Publications:

The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.

Nature Communications

Gebregiworgis, Teklab T; Kano, Yoshihito Y; St-Germain, Jonathan J; Radulovich, Nikolina N; Udaskin, Molly L ML; Mentes, Ahmet A; Huang, Richard R; Poon, Betty P K BPK; He, Wenguang W; Valencia-Sama, Ivette I; Robinson, Claire M CM; Huestis, Melissa M; Miao, Jinmin J; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Irwin, Meredith S MS; Lee, Jeffrey E JE; Tsao, Ming-Sound MS; Raught, Brian B; Marshall, Christopher B CB; Ohh, Michael M; Ikura, Mitsuhiko M

Publication Date: 2021-11-01

Variant appearance in text: KRAS: Y64F

PubMed Link: 34725361

Variant Present in the following documents:

• Main text
• 41467_2021_26526_MOESM1_ESM.pdf
• 41467_2021_Article_26526.pdf

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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.

Nature Communications

Kano, Yoshihito Y; Gebregiworgis, Teklab T; Marshall, Christopher B CB; Radulovich, Nikolina N; Poon, Betty P K BPK; St-Germain, Jonathan J; Cook, Jonathan D JD; Valencia-Sama, Ivette I; Grant, Benjamin M M BMM; Herrera, Silvia Gabriela SG; Miao, Jinmin J; Raught, Brian B; Irwin, Meredith S MS; Lee, Jeffrey E JE; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Tsao, Ming-Sound MS; Ikura, Mitsuhiko M; Ohh, Michael M

Publication Date: 2019-01-15

Variant appearance in text: KRAS: Y64F

PubMed Link: 30644389

Variant Present in the following documents:

• Main text
• 41467_2018_Article_8115.pdf

View BVdb publication page