KRAS c.321A>C ;(p.E107D)

Variant ID: 12-25378677-T-G

NM_004985.3(KRAS):c.321A>C;(p.E107D)

This variant was identified in 3 publications

View GRCh38 version.




Publications:


Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.

Nature
Abbosh, Christopher C; Frankell, Alexander M AM; Harrison, Thomas T; Kisistok, Judit J; Garnett, Aaron A; Johnson, Laura L; Veeriah, Selvaraju S; Moreau, Mike M; Chesh, Adrian A; Chaunzwa, Tafadzwa L TL; Weiss, Jakob J; Schroeder, Morgan R MR; Ward, Sophia S; Grigoriadis, Kristiana K; Shahpurwalla, Aamir A; Litchfield, Kevin K; Puttick, Clare C; Biswas, Dhruva D; Karasaki, Takahiro T; Black, James R M JRM; Martínez-Ruiz, Carlos C; Bakir, Maise Al MA; Pich, Oriol O; Watkins, Thomas B K TBK; Lim, Emilia L EL; Huebner, Ariana A; Moore, David A DA; Godin-Heymann, Nadia N; L'Hernault, Anne A; Bye, Hannah H; Odell, Aaron A; Roberts, Paula P; Gomes, Fabio F; Patel, Akshay J AJ; Manzano, Elizabeth E; Hiley, Crispin T CT; Carey, Nicolas N; Riley, Joan J; Cook, Daniel E DE; Hodgson, Darren D; Stetson, Daniel D; Barrett, J Carl JC; Kortlever, Roderik M RM; Evan, Gerard I GI; Hackshaw, Allan A; Daber, Robert D RD; Shaw, Jacqui A JA; Aerts, Hugo J W L HJWL; Licon, Abel A; Stahl, Josh J; Jamal-Hanjani, Mariam M; , ; Birkbak, Nicolai J NJ; McGranahan, Nicholas N; Swanton, Charles C
Publication Date: 2023-04-13

Variant appearance in text: KRAS: E107D
PubMed Link: 37055640
Variant Present in the following documents:
  • EMS176197-supplement-Supplementary_Table_1.xlsx, sheet 18
View BVdb publication page



KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe.

Nature Communications
Bery, Nicolas N; Legg, Sandrine S; Debreczeni, Judit J; Breed, Jason J; Embrey, Kevin K; Stubbs, Christopher C; Kolasinska-Zwierz, Paulina P; Barrett, Nathalie N; Marwood, Rose R; Watson, Jo J; Tart, Jon J; Overman, Ross R; Miller, Ami A; Phillips, Christopher C; Minter, Ralph R; Rabbitts, Terence H TH
Publication Date: 2019-06-13

Variant appearance in text: KRAS: E107D
PubMed Link: 31197133
Variant Present in the following documents:
  • Main text
  • 41467_2019_Article_10419.pdf
View BVdb publication page



Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction.

Proceedings Of The National Academy Of Sciences Of The United States Of America
Hillig, Roman C RC; Sautier, Brice B; Schroeder, Jens J; Moosmayer, Dieter D; Hilpmann, André A; Stegmann, Christian M CM; Werbeck, Nicolas D ND; Briem, Hans H; Boemer, Ulf U; Weiske, Joerg J; Badock, Volker V; Mastouri, Julia J; Petersen, Kirstin K; Siemeister, Gerhard G; Kahmann, Jan D JD; Wegener, Dennis D; Böhnke, Niels N; Eis, Knut K; Graham, Keith K; Wortmann, Lars L; von Nussbaum, Franz F; Bader, Benjamin B
Publication Date: 2019-02-12

Variant appearance in text: KRAS: E107D
PubMed Link: 30683722
Variant Present in the following documents:
  • pnas.1812963116.sapp.pdf
View BVdb publication page