KRAS, NRAS, BRAF, HER2 and MSI Status in a Large Consecutive Series of Colorectal Carcinomas.
International Journal Of Molecular Sciences
Martianov, Aleksandr S AS; Mitiushkina, Natalia V NV; Ershova, Anastasia N AN; Martynenko, Darya E DE; Bubnov, Mikhail G MG; Amankwah, Priscilla P; Yanus, Grigory A GA; Aleksakhina, Svetlana N SN; Tiurin, Vladislav I VI; Venina, Aigul R AR; Anuskina, Aleksandra A AA; Gorgul, Yuliy A YA; Shestakova, Anna D AD; Maidin, Mikhail A MA; Belyaev, Alexey M AM; Baboshkina, Liliya S LS; Iyevleva, Aglaya G AG; Imyanitov, Evgeny N EN
Pitfalls and Rewards of Setting Up a Liquid Biopsy Approach for the Detection of Driver Mutations in Circulating Tumor DNAs: Our Institutional Experience.
Journal Of Personalized Medicine
Chen, Michelle M; Jian, Damon D; Sidorov, Maxim M; Woo, Rinette W L RWL; Kim, Angela A; Stone, David E DE; Nazarian, Ari A; Nosrati, Mehdi M; Ice, Ryan J RJ; de Semir, David D; Dar, Altaf A AA; Luštrik, Roman R; Kokošar, Janez J; Ausec, Luka L; Rowbotham, Michael C MC; Tranah, Gregory J GJ; Kashani-Sabet, Mohammed M; Soroceanu, Liliana L; McAllister, Sean D SD; Desprez, Pierre-Yves PY
Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial.
Leukemia
Schwab, Claire C; Cranston, Ruth E RE; Ryan, Sarra L SL; Butler, Ellie E; Winterman, Emily E; Hawking, Zoe Z; Bashton, Matthew M; Enshaei, Amir A; Russell, Lisa J LJ; Kingsbury, Zoya Z; Peden, John F JF; Barretta, Emilio E; Murray, James J; Gibson, Jude J; Hinchliffe, Andrew C AC; Bain, Robert R; Vora, Ajay A; Bentley, David R DR; Ross, Mark T MT; Moorman, Anthony V AV; Harrison, Christine J CJ
Comprehensive pan-cancer genomic landscape of KRAS altered cancers and real-world outcomes in solid tumors.
Npj Precision Oncology
Lee, Jessica K JK; Sivakumar, Smruthy S; Schrock, Alexa B AB; Madison, Russell R; Fabrizio, David D; Gjoerup, Ole O; Ross, Jeffrey S JS; Frampton, Garrett M GM; Napalkov, Pavel P; Montesion, Meagan M; Schutzman, Jennifer L JL; Ye, Xin X; Hegde, Priti S PS; Nagasaka, Misako M; Oxnard, Geoffrey R GR; Sokol, Ethan S ES; Ou, Sai-Hong Ignatius SI; Shi, Zhen Z
Genome-wide analyses of 200,453 individuals yield new insights into the causes and consequences of clonal hematopoiesis.
Nature Genetics
Kar, Siddhartha P SP; Quiros, Pedro M PM; Gu, Muxin M; Jiang, Tao T; Mitchell, Jonathan J; Langdon, Ryan R; Iyer, Vivek V; Barcena, Clea C; Vijayabaskar, M S MS; Fabre, Margarete A MA; Carter, Paul P; Petrovski, Slavé S; Burgess, Stephen S; Vassiliou, George S GS
The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma.
Nature Communications
Vo, Josh N JN; Wu, Yi-Mi YM; Mishler, Jeanmarie J; Hall, Sarah S; Mannan, Rahul R; Wang, Lisha L; Ning, Yu Y; Zhou, Jin J; Hopkins, Alexander C AC; Estill, James C JC; Chan, Wallace K B WKB; Yesil, Jennifer J; Cao, Xuhong X; Rao, Arvind A; Tsodikov, Alexander A; Talpaz, Moshe M; Cole, Craig E CE; Ye, Jing C JC; , ; Bergsagel, P Leif PL; Auclair, Daniel D; Cho, Hearn Jay HJ; Robinson, Dan R DR; Chinnaiyan, Arul M AM
Publication Date: 2022-06-29
Variant appearance in text: KRAS: 179G>A; Gly60Asp
The longitudinal dynamics and natural history of clonal haematopoiesis.
Nature
Fabre, Margarete A MA; de Almeida, José Guilherme JG; Fiorillo, Edoardo E; Mitchell, Emily E; Damaskou, Aristi A; Rak, Justyna J; Orrù, Valeria V; Marongiu, Michele M; Chapman, Michael Spencer MS; Vijayabaskar, M S MS; Baxter, Joanna J; Hardy, Claire C; Abascal, Federico F; Williams, Nicholas N; Nangalia, Jyoti J; Martincorena, Iñigo I; Campbell, Peter J PJ; McKinney, Eoin F EF; Cucca, Francesco F; Gerstung, Moritz M; Vassiliou, George S GS
Pathophysiologic and clinical implications of molecular profiles resultant from deletion 5q.
Ebiomedicine
Adema, Vera V; Palomo, Laura L; Walter, Wencke W; Mallo, Mar M; Hutter, Stephan S; La Framboise, Thomas T; Arenillas, Leonor L; Meggendorfer, Manja M; Radivoyevitch, Tomas T; Xicoy, Blanca B; Pellagatti, Andrea A; Haferlach, Claudia C; Boultwood, Jacqueline J; Kern, Wolfgang W; Visconte, Valeria V; Sekeres, Mikkael M; Barnard, John J; Haferlach, Torsten T; Solé, Francesc F; Maciejewski, Jaroslaw P JP
Publication Date: 2022-06
Variant appearance in text: KRAS: 179G>A; Gly60Asp
Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.
International Journal Of Molecular Medicine
Chevrier, Sandy S; Brasselet, Astrid A; Carnet, Marion M; Chevriaux, Angélique A; Gibeaud, Anne A; Jourdain, Marine M; Mananet, Hugo H; Truntzer, Caroline C; Beltjens, Françoise F; Charon-Barra, Céline C; Arnould, Laurent L; Albuisson, Juliette J; Comte, Anthony A; Derangère, Valentin V; Goussot, Vincent V; Boidot, Romain R
Publication Date: 2022-05
Variant appearance in text: KRAS: 179G>A; Gly60Asp
Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations
Haematologica
Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP
Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations
Haematologica
Antić, Željko Ž; Yu, Jiangyan J; Van Reijmersdal, Simon V SV; Van Dijk, Anke A; Dekker, Linde L; Segerink, Wouter H WH; Sonneveld, Edwin E; Fiocco, Marta M; Pieters, Rob R; Hoogerbrugge, Peter M PM; Van Leeuwen, Frank N FN; Van Kessel, Ad Geurts AG; Waanders, Esme E; Kuiper, Roland P RP
Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.
Nature Communications
Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U
Clinical and genomic insights into circulating tumor DNA-based alterations across the spectrum of metastatic hormone-sensitive and castrate-resistant prostate cancer.
Ebiomedicine
Kohli, Manish M; Tan, Winston W; Zheng, Tiantian T; Wang, Amy A; Montesinos, Carlos C; Wong, Calven C; Du, Pan P; Jia, Shidong S; Yadav, Siddhartha S; Horvath, Lisa G LG; Mahon, Kate L KL; Kwan, Edmond M EM; Fettke, Heidi H; Yu, Jianjun J; Azad, Arun A AA
Targeted Gene Next-Generation Sequencing Panel in Patients with Advanced Lung Adenocarcinoma: Paving the Way for Clinical Implementation.
Cancers
Fernandes, Maria Gabriela O MGO; Jacob, Maria M; Martins, Natália N; Moura, Conceição Souto CS; Guimarães, Susana S; Reis, Joana Pereira JP; Justino, Ana A; Pina, Maria João MJ; Cirnes, Luís L; Sousa, Catarina C; Pinto, Josué J; Marques, José Agostinho JA; Machado, José Carlos JC; Hespanhol, Venceslau V; Costa, José Luis JL
Publication Date: 2019-08-22
Variant appearance in text: KRAS: 179G>A; Gly60Asp
RAS and BRAF mutations in cell-free DNA are predictive for outcome of cetuximab monotherapy in patients with tissue-tested RAS wild-type advanced colorectal cancer.
Molecular Oncology
van Helden, Erik J EJ; Angus, Lindsay L; Menke-van der Houven van Oordt, C Willemien CW; Heideman, Daniëlle A M DAM; Boon, Eline E; van Es, Suzanne C SC; Radema, Sandra A SA; van Herpen, Carla M L CML; de Groot, Derk Jan A DJA; de Vries, Elisabeth G E EGE; Jansen, Maurice P H M MPHM; Sleijfer, Stefan S; Verheul, Henk M W HMW
DNA methylation changes and somatic mutations as tumorigenic events in Lynch syndrome-associated adenomas retaining mismatch repair protein expression.
Ebiomedicine
Mäki-Nevala, Satu S; Valo, Satu S; Ristimäki, Ari A; Sarhadi, Virinder V; Knuutila, Sakari S; Nyström, Minna M; Renkonen-Sinisalo, Laura L; Lepistö, Anna A; Mecklin, Jukka-Pekka JP; Peltomäki, Päivi P
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.
Scientific Reports
Collord, Grace G; Tarpey, Patrick P; Kurbatova, Natalja N; Martincorena, Inigo I; Moran, Sebastian S; Castro, Manuel M; Nagy, Tibor T; Bignell, Graham G; Maura, Francesco F; Young, Matthew D MD; Berna, Jorge J; Tubio, Jose M C JMC; McMurran, Chris E CE; Young, Adam M H AMH; Sanders, Mathijs M; Noorani, Imran I; Price, Stephen J SJ; Watts, Colin C; Leipnitz, Elke E; Kirsch, Matthias M; Schackert, Gabriele G; Pearson, Danita D; Devadass, Abel A; Ram, Zvi Z; Collins, V Peter VP; Allinson, Kieren K; Jenkinson, Michael D MD; Zakaria, Rasheed R; Syed, Khaja K; Hanemann, C Oliver CO; Dunn, Jemma J; McDermott, Michael W MW; Kirollos, Ramez W RW; Vassiliou, George S GS; Esteller, Manel M; Behjati, Sam S; Brazma, Alvis A; Santarius, Thomas T; McDermott, Ultan U
appreci8: a pipeline for precise variant calling integrating 8 tools.
Bioinformatics (Oxford, England)
Sandmann, Sarah S; Karimi, Mohsen M; de Graaf, Aniek O AO; Rohde, Christian C; Göllner, Stefanie S; Varghese, Julian J; Ernsting, Jan J; Walldin, Gunilla G; van der Reijden, Bert A BA; Müller-Tidow, Carsten C; Malcovati, Luca L; Hellström-Lindberg, Eva E; Jansen, Joop H JH; Dugas, Martin M
Publication Date: 2018-12-15
Variant appearance in text: KRAS: 179G>A; Gly60Asp
Prevalence of Clonal Hematopoiesis Mutations in Tumor-Only Clinical Genomic Profiling of Solid Tumors.
Jama Oncology
Ptashkin, Ryan N RN; Mandelker, Diana L DL; Coombs, Catherine C CC; Bolton, Kelly K; Yelskaya, Zarina Z; Hyman, David M DM; Solit, David B DB; Baselga, José J; Arcila, Maria E ME; Ladanyi, Marc M; Zhang, Liying L; Levine, Ross L RL; Berger, Michael F MF; Zehir, Ahmet A
Analysis of the genomic landscape of multiple myeloma highlights novel prognostic markers and disease subgroups.
Leukemia
Bolli, Niccolo N; Biancon, Giulia G; Moarii, Matahi M; Gimondi, Silvia S; Li, Yilong Y; de Philippis, Chiara C; Maura, Francesco F; Sathiaseelan, Vijitha V; Tai, Yu-Tzu YT; Mudie, Laura L; O'Meara, Sarah S; Raine, Keiran K; Teague, Jon W JW; Butler, Adam P AP; Carniti, Cristiana C; Gerstung, Moritz M; Bagratuni, Tina T; Kastritis, Efstathios E; Dimopoulos, Meletios M; Corradini, Paolo P; Anderson, Kenneth C KC; Moreau, Philippe P; Minvielle, Stephane S; Campbell, Peter J PJ; Papaemmanuil, Elli E; Avet-Loiseau, Herve H; Munshi, Nikhil C NC
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
[Spectrum of somatic mutations and their prognostic significance in adult patients with B cell acute lymphoblastic leukemia].
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
Feng, J J; Gong, X Y XY; Jia, Y J YJ; Liu, K Q KQ; Li, Y Y; Dong, X B XB; Fang, Q Y QY; Ru, K K; Li, Q H QH; Wang, H J HJ; Zhao, X L XL; Jia, Y N YN; Song, Y Y; Tian, Z Z; Wang, M M; Tang, K J KJ; Wang, J X JX; Mi, Y C YC
Genomic analyses identify recurrent MEF2D fusions in acute lymphoblastic leukaemia.
Nature Communications
Gu, Zhaohui Z; Churchman, Michelle M; Roberts, Kathryn K; Li, Yongjin Y; Liu, Yu Y; Harvey, Richard C RC; McCastlain, Kelly K; Reshmi, Shalini C SC; Payne-Turner, Debbie D; Iacobucci, Ilaria I; Shao, Ying Y; Chen, I-Ming IM; Valentine, Marcus M; Pei, Deqing D; Mungall, Karen L KL; Mungall, Andrew J AJ; Ma, Yussanne Y; Moore, Richard R; Marra, Marco M; Stonerock, Eileen E; Gastier-Foster, Julie M JM; Devidas, Meenakshi M; Dai, Yunfeng Y; Wood, Brent B; Borowitz, Michael M; Larsen, Eric E EE; Maloney, Kelly K; Mattano, Leonard A LA; Angiolillo, Anne A; Salzer, Wanda L WL; Burke, Michael J MJ; Gianni, Francesca F; Spinelli, Orietta O; Radich, Jerald P JP; Minden, Mark D MD; Moorman, Anthony V AV; Patel, Bella B; Fielding, Adele K AK; Rowe, Jacob M JM; Luger, Selina M SM; Bhatia, Ravi R; Aldoss, Ibrahim I; Forman, Stephen J SJ; Kohlschmidt, Jessica J; Mrózek, Krzysztof K; Marcucci, Guido G; Bloomfield, Clara D CD; Stock, Wendy W; Kornblau, Steven S; Kantarjian, Hagop M HM; Konopleva, Marina M; Paietta, Elisabeth E; Willman, Cheryl L CL; Loh, Mignon L ML; Hunger, Stephen P SP; Mullighan, Charles G CG
KRAS mutations in blood circulating cell-free DNA: a pancreatic cancer case-control.
Oncotarget
Le Calvez-Kelm, Florence F; Foll, Matthieu M; Wozniak, Magdalena B MB; Delhomme, Tiffany M TM; Durand, Geoffroy G; Chopard, Priscilia P; Pertesi, Maroulio M; Fabianova, Eleonora E; Adamcakova, Zora Z; Holcatova, Ivana I; Foretova, Lenka L; Janout, Vladimir V; Vallee, Maxime P MP; Rinaldi, Sabina S; Brennan, Paul P; McKay, James D JD; Byrnes, Graham B GB; Scelo, Ghislaine G
Prognostic and therapeutic role of targetable lesions in B-lineage acute lymphoblastic leukemia without recurrent fusion genes.
Oncotarget
Messina, Monica M; Chiaretti, Sabina S; Wang, Jiguang J; Fedullo, Anna Lucia AL; Peragine, Nadia N; Gianfelici, Valentina V; Piciocchi, Alfonso A; Brugnoletti, Fulvia F; Di Giacomo, Filomena F; Pauselli, Simona S; Holmes, Antony B AB; Puzzolo, Maria Cristina MC; Ceglie, Giulia G; Apicella, Valerio V; Mancini, Marco M; Te Kronnie, Geertruy G; Testi, Anna Maria AM; Vitale, Antonella A; Vignetti, Marco M; Guarini, Anna A; Rabadan, Raul R; Foà, Robin R
KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor Metabolism.
Plos One
Chattopadhyay, Nibedita N; Berger, Allison J AJ; Koenig, Erik E; Bannerman, Bret B; Garnsey, James J; Bernard, Hugues H; Hales, Paul P; Maldonado Lopez, Angel A; Yang, Yu Y; Donelan, Jill J; Jordan, Kristen K; Tirrell, Stephen S; Stringer, Bradley B; Xia, Cindy C; Hather, Greg G; Galvin, Katherine K; Manfredi, Mark M; Rhodes, Nelson N; Amidon, Ben B
Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA.
Plos One
Lanman, Richard B RB; Mortimer, Stefanie A SA; Zill, Oliver A OA; Sebisanovic, Dragan D; Lopez, Rene R; Blau, Sibel S; Collisson, Eric A EA; Divers, Stephen G SG; Hoon, Dave S B DS; Kopetz, E Scott ES; Lee, Jeeyun J; Nikolinakos, Petros G PG; Baca, Arthur M AM; Kermani, Bahram G BG; Eltoukhy, Helmy H; Talasaz, AmirAli A
Amplicon sequencing of colorectal cancer: variant calling in frozen and formalin-fixed samples.
Plos One
Betge, Johannes J; Kerr, Grainne G; Miersch, Thilo T; Leible, Svenja S; Erdmann, Gerrit G; Galata, Christian L CL; Zhan, Tianzuo T; Gaiser, Timo T; Post, Stefan S; Ebert, Matthias P MP; Horisberger, Karoline K; Boutros, Michael M
Primary melanocytic tumors of the central nervous system: a review with focus on molecular aspects.
Brain Pathology (Zurich, Switzerland)
Küsters-Vandevelde, Heidi V N HV; Küsters, Benno B; van Engen-van Grunsven, Adriana C H AC; Groenen, Patricia J T A PJ; Wesseling, Pieter P; Blokx, Willeke A M WA
Melanotic tumors of the nervous system are characterized by distinct mutational, chromosomal and epigenomic profiles.
Brain Pathology (Zurich, Switzerland)
Koelsche, Christian C; Hovestadt, Volker V; Jones, David T W DT; Capper, David D; Sturm, Dominik D; Sahm, Felix F; Schrimpf, Daniel D; Adeberg, Sebastian S; Böhmer, Katja K; Hagenlocher, Christian C; Mechtersheimer, Gunhild G; Kohlhof, Patricia P; Mühleisen, Helmut H; Beschorner, Rudi R; Hartmann, Christian C; Braczynski, Anne Kristin AK; Mittelbronn, Michel M; Buslei, Rolf R; Becker, Albert A; Grote, Alexander A; Urbach, Horst H; Staszewski, Ori O; Prinz, Marco M; Hewer, Ekkehard E; Pfister, Stefan M SM; von Deimling, Andreas A; Reuss, David E DE
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
Nature
Zhang, Jinghui J; Ding, Li L; Holmfeldt, Linda L; Wu, Gang G; Heatley, Sue L SL; Payne-Turner, Debbie D; Easton, John J; Chen, Xiang X; Wang, Jianmin J; Rusch, Michael M; Lu, Charles C; Chen, Shann-Ching SC; Wei, Lei L; Collins-Underwood, J Racquel JR; Ma, Jing J; Roberts, Kathryn G KG; Pounds, Stanley B SB; Ulyanov, Anatoly A; Becksfort, Jared J; Gupta, Pankaj P; Huether, Robert R; Kriwacki, Richard W RW; Parker, Matthew M; McGoldrick, Daniel J DJ; Zhao, David D; Alford, Daniel D; Espy, Stephen S; Bobba, Kiran Chand KC; Song, Guangchun G; Pei, Deqing D; Cheng, Cheng C; Roberts, Stefan S; Barbato, Michael I MI; Campana, Dario D; Coustan-Smith, Elaine E; Shurtleff, Sheila A SA; Raimondi, Susana C SC; Kleppe, Maria M; Cools, Jan J; Shimano, Kristin A KA; Hermiston, Michelle L ML; Doulatov, Sergei S; Eppert, Kolja K; Laurenti, Elisa E; Notta, Faiyaz F; Dick, John E JE; Basso, Giuseppe G; Hunger, Stephen P SP; Loh, Mignon L ML; Devidas, Meenakshi M; Wood, Brent B; Winter, Stuart S; Dunsmore, Kimberley P KP; Fulton, Robert S RS; Fulton, Lucinda L LL; Hong, Xin X; Harris, Christopher C CC; Dooling, David J DJ; Ochoa, Kerri K; Johnson, Kimberly J KJ; Obenauer, John C JC; Evans, William E WE; Pui, Ching-Hon CH; Naeve, Clayton W CW; Ley, Timothy J TJ; Mardis, Elaine R ER; Wilson, Richard K RK; Downing, James R JR; Mullighan, Charles G CG