Publications:

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Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

Biorxiv : The Preprint Server For Biology

Ratnasinghe, Brian D BD; Haque, Neshatul N; Wagenknecht, Jessica B JB; Jensen, Davin R DR; Esparza, Guadalupe V GV; Leverence, Elise N EN; De Assuncao, Thiago Milech TM; Mathison, Angela J AJ; Lomberk, Gwen G; Smith, Brian C BC; Volkman, Brian F BF; Urrutia, Raul R; Zimmermann, Michael T MT

Publication Date: 2023-04-28

Variant appearance in text: KRAS: G60A

PubMed Link: 37207265

Variant Present in the following documents:

• Main text
• nihpp-2023.04.28.536249v1.pdf

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KRAS Inhibitor that Simultaneously Inhibits Nucleotide Exchange Activity and Effector Engagement.

Acs Bio & Med Chem Au

Pagba, Cynthia V CV; Gupta, Amit K AK; Naji, Ali K AK; van der Hoeven, Dharini D; Churion, Kelly K; Liang, Xiaowen X; Jakubec, Jacob J; Hook, Magnus M; Zuo, Yan Y; Martinez de Kraatz, Marisela M; Frost, Jeffrey A JA; Gorfe, Alemayehu A AA

Publication Date: 2022-12-21

Variant appearance in text: KRAS: G60a

PubMed Link: 37101428

Variant Present in the following documents:

• bg2c00045.pdf

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The path to the clinic: a comprehensive review on direct KRASG12C inhibitors.

Journal Of Experimental & Clinical Cancer Research : Cr

Kwan, Albert K AK; Piazza, Gary A GA; Keeton, Adam B AB; Leite, Caio A CA

Publication Date: 2022-01-19

Variant appearance in text: KRAS: G60A

PubMed Link: 35045886

Variant Present in the following documents:

• Main text

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The path to the clinic: a comprehensive review on direct KRASG12C inhibitors.

Journal Of Experimental & Clinical Cancer Research : Cr

Kwan, Albert K AK; Piazza, Gary A GA; Keeton, Adam B AB; Leite, Caio A CA

Publication Date: 2022-01-19

Variant appearance in text: KRAS: G60A

PubMed Link: 35045886

Variant Present in the following documents:

• Main text

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A structural model of a Ras-Raf signalosome.

Nature Structural & Molecular Biology

Mysore, Venkatesh P VP; Zhou, Zhi-Wei ZW; Ambrogio, Chiara C; Li, Lianbo L; Kapp, Jonas N JN; Lu, Chunya C; Wang, Qi Q; Tucker, Maxwell R MR; Okoro, Jeffrey J JJ; Nagy-Davidescu, Gabriela G; Bai, Xiaochen X; Plückthun, Andreas A; Jänne, Pasi A PA; Westover, Kenneth D KD; Shan, Yibing Y; Shaw, David E DE

Publication Date: 2021-10

Variant appearance in text: KRAS: G60A

PubMed Link: 34625747

Variant Present in the following documents:

• Main text

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KRAS Ubiquitination at Lysine 104 Retains Exchange Factor Regulation by Dynamically Modulating the Conformation of the Interface.

Iscience

Yin, Guowei G; Zhang, Jerry J; Nair, Vinay V; Truong, Vinh V; Chaia, Angelo A; Petela, Johnny J; Harrison, Joseph J; Gorfe, Alemayehu A AA; Campbell, Sharon L SL

Publication Date: 2020-08-10

Variant appearance in text: KRAS: G60A

PubMed Link: 32882514

Variant Present in the following documents:

• mmc2.xlsx, sheet 1

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IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.

Plos One

Gasilina, Anjelika A; Premnauth, Gurdat G; Gurjar, Purujit P; Biesiada, Jacek J; Hegde, Shailaja S; Milewski, David D; Ma, Gang G; Kalin, Tanya V TV; Merino, Edward E; Meller, Jarek J; Seibel, William W; Cancelas, José A JA; Vinnedge, Lisa Privette LP; Nassar, Nicolas N NN

Publication Date: 2020

Variant appearance in text: KRAS: G60A

PubMed Link: 32163428

Variant Present in the following documents:

• Main text
• pone.0229801.pdf

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Spiclomazine displays a preferential anti-tumor activity in mutant KRas-driven pancreatic cancer.

Oncotarget

Guo, Xiaoyu X; Zhao, Wenjing W; Liu, Zuojia Z; Wang, Jin J

Publication Date: 2018-01-23

Variant appearance in text: KRAS: G60A

PubMed Link: 29467941

Variant Present in the following documents:

• oncotarget-09-6938.pdf

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Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications

Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ

Publication Date: 2017-05-11

Variant appearance in text: KRAS: G60A

PubMed Link: 28492226

Variant Present in the following documents:

• ncomms15086-s3.xlsx, sheet 1

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Cancer spectrum and frequency among children with Noonan, Costello, and cardio-facio-cutaneous syndromes.

British Journal Of Cancer

Kratz, C P CP; Franke, L L; Peters, H H; Kohlschmidt, N N; Kazmierczak, B B; Finckh, U U; Bier, A A; Eichhorn, B B; Blank, C C; Kraus, C C; Kohlhase, J J; Pauli, S S; Wildhardt, G G; Kutsche, K K; Auber, B B; Christmann, A A; Bachmann, N N; Mitter, D D; Cremer, F W FW; Mayer, K K; Daumer-Haas, C C; Nevinny-Stickel-Hinzpeter, C C; Oeffner, F F; Schlüter, G G; Gencik, M M; Überlacker, B B; Lissewski, C C; Schanze, I I; Greene, M H MH; Spix, C C; Zenker, M M

Publication Date: 2015-04-14

Variant appearance in text: KRAS: G60A

PubMed Link: 25742478

Variant Present in the following documents:

• bjc201575a.pdf

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Structure-energy-based predictions and network modelling of RASopathy and cancer missense mutations.

Molecular Systems Biology

Kiel, Christina C; Serrano, Luis L

Publication Date: 2014-05-06

Variant appearance in text: KRAS: G60A

PubMed Link: 24803665

Variant Present in the following documents:

• MSB-10-5-727-s13.xls, sheet 1

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K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions.

Nature

Ostrem, Jonathan M JM; Peters, Ulf U; Sos, Martin L ML; Wells, James A JA; Shokat, Kevan M KM

Publication Date: 2013-11-28

Variant appearance in text: KRAS: G60A

PubMed Link: 24256730

Variant Present in the following documents:

• Main text

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Predicting the functional impact of protein mutations: application to cancer genomics.

Nucleic Acids Research

Reva, Boris B; Antipin, Yevgeniy Y; Sander, Chris C

Publication Date: 2011-09-01

Variant appearance in text: KRAS: G60A

PubMed Link: 21727090

Variant Present in the following documents:

• supp_gkr407_Supplement2_Table_SM1_COSMIC_mutations.xls, sheet 1

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The distinct conformational dynamics of K-Ras and H-Ras A59G.

Plos Computational Biology

Lukman, Suryani S; Grant, Barry J BJ; Gorfe, Alemayehu A AA; Grant, Guy H GH; McCammon, J Andrew JA

Publication Date: 2010-09-09

Variant appearance in text: K-Ras4B: G60A

PubMed Link: 20838576

Variant Present in the following documents:

• pcbi.1000922.pdf

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