Publications:

In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders.

Journal Of Chemical Information And Modeling

Leini, Renne R; Pantsar, Tatu T

Publication Date: 2023-02-28

Variant appearance in text: KRAS: S39C

PubMed Link: 36854010

Variant Present in the following documents:

• Main text
• ci2c01479.pdf

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Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor.

Journal Of Medicinal Chemistry

Bröker, Joachim J; Waterson, Alex G AG; Smethurst, Chris C; Kessler, Dirk D; Böttcher, Jark J; Mayer, Moriz M; Gmaschitz, Gerhard G; Phan, Jason J; Little, Andrew A; Abbott, Jason R JR; Sun, Qi Q; Gmachl, Michael M; Rudolph, Dorothea D; Arnhof, Heribert H; Rumpel, Klaus K; Savarese, Fabio F; Gerstberger, Thomas T; Mischerikow, Nikolai N; Treu, Matthias M; Herdeis, Lorenz L; Wunberg, Tobias T; Gollner, Andreas A; Weinstabl, Harald H; Mantoulidis, Andreas A; Krämer, Oliver O; McConnell, Darryl B DB; W Fesik, Stephen S

Publication Date: 2022-11-10

Variant appearance in text: KRAS: S39C

PubMed Link: 36300829

Variant Present in the following documents:

• Main text
• jm2c01120.pdf
• jm2c01120_si_001.pdf

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Oncogenic KRAS G12D mutation promotes dimerization through a second, phosphatidylserine-dependent interface: a model for KRAS oligomerization.

Chemical Science

Lee, Ki-Young KY; Enomoto, Masahiro M; Gebregiworgis, Teklab T; Gasmi-Seabrook, Geneviève M C GMC; Ikura, Mitsuhiko M; Marshall, Christopher B CB

Publication Date: 2021-10-06

Variant appearance in text: KRAS: S39C

PubMed Link: 34703570

Variant Present in the following documents:

• SC-012-D1SC03484G-s001.pdf

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