KRAS c.145G>A ;(p.E49K)

Variant ID: 12-25380313-C-T

NM_004985.3(KRAS):c.145G>A;(p.E49K)

This variant was identified in 15 publications

View GRCh38 version.




Publications:


In-depth plasma proteomics reveals increase in circulating PD-1 during anti-PD-1 immunotherapy in patients with metastatic cutaneous melanoma.

Journal For Immunotherapy Of Cancer
Babačić, Haris H; Lehtiö, Janne J; Pico de Coaña, Yago Y; Pernemalm, Maria M; Eriksson, Hanna H
Publication Date: 2020-05

Variant appearance in text: KRAS: 145G>A; E49K
PubMed Link: 32457125
Variant Present in the following documents:
  • jitc-2019-000204supp003.xlsx, sheet 3
View BVdb publication page



Molecular Neuropathology in Practice: Clinical Profiling and Integrative Analysis of Molecular Alterations in Glioblastoma.

Academic Pathology
Nasrallah, MacLean P MP; Binder, Zev A ZA; Oldridge, Derek A DA; Zhao, Jianhua J; Lieberman, David B DB; Roth, Jacquelyn J JJ; Watt, Christopher D CD; Sukhadia, Shrey S; Klinman, Eva E; Daber, Robert D RD; Desai, Arati A; Brem, Steven S; O'Rourke, Donald M DM; Morrissette, Jennifer J D JJD
Publication Date: 2019

Variant appearance in text: KRAS: E49K
PubMed Link: 31206012
Variant Present in the following documents:
  • Supplementary_Table_1.xlsx, sheet 1
View BVdb publication page



Challenges of Providing Concordant Interpretation of Somatic Variants in Non-Small Cell Lung Cancer: A Multicenter Study.

Journal Of Cancer
Gao, Peng P; Zhang, Rui R; Li, Ziyang Z; Ding, Jiansheng J; Xie, Jiehong J; Li, Jinming J
Publication Date: 2019

Variant appearance in text: KRAS: 145G>A; Glu49Lys
PubMed Link: 31205538
Variant Present in the following documents:
  • Main text
  • jcav10p1814s1.xls, sheet 1
  • jcav10p1814s1.xls, sheet 6
  • jcav10p1814.pdf
View BVdb publication page



K-Ras G-domain binding with signaling lipid phosphatidylinositol (4,5)-phosphate (PIP2): membrane association, protein orientation, and function.

The Journal Of Biological Chemistry
Cao, Shufen S; Chung, Stacey S; Kim, SoonJeung S; Li, Zhenlu Z; Manor, Danny D; Buck, Matthias M
Publication Date: 2019-04-26

Variant appearance in text: K-Ras4B: E49K
PubMed Link: 30792310
Variant Present in the following documents:
  • Main text
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: KRAS: E49K
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



The Effectiveness of Afatinib in a Patient with Advanced Lung Adenocarcinoma Harboring Rare G719X and S768I Mutations.

Internal Medicine (Tokyo, Japan)
Watanabe, Masahiro M; Oizumi, Satoshi S; Kiuchi, Shizuka S; Yamada, Noriyuki N; Yokouchi, Hiroshi H; Fukumoto, Shinichi S; Harada, Masao M
Publication Date: 2018-04-01

Variant appearance in text: KRAS: E49K
PubMed Link: 29225262
Variant Present in the following documents:
  • Main text
  • 1349-7235-57-0993.pdf
View BVdb publication page



Mutational landscape reflects the biological continuum of plasma cell dyscrasias.

Blood Cancer Journal
Rossi, A A; Voigtlaender, M M; Janjetovic, S S; Thiele, B B; Alawi, M M; März, M M; Brandt, A A; Hansen, T T; Radloff, J J; Schön, G G; Hegenbart, U U; Schönland, S S; Langer, C C; Bokemeyer, C C; Binder, M M
Publication Date: 2017-02-24

Variant appearance in text: KRAS: E49K
PubMed Link: 28234344
Variant Present in the following documents:
  • bcj201719a.pdf
View BVdb publication page



Clinical applicability and cost of a 46-gene panel for genomic analysis of solid tumours: Retrospective validation and prospective audit in the UK National Health Service.

Plos Medicine
Hamblin, Angela A; Wordsworth, Sarah S; Fermont, Jilles M JM; Page, Suzanne S; Kaur, Kulvinder K; Camps, Carme C; Kaisaki, Pamela P; Gupta, Avinash A; Talbot, Denis D; Middleton, Mark M; Henderson, Shirley S; Cutts, Anthony A; Vavoulis, Dimitrios V DV; Housby, Nick N; Tomlinson, Ian I; Taylor, Jenny C JC; Schuh, Anna A
Publication Date: 2017-02

Variant appearance in text: KRAS: E49K
PubMed Link: 28196074
Variant Present in the following documents:
  • pmed.1002230.s004.xlsx, sheet 2
View BVdb publication page



Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.

Molecular Cancer
Kovaleva, Valentina V; Geissler, Anna-Lena AL; Lutz, Lisa L; Fritsch, Ralph R; Makowiec, Frank F; Wiesemann, Sebastian S; Hopt, Ulrich T UT; Passlick, Bernward B; Werner, Martin M; Lassmann, Silke S
Publication Date: 2016-10-18

Variant appearance in text: KRAS: 145G>A; Glu49Lys
PubMed Link: 27756406
Variant Present in the following documents:
  • 12943_2016_549_MOESM2_ESM.xlsx, sheet 1
View BVdb publication page



Prognostic role of KRAS mutations in Sardinian patients with colorectal carcinoma.

Oncology Letters
Palomba, Grazia G; Cossu, Antonio A; Paliogiannis, Panagiotis P; Pazzola, Antonio A; Baldino, Giovanni G; Scartozzi, Mario M; Ionta, Maria Teresa MT; Ortu, Salvatore S; Capelli, Francesca F; Lanzillo, Annamaria A; Sedda, Tito T; Sanna, Giovanni G; Barca, Michela M; Virdis, Luciano L; Budroni, Mario M; Palmieri, Giuseppe G
Publication Date: 2016-08

Variant appearance in text: KRAS: 145G>A; E49K
PubMed Link: 27446446
Variant Present in the following documents:
  • Main text
  • ol-12-02-1415.pdf
View BVdb publication page



mutation3D: Cancer Gene Prediction Through Atomic Clustering of Coding Variants in the Structural Proteome.

Human Mutation
Meyer, Michael J MJ; Lapcevic, Ryan R; Romero, Alfonso E AE; Yoon, Mark M; Das, Jishnu J; Beltrán, Juan Felipe JF; Mort, Matthew M; Stenson, Peter D PD; Cooper, David N DN; Paccanaro, Alberto A; Yu, Haiyuan H
Publication Date: 2016-05

Variant appearance in text: KRAS: E49K
PubMed Link: 26841357
Variant Present in the following documents:
  • Main text
View BVdb publication page



Assessing the clinical value of targeted massively parallel sequencing in a longitudinal, prospective population-based study of cancer patients.

British Journal Of Cancer
Wong, S Q SQ; Fellowes, A A; Doig, K K; Ellul, J J; Bosma, T J TJ; Irwin, D D; Vedururu, R R; Tan, A Y-C AY; Weiss, J J; Chan, K S KS; Lucas, M M; Thomas, D M DM; Dobrovic, A A; Parisot, J P JP; Fox, S B SB
Publication Date: 2015-04-14

Variant appearance in text: KRAS: 145G>A; Glu49Lys
PubMed Link: 25742471
Variant Present in the following documents:
  • bjc201580x7.xls, sheet 1
View BVdb publication page



High-throughput profiling identifies clinically actionable mutations in salivary duct carcinoma.

Journal Of Translational Medicine
Ku, Bo Mi BM; Jung, Hyun Ae HA; Sun, Jong-Mu JM; Ko, Young Hyeh YH; Jeong, Han-Sin HS; Son, Young-Ik YI; Baek, Chung-Hwan CH; Park, Keunchil K; Ahn, Myung-Ju MJ
Publication Date: 2014-10-25

Variant appearance in text: KRAS: E49K
PubMed Link: 25343854
Variant Present in the following documents:
  • Main text
  • 12967_2014_Article_299.pdf
View BVdb publication page



High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer.

Bmc Cancer
Guedes, Joana G JG; Veiga, Isabel I; Rocha, Patrícia P; Pinto, Pedro P; Pinto, Carla C; Pinheiro, Manuela M; Peixoto, Ana A; Fragoso, Maria M; Raimundo, Ana A; Ferreira, Paula P; Machado, Manuela M; Sousa, Nuno N; Lopes, Paula P; Araújo, António A; Macedo, Joana J; Alves, Fernando F; Coutinho, Camila C; Henrique, Rui R; Santos, Lúcio L LL; Teixeira, Manuel R MR
Publication Date: 2013-04-01

Variant appearance in text: KRAS: 145G>A; Glu49Lys
PubMed Link: 23548132
Variant Present in the following documents:
  • Main text
View BVdb publication page



Prevalence of KRAS, BRAF, and PIK3CA somatic mutations in patients with colorectal carcinoma may vary in the same population: clues from Sardinia.

Journal Of Translational Medicine
Palomba, Grazia G; Colombino, Maria M; Contu, Antonio A; Massidda, Bruno B; Baldino, Giovanni G; Pazzola, Antonio A; Ionta, MariaTeresa M; Capelli, Francesca F; Trova, Vittorio V; Sedda, Tito T; Sanna, Giovanni G; Tanda, Francesco F; Budroni, Mario M; , ; Palmieri, Giuseppe G; Cossu, Antonio A; Contu, Marta M; Cuccu, Angelo A; Farris, Antonio A; Macciò, Antonio A; Mameli, Giuseppe G; Olmeo, Nina N; Ortu, Salvatore S; Petretto, Elisabetta E; Pusceddu, Valeria V; Virdis, Luciano L
Publication Date: 2012-08-29

Variant appearance in text: KRAS: E49K
PubMed Link: 22931052
Variant Present in the following documents:
  • Main text
  • 1479-5876-10-178.pdf
View BVdb publication page