A KRAS-responsive long non-coding RNA controls microRNA processing.
Nature Communications
Shi, Lei L; Magee, Peter P; Fassan, Matteo M; Sahoo, Sudhakar S; Leong, Hui Sun HS; Lee, Dave D; Sellers, Robert R; Brullé-Soumaré, Laura L; Cairo, Stefano S; Monteverde, Tiziana T; Volinia, Stefano S; Smith, Duncan D DD; Di Leva, Gianpiero G; Galuppini, Francesca F; Paliouras, Athanasios R AR; Zeng, Kang K; O'Keefe, Raymond R; Garofalo, Michela M
Inactivation of tumor suppressor gene Clusterin leads to hyperactivation of TAK1-NF-κB signaling axis in lung cancer cells and denotes a therapeutic opportunity.