Zhenlu Z; Manor, Danny D; Buck, Matthias M
Publication Date: 2019-04-26

Variant appearance in text: K-Ras4B: R135A
PubMed Link: 30792310
Variant Present in the following documents:
  • Main text
View BVdb publication page



Specific cancer-associated mutations in the switch III region of Ras increase tumorigenicity by nanocluster augmentation.

Elife
Šolman, Maja M; Ligabue, Alessio A; Blaževitš, Olga O; Jaiswal, Alok A; Zhou, Yong Y; Liang, Hong H; Lectez, Benoit B; Kopra, Kari K; Guzmán, Camilo C; Härmä, Harri H; Hancock, John F JF; Aittokallio, Tero T; Abankwa, Daniel D
Publication Date: 2015-08-14

Variant appearance in text: KRAS: R135A
PubMed Link: 26274561
Variant Present in the following documents:
  • Main text
  • elife08905.pdf
View BVdb publication page