Publications:

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Recent Advances in Covalent Drug Discovery.

Pharmaceuticals (Basel, Switzerland)

Schaefer, Daniel D; Cheng, Xinlai X

Publication Date: 2023-04-28

Variant appearance in text: KRAS: Y96D

PubMed Link: 37242447

Variant Present in the following documents:

• Main text
• pharmaceuticals-16-00663.pdf

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Targeting small GTPases: emerging grasps on previously untamable targets, pioneered by KRAS.

Signal Transduction And Targeted Therapy

Yin, Guowei G; Huang, Jing J; Petela, Johnny J; Jiang, Hongmei H; Zhang, Yuetong Y; Gong, Siqi S; Wu, Jiaxin J; Liu, Bei B; Shi, Jianyou J; Gao, Yijun Y

Publication Date: 2023-05-23

Variant appearance in text: KRAS: Y96D

PubMed Link: 37221195

Variant Present in the following documents:

• 41392_2023_Article_1441.pdf

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The Therapeutic Landscape for KRAS-Mutated Colorectal Cancers.

Cancers

Tria, Simon Manuel SM; Burge, Matthew E ME; Whitehall, Vicki L J VLJ

Publication Date: 2023-04-19

Variant appearance in text: KRAS: Y96D

PubMed Link: 37190303

Variant Present in the following documents:

• Main text
• cancers-15-02375.pdf

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Treatment Strategies for KRAS-Mutated Non-Small-Cell Lung Cancer.

Cancers

O'Sullivan, Éabha É; Keogh, Anna A; Henderson, Brian B; Finn, Stephen P SP; Gray, Steven G SG; Gately, Kathy K

Publication Date: 2023-03-07

Variant appearance in text: KRAS: Y96D

PubMed Link: 36980522

Variant Present in the following documents:

• Main text
• cancers-15-01635.pdf

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Direct GDP-KRASG12C inhibitors and mechanisms of resistance: the tip of the iceberg.

Therapeutic Advances In Medical Oncology

Rosen, Joshua C JC; Sacher, Adrian A; Tsao, Ming-Sound MS

Publication Date: 2023

Variant appearance in text: KRAS: Y96D

PubMed Link: 36950276

Variant Present in the following documents:

• Main text
• 10.1177_17588359231160141.pdf

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KRAS-Mutant Lung Cancer: Targeting Molecular and Immunologic Pathways, Therapeutic Advantages and Restrictions.

Cells

Karimi, Nastaran N; Moghaddam, Seyed Javad SJ

Publication Date: 2023-02-26

Variant appearance in text: KRAS: Y96D

PubMed Link: 36899885

Variant Present in the following documents:

• Main text
• cells-12-00749.pdf

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Targeted therapies for KRAS-mutant non-small cell lung cancer: from preclinical studies to clinical development-a narrative review.

Translational Lung Cancer Research

Santarpia, Mariacarmela M; Ciappina, Giuliana G; Spagnolo, Calogera Claudia CC; Squeri, Andrea A; Passalacqua, Maria Ilenia MI; Aguilar, Andrés A; Gonzalez-Cao, Maria M; Giovannetti, Elisa E; Silvestris, Nicola N; Rosell, Rafael R

Publication Date: 2023-02-28

Variant appearance in text: KRAS: Y96D

PubMed Link: 36895930

Variant Present in the following documents:

• Main text
• tlcr-12-02-346.pdf

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Cancer immune evasion through KRAS and PD-L1 and potential therapeutic interventions.

Cell Communication And Signaling : Ccs

Watterson, Alex A; Coelho, Matthew A MA

Publication Date: 2023-03-02

Variant appearance in text: KRAS: Y96D

PubMed Link: 36864508

Variant Present in the following documents:

• Main text

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Combined KRAS G12C and SOS1 inhibition enhances and extends the anti-tumor response in KRAS G12C -driven cancers by addressing intrinsic and acquired resistance.

Biorxiv : The Preprint Server For Biology

Thatikonda, Venu V; Lu, Hengyu H; Jurado, Sabine S; Kostyrko, Kaja K; Bristow, Christopher A CA; Bosch, Karin K; Feng, Ningping N; Gao, Sisi S; Gerlach, Daniel D; Gmachl, Michael M; Lieb, Simone S; Jeschko, Astrid A; Machado, Annette A AA; Marszalek, Ethan D ED; Mahendra, Mikhila M; Jaeger, Philipp A PA; Sorokin, Alexey A; Strauss, Sandra S; Trapani, Francesca F; Kopetz, Scott S; Vellano, Christopher P CP; Petronczki, Mark M; Kraut, Norbert N; Heffernan, Timothy P TP; Marszalek, Joseph R JR; Pearson, Mark M; Waizenegger, Irene I; Hofmann, Marco H MH

Publication Date: 2023-01-23

Variant appearance in text: KRAS: Y96D

PubMed Link: 36747713

Variant Present in the following documents:

• media-1.xlsx, sheet 4

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Eliminating oncogenic RAS: back to the future at the drawing board.

Biochemical Society Transactions

Steffen, Candy Laura CL; Kaya, Pelin P; Schaffner-Reckinger, Elisabeth E; Abankwa, Daniel D

Publication Date: 2023-01-23

Variant appearance in text: KRAS: Y96D

PubMed Link: 36688434

Variant Present in the following documents:

• Main text
• BST-51-447.pdf

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KRAS Mutations in Solid Tumors: Characteristics, Current Therapeutic Strategy, and Potential Treatment Exploration.

Journal Of Clinical Medicine

Yang, Yunkai Y; Zhang, Huan H; Huang, Shanshan S; Chu, Qian Q

Publication Date: 2023-01-16

Variant appearance in text: KRAS: Y96D

PubMed Link: 36675641

Variant Present in the following documents:

• Main text
• jcm-12-00709.pdf

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Targeting KRAS G12C mutations in colorectal cancer.

Gastroenterology Report

Zhao, Ming-He MH; Wu, Ai-Wen AW

Publication Date: 2023

Variant appearance in text: KRAS: Y96D

PubMed Link: 36632627

Variant Present in the following documents:

• Main text
• goac083.pdf

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In Silico Study of the Acquired Resistance Caused by the Secondary Mutations of KRAS G12C Protein Using Long Time Molecular Dynamics Simulation and Markov State Model Analysis.

International Journal Of Molecular Sciences

Tu, Gao G; Liu, Qing Q; Qiu, Yue Y; Leung, Elaine Lai-Han EL; Yao, Xiaojun X

Publication Date: 2022-11-10

Variant appearance in text: KRAS: Y96D

PubMed Link: 36430323

Variant Present in the following documents:

• Main text
• ijms-23-13845.pdf

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A Long Overdue Targeted Treatment for KRAS Mutations in NSCLC: Spotlight on Adagrasib.

Lung Cancer (Auckland, N.Z.)

Brazel, Danielle D; Arter, Zhaohui Z; Nagasaka, Misako M

Publication Date: 2022

Variant appearance in text: KRAS: Y96D

PubMed Link: 36387582

Variant Present in the following documents:

• Main text
• lctt-13-75.pdf

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Enhancing an Oxidative "Trojan Horse" Action of Vitamin C with Arsenic Trioxide for Effective Suppression of KRAS-Mutant Cancers: A Promising Path at the Bedside.

Cells

Burska, Agata N AN; Ilyassova, Bayansulu B; Dildabek, Aruzhan A; Khamijan, Medina M; Begimbetova, Dinara D; Molnár, Ferdinand F; Sarbassov, Dos D DD

Publication Date: 2022-11-01

Variant appearance in text: KRAS: Y96D

PubMed Link: 36359850

Variant Present in the following documents:

• Main text
• cells-11-03454.pdf

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KRAS in NSCLC: State of the Art and Future Perspectives.

Cancers

Cascetta, Priscilla P; Marinello, Arianna A; Lazzari, Chiara C; Gregorc, Vanesa V; Planchard, David D; Bianco, Roberto R; Normanno, Nicola N; Morabito, Alessandro A

Publication Date: 2022-11-04

Variant appearance in text: KRAS: Y96D

PubMed Link: 36358848

Variant Present in the following documents:

• Main text
• cancers-14-05430.pdf

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Molecular characterization of acquired resistance to KRAS G12C-EGFR inhibition in colorectal cancer.

Cancer Discovery

Yaeger, Rona R; Mezzadra, Riccardo R; Sinopoli, Jenna J; Bian, Yu Y; Marasco, Michelangelo M; Kaplun, Esther E; Gao, Yijun Y; Zhao, HuiYong H; Da Cruz Paula, Arnaud A; Zhu, Yingjie Y; Chaves Perez, Almudena A; Chadalavada, Kalyani K; Tse, Edison E; Chowdhry, Sudhir S; Bowker, Sydney S; Chang, Qing Q; Qeriqi, Besnik B; Weigelt, Britta B; Nanjangud, Gouri J GJ; Berger, Michael F MF; Der-Torossian, Hirak H; Anderes, Kenna K; Socci, Nicholas D ND; Shia, Jinru J; Riely, Gregory J GJ; Murciano-Goroff, Yonina R YR; Li, Bob T BT; Christensen, James G JG; Reis-Filho, Jorge S JS; Solit, David B DB; de Stanchina, Elisa E; Lowe, Scott W SW; Rosen, Neal N; Misale, Sandra S

Publication Date: 2022-11-10

Variant appearance in text: KRAS: Y96D

PubMed Link: 36355783

Variant Present in the following documents:

• Main text
• 41.pdf

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Targeting RAS mutants in malignancies: successes, failures, and reasons for hope.

Cancer Communications (London, England)

Yang, Hang H; Zhou, Xinyi X; Fu, Dongliang D; Le, Chenqin C; Wang, Jiafeng J; Zhou, Quan Q; Liu, Xiangrui X; Yuan, Ying Y; Ding, Kefeng K; Xiao, Qian Q

Publication Date: 2022-10-31

Variant appearance in text: KRAS: Y96D

PubMed Link: 36316602

Variant Present in the following documents:

• Main text

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Drugging KRAS: current perspectives and state-of-art review.

Journal Of Hematology & Oncology

Parikh, Kaushal K; Banna, Giuseppe G; Liu, Stephen V SV; Friedlaender, Alex A; Desai, Aakash A; Subbiah, Vivek V; Addeo, Alfredo A

Publication Date: 2022-10-25

Variant appearance in text: KRAS: Y96D

PubMed Link: 36284306

Variant Present in the following documents:

• Main text
• 13045_2022_Article_1375.pdf

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Current Landscape of Therapeutic Resistance in Lung Cancer and Promising Strategies to Overcome Resistance.

Cancers

Ashrafi, Adnin A; Akter, Zakia Z; Modareszadeh, Pouya P; Modareszadeh, Parsa P; Berisha, Eranda E; Alemi, Parinaz Sadat PS; Chacon Castro, Maria Del Carmen MDC; Deese, Alexander R AR; Zhang, Li L

Publication Date: 2022-09-20

Variant appearance in text: KRAS: Y96D

PubMed Link: 36230484

Variant Present in the following documents:

• Main text
• cancers-14-04562.pdf

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Emerging insights to lung cancer drug resistance.

Cancer Drug Resistance (Alhambra, Calif.)

Su, Chunxia C

Publication Date: 2022

Variant appearance in text: KRAS: Y96D

PubMed Link: 36176761

Variant Present in the following documents:

• cdr-5-3-534.pdf

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KRAS-Mutant Non-Small-Cell Lung Cancer: From Past Efforts to Future Challenges.

International Journal Of Molecular Sciences

Ceddia, Serena S; Landi, Lorenza L; Cappuzzo, Federico F

Publication Date: 2022-08-20

Variant appearance in text: KRAS: Y96D

PubMed Link: 36012655

Variant Present in the following documents:

• Main text
• ijms-23-09391.pdf

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Conquering oncogenic KRAS and its bypass mechanisms.

Theranostics

Hou, Pingping P; Wang, Y Alan YA

Publication Date: 2022

Variant appearance in text: KRAS: Y96D

PubMed Link: 35966590

Variant Present in the following documents:

• Main text
• thnov12p5691.pdf

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Targeting KRAS mutant cancers: from druggable therapy to drug resistance.

Molecular Cancer

Zhu, Chunxiao C; Guan, Xiaoqing X; Zhang, Xinuo X; Luan, Xin X; Song, Zhengbo Z; Cheng, Xiangdong X; Zhang, Weidong W; Qin, Jiang-Jiang JJ

Publication Date: 2022-08-04

Variant appearance in text: KRAS: Y96D

PubMed Link: 35922812

Variant Present in the following documents:

• Main text
• 12943_2022_Article_1629.pdf

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Targeting KRAS G12C-Mutated Advanced Colorectal Cancer: Research and Clinical Developments.

Oncotargets And Therapy

Ji, Jingran J; Wang, Chongkai C; Fakih, Marwan M

Publication Date: 2022

Variant appearance in text: KRAS: Y96D

PubMed Link: 35837349

Variant Present in the following documents:

• Main text
• ott-15-747.pdf

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The Next Frontier in Pancreatic Cancer: Targeting the Tumor Immune Milieu and Molecular Pathways.

Cancers

Yin, Chao C; Alqahtani, Ali A; Noel, Marcus S MS

Publication Date: 2022-05-25

Variant appearance in text: KRAS: Y96D

PubMed Link: 35681599

Variant Present in the following documents:

• Main text
• cancers-14-02619.pdf

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Daily Practice Assessment of KRAS Status in NSCLC Patients: A New Challenge for the Thoracic Pathologist Is Right around the Corner.

Cancers

Bontoux, Christophe C; Hofman, Véronique V; Brest, Patrick P; Ilié, Marius M; Mograbi, Baharia B; Hofman, Paul P

Publication Date: 2022-03-23

Variant appearance in text: KRAS: Y96D

PubMed Link: 35406400

Variant Present in the following documents:

• Main text
• cancers-14-01628.pdf

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Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C.

Cancer Discovery

Weiss, Andreas A; Lorthiois, Edwige E; Barys, Louise L; Beyer, Kim S KS; Bomio-Confaglia, Claudio C; Burks, Heather H; Chen, Xueying X; Cui, Xiaoming X; de Kanter, Ruben R; Dharmarajan, Lekshmi L; Fedele, Carmine C; Gerspacher, Marc M; Guthy, Daniel Alexander DA; Head, Victoria V; Jaeger, Ashley A; Núñez, Eloísa Jiménez EJ; Kearns, Jeffrey D JD; Leblanc, Catherine C; Maira, Sauveur-Michel SM; Murphy, Jason J; Oakman, Helen H; Ostermann, Nils N; Ottl, Johannes J; Rigollier, Pascal P; Roman, Danielle D; Schnell, Christian C; Sedrani, Richard R; Shimizu, Toshio T; Stringer, Rowan R; Vaupel, Andrea A; Voshol, Hans H; Wessels, Peter P; Widmer, Toni T; Wilcken, Rainer R; Xu, Kun K; Zecri, Frederic F; Farago, Anna F AF; Cotesta, Simona S; Brachmann, Saskia M SM

Publication Date: 2022-06-02

Variant appearance in text: KRAS: Y96D

PubMed Link: 35404998

Variant Present in the following documents:

• cd-22-0158_supp1.pdf

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KRAS is vulnerable to reversible switch-II pocket engagement in cells.

Nature Chemical Biology

Vasta, James D JD; Peacock, D Matthew DM; Zheng, Qinheng Q; Walker, Joel A JA; Zhang, Ziyang Z; Zimprich, Chad A CA; Thomas, Morgan R MR; Beck, Michael T MT; Binkowski, Brock F BF; Corona, Cesear R CR; Robers, Matthew B MB; Shokat, Kevan M KM

Publication Date: 2022-06

Variant appearance in text: KRAS: Y96D

PubMed Link: 35314814

Variant Present in the following documents:

• Main text
• 41589_2022_985_MOESM1_ESM.pdf
• 41589_2022_Article_985.pdf

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Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies.

Frontiers In Oncology

Désage, Anne-Laure AL; Léonce, Camille C; Swalduz, Aurélie A; Ortiz-Cuaran, Sandra S

Publication Date: 2022

Variant appearance in text: KRAS: Y96D

PubMed Link: 35251972

Variant Present in the following documents:

• Main text
• fonc-12-796832.pdf

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RAS-mediated tumor stress adaptation and the targeting opportunities it presents.

Disease Models & Mechanisms

Redding, Alexandra A; Aplin, Andrew E AE; Grabocka, Elda E

Publication Date: 2022-02-01

Variant appearance in text: KRAS: Y96D

PubMed Link: 35147163

Variant Present in the following documents:

• Main text

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RAS-mediated tumor stress adaptation and the targeting opportunities it presents.

Disease Models & Mechanisms

Redding, Alexandra A; Aplin, Andrew E AE; Grabocka, Elda E

Publication Date: 2022-02-01

Variant appearance in text: KRAS: Y96D

PubMed Link: 35147163

Variant Present in the following documents:

• Main text

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Targeting KRAS in Non-Small Cell Lung Cancer.

Frontiers In Oncology

Corral de la Fuente, Elena E; Olmedo Garcia, Maria Eugenia ME; Gomez Rueda, Ana A; Lage, Yolanda Y; Garrido, Pilar P

Publication Date: 2021

Variant appearance in text: KRAS: Y96D

PubMed Link: 35083149

Variant Present in the following documents:

• Main text

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A Breakthrough Brought about by Targeting KRASG12C: Nonconformity Is Punished.

Cancers

Ning, Wenjuan W; Yang, Zhang Z; Kocher, Gregor J GJ; Dorn, Patrick P; Peng, Ren-Wang RW

Publication Date: 2022-01-13

Variant appearance in text: KRAS: Y96D

PubMed Link: 35053550

Variant Present in the following documents:

• Main text

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A Breakthrough Brought about by Targeting KRASG12C: Nonconformity Is Punished.

Cancers

Ning, Wenjuan W; Yang, Zhang Z; Kocher, Gregor J GJ; Dorn, Patrick P; Peng, Ren-Wang RW

Publication Date: 2022-01-13

Variant appearance in text: KRAS: Y96D

PubMed Link: 35053550

Variant Present in the following documents:

• Main text

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Targeting the undruggable oncogenic KRAS: the dawn of hope.

Jci Insight

Asimgil, Hande H; Ertetik, Utku U; Çevik, Nedim Can NC; Ekizce, Menar M; Doğruöz, Alper A; Gökalp, Muazzez M; Arık-Sever, Elif E; Istvanffy, Rouzanna R; Friess, Helmut H; Ceyhan, Güralp Onur GO; Demir, Ihsan Ekin IE

Publication Date: 2022-01-11

Variant appearance in text: KRAS: Y96D

PubMed Link: 35014625

Variant Present in the following documents:

• Main text
• jciinsight-7-153688.pdf

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Targeting the undruggable oncogenic KRAS: the dawn of hope.

Jci Insight

Asimgil, Hande H; Ertetik, Utku U; Çevik, Nedim Can NC; Ekizce, Menar M; Doğruöz, Alper A; Gökalp, Muazzez M; Arık-Sever, Elif E; Istvanffy, Rouzanna R; Friess, Helmut H; Ceyhan, Güralp Onur GO; Demir, Ihsan Ekin IE

Publication Date: 2022-01-11

Variant appearance in text: KRAS: Y96D

PubMed Link: 35014625

Variant Present in the following documents:

• Main text
• jciinsight-7-153688.pdf

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Resistance to KRASG12C Inhibitors in Non-Small Cell Lung Cancer.

Frontiers In Oncology

Blaquier, Juan Bautista JB; Cardona, Andrés Felipe AF; Recondo, Gonzalo G

Publication Date: 2021

Variant appearance in text: KRAS: Y96D

PubMed Link: 35004309

Variant Present in the following documents:

• Main text

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Rapid idiosyncratic mechanisms of clinical resistance to KRAS G12C inhibition.

The Journal Of Clinical Investigation

Tsai, Yihsuan S YS; Woodcock, Mark G MG; Azam, Salma H SH; Thorne, Leigh B LB; Kanchi, Krishna L KL; Parker, Joel S JS; Vincent, Benjamin G BG; Pecot, Chad V CV

Publication Date: 2022-01-06

Variant appearance in text: KRAS: Y96D

PubMed Link: 34990404

Variant Present in the following documents:

• Main text

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Rapid idiosyncratic mechanisms of clinical resistance to KRAS G12C inhibition.

The Journal Of Clinical Investigation

Tsai, Yihsuan S YS; Woodcock, Mark G MG; Azam, Salma H SH; Thorne, Leigh B LB; Kanchi, Krishna L KL; Parker, Joel S JS; Vincent, Benjamin G BG; Pecot, Chad V CV

Publication Date: 2022-02-15

Variant appearance in text: KRAS: Y96D

PubMed Link: 34990404

Variant Present in the following documents:

• Main text

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Targeting KRAS mutant lung cancer: light at the end of the tunnel.

Molecular Oncology

Drosten, Matthias M; Barbacid, Mariano M

Publication Date: 2022-03

Variant appearance in text: KRAS: Y96D

PubMed Link: 34951114

Variant Present in the following documents:

• Main text
• MOL2-16-1057.pdf

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Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer.

Cancers

Sunaga, Noriaki N; Miura, Yosuke Y; Kasahara, Norimitsu N; Sakurai, Reiko R

Publication Date: 2021-11-26

Variant appearance in text: KRAS: Y96D

PubMed Link: 34885068

Variant Present in the following documents:

• Main text
• cancers-13-05956.pdf

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Targeting Oncogenic KRAS in Non-Small-Cell Lung Cancer.

Cancers

Sunaga, Noriaki N; Miura, Yosuke Y; Kasahara, Norimitsu N; Sakurai, Reiko R

Publication Date: 2021-11-26

Variant appearance in text: KRAS: Y96D

PubMed Link: 34885068

Variant Present in the following documents:

• Main text
• cancers-13-05956.pdf

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