Publications:

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Genomic mutation features identify distinct BRCA-associated mutation characteristics in endometrioid carcinoma and endometrioid ovarian carcinoma.

Aging

Cao, Canhui C; Yu, Ruidi R; Gong, Wenjian W; Liu, Dan D; Zhang, Xiaoxue X; Fang, Yong Y; Xia, Yu Y; Zhang, Wei W; Gao, Qinglei Q

Publication Date: 2021-11-27

Variant appearance in text: KRAS: 95A>T

PubMed Link: 34837690

Variant Present in the following documents:

• aging-13-203710-s004.xlsx, sheet 1

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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.

Nature Communications

Gebregiworgis, Teklab T; Kano, Yoshihito Y; St-Germain, Jonathan J; Radulovich, Nikolina N; Udaskin, Molly L ML; Mentes, Ahmet A; Huang, Richard R; Poon, Betty P K BPK; He, Wenguang W; Valencia-Sama, Ivette I; Robinson, Claire M CM; Huestis, Melissa M; Miao, Jinmin J; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Irwin, Meredith S MS; Lee, Jeffrey E JE; Tsao, Ming-Sound MS; Raught, Brian B; Marshall, Christopher B CB; Ohh, Michael M; Ikura, Mitsuhiko M

Publication Date: 2021-11-01

Variant appearance in text: KRAS: Y32F

PubMed Link: 34725361

Variant Present in the following documents:

• Main text
• 41467_2021_26526_MOESM1_ESM.pdf

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Structural impact of GTP binding on downstream KRAS signaling.

Chemical Science

Menyhárd, Dóra K DK; Pálfy, Gyula G; Orgován, Zoltán Z; Vida, István I; Keserű, György M GM; Perczel, András A

Publication Date: 2020-08-19

Variant appearance in text: KRAS: Y32F

PubMed Link: 34094198

Variant Present in the following documents:

• Main text
• SC-011-D0SC03441J.pdf

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Genomic Profiling of Uterine Aspirates and cfDNA as an Integrative Liquid Biopsy Strategy in Endometrial Cancer.

Journal Of Clinical Medicine

Casas-Arozamena, Carlos C; Díaz, Eva E; Moiola, Cristian Pablo CP; Alonso-Alconada, Lorena L; Ferreirós, Alba A; Abalo, Alicia A; Gil, Carlos López CL; Oltra, Sara S SS; de Santiago, Javier J; Cabrera, Silvia S; Sampayo, Victoria V; Bouso, Marta M; Arias, Efigenia E; Cueva, Juan J; Colas, Eva E; Vilar, Ana A; Gil-Moreno, Antonio A; Abal, Miguel M; Moreno-Bueno, Gema G; Muinelo-Romay, Laura L

Publication Date: 2020-02-21

Variant appearance in text: KRAS: 95A>T

PubMed Link: 32098121

Variant Present in the following documents:

• jcm-09-00585-s001.pdf

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Development, Implementation and Assessment of Molecular Diagnostics by Next Generation Sequencing in Personalized Treatment of Cancer: Experience of a Public Reference Healthcare Hospital.

Cancers

Simarro, Javier J; Murria, Rosa R; Pérez-Simó, Gema G; Llop, Marta M; Mancheño, Nuria N; Ramos, David D; Juan, Inmaculada de I; Barragán, Eva E; Laiz, Begoña B; Cases, Enrique E; Ansótegui, Emilio E; Gómez-Codina, José J; Aparicio, Jorge J; Salvador, Carmen C; Juan, Óscar Ó; Palanca, Sarai S

Publication Date: 2019-08-16

Variant appearance in text: KRAS: 95A>T

PubMed Link: 31426418

Variant Present in the following documents:

• cancers-11-01196-s001.pdf

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Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.

Nature Communications

Kano, Yoshihito Y; Gebregiworgis, Teklab T; Marshall, Christopher B CB; Radulovich, Nikolina N; Poon, Betty P K BPK; St-Germain, Jonathan J; Cook, Jonathan D JD; Valencia-Sama, Ivette I; Grant, Benjamin M M BMM; Herrera, Silvia Gabriela SG; Miao, Jinmin J; Raught, Brian B; Irwin, Meredith S MS; Lee, Jeffrey E JE; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Tsao, Ming-Sound MS; Ikura, Mitsuhiko M; Ohh, Michael M

Publication Date: 2019-01-15

Variant appearance in text: KRAS: Y32F

PubMed Link: 30644389

Variant Present in the following documents:

• Main text
• 41467_2018_Article_8115.pdf

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Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis.

Nature Communications

Bunda, Severa S; Burrell, Kelly K; Heir, Pardeep P; Zeng, Lifan L; Alamsahebpour, Amir A; Kano, Yoshihito Y; Raught, Brian B; Zhang, Zhong-Yin ZY; Zadeh, Gelareh G; Ohh, Michael M

Publication Date: 2015-11-30

Variant appearance in text: KRAS: Y32F

PubMed Link: 26617336

Variant Present in the following documents:

• ncomms9859.pdf

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The distinct conformational dynamics of K-Ras and H-Ras A59G.

Plos Computational Biology

Lukman, Suryani S; Grant, Barry J BJ; Gorfe, Alemayehu A AA; Grant, Guy H GH; McCammon, J Andrew JA

Publication Date: 2010-09-09

Variant appearance in text: K-Ras4B: Y32F

PubMed Link: 20838576

Variant Present in the following documents:

• Main text
• pcbi.1000922.pdf

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