KRAS c.134T>C ;(p.V45A)

Variant ID: 12-25380324-A-G

NM_004985.3(KRAS):c.134T>C;(p.V45A)

This variant was identified in 2 publications

View GRCh38 version.




Publications:


KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.

Nature Communications
Tran, Timothy H TH; Chan, Albert H AH; Young, Lucy C LC; Bindu, Lakshman L; Neale, Chris C; Messing, Simon S; Dharmaiah, Srisathiyanarayanan S; Taylor, Troy T; Denson, John-Paul JP; Esposito, Dominic D; Nissley, Dwight V DV; Stephen, Andrew G AG; McCormick, Frank F; Simanshu, Dhirendra K DK
Publication Date: 2021-02-19

Variant appearance in text: KRAS: V45A
PubMed Link: 33608534
Variant Present in the following documents:
  • 41467_2021_21422_MOESM1_ESM.pdf
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: KRAS: V45A
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 1
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page