Publications:

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Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

Biorxiv : The Preprint Server For Biology

Ratnasinghe, Brian D BD; Haque, Neshatul N; Wagenknecht, Jessica B JB; Jensen, Davin R DR; Esparza, Guadalupe V GV; Leverence, Elise N EN; De Assuncao, Thiago Milech TM; Mathison, Angela J AJ; Lomberk, Gwen G; Smith, Brian C BC; Volkman, Brian F BF; Urrutia, Raul R; Zimmermann, Michael T MT

Publication Date: 2023-04-28

Variant appearance in text: KRAS: Q61A

PubMed Link: 37207265

Variant Present in the following documents:

• media-1.pdf

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Delineating the RAS Conformational Landscape.

Cancer Research

Parker, Mitchell I MI; Meyer, Joshua E JE; Golemis, Erica A EA; Dunbrack, Roland L RL

Publication Date: 2022-07-05

Variant appearance in text: KRAS: Q61A

PubMed Link: 35536216

Variant Present in the following documents:

• can-22-0804_supplementary_datasets_s1-s4_suppsds1-sds4.xlsx, sheet 1

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Q61 mutant-mediated dynamics changes of the GTP-KRAS complex probed by Gaussian accelerated molecular dynamics and free energy landscapes.

Rsc Advances

Chen, Jianzhong J; Zeng, Qingkai Q; Wang, Wei W; Hu, Qingquan Q; Bao, Huayin H

Publication Date: 2022-01-05

Variant appearance in text: KRAS: Q61A

PubMed Link: 35425180

Variant Present in the following documents:

• Main text
• RA-012-D1RA07936K.pdf
• RA-012-D1RA07936K-s001.pdf

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Understanding the influence of AMG 510 on the structure of KRASG12C empowered by molecular dynamics simulation.

Computational And Structural Biotechnology Journal

Li, Yu Y; Han, Lei L; Zhang, Ziding Z

Publication Date: 2022

Variant appearance in text: KRAS: Q61A

PubMed Link: 35284050

Variant Present in the following documents:

• main.pdf

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Structural impact of GTP binding on downstream KRAS signaling.

Chemical Science

Menyhárd, Dóra K DK; Pálfy, Gyula G; Orgován, Zoltán Z; Vida, István I; Keserű, György M GM; Perczel, András A

Publication Date: 2020-08-19

Variant appearance in text: KRAS: Q61A

PubMed Link: 34094198

Variant Present in the following documents:

• SC-011-D0SC03441J-s001.pdf

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The origins and genetic interactions of KRAS mutations are allele- and tissue-specific.

Nature Communications

Cook, Joshua H JH; Melloni, Giorgio E M GEM; Gulhan, Doga C DC; Park, Peter J PJ; Haigis, Kevin M KM

Publication Date: 2021-03-22

Variant appearance in text: KRAS: Q61A

PubMed Link: 33753749

Variant Present in the following documents:

• 41467_2021_22125_MOESM4_ESM.xlsx, sheet 4

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Comprehensive Validation of Snapback Primer-Based Melting Curve Analysis to Detect Nucleotide Variation in the Codon 12 and 13 of KRAS Gene.

Biomed Research International

Zhang, Qunfeng Q; Du, Yiqiao Y; Zhang, Xinju X; Kang, Zhihua Z; Guan, Ming M; Wu, Zhiyuan Z

Publication Date: 2018

Variant appearance in text: KRAS: Q61A

PubMed Link: 30406144

Variant Present in the following documents:

• BMRI2018-8727941.pdf

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Antibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration.

Nature Communications

Shin, Seung-Min SM; Choi, Dong-Ki DK; Jung, Keunok K; Bae, Jeomil J; Kim, Ji-Sun JS; Park, Seong-Wook SW; Song, Ki-Hoon KH; Kim, Yong-Sung YS

Publication Date: 2017-05-10

Variant appearance in text: KRAS: Q61A

PubMed Link: 28489072

Variant Present in the following documents:

• ncomms15090.pdf

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