Publications:

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Targeting oncogenic KRasG13C with nucleotide-based covalent inhibitors.

Elife

Goebel, Lisa L; Kirschner, Tonia T; Koska, Sandra S; Rai, Amrita A; Janning, Petra P; Maffini, Stefano S; Vatheuer, Helge H; Czodrowski, Paul P; Goody, Roger S RS; Müller, Matthias P MP; Rauh, Daniel D

Publication Date: 2023-03-27

Variant appearance in text: KRAS: C80L

PubMed Link: 36972177

Variant Present in the following documents:

• Main text
• elife-82184.pdf

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Chemoselective Covalent Modification of K-Ras(G12R) with a Small Molecule Electrophile.

Journal Of The American Chemical Society

Zhang, Ziyang Z; Morstein, Johannes J; Ecker, Andrew K AK; Guiley, Keelan Z KZ; Shokat, Kevan M KM

Publication Date: 2022-09-07

Variant appearance in text: KRAS: C80L

PubMed Link: 36001446

Variant Present in the following documents:

• ja2c05377_si_001.pdf

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Modeling receptor flexibility in the structure-based design of KRASG12C inhibitors.

Journal Of Computer-Aided Molecular Design

Zhu, Kai K; Li, Cui C; Wu, Kingsley Y KY; Mohr, Christopher C; Li, Xun X; Lanman, Brian B

Publication Date: 2022-08

Variant appearance in text: KRAS: C80L

PubMed Link: 35930206

Variant Present in the following documents:

• Main text

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Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S).

Nature Chemical Biology

Zhang, Ziyang Z; Guiley, Keelan Z KZ; Shokat, Kevan M KM

Publication Date: 2022-11

Variant appearance in text: KRAS: C80L

PubMed Link: 35864332

Variant Present in the following documents:

• Main text
• 41589_2022_Article_1065.pdf

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Oncogenic KRAS G12C: Kinetic and redox characterization of covalent inhibition.

The Journal Of Biological Chemistry

Huynh, Minh V MV; Parsonage, Derek D; Forshaw, Tom E TE; Chirasani, Venkat R VR; Hobbs, G Aaron GA; Wu, Hanzhi H; Lee, Jingyun J; Furdui, Cristina M CM; Poole, Leslie B LB; Campbell, Sharon L SL

Publication Date: 2022-08

Variant appearance in text: KRAS: C80L

PubMed Link: 35753348

Variant Present in the following documents:

• Main text

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Delineating the RAS Conformational Landscape.

Cancer Research

Parker, Mitchell I MI; Meyer, Joshua E JE; Golemis, Erica A EA; Dunbrack, Roland L RL

Publication Date: 2022-07-05

Variant appearance in text: KRAS: C80L

PubMed Link: 35536216

Variant Present in the following documents:

• can-22-0804_supplementary_datasets_s1-s4_suppsds1-sds4.xlsx, sheet 1

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Understanding the influence of AMG 510 on the structure of KRASG12C empowered by molecular dynamics simulation.

Computational And Structural Biotechnology Journal

Li, Yu Y; Han, Lei L; Zhang, Ziding Z

Publication Date: 2022

Variant appearance in text: KRAS: C80L

PubMed Link: 35284050

Variant Present in the following documents:

• Main text
• main.pdf

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GTP-State-Selective Cyclic Peptide Ligands of K-Ras(G12D) Block Its Interaction with Raf.

Acs Central Science

Zhang, Ziyang Z; Gao, Rong R; Hu, Qi Q; Peacock, Hayden H; Peacock, D Matthew DM; Dai, Shizhong S; Shokat, Kevan M KM; Suga, Hiroaki H

Publication Date: 2020-10-28

Variant appearance in text: KRAS: C80L

PubMed Link: 33145412

Variant Present in the following documents:

• oc0c00514_si_001.pdf

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KRAS(G12C)-AMG 510 interaction dynamics revealed by all-atom molecular dynamics simulations.

Scientific Reports

Pantsar, Tatu T

Publication Date: 2020-07-20

Variant appearance in text: KRAS: C80L

PubMed Link: 32686745

Variant Present in the following documents:

• Main text
• 41598_2020_Article_68950.pdf

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Computationally Empowered Workflow Identifies Novel Covalent Allosteric Binders for KRASG12C.

Chemmedchem

Mortier, Jérémie J; Friberg, Anders A; Badock, Volker V; Moosmayer, Dieter D; Schroeder, Jens J; Steigemann, Patrick P; Siegel, Franziska F; Gradl, Stefan S; Bauser, Marcus M; Hillig, Roman C RC; Briem, Hans H; Eis, Knut K; Bader, Benjamin B; Nguyen, Duy D; Christ, Clara D CD

Publication Date: 2020-05-19

Variant appearance in text: KRAS: C80L

PubMed Link: 32237114

Variant Present in the following documents:

• CMDC-15-827-s001.pdf

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The current understanding of KRAS protein structure and dynamics.

Computational And Structural Biotechnology Journal

Pantsar, Tatu T

Publication Date: 2020

Variant appearance in text: KRAS: C80L

PubMed Link: 31988705

Variant Present in the following documents:

• Main text
• main.pdf

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Drugging an undruggable pocket on KRAS.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Kessler, Dirk D; Gmachl, Michael M; Mantoulidis, Andreas A; Martin, Laetitia J LJ; Zoephel, Andreas A; Mayer, Moriz M; Gollner, Andreas A; Covini, David D; Fischer, Silke S; Gerstberger, Thomas T; Gmaschitz, Teresa T; Goodwin, Craig C; Greb, Peter P; Häring, Daniela D; Hela, Wolfgang W; Hoffmann, Johann J; Karolyi-Oezguer, Jale J; Knesl, Petr P; Kornigg, Stefan S; Koegl, Manfred M; Kousek, Roland R; Lamarre, Lyne L; Moser, Franziska F; Munico-Martinez, Silvia S; Peinsipp, Christoph C; Phan, Jason J; Rinnenthal, Jörg J; Sai, Jiqing J; Salamon, Christian C; Scherbantin, Yvonne Y; Schipany, Katharina K; Schnitzer, Renate R; Schrenk, Andreas A; Sharps, Bernadette B; Siszler, Gabriella G; Sun, Qi Q; Waterson, Alex A; Wolkerstorfer, Bernhard B; Zeeb, Markus M; Pearson, Mark M; Fesik, Stephen W SW; McConnell, Darryl B DB

Publication Date: 2019-08-06

Variant appearance in text: KRAS: C80L

PubMed Link: 31332011

Variant Present in the following documents:

• pnas.1904529116.sapp.pdf

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Nucleotide based covalent inhibitors of KRas can only be efficient in vivo if they bind reversibly with GTP-like affinity.

Scientific Reports

Müller, Matthias P MP; Jeganathan, Sadasivam S; Heidrich, Angelika A; Campos, Jeremy J; Goody, Roger S RS

Publication Date: 2017-06-16

Variant appearance in text: KRAS: C80L

PubMed Link: 28623374

Variant Present in the following documents:

• 41598_2017_Article_3973.pdf

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.

Nature

Ostrem, Jonathan M JM; Peters, Ulf U; Sos, Martin L ML; Wells, James A JA; Shokat, Kevan M KM

Publication Date: 2013-11-28

Variant appearance in text: KRAS: C80L

PubMed Link: 24256730

Variant Present in the following documents:

• Main text

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