Publications:

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Novel mutant KRAS addiction signature predicts response to the combination of ERBB and MEK inhibitors in lung and pancreatic cancers.

Iscience

Tyc, Katarzyna M KM; Kazi, Aslamuzzaman A; Ranjan, Alok A; Wang, Rui R; Sebti, Said M SM

Publication Date: 2023-03-17

Variant appearance in text: KRAS: P121H

PubMed Link: 36852277

Variant Present in the following documents:

• mmc2.xlsx, sheet 2

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PP4 inhibition sensitizes ovarian cancer to NK cell-mediated cytotoxicity via STAT1 activation and inflammatory signaling.

Journal For Immunotherapy Of Cancer

Raja, Remya R; Wu, Christopher C; Bassoy, Esen Yonca EY; Rubino, Thomas E TE; Utagawa, Emma C EC; Magtibay, Paul M PM; Butler, Kristina A KA; Curtis, Marion M

Publication Date: 2022-12

Variant appearance in text: KRAS: P121H

PubMed Link: 36564125

Variant Present in the following documents:

• jitc-2022-005026supp021.pdf

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Development and evaluation of ActSeq: A targeted next-generation sequencing panel for clinical oncology use.

Plos One

Shi, Zonggao Z; Lopez, Jacqueline J; Kalliney, William W; Sutton, Bobbie B; Simpson, Joyce J; Maggert, Kevin K; Liu, Sheng S; Wan, Jun J; Stack, M Sharon MS

Publication Date: 2022

Variant appearance in text: KRAS: P121H

PubMed Link: 35446881

Variant Present in the following documents:

• Main text
• pone.0266914.pdf

View BVdb publication page

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Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

International Journal Of Molecular Medicine

Chevrier, Sandy S; Brasselet, Astrid A; Carnet, Marion M; Chevriaux, Angélique A; Gibeaud, Anne A; Jourdain, Marine M; Mananet, Hugo H; Truntzer, Caroline C; Beltjens, Françoise F; Charon-Barra, Céline C; Arnould, Laurent L; Albuisson, Juliette J; Comte, Anthony A; Derangère, Valentin V; Goussot, Vincent V; Boidot, Romain R

Publication Date: 2022-05

Variant appearance in text: KRAS: 362C>A; Pro121His

PubMed Link: 35244186

Variant Present in the following documents:

• Supplementary_Data2.xlsx, sheet 1

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The Anti-Proliferative Effect of PI3K/mTOR and ERK Inhibition in Monolayer and Three-Dimensional Ovarian Cancer Cell Models.

Cancers

Dunn, Elizabeth E; Chitcholtan, Kenny K; Sykes, Peter P; Garrill, Ashley A

Publication Date: 2022-01-13

Variant appearance in text: KRAS: P121H

PubMed Link: 35053555

Variant Present in the following documents:

• Main text
• cancers-14-00395.pdf

View BVdb publication page

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The Anti-Proliferative Effect of PI3K/mTOR and ERK Inhibition in Monolayer and Three-Dimensional Ovarian Cancer Cell Models.

Cancers

Dunn, Elizabeth E; Chitcholtan, Kenny K; Sykes, Peter P; Garrill, Ashley A

Publication Date: 2022-01-13

Variant appearance in text: KRAS: P121H

PubMed Link: 35053555

Variant Present in the following documents:

• Main text
• cancers-14-00395.pdf

View BVdb publication page

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The Claudin-Low Subtype of High-Grade Serous Ovarian Carcinoma Exhibits Stem Cell Features.

Cancers

Romani, Chiara C; Capoferri, Davide D; Grillo, Elisabetta E; Silvestri, Marco M; Corsini, Michela M; Zanotti, Laura L; Todeschini, Paola P; Ravaggi, Antonella A; Bignotti, Eliana E; Odicino, Franco F; Sartori, Enrico E; Calza, Stefano S; Mitola, Stefania S

Publication Date: 2021-02-22

Variant appearance in text: KRAS: P121H

PubMed Link: 33671478

Variant Present in the following documents:

• Main text
• cancers-13-00906.pdf

View BVdb publication page

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False-negative errors in next-generation sequencing contribute substantially to inconsistency of mutation databases.

Plos One

Kim, Young-Ho YH; Song, Yura Y; Kim, Jong-Kwang JK; Kim, Tae-Min TM; Sim, Hye Won HW; Kim, Hyung-Lae HL; Jang, Hyonchol H; Kim, Young-Woo YW; Hong, Kyeong-Man KM

Publication Date: 2019

Variant appearance in text: KRAS: 362C>A; P121H

PubMed Link: 31513681

Variant Present in the following documents:

• pone.0222535.s006.xlsx, sheet 1

View BVdb publication page

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Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy.

Cancer Cell

Fang, Yong Y; McGrail, Daniel J DJ; Sun, Chaoyang C; Labrie, Marilyne M; Chen, Xiaohua X; Zhang, Dong D; Ju, Zhenlin Z; Vellano, Christopher P CP; Lu, Yiling Y; Li, Yongsheng Y; Jeong, Kang Jin KJ; Ding, Zhiyong Z; Liang, Jiyong J; Wang, Steven W SW; Dai, Hui H; Lee, Sanghoon S; Sahni, Nidhi N; Mercado-Uribe, Imelda I; Kim, Tae-Beom TB; Chen, Ken K; Lin, Shiaw-Yih SY; Peng, Guang G; Westin, Shannon N SN; Liu, Jinsong J; O'Connor, Mark J MJ; Yap, Timothy A TA; Mills, Gordon B GB

Publication Date: 2019-06-10

Variant appearance in text: KRAS: P121H

PubMed Link: 31185210

Variant Present in the following documents:

• Main text

View BVdb publication page

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Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports

Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS

Publication Date: 2018-04-03

Variant appearance in text: KRAS: 362C>A

PubMed Link: 29617658

Variant Present in the following documents:

• NIHMS958974-supplement-6.xlsx, sheet 1
• NIHMS958974-supplement-5.xlsx, sheet 1

View BVdb publication page

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BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency.

Cancer Cell

Sun, Chaoyang C; Yin, Jun J; Fang, Yong Y; Chen, Jian J; Jeong, Kang Jin KJ; Chen, Xiaohua X; Vellano, Christopher P CP; Ju, Zhenlin Z; Zhao, Wei W; Zhang, Dong D; Lu, Yiling Y; Meric-Bernstam, Funda F; Yap, Timothy A TA; Hattersley, Maureen M; O'Connor, Mark J MJ; Chen, Huawei H; Fawell, Stephen S; Lin, Shiaw-Yih SY; Peng, Guang G; Mills, Gordon B GB

Publication Date: 2018-03-12

Variant appearance in text: KRAS: P121H

PubMed Link: 29533782

Variant Present in the following documents:

• Main text

View BVdb publication page

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Orthologous CRISPR-Cas9 enzymes for combinatorial genetic screens.

Nature Biotechnology

Najm, Fadi J FJ; Strand, Christine C; Donovan, Katherine F KF; Hegde, Mudra M; Sanson, Kendall R KR; Vaimberg, Emma W EW; Sullender, Meagan E ME; Hartenian, Ella E; Kalani, Zohra Z; Fusi, Nicolo N; Listgarten, Jennifer J; Younger, Scott T ST; Bernstein, Bradley E BE; Root, David E DE; Doench, John G JG

Publication Date: 2018-02

Variant appearance in text: KRAS: P121H

PubMed Link: 29251726

Variant Present in the following documents:

• Main text
• nihms925040.pdf

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Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers.

Science Translational Medicine

Sun, Chaoyang C; Fang, Yong Y; Yin, Jun J; Chen, Jian J; Ju, Zhenlin Z; Zhang, Dong D; Chen, Xiaohua X; Vellano, Christopher P CP; Jeong, Kang Jin KJ; Ng, Patrick Kwok-Shing PK; Eterovic, Agda Karina B AKB; Bhola, Neil H NH; Lu, Yiling Y; Westin, Shannon N SN; Grandis, Jennifer R JR; Lin, Shiaw-Yih SY; Scott, Kenneth L KL; Peng, Guang G; Brugge, Joan J; Mills, Gordon B GB

Publication Date: 2017-05-31

Variant appearance in text: KRAS: P121H

PubMed Link: 28566428

Variant Present in the following documents:

• Main text

View BVdb publication page

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Targeted exome sequencing reveals distinct pathogenic variants in Iranians with colorectal cancer.

Oncotarget

Ashktorab, Hassan H; Mokarram, Pooneh P; Azimi, Hamed H; Olumi, Hasti H; Varma, Sudhir S; Nickerson, Michael L ML; Brim, Hassan H

Publication Date: 2017-01-31

Variant appearance in text: KRAS: P121H

PubMed Link: 28002797

Variant Present in the following documents:

• oncotarget-08-7852-s002.xlsx, sheet 3

View BVdb publication page

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A Landscape of Pharmacogenomic Interactions in Cancer.

Cell

Iorio, Francesco F; Knijnenburg, Theo A TA; Vis, Daniel J DJ; Bignell, Graham R GR; Menden, Michael P MP; Schubert, Michael M; Aben, Nanne N; Gonçalves, Emanuel E; Barthorpe, Syd S; Lightfoot, Howard H; Cokelaer, Thomas T; Greninger, Patricia P; van Dyk, Ewald E; Chang, Han H; de Silva, Heshani H; Heyn, Holger H; Deng, Xianming X; Egan, Regina K RK; Liu, Qingsong Q; Mironenko, Tatiana T; Mitropoulos, Xeni X; Richardson, Laura L; Wang, Jinhua J; Zhang, Tinghu T; Moran, Sebastian S; Sayols, Sergi S; Soleimani, Maryam M; Tamborero, David D; Lopez-Bigas, Nuria N; Ross-Macdonald, Petra P; Esteller, Manel M; Gray, Nathanael S NS; Haber, Daniel A DA; Stratton, Michael R MR; Benes, Cyril H CH; Wessels, Lodewyk F A LFA; Saez-Rodriguez, Julio J; McDermott, Ultan U; Garnett, Mathew J MJ

Publication Date: 2016-07-28

Variant appearance in text: KRAS: 362C>A; P121H

PubMed Link: 27397505

Variant Present in the following documents:

• mmc3.xlsx, sheet 3

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Heterogeneity of resistance mutations detectable by nextgeneration sequencing in TKI-treated lung adenocarcinoma.

Oncotarget

Belchis, Deborah A DA; Tseng, Li-Hui LH; Gniadek, Thomas T; Haley, Lisa L; Lokhandwala, Parvez P; Illei, Peter P; Gocke, Christopher D CD; Forde, Patrick P; Brahmer, Julie J; Askin, Frederic B FB; Eshleman, James R JR; Lin, Ming-Tseh MT

Publication Date: 2016-07-19

Variant appearance in text: KRAS: P121H

PubMed Link: 27304188

Variant Present in the following documents:

• Main text
• oncotarget-07-45237.pdf

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LowMACA: exploiting protein family analysis for the identification of rare driver mutations in cancer.

Bmc Bioinformatics

Melloni, Giorgio E M GE; de Pretis, Stefano S; Riva, Laura L; Pelizzola, Mattia M; Céol, Arnaud A; Costanza, Jole J; Müller, Heiko H; Zammataro, Luca L

Publication Date: 2016-02-09

Variant appearance in text: KRAS: P121H

PubMed Link: 26860319

Variant Present in the following documents:

• 12859_2016_935_MOESM2_ESM.xlsx, sheet 1

View BVdb publication page

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Discovery of novel AKT inhibitors with enhanced anti-tumor effects in combination with the MEK inhibitor.

Plos One

Dumble, Melissa M; Crouthamel, Ming-Chih MC; Zhang, Shu-Yun SY; Schaber, Michael M; Levy, Dana D; Robell, Kimberly K; Liu, Qi Q; Figueroa, David J DJ; Minthorn, Elisabeth A EA; Seefeld, Mark A MA; Rouse, Meagan B MB; Rabindran, Sridhar K SK; Heerding, Dirk A DA; Kumar, Rakesh R

Publication Date: 2014

Variant appearance in text: KRAS: P121H

PubMed Link: 24978597

Variant Present in the following documents:

• pone.0100880.s006.xlsx, sheet 1

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Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer.

Gynecologic Oncology

Shah, Nina R NR; Tancioni, Isabelle I; Ward, Kristy K KK; Lawson, Christine C; Chen, Xiao Lei XL; Jean, Christine C; Sulzmaier, Florian J FJ; Uryu, Sean S; Miller, Nichol L G NL; Connolly, Denise C DC; Schlaepfer, David D DD

Publication Date: 2014-07

Variant appearance in text: KRAS: P121H

PubMed Link: 24786638

Variant Present in the following documents:

• Main text

View BVdb publication page

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