Publications:

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RAS-targeted cancer therapy: Advances in drugging specific mutations.

Medcomm

Liu, Cen C; Ye, Danyang D; Yang, Hongliu H; Chen, Xu X; Su, Zhijun Z; Li, Xia X; Ding, Mei M; Liu, Yonggang Y

Publication Date: 2023-06

Variant appearance in text: KRAS: K104Q

PubMed Link: 37250144

Variant Present in the following documents:

• MCO2-4-e285.pdf

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Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS.

Signal Transduction And Targeted Therapy

Yin, Guowei G; Huang, Jing J; Petela, Johnny J; Jiang, Hongmei H; Zhang, Yuetong Y; Gong, Siqi S; Wu, Jiaxin J; Liu, Bei B; Shi, Jianyou J; Gao, Yijun Y

Publication Date: 2023-05-23

Variant appearance in text: KRAS: K104Q

PubMed Link: 37221195

Variant Present in the following documents:

• 41392_2023_Article_1441.pdf

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The Four Homeostasis Knights: In Balance upon Post-Translational Modifications.

International Journal Of Molecular Sciences

Pieroni, Stefania S; Castelli, Marilena M; Piobbico, Danilo D; Ferracchiato, Simona S; Scopetti, Damiano D; Di-Iacovo, Nicola N; Della-Fazia, Maria Agnese MA; Servillo, Giuseppe G

Publication Date: 2022-11-21

Variant appearance in text: KRAS: K104Q

PubMed Link: 36430960

Variant Present in the following documents:

• ijms-23-14480.pdf

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Thermal Shift Assay for Small GTPase Stability Screening: Evaluation and Suitability.

International Journal Of Molecular Sciences

Kopra, Kari K; Valtonen, Salla S; Mahran, Randa R; Kapp, Jonas N JN; Hassan, Nazia N; Gillette, William W; Dennis, Bryce B; Li, Lianbo L; Westover, Kenneth D KD; Plückthun, Andreas A; Härmä, Harri H

Publication Date: 2022-06-26

Variant appearance in text: KRAS: K104Q

PubMed Link: 35806100

Variant Present in the following documents:

• ijms-23-07095.pdf

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Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.

The Journal Of Biological Chemistry

Huynh, Minh V MV; Parsonage, Derek D; Forshaw, Tom E TE; Chirasani, Venkat R VR; Hobbs, G Aaron GA; Wu, Hanzhi H; Lee, Jingyun J; Furdui, Cristina M CM; Poole, Leslie B LB; Campbell, Sharon L SL

Publication Date: 2022-08

Variant appearance in text: KRAS: K104Q

PubMed Link: 35753348

Variant Present in the following documents:

• main.pdf

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Delineating the RAS Conformational Landscape.

Cancer Research

Parker, Mitchell I MI; Meyer, Joshua E JE; Golemis, Erica A EA; Dunbrack, Roland L RL

Publication Date: 2022-07-05

Variant appearance in text: KRAS: K104Q

PubMed Link: 35536216

Variant Present in the following documents:

• can-22-0804_supplementary_datasets_s1-s4_suppsds1-sds4.xlsx, sheet 1

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Identification of New KRAS G12D Inhibitors through Computer-Aided Drug Discovery Methods.

International Journal Of Molecular Sciences

Kulkarni, Apoorva M AM; Kumar, Vikas V; Parate, Shraddha S; Lee, Gihwan G; Yoon, Sanghwa S; Lee, Keun Woo KW

Publication Date: 2022-01-24

Variant appearance in text: KRAS: K104Q

PubMed Link: 35163234

Variant Present in the following documents:

• ijms-23-01309.pdf

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Identification of New KRAS G12D Inhibitors through Computer-Aided Drug Discovery Methods.

International Journal Of Molecular Sciences

Kulkarni, Apoorva M AM; Kumar, Vikas V; Parate, Shraddha S; Lee, Gihwan G; Yoon, Sanghwa S; Lee, Keun Woo KW

Publication Date: 2022-01-24

Variant appearance in text: KRAS: K104Q

PubMed Link: 35163234

Variant Present in the following documents:

• ijms-23-01309.pdf

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KRAS K104 modification affects the KRASG12D-GEF interaction and mediates cell growth and motility.

Scientific Reports

Chen, Chih-Chieh CC; Hsu, Chia-Yi CY; Lin, Hsiao-Yun HY; Zeng, Hong-Qi HQ; Cheng, Kuang-Hung KH; Wu, Chia-Wei CW; Tsai, Eing-Mei EM; Hsieh, Tsung-Hua TH

Publication Date: 2020-10-15

Variant appearance in text: KRAS: K104Q

PubMed Link: 33060649

Variant Present in the following documents:

• Main text

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KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface.

Iscience

Yin, Guowei G; Zhang, Jerry J; Nair, Vinay V; Truong, Vinh V; Chaia, Angelo A; Petela, Johnny J; Harrison, Joseph J; Gorfe, Alemayehu A AA; Campbell, Sharon L SL

Publication Date: 2020-08-10

Variant appearance in text: KRAS: K104Q

PubMed Link: 32882514

Variant Present in the following documents:

• Main text
• mmc1.pdf
• main.pdf

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Dynamically encoded reactivity of Ras enzymes: opening new frontiers for drug discovery.

Cancer Metastasis Reviews

Pálfy, Gyula G; Menyhárd, Dóra K DK; Perczel, András A

Publication Date: 2020-12

Variant appearance in text: K-Ras4B: K104Q

PubMed Link: 32815102

Variant Present in the following documents:

• Main text
• 10555_2020_Article_9917.pdf

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Biology, pathology, and therapeutic targeting of RAS.

Advances In Cancer Research

Rhett, J Matthew JM; Khan, Imran I; O'Bryan, John P JP

Publication Date: 2020

Variant appearance in text: KRAS: K104Q

PubMed Link: 32723567

Variant Present in the following documents:

• Main text

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KIAA1109 gene mutation in surviving patients with Alkuraya-Kučinskas syndrome: a review of literature.

Bmc Medical Genetics

Kumar, Kishore K; Bellad, Anikha A; Prasad, Pramada P; Girimaji, Satish Chandra SC; Muthusamy, Babylakshmi B

Publication Date: 2020-06-26

Variant appearance in text: KRAS: K104Q

PubMed Link: 32590954

Variant Present in the following documents:

• 12881_2020_1074_MOESM1_ESM.xlsx, sheet 1

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PBRM1 acts as a p53 lysine-acetylation reader to suppress renal tumor growth.

Nature Communications

Cai, Weijia W; Su, Liya L; Liao, Lili L; Liu, Zongzhi Z ZZ; Langbein, Lauren L; Dulaimi, Essel E; Testa, Joseph R JR; Uzzo, Robert G RG; Zhong, Zhijiu Z; Jiang, Wei W; Yan, Qin Q; Zhang, Qing Q; Yang, Haifeng H

Publication Date: 2019-12-20

Variant appearance in text: KRAS: K104Q

PubMed Link: 31863007

Variant Present in the following documents:

• 41467_2019_13608_MOESM2_ESM.pdf

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Therapeutic targeting of RAS: New hope for drugging the "undruggable".

Biochimica Et Biophysica Acta. Molecular Cell Research

Khan, Imran I; Rhett, J Matthew JM; O'Bryan, John P JP

Publication Date: 2020-02

Variant appearance in text: KRAS: K104Q

PubMed Link: 31678118

Variant Present in the following documents:

• Main text

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Implications of the HDAC6-ERK1 feed-forward loop in immunotherapy.

Journal Of Immunological Sciences

Wu, Jheng-Yu JY; Moses, Niko N; Bai, Wenlong W; Zhang, Xiaohong Mary XM

Publication Date: 2018

Variant appearance in text: KRAS: K104Q

PubMed Link: 30854521

Variant Present in the following documents:

• Main text

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K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and function.

The Journal Of Biological Chemistry

Cao, Shufen S; Chung, Stacey S; Kim, SoonJeung S; Li, Zhenlu Z; Manor, Danny D; Buck, Matthias M

Publication Date: 2019-04-26

Variant appearance in text: K-Ras4B: K104Q

PubMed Link: 30792310

Variant Present in the following documents:

• Main text

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A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation.

The Journal Of Biological Chemistry

Yin, Guowei G; Kistler, Samantha S; George, Samuel D SD; Kuhlmann, Nora N; Garvey, Leslie L; Huynh, Minh M; Bagni, Rachel K RK; Lammers, Michael M; Der, Channing J CJ; Campbell, Sharon L SL

Publication Date: 2017-03-17

Variant appearance in text: KRAS: K104Q

PubMed Link: 28154176

Variant Present in the following documents:

• Main text

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