Publications:

Delineating the RAS Conformational Landscape.

Cancer Research

Parker, Mitchell I MI; Meyer, Joshua E JE; Golemis, Erica A EA; Dunbrack, Roland L RL

Publication Date: 2022-07-05

Variant appearance in text: KRAS: D126E

PubMed Link: 35536216

Variant Present in the following documents:

• can-22-0804_supplementary_datasets_s1-s4_suppsds1-sds4.xlsx, sheet 1

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Membrane interactions of the globular domain and the hypervariable region of KRAS4b define its unique diffusion behavior.

Elife

Goswami, Debanjan D; Chen, De ; Yang, Yue Y; Gudla, Prabhakar R PR; Columbus, John J; Worthy, Karen K; Rigby, Megan M; Wheeler, Madeline M; Mukhopadhyay, Suman S; Powell, Katie K; Burgan, William W; Wall, Vanessa V; Esposito, Dominic D; Simanshu, Dhirendra K DK; Lightstone, Felice C FC; Nissley, Dwight V DV; McCormick, Frank F; Turbyville, Thomas T

Publication Date: 2020-01-20

Variant appearance in text: KRAS: D126E

PubMed Link: 31958057

Variant Present in the following documents:

• Main text
• elife-47654.pdf

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Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Hillig, Roman C RC; Sautier, Brice B; Schroeder, Jens J; Moosmayer, Dieter D; Hilpmann, André A; Stegmann, Christian M CM; Werbeck, Nicolas D ND; Briem, Hans H; Boemer, Ulf U; Weiske, Joerg J; Badock, Volker V; Mastouri, Julia J; Petersen, Kirstin K; Siemeister, Gerhard G; Kahmann, Jan D JD; Wegener, Dennis D; Böhnke, Niels N; Eis, Knut K; Graham, Keith K; Wortmann, Lars L; von Nussbaum, Franz F; Bader, Benjamin B

Publication Date: 2019-02-12

Variant appearance in text: KRAS: D126E

PubMed Link: 30683722

Variant Present in the following documents:

• Main text
• pnas.201812963.pdf
• pnas.1812963116.sapp.pdf

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Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One

Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS

Publication Date: 2018

Variant appearance in text: KRAS: D126E

PubMed Link: 29698444

Variant Present in the following documents:

• pone.0196434.s001.xlsx, sheet 2
• pone.0196434.s001.xlsx, sheet 3
• pone.0196434.s001.xlsx, sheet 1

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