Publications:

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ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.

The Biochemical Journal

Balmanno, Kathryn K; Kidger, Andrew M AM; Byrne, Dominic P DP; Sale, Matthew J MJ; Nassman, Nejma N; Eyers, Patrick A PA; Cook, Simon J SJ

Publication Date: 2023-04-05

Variant appearance in text: KRAS: p110a

PubMed Link: 37018014

Variant Present in the following documents:

• BCJ-480-587.pdf

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Rethinking glutamine metabolism and the regulation of glutamine addiction by oncogenes in cancer.

Frontiers In Oncology

Ni, Rui R; Li, Ziwei Z; Li, Li L; Peng, Dan D; Ming, Yue Y; Li, Lin L; Liu, Yao Y

Publication Date: 2023

Variant appearance in text: KRAS: p110a

PubMed Link: 36959802

Variant Present in the following documents:

• fonc-13-1143798.pdf

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Phosphoinositide 3-Kinase (PI3K) Inhibitors and Breast Cancer: An Overview of Current Achievements.

Cancers

Bertucci, Alexandre A; Bertucci, François F; Gonçalves, Anthony A

Publication Date: 2023-02-23

Variant appearance in text: KRAS: p110a

PubMed Link: 36900211

Variant Present in the following documents:

• cancers-15-01416.pdf

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PIK3CAMutations in Breast Cancer Subtypes Other Than HR-Positive/HER2-Negative.

Journal Of Personalized Medicine

Ascione, Liliana L; Zagami, Paola P; Nicolò, Eleonora E; Crimini, Edoardo E; Curigliano, Giuseppe G; Criscitiello, Carmen C

Publication Date: 2022-10-31

Variant appearance in text: KRAS: P110a

PubMed Link: 36579519

Variant Present in the following documents:

• jpm-12-01793.pdf

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A New View of Activating Mutations in Cancer.

Cancer Research

Nussinov, Ruth R; Tsai, Chung-Jung CJ; Jang, Hyunbum H

Publication Date: 2022-11-15

Variant appearance in text: K-Ras4B: p110a

PubMed Link: 36069825

Variant Present in the following documents:

• 4114.pdf

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Taohong Siwu Decoction exerts anticancer effects on breast cancer via regulating MYC, BIRC5, EGF and PIK3R1 revealed by HTS2 technology.

Computational And Structural Biotechnology Journal

Gui, Yu Y; Dai, Yifei Y; Wang, Yumei Y; Li, Shengrong S; Xiang, Lei L; Tang, Yuqin Y; Tan, Xue X; Pei, Tianli T; Bao, Xilinqiqige X; Wang, Dong D

Publication Date: 2022

Variant appearance in text: KRAS: p110a

PubMed Link: 35860405

Variant Present in the following documents:

• main.pdf

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Using an Improved Residual Network to Identify PIK3CA Mutation Status in Breast Cancer on Ultrasound Image.

Frontiers In Oncology

Shen, Wen-Qian WQ; Guo, Yanhui Y; Ru, Wan-Er WE; Li, Cheukfai C; Zhang, Guo-Chun GC; Liao, Ning N; Du, Guo-Qing GQ

Publication Date: 2022

Variant appearance in text: KRAS: p110a

PubMed Link: 35719907

Variant Present in the following documents:

• fonc-12-850515.pdf

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Recent advances in targeted drug delivery systems for resistant colorectal cancer.

Cancer Cell International

Sharifi-Azad, Masoumeh M; Fathi, Marziyeh M; Cho, William C WC; Barzegari, Abolfazl A; Dadashi, Hamed H; Dadashpour, Mehdi M; Jahanban-Esfahlan, Rana R

Publication Date: 2022-05-19

Variant appearance in text: KRAS: P110a

PubMed Link: 35590367

Variant Present in the following documents:

• Main text
• 12935_2022_Article_2605.pdf

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Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study.

Journal Of Enzyme Inhibition And Medicinal Chemistry

Sun, Yin Y; Tang, Haotian H; Wang, Xiaoyan X; Feng, Fang F; Fan, Tiantian T; Zhao, Dongmei D; Xiong, Bing B; Xie, Hua H; Liu, Tongchao T

Publication Date: 2022-12

Variant appearance in text: KRAS: p110a

PubMed Link: 35587686

Variant Present in the following documents:

• Main text
• IENZ_37_2076674.pdf

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Liquid Biopsy and Artificial Intelligence as Tools to Detect Signatures of Colorectal Malignancies: A Modern Approach in Patient's Stratification.

Frontiers In Oncology

Ginghina, Octav O; Hudita, Ariana A; Zamfir, Marius M; Spanu, Andrada A; Mardare, Mara M; Bondoc, Irina I; Buburuzan, Laura L; Georgescu, Sergiu Emil SE; Costache, Marieta M; Negrei, Carolina C; Nitipir, Cornelia C; Galateanu, Bianca B

Publication Date: 2022

Variant appearance in text: KRAS: p110a

PubMed Link: 35356214

Variant Present in the following documents:

• Main text
• fonc-12-856575.pdf

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Role of ctDNA in Breast Cancer.

Cancers

Sant, Marta M; Bernat-Peguera, Adrià A; Felip, Eudald E; Margelí, Mireia M

Publication Date: 2022-01-09

Variant appearance in text: KRAS: p110a

PubMed Link: 35053474

Variant Present in the following documents:

• Main text
• cancers-14-00310.pdf

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Role of ctDNA in Breast Cancer.

Cancers

Sant, Marta M; Bernat-Peguera, Adrià A; Felip, Eudald E; Margelí, Mireia M

Publication Date: 2022-01-09

Variant appearance in text: KRAS: p110a

PubMed Link: 35053474

Variant Present in the following documents:

• Main text
• cancers-14-00310.pdf

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Personalizing first-line treatment in advanced colorectal cancer: Present status and future perspectives.

Journal Of Clinical And Translational Research

Motta, Rodrigo R; Cabezas-Camarero, Santiago S; Torres-Mattos, Cesar C; Riquelme, Alejandro A; Calle, Ana A; Montenegro, Paola P; Sotelo, Miguel J MJ

Publication Date: 2021-12-28

Variant appearance in text: KRAS: p110a

PubMed Link: 34988329

Variant Present in the following documents:

• Main text

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Targeting KRAS mutant lung cancer: light at the end of the tunnel.

Molecular Oncology

Drosten, Matthias M; Barbacid, Mariano M

Publication Date: 2022-03

Variant appearance in text: KRAS: p110a

PubMed Link: 34951114

Variant Present in the following documents:

• MOL2-16-1057.pdf

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Therapeutic Suppression of FAK-AKT Signaling Overcomes Resistance to SHP2 Inhibition in Colorectal Carcinoma.

Frontiers In Pharmacology

Li, Ye Y; Yuan, Yuncang Y; Zhang, Fan F; Guo, Aizhen A; Cao, Fuao F; Song, Mengmeng M; Fu, Yating Y; Xu, Xiaowen X; Shen, Hao H; Zheng, Shangyong S; Pan, Yamin Y; Chang, Wenjun W

Publication Date: 2021

Variant appearance in text: KRAS: p110a

PubMed Link: 34790119

Variant Present in the following documents:

• Main text
• fphar-12-739501.pdf

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Emerging Perspectives on Leukemia Inhibitory Factor and its Receptor in Cancer.

Frontiers In Oncology

Christianson, Joe J; Oxford, Julia Thom JT; Jorcyk, Cheryl L CL

Publication Date: 2021

Variant appearance in text: KRAS: P110a

PubMed Link: 34395259

Variant Present in the following documents:

• fonc-11-693724.pdf

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Targeting PI3K/AKT/mTOR Signaling Pathway in Breast Cancer.

Cancers

Li, Huayi H; Prever, Lorenzo L; Hirsch, Emilio E; Gulluni, Federico F

Publication Date: 2021-07-14

Variant appearance in text: KRAS: p110a

PubMed Link: 34298731

Variant Present in the following documents:

• Main text
• cancers-13-03517.pdf

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Targeting the PI3K and MAPK pathways to improve response to HER2-targeted therapies in HER2-positive gastric cancer.

Journal Of Translational Medicine

Mezynski, M Janusz MJ; Farrelly, Angela M AM; Cremona, Mattia M; Carr, Aoife A; Morgan, Clare C; Workman, Julie J; Armstrong, Paul P; McAuley, Jennifer J; Madden, Stephen S; Fay, Joanna J; Sheehan, Katherine M KM; Kay, Elaine W EW; Holohan, Ciara C; Elamin, Yasir Y; Rafee, Shereen S; Morris, Patrick G PG; Breathnach, Oscar O; Grogan, Liam L; Hennessy, Bryan T BT; Toomey, Sinead S

Publication Date: 2021-05-01

Variant appearance in text: KRAS: p110a

PubMed Link: 33933113

Variant Present in the following documents:

• Main text

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Metabolic Codependencies in the Tumor Microenvironment.

Cancer Discovery

Dey, Prasenjit P; Kimmelman, Alec C AC; DePinho, Ronald A RA

Publication Date: 2021-05

Variant appearance in text: KRAS: p110a

PubMed Link: 33504580

Variant Present in the following documents:

• Main text

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Feedback activation of STAT3 limits the response to PI3K/AKT/mTOR inhibitors in PTEN-deficient cancer cells.

Oncogenesis

Wang, Jian J; Lv, Xiaoye X; Guo, Xiutian X; Dong, Yanbo Y; Peng, Peipei P; Huang, Fang F; Wang, Peng P; Zhang, Haoqian H; Zhou, Jianguang J; Wang, Youliang Y; Wei, Bo B; Shang, Zeng-Fu ZF; Li, Shanhu S

Publication Date: 2021-01-05

Variant appearance in text: KRAS: p110a

PubMed Link: 33431808

Variant Present in the following documents:

• 41389_2020_Article_292.pdf

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Dacomitinib and gedatolisib in combination with fractionated radiation in head and neck cancer.

Clinical And Translational Radiation Oncology

Wilson, George D GD; Wilson, Thomas G TG; Hanna, Alaa A; Dabjan, Mohamad M; Buelow, Katie K; Torma, John J; Marples, Brian B; Galoforo, Sandra S

Publication Date: 2021-01

Variant appearance in text: KRAS: p110a

PubMed Link: 33251343

Variant Present in the following documents:

• main.pdf

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Clinical Features and Genomic Characterization of Post-Colonoscopy Colorectal Cancer.

Clinical And Translational Gastroenterology

Tanaka, Hidenori H; Urabe, Yuji Y; Oka, Shiro S; Shimohara, Yasutsugu Y; Nishimura, Tomoyuki T; Inagaki, Katsuaki K; Okamoto, Yuki Y; Matsumoto, Kenta K; Yamashita, Ken K; Sumimoto, Kyoku K; Ninomiya, Yuki Y; Yuge, Ryo R; Tanaka, Shinji S; Chayama, Kazuaki K

Publication Date: 2020-10

Variant appearance in text: KRAS: p110a

PubMed Link: 33031197

Variant Present in the following documents:

• ct9-11-e00246.pdf

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Targeting KRAS Mutant Non-Small-Cell Lung Cancer: Past, Present and Future.

International Journal Of Molecular Sciences

Uras, Iris Z IZ; Moll, Herwig P HP; Casanova, Emilio E

Publication Date: 2020-06-17

Variant appearance in text: KRAS: p110a

PubMed Link: 32560574

Variant Present in the following documents:

• ijms-21-04325.pdf

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Prevalence and prognostic role of PIK3CA E545K mutation in Iranian colorectal cancer patients.

Gastroenterology And Hepatology From Bed To Bench

Ranjbar, Reza R; Mohammadpour, Somayeh S; Torshizi Esfahani, Amir A; Namazian, Sina S; Yaghob-Taleghani, Mohammad M; Baghaei, Kaveh K; Mortazavi Tabatabaei, Seyed Abdolreza SA; Pasharavesh, Leila L; Nazemalhosseini-Mojarad, Ehsan E

Publication Date: 2019

Variant appearance in text: KRAS: p110a

PubMed Link: 32099598

Variant Present in the following documents:

• Main text
• GHFBB-12-S22.pdf

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PIK3CA Gene Mutations in Solid Malignancies: Association with Clinicopathological Parameters and Prognosis.

Cancers

Alqahtani, Ali A; Ayesh, Hazem S K HSK; Halawani, Hafez H

Publication Date: 2019-12-30

Variant appearance in text: KRAS: p110a

PubMed Link: 31905960

Variant Present in the following documents:

• Main text

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Diet, Microbiota, and Colorectal Cancer.

Iscience

Grazioso, Tatiana P TP; Brandt, Marta M; Djouder, Nabil N

Publication Date: 2019-11-22

Variant appearance in text: KRAS: p110a

PubMed Link: 31669832

Variant Present in the following documents:

• main.pdf

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The Small GTPase ARF6 Activates PI3K in Melanoma to Induce a Prometastatic State.

Cancer Research

Yoo, Jae Hyuk JH; Brady, Samuel W SW; Acosta-Alvarez, Lehi L; Rogers, Aaron A; Peng, Jingfu J; Sorensen, Lise K LK; Wolff, Roger K RK; Mleynek, Tara T; Shin, Donghan D; Rich, Coulson P CP; Kircher, David A DA; Bild, Andrea A; Odelberg, Shannon J SJ; Li, Dean Y DY; Holmen, Sheri L SL; Grossmann, Allie H AH

Publication Date: 2019-06-01

Variant appearance in text: KRAS: p110a

PubMed Link: 31048499

Variant Present in the following documents:

• Main text

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Oncogenic PIK3CA mutations increase dependency on the mRNA cap methyltransferase, RNMT, in breast cancer cells.

Open Biology

Dunn, Sianadh S; Lombardi, Olivia O; Lukoszek, Radoslaw R; Cowling, Victoria H VH

Publication Date: 2019-04-26

Variant appearance in text: KRAS: p110a

PubMed Link: 30991934

Variant Present in the following documents:

• Main text
• rsob-9-190052.pdf

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Targeting PI3K in cancer: mechanisms and advances in clinical trials.

Molecular Cancer

Yang, Jing J; Nie, Ji J; Ma, Xuelei X; Wei, Yuquan Y; Peng, Yong Y; Wei, Xiawei X

Publication Date: 2019-02-19

Variant appearance in text: KRAS: p110a

PubMed Link: 30782187

Variant Present in the following documents:

• Main text
• 12943_2019_Article_954.pdf

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Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer.

Cell Reports

Murillo, Miguel M MM; Rana, Sareena S; Spencer-Dene, Bradley B; Nye, Emma E; Stamp, Gordon G; Downward, Julian J

Publication Date: 2018-12-26

Variant appearance in text: KRAS: p110a

PubMed Link: 30590030

Variant Present in the following documents:

• mmc2.pdf

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PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue.

Bmc Cancer

Yokota, Tomoya T; Serizawa, Masakuni M; Hosokawa, Ayumu A; Kusafuka, Kimihide K; Mori, Keita K; Sugiyama, Toshiro T; Tsubosa, Yasuhiro Y; Koh, Yasuhiro Y

Publication Date: 2018-08-16

Variant appearance in text: KRAS: p110a

PubMed Link: 30115035

Variant Present in the following documents:

• Main text

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Prognostic significance of PIK3CA mutation in stage IIB to IVA cervical cancers treated by concurrent chemoradiotherapy with weekly cisplatin.

Medicine

Lachkar, Bouchra B; Minaguchi, Takeo T; Akiyama, Azusa A; Liu, Shuling S; Zhang, Shuang S; Xu, Chenyang C; Shikama, Ayumi A; Tasaka, Nobutaka N; Sakurai, Manabu M; Nakao, Sari S; Ochi, Hiroyuki H; Yoshikawa, Hiroyuki H; Satoh, Toyomi T

Publication Date: 2018-08

Variant appearance in text: KRAS: p110a

PubMed Link: 30075505

Variant Present in the following documents:

• medi-97-e11392.pdf

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PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer.

Cell Death & Disease

Wang, Qiang Q; Shi, Yan-Long YL; Zhou, Kai K; Wang, Li-Li LL; Yan, Ze-Xuan ZX; Liu, Yu-Lin YL; Xu, Li-Li LL; Zhao, Shi-Wei SW; Chu, Hui-Li HL; Shi, Ting-Ting TT; Ma, Qing-Hua QH; Bi, Jingwang J

Publication Date: 2018-07-03

Variant appearance in text: KRAS: p110a

PubMed Link: 29970892

Variant Present in the following documents:

• Main text
• 41419_2018_Article_776.pdf

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Correlation between circulating cell-free PIK3CA tumor DNA levels and treatment response in patients with PIK3CA-mutated metastatic breast cancer.

Molecular Oncology

Kodahl, Annette R AR; Ehmsen, Sidse S; Pallisgaard, Niels N; Jylling, Anne M B AMB; Jensen, Jeanette D JD; Laenkholm, Anne-Vibeke AV; Knoop, Ann S AS; Ditzel, Henrik J HJ

Publication Date: 2018-06

Variant appearance in text: KRAS: p110a

PubMed Link: 29689598

Variant Present in the following documents:

• MOL2-12-925.pdf

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MTOR inhibitor-based combination therapies for pancreatic cancer.

British Journal Of Cancer

Hassan, Zonera Z; Schneeweis, Christian C; Wirth, Matthias M; Veltkamp, Christian C; Dantes, Zahra Z; Feuerecker, Benedikt B; Ceyhan, Güralp O GO; Knauer, Shirley K SK; Weichert, Wilko W; Schmid, Roland M RM; Stauber, Roland R; Arlt, Alexander A; Krämer, Oliver H OH; Rad, Roland R; Reichert, Maximilian M; Saur, Dieter D; Schneider, Günter G

Publication Date: 2018-02-06

Variant appearance in text: KRAS: p110a

PubMed Link: 29384525

Variant Present in the following documents:

• bjc2017421a.pdf

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Primary and acquired resistance to biologic therapies in gastrointestinal cancers.

Journal Of Gastrointestinal Oncology

Lubner, Sam J SJ; Uboha, Nataliya V NV; Deming, Dustin A DA

Publication Date: 2017-06

Variant appearance in text: KRAS: p110a

PubMed Link: 28736637

Variant Present in the following documents:

• Main text

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A Pan-Cancer Proteogenomic Atlas of PI3K/AKT/mTOR Pathway Alterations.

Cancer Cell

Zhang, Yiqun Y; Kwok-Shing Ng, Patrick P; Kucherlapati, Melanie M; Chen, Fengju F; Liu, Yuexin Y; Tsang, Yiu Huen YH; de Velasco, Guillermo G; Jeong, Kang Jin KJ; Akbani, Rehan R; Hadjipanayis, Angela A; Pantazi, Angeliki A; Bristow, Christopher A CA; Lee, Eunjung E; Mahadeshwar, Harshad S HS; Tang, Jiabin J; Zhang, Jianhua J; Yang, Lixing L; Seth, Sahil S; Lee, Semin S; Ren, Xiaojia X; Song, Xingzhi X; Sun, Huandong H; Seidman, Jonathan J; Luquette, Lovelace J LJ; Xi, Ruibin R; Chin, Lynda L; Protopopov, Alexei A; Westbrook, Thomas F TF; Shelley, Carl Simon CS; Choueiri, Toni K TK; Ittmann, Michael M; Van Waes, Carter C; Weinstein, John N JN; Liang, Han H; Henske, Elizabeth P EP; Godwin, Andrew K AK; Park, Peter J PJ; Kucherlapati, Raju R; Scott, Kenneth L KL; Mills, Gordon B GB; Kwiatkowski, David J DJ; Creighton, Chad J CJ

Publication Date: 2017-06-12

Variant appearance in text: KRAS: p110a

PubMed Link: 28528867

Variant Present in the following documents:

• Main text

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Progression inference for somatic mutations in cancer.

Heliyon

Peterson, Leif E LE; Kovyrshina, Tatiana T

Publication Date: 2017-04

Variant appearance in text: KRAS: p110a

PubMed Link: 28492066

Variant Present in the following documents:

• main.pdf

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Mechanisms of resistance to anti-EGFR therapy in colorectal cancer.

Oncotarget

Zhao, Ben B; Wang, Lu L; Qiu, Hong H; Zhang, Mingsheng M; Sun, Li L; Peng, Ping P; Yu, Qianqian Q; Yuan, Xianglin X

Publication Date: 2017-01-17

Variant appearance in text: KRAS: p110a

PubMed Link: 28002810

Variant Present in the following documents:

• Main text
• oncotarget-08-3980.pdf

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The Multidisciplinary Management of Colorectal Cancer: Present and Future Paradigms.

Clinics In Colon And Rectal Surgery

Sievers, Chelsie K CK; Kratz, Jeremy D JD; Zurbriggen, Luke D LD; LoConte, Noelle K NK; Lubner, Sam J SJ; Uboha, Natalya N; Mulkerin, Daniel D; Matkowskyj, Kristina A KA; Deming, Dustin A DA

Publication Date: 2016-09

Variant appearance in text: KRAS: p110a

PubMed Link: 27582648

Variant Present in the following documents:

• Main text

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Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer.

Nature Communications

Hao, Yujun Y; Samuels, Yardena Y; Li, Qingling Q; Krokowski, Dawid D; Guan, Bo-Jhih BJ; Wang, Chao C; Jin, Zhicheng Z; Dong, Bohan B; Cao, Bo B; Feng, Xiujing X; Xiang, Min M; Xu, Claire C; Fink, Stephen S; Meropol, Neal J NJ; Xu, Yan Y; Conlon, Ronald A RA; Markowitz, Sanford S; Kinzler, Kenneth W KW; Velculescu, Victor E VE; Brunengraber, Henri H; Willis, Joseph E JE; LaFramboise, Thomas T; Hatzoglou, Maria M; Zhang, Guo-Fang GF; Vogelstein, Bert B; Wang, Zhenghe Z

Publication Date: 2016-06-20

Variant appearance in text: KRAS: p110a

PubMed Link: 27321283

Variant Present in the following documents:

• ncomms11971.pdf

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TP53, PIK3CA, FBXW7 and KRAS Mutations in Esophageal Cancer Identified by Targeted Sequencing.

Cancer Genomics & Proteomics

Zheng, Huili H; Wang, Yan Y; Tang, Chuanning C; Jones, Lindsey L; Ye, Hua H; Zhang, Guangchun G; Cao, Weihai W; Li, Jingwen J; Liu, Lifeng L; Liu, Zhencong Z; Zhang, Chao C; Lou, Feng F; Liu, Zhiyuan Z; Li, Yangyang Y; Shi, Zhenfen Z; Zhang, Jingbo J; Zhang, Dandan D; Sun, Hong H; Dong, Haichao H; Dong, Zhishou Z; Guo, Baishuai B; Yan, H E HE; Lu, Qingyu Q; Huang, Xue X; Chen, Si-Yi SY

Publication Date: 2016

Variant appearance in text: KRAS: p110a

PubMed Link: 27107065

Variant Present in the following documents:

• Main text

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KRAS insertion mutations are oncogenic and exhibit distinct functional properties.

Nature Communications

White, Yasmine Y; Bagchi, Aditi A; Van Ziffle, Jessica J; Inguva, Anagha A; Bollag, Gideon G; Zhang, Chao C; Carias, Heidi H; Dickens, David D; Loh, Mignon M; Shannon, Kevin K; Firestone, Ari J AJ

Publication Date: 2016-02-08

Variant appearance in text: KRAS: p110a

PubMed Link: 26854029

Variant Present in the following documents:

• ncomms10647.pdf

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Dual Inhibition of MEK and PI3K Pathway in KRAS and BRAF Mutated Colorectal Cancers.

International Journal Of Molecular Sciences

Temraz, Sally S; Mukherji, Deborah D; Shamseddine, Ali A

Publication Date: 2015-09-23

Variant appearance in text: KRAS: p110a

PubMed Link: 26404261

Variant Present in the following documents:

• Main text

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PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer.

Cancer Medicine

Manceau, Gilles G; Marisa, Laetitia L; Boige, Valérie V; Duval, Alex A; Gaub, Marie-Pierre MP; Milano, Gérard G; Selves, Janick J; Olschwang, Sylviane S; Jooste, Valérie V; le Legrain, Michè M; Lecorre, Delphine D; Guenot, Dominique D; Etienne-Grimaldi, Marie-Christine MC; Kirzin, Sylvain S; Martin, Laurent L; Lepage, Come C; Bouvier, Anne-Marie AM; Laurent-Puig, Pierre P

Publication Date: 2015-03

Variant appearance in text: KRAS: p110a

PubMed Link: 25641861

Variant Present in the following documents:

• cam40004-0371.pdf

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Mutational analysis of merkel cell carcinoma.

Cancers

Erstad, Derek J DJ; Cusack, James C JC

Publication Date: 2014-10-17

Variant appearance in text: KRAS: p110a

PubMed Link: 25329450

Variant Present in the following documents:

• Main text

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Diagnostic application of PIK3CA mutation analysis in Chinese esophageal cancer patients.

Diagnostic Pathology

Ming, Zizhen Z; Jiang, Dongxian D; Hu, Qin Q; Li, Xiaojing X; Huang, Jie J; Xu, Yifan Y; Liu, Yalan Y; Xu, Chen C; Hua, Xiuguo X; Hou, Yingyong Y

Publication Date: 2014-08-09

Variant appearance in text: KRAS: p110a

PubMed Link: 25106743

Variant Present in the following documents:

• Main text

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The PI3K/AKT/mTOR pathway in breast cancer: targets, trials and biomarkers.

Therapeutic Advances In Medical Oncology

Paplomata, Elisavet E; O'Regan, Ruth R

Publication Date: 2014-07

Variant appearance in text: KRAS: p110a

PubMed Link: 25057302

Variant Present in the following documents:

• Main text

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Coexistence of EGFR with KRAS, or BRAF, or PIK3CA somatic mutations in lung cancer: a comprehensive mutation profiling from 5125 Chinese cohorts.

British Journal Of Cancer

Li, S S; Li, L L; Zhu, Y Y; Huang, C C; Qin, Y Y; Liu, H H; Ren-Heidenreich, L L; Shi, B B; Ren, H H; Chu, X X; Kang, J J; Wang, W W; Xu, J J; Tang, K K; Yang, H H; Zheng, Y Y; He, J J; Yu, G G; Liang, N N

Publication Date: 2014-05-27

Variant appearance in text: KRAS: p110a

PubMed Link: 24743704

Variant Present in the following documents:

• bjc2014210a.pdf

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Molecular pathways and therapeutic targets in lung cancer.

Oncotarget

Shtivelman, Emma E; Hensing, Thomas T; Simon, George R GR; Dennis, Phillip A PA; Otterson, Gregory A GA; Bueno, Raphael R; Salgia, Ravi R

Publication Date: 2014-03-30

Variant appearance in text: KRAS: p110a

PubMed Link: 24722523

Variant Present in the following documents:

• Main text

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The deubiquitylase Ataxin-3 restricts PTEN transcription in lung cancer cells.

Oncogene

Sacco, J J JJ; Yau, T Y TY; Darling, S S; Patel, V V; Liu, H H; Urbé, S S; Clague, M J MJ; Coulson, J M JM

Publication Date: 2014-08-14

Variant appearance in text: KRAS: p110a

PubMed Link: 24292675

Variant Present in the following documents:

• onc2013512a.pdf

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The dual PI3K/mTOR inhibitor NVP-BEZ235 enhances nab-paclitaxel antitumor response in experimental gastric cancer.

International Journal Of Oncology

Zhang, Chang-Ηua CΗ; Awasthi, Niranjan N; Schwarz, Margaret A MA; Schwarz, Roderich E RE

Publication Date: 2013-11

Variant appearance in text: KRAS: p110a

PubMed Link: 24042258

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Coordinate direct input of both KRAS and IGF1 receptor to activation of PI3 kinase in KRAS-mutant lung cancer.

Cancer Discovery

Molina-Arcas, Miriam M; Hancock, David C DC; Sheridan, Clare C; Kumar, Madhu S MS; Downward, Julian J

Publication Date: 2013-05

Variant appearance in text: KRAS: p110a

PubMed Link: 23454899

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Targeted approach to metastatic colorectal cancer: what comes beyond epidermal growth factor receptor antibodies and bevacizumab?

Therapeutic Advances In Medical Oncology

Troiani, Teresa T; Martinelli, Erika E; Morgillo, Floriana F; Capasso, Anna A; Nappi, Anna A; Sforza, Vincenzo V; Ciardiello, Fortunato F

Publication Date: 2013-01

Variant appearance in text: KRAS: p110a

PubMed Link: 23323147

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K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo.

Plos One

Hofmann, Irmgard I; Weiss, Andreas A; Elain, Gaelle G; Schwaederle, Maria M; Sterker, Dario D; Romanet, Vincent V; Schmelzle, Tobias T; Lai, Albert A; Brachmann, Saskia M SM; Bentires-Alj, Mohamed M; Roberts, Thomas M TM; Sellers, William R WR; Hofmann, Francesco F; Maira, Sauveur-Michel SM

Publication Date: 2012

Variant appearance in text: KRAS: p110a

PubMed Link: 22952903

Variant Present in the following documents:

• pone.0044146.pdf

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Phosphoinositide-3-kinase, catalytic, alpha polypeptide RNA interference inhibits growth of colon cancer cell SW948.

World Journal Of Gastroenterology

Huang, Wen-Sheng WS; Wang, Tian-Bao TB; He, Yao Y; Chen, Yu-Jun YJ; Zhong, Shi-Long SL; Tan, Min M

Publication Date: 2012-07-14

Variant appearance in text: KRAS: p110a

PubMed Link: 22807617

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Perifosine plus docetaxel in patients with platinum and taxane resistant or refractory high-grade epithelial ovarian cancer.

Gynecologic Oncology

Fu, Siqing S; Hennessy, Bryan T BT; Ng, Chaan S CS; Ju, Zhenlin Z; Coombes, Kevin R KR; Wolf, Judith K JK; Sood, Anil K AK; Levenback, Charles F CF; Coleman, Robert L RL; Kavanagh, John J JJ; Gershenson, David M DM; Markman, Maurie M; Dice, Kristine K; Howard, Adrienne A; Li, Jane J; Li, Yang Y; Stemke-Hale, Katherine K; Dyer, Mary M; Atkinson, Edward E; Jackson, Ed E; Kundra, Vikas V; Kurzrock, Razelle R; Bast, Robert C RC; Mills, Gordon B GB

Publication Date: 2012-07

Variant appearance in text: KRAS: p110a

PubMed Link: 22487539

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KRAS Mouse Models: Modeling Cancer Harboring KRAS Mutations.

Genes & Cancer

O'Hagan, Rónán C RC; Heyer, Joerg J

Publication Date: 2011-03

Variant appearance in text: KRAS: p110a

PubMed Link: 21779503

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Using tandem mass spectrometry in targeted mode to identify activators of class IA PI3K in cancer.

Cancer Research

Yang, Xuemei X; Turke, Alexa B AB; Qi, Jie J; Song, Youngchul Y; Rexer, Brent N BN; Miller, Todd W TW; Jänne, Pasi A PA; Arteaga, Carlos L CL; Cantley, Lewis C LC; Engelman, Jeffrey A JA; Asara, John M JM

Publication Date: 2011-09-15

Variant appearance in text: KRAS: p110a

PubMed Link: 21775521

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Selective BRAFV600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance.

Plos One

Oikonomou, Eftychia E; Koc, Michal M; Sourkova, Vladimira V; Andera, Ladislav L; Pintzas, Alexander A

Publication Date: 2011

Variant appearance in text: KRAS: p110a

PubMed Link: 21738740

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