Publications:

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Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

Biorxiv : The Preprint Server For Biology

Ratnasinghe, Brian D BD; Haque, Neshatul N; Wagenknecht, Jessica B JB; Jensen, Davin R DR; Esparza, Guadalupe V GV; Leverence, Elise N EN; De Assuncao, Thiago Milech TM; Mathison, Angela J AJ; Lomberk, Gwen G; Smith, Brian C BC; Volkman, Brian F BF; Urrutia, Raul R; Zimmermann, Michael T MT

Publication Date: 2023-04-28

Variant appearance in text: KRAS: D33E

PubMed Link: 37207265

Variant Present in the following documents:

• Main text
• nihpp-2023.04.28.536249v1.pdf
• media-1.pdf

View BVdb publication page

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Impact of Clonal Architecture on Clinical Course and Prognosis in Patients With Myeloproliferative Neoplasms.

Hemasphere

Luque Paz, Damien D; Bader, Michael S MS; Nienhold, Ronny R; Rai, Shivam S; Almeida Fonseca, Tiago T; Stetka, Jan J; Hao-Shen, Hui H; Mild-Schneider, Gabriele G; Passweg, Jakob R JR; Skoda, Radek C RC

Publication Date: 2023-05

Variant appearance in text: KRAS: D33E

PubMed Link: 37153874

Variant Present in the following documents:

• hs9-7-e885-s001.xlsx, sheet 2
• hs9-7-e885-s003.pdf

View BVdb publication page

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In Silico Evaluation of the Thr58-Associated Conserved Water with KRAS Switch-II Pocket Binders.

Journal Of Chemical Information And Modeling

Leini, Renne R; Pantsar, Tatu T

Publication Date: 2023-02-28

Variant appearance in text: KRAS: D33E

PubMed Link: 36854010

Variant Present in the following documents:

• ci2c01479_si_002.xlsx, sheet 1

View BVdb publication page

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Efficacy and clinicogenomic correlates of response to immune checkpoint inhibitors alone or with chemotherapy in non-small cell lung cancer.

Nature Communications

Hong, Lingzhi L; Aminu, Muhammad M; Li, Shenduo S; Lu, Xuetao X; Petranovic, Milena M; Saad, Maliazurina B MB; Chen, Pingjun P; Qin, Kang K; Varghese, Susan S; Rinsurongkawong, Waree W; Rinsurongkawong, Vadeerat V; Spelman, Amy A; Elamin, Yasir Y YY; Negrao, Marcelo V MV; Skoulidis, Ferdinandos F; Gay, Carl M CM; Cascone, Tina T; Gandhi, Saumil J SJ; Lin, Steven H SH; Lee, Percy P PP; Carter, Brett W BW; Wu, Carol C CC; Antonoff, Mara B MB; Sepesi, Boris B; Lewis, Jeff J; Gibbons, Don L DL; Vaporciyan, Ara A AA; Le, Xiuning X; Jack Lee, J J; Roy-Chowdhuri, Sinchita S; Routbort, Mark J MJ; Gainor, Justin F JF; Heymach, John V JV; Lou, Yanyan Y; Wu, Jia J; Zhang, Jianjun J; Vokes, Natalie I NI

Publication Date: 2023-02-08

Variant appearance in text: KRAS: 99T>G; D33E

PubMed Link: 36755027

Variant Present in the following documents:

• 41467_2023_36328_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Molecular-Targeted Therapy for Tumor-Agnostic Mutations in Acute Myeloid Leukemia.

Biomedicines

Arai, Hironori H; Minami, Yosuke Y; Chi, SungGi S; Utsu, Yoshikazu Y; Masuda, Shinichi S; Aotsuka, Nobuyuki N

Publication Date: 2022-11-22

Variant appearance in text: KRAS: D33E

PubMed Link: 36551764

Variant Present in the following documents:

• Main text
• biomedicines-10-03008.pdf

View BVdb publication page

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Somatic mutation distribution across tumour cohorts provides a signal for positive selection in cancer.

Nature Communications

Boström, Martin M; Larsson, Erik E

Publication Date: 2022-11-17

Variant appearance in text: KRAS: D33E

PubMed Link: 36396655

Variant Present in the following documents:

• 41467_2022_34746_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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Phenotypic plasticity and genetic control in colorectal cancer evolution.

Nature

Househam, Jacob J; Heide, Timon T; Cresswell, George D GD; Spiteri, Inmaculada I; Kimberley, Chris C; Zapata, Luis L; Lynn, Claire C; James, Chela C; Mossner, Maximilian M; Fernandez-Mateos, Javier J; Vinceti, Alessandro A; Baker, Ann-Marie AM; Gabbutt, Calum C; Berner, Alison A; Schmidt, Melissa M; Chen, Bingjie B; Lakatos, Eszter E; Gunasri, Vinaya V; Nichol, Daniel D; Costa, Helena H; Mitchinson, Miriam M; Ramazzotti, Daniele D; Werner, Benjamin B; Iorio, Francesco F; Jansen, Marnix M; Caravagna, Giulio G; Barnes, Chris P CP; Shibata, Darryl D; Bridgewater, John J; Rodriguez-Justo, Manuel M; Magnani, Luca L; Sottoriva, Andrea A; Graham, Trevor A TA

Publication Date: 2022-11

Variant appearance in text: KRAS: D33E

PubMed Link: 36289336

Variant Present in the following documents:

• 41586_2022_5311_MOESM10_ESM.xlsx, sheet 1

View BVdb publication page

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The mutational landscape of cancer's vulnerability to ionizing radiation.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Gopal, Priyanka P; Yard, Brian D BD; Petty, Aaron A; Lal, Jessica C JC; Bera, Titas K TK; Hoang, Trung Q TQ; Buhimschi, Alexandru B AB; Abazeed, Mohamed E ME

Publication Date: 2022-10-12

Variant appearance in text: KRAS: D33E

PubMed Link: 36222846

Variant Present in the following documents:

• ccr-22-1914_supplementary_data_2_suppds2.xlsx, sheet 1
• ccr-22-1914_supplementary_data_3_suppds3.xlsx, sheet 1

View BVdb publication page

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Mechanistic insights into the clinical Y96D mutation with acquired resistance to AMG510 in the KRASG12C.

Frontiers In Oncology

Zhuang, Haiming H; Fan, Jigang J; Li, Mingyu M; Zhang, Hao H; Yang, Xiuyan X; Lin, Ligen L; Lu, Shaoyong S; Wang, Qing Q; Liu, Yaqin Y

Publication Date: 2022

Variant appearance in text: KRAS: D33E

PubMed Link: 36033504

Variant Present in the following documents:

• Main text
• fonc-12-915512.pdf

View BVdb publication page

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Integrated genomic analyses of acral and mucosal melanomas nominate novel driver genes.

Genome Medicine

Wang, Meng M; Banik, Ishani I; Shain, A Hunter AH; Yeh, Iwei I; Bastian, Boris C BC

Publication Date: 2022-06-16

Variant appearance in text: KRAS: D33E

PubMed Link: 35706047

Variant Present in the following documents:

• 13073_2022_1068_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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The longitudinal dynamics and natural history of clonal haematopoiesis.

Nature

Fabre, Margarete A MA; de Almeida, José Guilherme JG; Fiorillo, Edoardo E; Mitchell, Emily E; Damaskou, Aristi A; Rak, Justyna J; Orrù, Valeria V; Marongiu, Michele M; Chapman, Michael Spencer MS; Vijayabaskar, M S MS; Baxter, Joanna J; Hardy, Claire C; Abascal, Federico F; Williams, Nicholas N; Nangalia, Jyoti J; Martincorena, Iñigo I; Campbell, Peter J PJ; McKinney, Eoin F EF; Cucca, Francesco F; Gerstung, Moritz M; Vassiliou, George S GS

Publication Date: 2022-06

Variant appearance in text: N/A

PubMed Link: 35650444

Variant Present in the following documents:

View BVdb publication page

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Delineating the RAS Conformational Landscape.

Cancer Research

Parker, Mitchell I MI; Meyer, Joshua E JE; Golemis, Erica A EA; Dunbrack, Roland L RL

Publication Date: 2022-07-05

Variant appearance in text: KRAS: D33E

PubMed Link: 35536216

Variant Present in the following documents:

• 2485.pdf
• can-22-0804_supplementary_datasets_s1-s4_suppsds1-sds4.xlsx, sheet 1

View BVdb publication page

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Third reported patient with RAP1B-related syndromic thrombocytopenia and novel clinical findings.

American Journal Of Medical Genetics. Part A

Miller, Dana D; Saeed, Azhar A; Nelson, Andrew C AC; Bower, Matthew M; Aggarwal, Anjali A

Publication Date: 2022-09

Variant appearance in text: KRAS: D33E

PubMed Link: 35451551

Variant Present in the following documents:

• AJMG-188-2808.pdf

View BVdb publication page

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KRAS Mutation in Rare Tumors: A Landscape Analysis of 3453 Chinese Patients.

Frontiers In Molecular Biosciences

Wang, Shuhang S; Li, Qin Q; Ma, Peiwen P; Fang, Yuan Y; Yu, Yue Y; Jiang, Ning N; Miao, Huilei H; Tang, Qiyu Q; Yang, Yuqi Y; Xing, Shujun S; Chen, Rongrong R; Yi, Xin X; Li, Ning N

Publication Date: 2022

Variant appearance in text: KRAS: D33E

PubMed Link: 35359599

Variant Present in the following documents:

• Main text

View BVdb publication page

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Systematic review and meta-analysis of genomic alterations in acral melanoma.

Pigment Cell & Melanoma Research

Broit, Natasa N; Johansson, Peter A PA; Rodgers, Chloe B CB; Walpole, Sebastian T ST; Hayward, Nicholas K NK; Pritchard, Antonia L AL

Publication Date: 2022-05

Variant appearance in text: KRAS: D33E

PubMed Link: 35229492

Variant Present in the following documents:

• PCMR-35-369-s003.xlsx, sheet 12

View BVdb publication page

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Identification of the nucleotide-free state as a therapeutic vulnerability for inhibition of selected oncogenic RAS mutants.

Cell Reports

Khan, Imran I; Koide, Akiko A; Zuberi, Mariyam M; Ketavarapu, Gayatri G; Denbaum, Eric E; Teng, Kai Wen KW; Rhett, J Matthew JM; Spencer-Smith, Russell R; Hobbs, G Aaron GA; Camp, Ernest Ramsay ER; Koide, Shohei S; O'Bryan, John P JP

Publication Date: 2022-02-08

Variant appearance in text: KRAS: D33E

PubMed Link: 35139380

Variant Present in the following documents:

• nihms-1778820.pdf

View BVdb publication page

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Discovery of Small Molecule NSC290956 as a Therapeutic Agent for KRas Mutant Non-Small-Cell Lung Cancer.

Frontiers In Pharmacology

Zhang, Jiaxin J; Liu, Zuojia Z; Zhao, Wenjing W; Yin, Xunzhe X; Zheng, Xiliang X; Liu, Chuanbo C; Wang, Jin J; Wang, Erkang E

Publication Date: 2021

Variant appearance in text: KRAS: D33E

PubMed Link: 35069209

Variant Present in the following documents:

• fphar-12-797821.pdf

View BVdb publication page

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Identification of RAS mutant biomarkers for EGFR inhibitor sensitivity using a systems biochemical approach.

Cell Reports

McFall, Thomas T; Stites, Edward C EC

Publication Date: 2021-12-14

Variant appearance in text: KRAS: D33E

PubMed Link: 34910921

Variant Present in the following documents:

• Main text
• NIHMS1764636-supplement-2.pdf
• nihms-1764636.pdf

View BVdb publication page

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Mutation analysis of a 10-gene panel for colorectal cancer in Huizhou, Guangdong Province of China.

The Journal Of International Medical Research

Li, Jun J; Sun, Aihua A; Zhong, Guofang G; He, Ying Y; Xiong, Hailin H; Yuan, Xia X

Publication Date: 2021-11

Variant appearance in text: KRAS: 99T>G

PubMed Link: 34851763

Variant Present in the following documents:

• 10.1177_03000605211061040.pdf

View BVdb publication page

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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Frontiers In Endocrinology

Hescheler, Daniel A DA; Riemann, Burkhard B; Hartmann, Milan J M MJM; Michel, Maximilian M; Faust, Michael M; Bruns, Christiane J CJ; Alakus, Hakan H; Chiapponi, Costanza C

Publication Date: 2021

Variant appearance in text: KRAS: D33E

PubMed Link: 34630336

Variant Present in the following documents:

• Table_1.xlsx, sheet 2

View BVdb publication page

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E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.

The Journal Of Experimental Medicine

Li, Ke K; Zheng, Xufen X; Tang, Hua H; Zang, Yuan-Sheng YS; Zeng, Chunling C; Liu, Xiaoxiao X; Shen, Yanying Y; Pang, Yuzhi Y; Wang, Simin S; Xie, Feifei F; Lu, Xiaojing X; Luo, Yuxiang Y; Li, Zhang Z; Bi, Wenbo W; Jia, Xiaona X; Huang, Tao T; Wei, Rongqiang R; Huang, Kenan K; Chen, Zihao Z; Zhu, Qingchen Q; He, Yi Y; Zhang, Miaoying M; Gu, Zhizhan Z; Xiao, Yichuan Y; Zhang, Xiaoyang X; Fletcher, Jonathan A JA; Wang, Yuexiang Y

Publication Date: 2021-08-02

Variant appearance in text: KRAS: D33E

PubMed Link: 34143182

Variant Present in the following documents:

• Main text

View BVdb publication page

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E3 ligase MKRN3 is a tumor suppressor regulating PABPC1 ubiquitination in non-small cell lung cancer.

The Journal Of Experimental Medicine

Li, Ke K; Zheng, Xufen X; Tang, Hua H; Zang, Yuan-Sheng YS; Zeng, Chunling C; Liu, Xiaoxiao X; Shen, Yanying Y; Pang, Yuzhi Y; Wang, Simin S; Xie, Feifei F; Lu, Xiaojing X; Luo, Yuxiang Y; Li, Zhang Z; Bi, Wenbo W; Jia, Xiaona X; Huang, Tao T; Wei, Rongqiang R; Huang, Kenan K; Chen, Zihao Z; Zhu, Qingchen Q; He, Yi Y; Zhang, Miaoying M; Gu, Zhizhan Z; Xiao, Yichuan Y; Zhang, Xiaoyang X; Fletcher, Jonathan A JA; Wang, Yuexiang Y

Publication Date: 2021-08-02

Variant appearance in text: KRAS: D33E

PubMed Link: 34143182

Variant Present in the following documents:

• Main text

View BVdb publication page

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Clinical and Functional Characterization of Atypical KRAS/NRAS Mutations in Metastatic Colorectal Cancer.

Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research

Loree, Jonathan M JM; Wang, Yucai Y; Syed, Muddassir A MA; Sorokin, Alexey V AV; Coker, Oluwadara O; Xiu, Joanne J; Weinberg, Benjamin A BA; Vanderwalde, Ari M AM; Tesfaye, Anteneh A; Raymond, Victoria M VM; Miron, Benjamin B; Tarcic, Gabi G; Zelichov, Ori O; Broaddus, Russell R RR; Ng, Patrick Kwok Shing PKS; Jeong, Kang Jin KJ; Tsang, Yiu Huen YH; Mills, Gordon B GB; Overman, Michael J MJ; Grothey, Axel A; Marshall, John L JL; Kopetz, Scott S

Publication Date: 2021-08-15

Variant appearance in text: KRAS: D33E

PubMed Link: 34117033

Variant Present in the following documents:

• Main text

View BVdb publication page

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Structural impact of GTP binding on downstream KRAS signaling.

Chemical Science

Menyhárd, Dóra K DK; Pálfy, Gyula G; Orgován, Zoltán Z; Vida, István I; Keserű, György M GM; Perczel, András A

Publication Date: 2020-08-19

Variant appearance in text: KRAS: D33E

PubMed Link: 34094198

Variant Present in the following documents:

• SC-011-D0SC03441J-s001.pdf

View BVdb publication page

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Postoperative circulating tumor DNA as markers of recurrence risk in stages II to III colorectal cancer.

Journal Of Hematology & Oncology

Chen, Gong G; Peng, Junjie J; Xiao, Qian Q; Wu, Hao-Xiang HX; Wu, Xiaojun X; Wang, Fulong F; Li, Liren L; Ding, Peirong P; Zhao, Qi Q; Li, Yaqi Y; Wang, Da D; Shao, Yang Y; Bao, Hua H; Pan, Zhizhong Z; Ding, Ke-Feng KF; Cai, Sanjun S; Wang, Feng F; Xu, Rui-Hua RH

Publication Date: 2021-05-17

Variant appearance in text: KRAS: D33E

PubMed Link: 34001194

Variant Present in the following documents:

• 13045_2021_1089_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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A KRAS-responsive long non-coding RNA controls microRNA processing.

Nature Communications

Shi, Lei L; Magee, Peter P; Fassan, Matteo M; Sahoo, Sudhakar S; Leong, Hui Sun HS; Lee, Dave D; Sellers, Robert R; Brullé-Soumaré, Laura L; Cairo, Stefano S; Monteverde, Tiziana T; Volinia, Stefano S; Smith, Duncan D DD; Di Leva, Gianpiero G; Galuppini, Francesca F; Paliouras, Athanasios R AR; Zeng, Kang K; O'Keefe, Raymond R; Garofalo, Michela M

Publication Date: 2021-04-01

Variant appearance in text: KRAS: D33E

PubMed Link: 33795683

Variant Present in the following documents:

• 41467_2021_22337_MOESM4_ESM.xlsx, sheet 1

View BVdb publication page

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EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.

Leukemia

Berg, Johannes Lorenz JL; Perfler, Bianca B; Hatzl, Stefan S; Uhl, Barbara B; Reinisch, Andreas A; Pregartner, Gudrun G; Berghold, Andrea A; Penz, Thomas T; Schuster, Michael M; Geissler, Klaus K; Prokesch, Andreas A; Müller-Tidow, Carsten C; Hoefler, Gerald G; Kashofer, Karl K; Wölfler, Albert A; Sill, Heinz H; Caraffini, Veronica V; Zebisch, Armin A

Publication Date: 2021-05

Variant appearance in text: KRAS: D33E

PubMed Link: 33589750

Variant Present in the following documents:

• 41375_2021_1161_MOESM1_ESM.pdf

View BVdb publication page

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Molecular Characterization of Ovarian Yolk Sac Tumor (OYST).

Cancers

Hodroj, Khalil K; Stevovic, Aleksandra A; Attignon, Valery V; Ferraioli, Domenico D; Meeus, Pierre P; Croce, Sabrina S; Chopin, Nicolas N; Rossi, Lea L; Floquet, Anne A; Rousset-Jablonski, Christine C; Tredan, Olivier O; Guyon, Frédéric F; Treilleux, Isabelle I; Rannou, Corinne C; Morfouace, Marie M; Ray-Coquard, Isabelle I

Publication Date: 2021-01-09

Variant appearance in text: KRAS: D33E

PubMed Link: 33435376

Variant Present in the following documents:

• Main text
• cancers-13-00220.pdf

View BVdb publication page

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Pan-cancer circulating tumor DNA detection in over 10,000 Chinese patients.

Nature Communications

Zhang, Yongliang Y; Yao, Yu Y; Xu, Yaping Y; Li, Lifeng L; Gong, Yan Y; Zhang, Kai K; Zhang, Meng M; Guan, Yanfang Y; Chang, Lianpeng L; Xia, Xuefeng X; Li, Lin L; Jia, Shuqin S; Zeng, Qiang Q

Publication Date: 2021-01-04

Variant appearance in text: KRAS: 99T>G; D33E

PubMed Link: 33397889

Variant Present in the following documents:

• 41467_2020_20162_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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KRAS Codon 12 Mutation is Associated with More Aggressive Invasiveness in Synchronous Metastatic Colorectal Cancer (mCRC): Retrospective Research.

Oncotargets And Therapy

He, Kang K; Wang, Yajing Y; Zhong, Yuejiao Y; Pan, Xiaohua X; Si, Lixiang L; Lu, Jianwei J

Publication Date: 2020

Variant appearance in text: KRAS: D33E

PubMed Link: 33335401

Variant Present in the following documents:

• Main text

View BVdb publication page

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First results of the EORTC-SPECTA/Arcagen study exploring the genomics of rare cancers in collaboration with the European reference network EURACAN.

Esmo Open

Morfouace, Marie M; Stevovic, Aleksandra A; Vinches, Marie M; Golfinopoulos, Vassilis V; Jin, Dexter X DX; Holmes, Oliver O; Erlich, Rachel R; Fayette, Jerome J; Croce, Sabrina S; Ray-Coquard, Isabelle I; Girard, Nicolas N; Blay, Jean-Yves JY

Publication Date: 2020-12

Variant appearance in text: KRAS: D33E

PubMed Link: 33262201

Variant Present in the following documents:

• Main text
• esmoopen-2020-001075.pdf

View BVdb publication page

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Whole-genome sequencing of acral melanoma reveals genomic complexity and diversity.

Nature Communications

Newell, Felicity F; Wilmott, James S JS; Johansson, Peter A PA; Nones, Katia K; Addala, Venkateswar V; Mukhopadhyay, Pamela P; Broit, Natasa N; Amato, Carol M CM; Van Gulick, Robert R; Kazakoff, Stephen H SH; Patch, Ann-Marie AM; Koufariotis, Lambros T LT; Lakis, Vanessa V; Leonard, Conrad C; Wood, Scott S; Holmes, Oliver O; Xu, Qinying Q; Lewis, Karl K; Medina, Theresa T; Gonzalez, Rene R; Saw, Robyn P M RPM; Spillane, Andrew J AJ; Stretch, Jonathan R JR; Rawson, Robert V RV; Ferguson, Peter M PM; Dodds, Tristan J TJ; Thompson, John F JF; Long, Georgina V GV; Levesque, Mitchell P MP; Robinson, William A WA; Pearson, John V JV; Mann, Graham J GJ; Scolyer, Richard A RA; Waddell, Nicola N; Hayward, Nicholas K NK

Publication Date: 2020-10-16

Variant appearance in text: KRAS: 99T>G; Asp33Glu

PubMed Link: 33067454

Variant Present in the following documents:

• 41467_2020_18988_MOESM6_ESM.xlsx, sheet 1

View BVdb publication page

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Comparative MD simulations and advanced analytics based studies on wild-type and hot-spot mutant A59G HRas.

Plos One

Sharma, Neeru N; Sonavane, Uddhavesh U; Joshi, Rajendra R

Publication Date: 2020

Variant appearance in text: KRAS: D33E

PubMed Link: 33064725

Variant Present in the following documents:

• Main text
• pone.0234836.pdf

View BVdb publication page

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Identification of relevant genetic alterations in cancer using topological data analysis.

Nature Communications

Rabadán, Raúl R; Mohamedi, Yamina Y; Rubin, Udi U; Chu, Tim T; Alghalith, Adam N AN; Elliott, Oliver O; Arnés, Luis L; Cal, Santiago S; Obaya, Álvaro J ÁJ; Levine, Arnold J AJ; Cámara, Pablo G PG

Publication Date: 2020-07-30

Variant appearance in text: KRAS: D33E

PubMed Link: 32732999

Variant Present in the following documents:

• 41467_2020_17659_MOESM3_ESM.xls, sheet 1

View BVdb publication page

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Genomic landscape of platinum resistant and sensitive testicular cancers.

Nature Communications

Loveday, Chey C; Litchfield, Kevin K; Proszek, Paula Z PZ; Cornish, Alex J AJ; Santo, Flavia F; Levy, Max M; Macintyre, Geoff G; Holryod, Amy A; Broderick, Peter P; Dudakia, Darshna D; Benton, Barbara B; Bakir, Maise Al MA; Hiley, Crispin C; Grist, Emily E; Swanton, Charles C; Huddart, Robert R; Powles, Tom T; Chowdhury, Simon S; Shipley, Janet J; O'Connor, Simon S; Brenton, James D JD; Reid, Alison A; de Castro, David Gonzalez DG; Houlston, Richard S RS; Turnbull, Clare C

Publication Date: 2020-05-04

Variant appearance in text: KRAS: D33E

PubMed Link: 32366847

Variant Present in the following documents:

• 41467_2020_15768_MOESM7_ESM.xlsx, sheet 2

View BVdb publication page

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Identification of targeted therapy options for gastric adenocarcinoma by comprehensive analysis of genomic data.

Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association

Hescheler, Daniel A DA; Plum, Patrick S PS; Zander, Thomas T; Quaas, Alexander A; Korenkov, Michael M; Gassa, Asmae A; Michel, Maximilian M; Bruns, Christiane J CJ; Alakus, Hakan H

Publication Date: 2020-07

Variant appearance in text: KRAS: D33E

PubMed Link: 32107691

Variant Present in the following documents:

• 10120_2020_1045_MOESM1_ESM.xlsx, sheet 12

View BVdb publication page

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The current understanding of KRAS protein structure and dynamics.

Computational And Structural Biotechnology Journal

Pantsar, Tatu T

Publication Date: 2020

Variant appearance in text: KRAS: D33E

PubMed Link: 31988705

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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An integrative pharmacogenomics analysis identifies therapeutic targets in KRAS-mutant lung cancer.

Ebiomedicine

Wang, Haiyun H; Lv, Qi Q; Xu, Yue Y; Cai, Zhaoqing Z; Zheng, Jie J; Cheng, Xiaojie X; Dai, Yao Y; Jänne, Pasi A PA; Ambrogio, Chiara C; Köhler, Jens J

Publication Date: 2019-11

Variant appearance in text: KRAS: D33E

PubMed Link: 31668570

Variant Present in the following documents:

• Main text
• main.pdf

View BVdb publication page

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Structures of N-terminally processed KRAS provide insight into the role of N-acetylation.

Scientific Reports

Dharmaiah, Srisathiyanarayanan S; Tran, Timothy H TH; Messing, Simon S; Agamasu, Constance C; Gillette, William K WK; Yan, Wupeng W; Waybright, Timothy T; Alexander, Patrick P; Esposito, Dominic D; Nissley, Dwight V DV; McCormick, Frank F; Stephen, Andrew G AG; Simanshu, Dhirendra K DK

Publication Date: 2019-07-19

Variant appearance in text: KRAS: D33E

PubMed Link: 31324887

Variant Present in the following documents:

• 41598_2019_Article_46846.pdf

View BVdb publication page

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Temporal and spatial effects and survival outcomes associated with concordance between tissue and blood KRAS alterations in the pan-cancer setting.

International Journal Of Cancer

Mardinian, Kristina K; Okamura, Ryosuke R; Kato, Shumei S; Kurzrock, Razelle R

Publication Date: 2020-01-15

Variant appearance in text: KRAS: D33E

PubMed Link: 31199507

Variant Present in the following documents:

• Main text

View BVdb publication page

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Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers.

Plos Computational Biology

Nussinov, Ruth R; Jang, Hyunbum H; Tsai, Chung-Jung CJ; Cheng, Feixiong F

Publication Date: 2019-03

Variant appearance in text: KRAS: D33E

PubMed Link: 30921324

Variant Present in the following documents:

• Main text
• pcbi.1006658.pdf

View BVdb publication page

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Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients.

Bmc Cancer

Koyama, Takahiko T; Rhrissorrakrai, Kahn K; Parida, Laxmi L

Publication Date: 2019-02-01

Variant appearance in text: KRAS: 99T>G; D33E

PubMed Link: 30709382

Variant Present in the following documents:

• 12885_2019_5313_MOESM3_ESM.xlsx, sheet 1

View BVdb publication page

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Comprehensive Validation of Snapback Primer-Based Melting Curve Analysis to Detect Nucleotide Variation in the Codon 12 and 13 of KRAS Gene.

Biomed Research International

Zhang, Qunfeng Q; Du, Yiqiao Y; Zhang, Xinju X; Kang, Zhihua Z; Guan, Ming M; Wu, Zhiyuan Z

Publication Date: 2018

Variant appearance in text: KRAS: D33E

PubMed Link: 30406144

Variant Present in the following documents:

• BMRI2018-8727941.pdf

View BVdb publication page

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Integrative omics analyses broaden treatment targets in human cancer.

Genome Medicine

Sengupta, Sohini S; Sun, Sam Q SQ; Huang, Kuan-Lin KL; Oh, Clara C; Bailey, Matthew H MH; Varghese, Rajees R; Wyczalkowski, Matthew A MA; Ning, Jie J; Tripathi, Piyush P; McMichael, Joshua F JF; Johnson, Kimberly J KJ; Kandoth, Cyriac C; Welch, John J; Ma, Cynthia C; Wendl, Michael C MC; Payne, Samuel H SH; Fenyö, David D; Townsend, Reid R RR; Dipersio, John F JF; Chen, Feng F; Ding, Li L

Publication Date: 2018-07-27

Variant appearance in text: KRAS: D33E

PubMed Link: 30053901

Variant Present in the following documents:

• 13073_2018_564_MOESM2_ESM.xlsx, sheet 13
• 13073_2018_564_MOESM2_ESM.xlsx, sheet 19

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Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.

Cancer Cell

Hellmann, Matthew D MD; Nathanson, Tavi T; Rizvi, Hira H; Creelan, Benjamin C BC; Sanchez-Vega, Francisco F; Ahuja, Arun A; Ni, Ai A; Novik, Jacki B JB; Mangarin, Levi M B LMB; Abu-Akeel, Mohsen M; Liu, Cailian C; Sauter, Jennifer L JL; Rekhtman, Natasha N; Chang, Eliza E; Callahan, Margaret K MK; Chaft, Jamie E JE; Voss, Martin H MH; Tenet, Megan M; Li, Xue-Mei XM; Covello, Kelly K; Renninger, Andrea A; Vitazka, Patrik P; Geese, William J WJ; Borghaei, Hossein H; Rudin, Charles M CM; Antonia, Scott J SJ; Swanton, Charles C; Hammerbacher, Jeff J; Merghoub, Taha T; McGranahan, Nicholas N; Snyder, Alexandra A; Wolchok, Jedd D JD

Publication Date: 2018-05-14

Variant appearance in text: N/A

PubMed Link: 29657128

Variant Present in the following documents:

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Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas.

Cell Reports

Way, Gregory P GP; Sanchez-Vega, Francisco F; La, Konnor K; Armenia, Joshua J; Chatila, Walid K WK; Luna, Augustin A; Sander, Chris C; Cherniack, Andrew D AD; Mina, Marco M; Ciriello, Giovanni G; Schultz, Nikolaus N; , ; Sanchez, Yolanda Y; Greene, Casey S CS

Publication Date: 2018-04-03

Variant appearance in text: KRAS: 99T>G

PubMed Link: 29617658

Variant Present in the following documents:

• NIHMS958974-supplement-5.xlsx, sheet 1
• NIHMS958974-supplement-6.xlsx, sheet 1

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KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation.

Biochemistry

Lu, Jia J; Bera, Asim K AK; Gondi, Sudershan S; Westover, Kenneth D KD

Publication Date: 2018-01-23

Variant appearance in text: KRAS: D33E

PubMed Link: 29235861

Variant Present in the following documents:

• Main text

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KRAS Alleles: The Devil Is in the Detail.

Trends In Cancer

Haigis, Kevin M KM

Publication Date: 2017-10

Variant appearance in text: KRAS: D33E

PubMed Link: 28958387

Variant Present in the following documents:

• Main text

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3D clusters of somatic mutations in cancer reveal numerous rare mutations as functional targets.

Genome Medicine

Gao, Jianjiong J; Chang, Matthew T MT; Johnsen, Hannah C HC; Gao, Sizhi Paul SP; Sylvester, Brooke E BE; Sumer, Selcuk Onur SO; Zhang, Hongxin H; Solit, David B DB; Taylor, Barry S BS; Schultz, Nikolaus N; Sander, Chris C

Publication Date: 2017-01-23

Variant appearance in text: KRAS: D33E

PubMed Link: 28115009

Variant Present in the following documents:

• Main text

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The RAS-related GTPase RHOB confers resistance to EGFR-tyrosine kinase inhibitors in non-small-cell lung cancer via an AKT-dependent mechanism.

Embo Molecular Medicine

Calvayrac, Olivier O; Mazières, Julien J; Figarol, Sarah S; Marty-Detraves, Claire C; Raymond-Letron, Isabelle I; Bousquet, Emilie E; Farella, Magali M; Clermont-Taranchon, Estelle E; Milia, Julie J; Rouquette, Isabelle I; Guibert, Nicolas N; Lusque, Amélie A; Cadranel, Jacques J; Mathiot, Nathalie N; Savina, Ariel A; Pradines, Anne A; Favre, Gilles G

Publication Date: 2017-02

Variant appearance in text: KRAS: D33E

PubMed Link: 28003335

Variant Present in the following documents:

• EMMM-9-238-s001.pdf
• EMMM-9-238-s007.pdf

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Comprehensive screening of target molecules by next-generation sequencing in patients with malignant solid tumors: guiding entry into phase I clinical trials.

Molecular Cancer

Tanabe, Yuko Y; Ichikawa, Hitoshi H; Kohno, Takashi T; Yoshida, Hiroshi H; Kubo, Takashi T; Kato, Mamoru M; Iwasa, Satoru S; Ochiai, Atsushi A; Yamamoto, Noboru N; Fujiwara, Yasuhiro Y; Tamura, Kenji K

Publication Date: 2016-11-16

Variant appearance in text: KRAS: D33E

PubMed Link: 27852271

Variant Present in the following documents:

• 12943_2016_553_MOESM3_ESM.xlsx, sheet 1

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High-throughput Phenotyping of Lung Cancer Somatic Mutations.

Cancer Cell

Berger, Alice H AH; Brooks, Angela N AN; Wu, Xiaoyun X; Shrestha, Yashaswi Y; Chouinard, Candace C; Piccioni, Federica F; Bagul, Mukta M; Kamburov, Atanas A; Imielinski, Marcin M; Hogstrom, Larson L; Zhu, Cong C; Yang, Xiaoping X; Pantel, Sasha S; Sakai, Ryo R; Watson, Jacqueline J; Kaplan, Nathan N; Campbell, Joshua D JD; Singh, Shantanu S; Root, David E DE; Narayan, Rajiv R; Natoli, Ted T; Lahr, David L DL; Tirosh, Itay I; Tamayo, Pablo P; Getz, Gad G; Wong, Bang B; Doench, John J; Subramanian, Aravind A; Golub, Todd R TR; Meyerson, Matthew M; Boehm, Jesse S JS

Publication Date: 2016-08-08

Variant appearance in text: KRAS: D33E

PubMed Link: 27478040

Variant Present in the following documents:

• Main text

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PredictSNP2: A Unified Platform for Accurately Evaluating SNP Effects by Exploiting the Different Characteristics of Variants in Distinct Genomic Regions.

Plos Computational Biology

Bendl, Jaroslav J; Musil, Miloš M; Štourač, Jan J; Zendulka, Jaroslav J; Damborský, Jiří J; Brezovský, Jan J

Publication Date: 2016-05

Variant appearance in text: KRAS: D33E

PubMed Link: 27224906

Variant Present in the following documents:

• pcbi.1004962.s005.xlsx, sheet 1

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Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.

Cell Reports

Giannakis, Marios M; Mu, Xinmeng Jasmine XJ; Shukla, Sachet A SA; Qian, Zhi Rong ZR; Cohen, Ofir O; Nishihara, Reiko R; Bahl, Samira S; Cao, Yin Y; Amin-Mansour, Ali A; Yamauchi, Mai M; Sukawa, Yasutaka Y; Stewart, Chip C; Rosenberg, Mara M; Mima, Kosuke K; Inamura, Kentaro K; Nosho, Katsuhiko K; Nowak, Jonathan A JA; Lawrence, Michael S MS; Giovannucci, Edward L EL; Chan, Andrew T AT; Ng, Kimmie K; Meyerhardt, Jeffrey A JA; Van Allen, Eliezer M EM; Getz, Gad G; Gabriel, Stacey B SB; Lander, Eric S ES; Wu, Catherine J CJ; Fuchs, Charles S CS; Ogino, Shuji S; Garraway, Levi A LA

Publication Date: 2016-04-26

Variant appearance in text: KRAS: D33E

PubMed Link: 27149842

Variant Present in the following documents:

• mmc2.xlsx, sheet 4

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Systematic Functional Interrogation of Rare Cancer Variants Identifies Oncogenic Alleles.

Cancer Discovery

Kim, Eejung E; Ilic, Nina N; Shrestha, Yashaswi Y; Zou, Lihua L; Kamburov, Atanas A; Zhu, Cong C; Yang, Xiaoping X; Lubonja, Rakela R; Tran, Nancy N; Nguyen, Cindy C; Lawrence, Michael S MS; Piccioni, Federica F; Bagul, Mukta M; Doench, John G JG; Chouinard, Candace R CR; Wu, Xiaoyun X; Hogstrom, Larson L; Natoli, Ted T; Tamayo, Pablo P; Horn, Heiko H; Corsello, Steven M SM; Lage, Kasper K; Root, David E DE; Subramanian, Aravind A; Golub, Todd R TR; Getz, Gad G; Boehm, Jesse S JS; Hahn, William C WC

Publication Date: 2016-07

Variant appearance in text: KRAS: D33E

PubMed Link: 27147599

Variant Present in the following documents:

• Main text

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Evidence that synthetic lethality underlies the mutual exclusivity of oncogenic KRAS and EGFR mutations in lung adenocarcinoma.

Elife

Unni, Arun M AM; Lockwood, William W WW; Zejnullahu, Kreshnik K; Lee-Lin, Shih-Queen SQ; Varmus, Harold H

Publication Date: 2015-06-05

Variant appearance in text: KRAS: D33E

PubMed Link: 26047463

Variant Present in the following documents:

• Main text
• elife06907.pdf

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Applicability of next-generation sequencing to decalcified formalin-fixed and paraffin-embedded chronic myelomonocytic leukaemia samples.

International Journal Of Clinical And Experimental Pathology

Bernard, Veronica V; Gebauer, Niklas N; Dinh, Thomas T; Stegemann, Judith J; Feller, Alfred C AC; Merz, Hartmut H

Publication Date: 2014

Variant appearance in text: KRAS: D33E

PubMed Link: 24817963

Variant Present in the following documents:

• Main text

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Modelling mutational landscapes of human cancers in vitro.

Scientific Reports

Olivier, Magali M; Weninger, Annette A; Ardin, Maude M; Huskova, Hana H; Castells, Xavier X; Vallée, Maxime P MP; McKay, James J; Nedelko, Tatiana T; Muehlbauer, Karl-Rudolf KR; Marusawa, Hiroyuki H; Alexander, John J; Hazelwood, Lee L; Byrnes, Graham G; Hollstein, Monica M; Zavadil, Jiri J

Publication Date: 2014-03-27

Variant appearance in text: KRAS: D33E

PubMed Link: 24670820

Variant Present in the following documents:

• srep04482-s4.xls, sheet 19

View BVdb publication page

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