KRAS c.91G>A ;(p.E31K)

Variant ID: 12-25398228-C-T

NM_004985.3(KRAS):c.91G>A;(p.E31K)

This variant was identified in 23 publications

View GRCh38 version.




Publications:


Mutually exclusive genetic interactions and gene essentiality shape the genomic landscape of primary melanoma.

The Journal Of Pathology
Birkeälv, Sofia S; Harland, Mark M; Matsuyama, Larissa Satiko Alcantara Sekimoto LSAS; Rashid, Mamun M; Mehta, Ishan I; Laye, Jonathan P JP; Haase, Kerstin K; Mell, Tracey T; Iyer, Vivek V; Robles-Espinoza, Carla Daniela CD; McDermott, Ultan U; van Loo, Peter P; Kuijjer, Marieke L ML; Possik, Patricia A PA; Maria Engler, Silvya Stuchi SS; Bishop, D Timothy DT; Newton-Bishop, Julia J; Adams, David J DJ
Publication Date: 2022-10-11

Variant appearance in text: KRAS: E31K
PubMed Link: 36219477
Variant Present in the following documents:
  • PATH-259-56-s006.xlsx, sheet 2
  • PATH-259-56-s004.xlsx, sheet 2
View BVdb publication page



Correlation of changes in subclonal architecture with progression in the MMRF CoMMpass study.

Translational Oncology
Kaur, Gurvinder G; Jena, Lingaraja L; Gupta, Ritu R; Farswan, Akanksha A; Gupta, Anubha A; Sriram, K K
Publication Date: 2022-06-28

Variant appearance in text: KRAS: 91G>A
PubMed Link: 35777247
Variant Present in the following documents:
  • mmc5.xls, sheet 3
View BVdb publication page



Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

International Journal Of Molecular Medicine
Chevrier, Sandy S; Brasselet, Astrid A; Carnet, Marion M; Chevriaux, Angélique A; Gibeaud, Anne A; Jourdain, Marine M; Mananet, Hugo H; Truntzer, Caroline C; Beltjens, Françoise F; Charon-Barra, Céline C; Arnould, Laurent L; Albuisson, Juliette J; Comte, Anthony A; Derangère, Valentin V; Goussot, Vincent V; Boidot, Romain R
Publication Date: 2022-05

Variant appearance in text: KRAS: 91G>A; Glu31Lys
PubMed Link: 35244186
Variant Present in the following documents:
  • Supplementary_Data3.xlsx, sheet 1
  • Supplementary_Data2.xlsx, sheet 1
View BVdb publication page



A full-proteome, interaction-specific characterization of mutational hotspots across human cancers.

Genome Research
Chen, Siwei S; Liu, Yuan Y; Zhang, Yingying Y; Wierbowski, Shayne D SD; Lipkin, Steven M SM; Wei, Xiaomu X; Yu, Haiyuan H
Publication Date: 2022-01

Variant appearance in text: KRAS: E31K
PubMed Link: 34963661
Variant Present in the following documents:
  • supp_gr.275437.121_Supplementary_Table_1.xlsx, sheet 3
View BVdb publication page



Discovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients.

Bioengineered
Rasool, Mahmood M; Carracedo, Angel A; Sibiany, Abdulrahman A; Al-Sayes, Faten F; Karim, Sajjad S; Haque, Absarul A; Natesan Pushparaj, Peter P; Asif, Muhammad M; Achakzai, Niaz M NM
Publication Date: 2021-12

Variant appearance in text: KRAS: 91G>A; Glu31Lys
PubMed Link: 34369256
Variant Present in the following documents:
  • Main text
  • KBIE_12_1960715.pdf
View BVdb publication page



Discovery of a novel and a rare Kristen rat sarcoma viral oncogene homolog (KRAS) gene mutation in colorectal cancer patients.

Bioengineered
Rasool, Mahmood M; Carracedo, Angel A; Sibiany, Abdulrahman A; Al-Sayes, Faten F; Karim, Sajjad S; Haque, Absarul A; Natesan Pushparaj, Peter P; Asif, Muhammad M; Achakzai, Niaz M NM
Publication Date: 2021-12

Variant appearance in text: KRAS: 91G>A; Glu31Lys
PubMed Link: 34369256
Variant Present in the following documents:
  • Main text
  • KBIE_12_1960715.pdf
View BVdb publication page



Reprogramming of bivalent chromatin states in NRAS mutant melanoma suggests PRC2 inhibition as a therapeutic strategy.

Cell Reports
Terranova, Christopher J CJ; Tang, Ming M; Maitituoheti, Mayinuer M; Raman, Ayush T AT; Ghosh, Archit K AK; Schulz, Jonathan J; Amin, Samir B SB; Orouji, Elias E; Tomczak, Katarzyna K; Sarkar, Sharmistha S; Oba, Junna J; Creasy, Caitlin C; Wu, Chang-Jiun CJ; Khan, Samia S; Lazcano, Rossana R; Wani, Khalida K; Singh, Anand A; Barrodia, Praveen P; Zhao, Dongyu D; Chen, Kaifu K; Haydu, Lauren E LE; Wang, Wei-Lien WL; Lazar, Alexander J AJ; Woodman, Scott E SE; Bernatchez, Chantale C; Rai, Kunal K
Publication Date: 2021-07-20

Variant appearance in text: KRAS: E31K
PubMed Link: 34289358
Variant Present in the following documents:
  • NIHMS1727018-supplement-2.xlsx, sheet 2
View BVdb publication page



KRAS G12C mutations in Asia: a landscape analysis of 11,951 Chinese tumor samples.

Translational Lung Cancer Research
Loong, Herbert Ho-Fung HH; Du, Nan N; Cheng, Chunyan C; Lin, Hanqing H; Guo, Jian J; Lin, Gen G; Li, Mingjiang M; Jiang, Tao T; Shi, Zhihua Z; Cui, Yanzhi Y; Jin, Xianfeng X; Yao, Jicheng J; Xing, Yutong Y; Yao, Ming M; Wang, Kai K; Mok, Tony S K TSK; Liu, Lunxu L
Publication Date: 2020-10

Variant appearance in text: KRAS: E31K
PubMed Link: 33209599
Variant Present in the following documents:
  • Main text
  • tlcr-09-05-1759.pdf
View BVdb publication page



Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.

Nature Communications
Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U
Publication Date: 2020-07-20

Variant appearance in text: KRAS: E31K
PubMed Link: 32686686
Variant Present in the following documents:
  • 41467_2020_17386_MOESM4_ESM.xlsx, sheet 1
View BVdb publication page



The Mystery of Rap1 Suppression of Oncogenic Ras.

Trends In Cancer
Nussinov, Ruth R; Jang, Hyunbum H; Zhang, Mingzhen M; Tsai, Chung-Jung CJ; Sablina, Anna A AA
Publication Date: 2020-05

Variant appearance in text: KRAS: E31K
PubMed Link: 32249186
Variant Present in the following documents:
  • Main text
View BVdb publication page



A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Frontiers In Oncology
Muñoz-Maldonado, Carmen C; Zimmer, Yitzhak Y; Medová, Michaela M
Publication Date: 2019

Variant appearance in text: KRAS: E31K
PubMed Link: 31681616
Variant Present in the following documents:
  • Main text
  • fonc-09-01088.pdf
View BVdb publication page



Molecular association of functioning stroma with carcinoma cells in the ovary: A preliminary study.

Oncology Letters
Narikiyo, Mika M; Yano, Mitsutake M; Kamada, Kouichi K; Katoh, Tomomi T; Ito, Kozue K; Shuto, Masayo M; Kayano, Hidekazu H; Yasuda, Masanori M
Publication Date: 2019-03

Variant appearance in text: KRAS: E31K
PubMed Link: 30867798
Variant Present in the following documents:
  • Main text
View BVdb publication page



Analysis on GENIE reveals novel recurrent variants that affect molecular diagnosis of sizable number of cancer patients.

Bmc Cancer
Koyama, Takahiko T; Rhrissorrakrai, Kahn K; Parida, Laxmi L
Publication Date: 2019-02-01

Variant appearance in text: KRAS: 91G>A; E31K
PubMed Link: 30709382
Variant Present in the following documents:
  • 12885_2019_5313_MOESM3_ESM.xlsx, sheet 1
View BVdb publication page



Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.

Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Publication Date: 2018

Variant appearance in text: KRAS: E31K
PubMed Link: 29698444
Variant Present in the following documents:
  • pone.0196434.s001.xlsx, sheet 3
  • pone.0196434.s001.xlsx, sheet 1
  • pone.0196434.s001.xlsx, sheet 2
View BVdb publication page



Scalable whole-exome sequencing of cell-free DNA reveals high concordance with metastatic tumors.

Nature Communications
Adalsteinsson, Viktor A VA; Ha, Gavin G; Freeman, Samuel S SS; Choudhury, Atish D AD; Stover, Daniel G DG; Parsons, Heather A HA; Gydush, Gregory G; Reed, Sarah C SC; Rotem, Denisse D; Rhoades, Justin J; Loginov, Denis D; Livitz, Dimitri D; Rosebrock, Daniel D; Leshchiner, Ignaty I; Kim, Jaegil J; Stewart, Chip C; Rosenberg, Mara M; Francis, Joshua M JM; Zhang, Cheng-Zhong CZ; Cohen, Ofir O; Oh, Coyin C; Ding, Huiming H; Polak, Paz P; Lloyd, Max M; Mahmud, Sairah S; Helvie, Karla K; Merrill, Margaret S MS; Santiago, Rebecca A RA; O'Connor, Edward P EP; Jeong, Seong H SH; Leeson, Rachel R; Barry, Rachel M RM; Kramkowski, Joseph F JF; Zhang, Zhenwei Z; Polacek, Laura L; Lohr, Jens G JG; Schleicher, Molly M; Lipscomb, Emily E; Saltzman, Andrea A; Oliver, Nelly M NM; Marini, Lori L; Waks, Adrienne G AG; Harshman, Lauren C LC; Tolaney, Sara M SM; Van Allen, Eliezer M EM; Winer, Eric P EP; Lin, Nancy U NU; Nakabayashi, Mari M; Taplin, Mary-Ellen ME; Johannessen, Cory M CM; Garraway, Levi A LA; Golub, Todd R TR; Boehm, Jesse S JS; Wagle, Nikhil N; Getz, Gad G; Love, J Christopher JC; Meyerson, Matthew M
Publication Date: 2017-11-06

Variant appearance in text: KRAS: E31K
PubMed Link: 29109393
Variant Present in the following documents:
  • 41467_2017_965_MOESM7_ESM.xlsx, sheet 1
  • 41467_2017_965_MOESM7_ESM.xlsx, sheet 5
View BVdb publication page



Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers.

Gastroenterology
Cho, Soo Young SY; Park, Jun Won JW; Liu, Yang Y; Park, Young Soo YS; Kim, Ju Hee JH; Yang, Hanna H; Um, Hyejin H; Ko, Woo Ri WR; Lee, Byung Il BI; Kwon, Sun Young SY; Ryu, Seung Wan SW; Kwon, Chae Hwa CH; Park, Do Youn DY; Lee, Jae-Hyuk JH; Lee, Sang Il SI; Song, Kyu Sang KS; Hur, Hoon H; Han, Sang-Uk SU; Chang, Heekyung H; Kim, Su-Jin SJ; Kim, Byung-Sik BS; Yook, Jeong-Hwan JH; Yoo, Moon-Won MW; Kim, Beom-Su BS; Lee, In-Seob IS; Kook, Myeong-Cherl MC; Thiessen, Nina N; He, An A; Stewart, Chip C; Dunford, Andrew A; Kim, Jaegil J; Shih, Juliann J; Saksena, Gordon G; Cherniack, Andrew D AD; Schumacher, Steven S; Weiner, Amaro-Taylor AT; Rosenberg, Mara M; Getz, Gad G; Yang, Eun Gyeong EG; Ryu, Min-Hee MH; Bass, Adam J AJ; Kim, Hark Kyun HK
Publication Date: 2017-08

Variant appearance in text: KRAS: 91G>A; Glu31Lys
PubMed Link: 28522256
Variant Present in the following documents:
  • NIHMS1058936-supplement-Table_S3.xlsx, sheet 1
View BVdb publication page



Circulating tumour DNA sequence analysis as an alternative to multiple myeloma bone marrow aspirates.

Nature Communications
Kis, Olena O; Kaedbey, Rayan R; Chow, Signy S; Danesh, Arnavaz A; Dowar, Mark M; Li, Tiantian T; Li, Zhihua Z; Liu, Jessica J; Mansour, Mark M; Masih-Khan, Esther E; Zhang, Tong T; Bratman, Scott V SV; Oza, Amit M AM; Kamel-Reid, Suzanne S; Trudel, Suzanne S; Pugh, Trevor J TJ
Publication Date: 2017-05-11

Variant appearance in text: KRAS: 91G>A
PubMed Link: 28492226
Variant Present in the following documents:
  • ncomms15086-s3.xlsx, sheet 1
View BVdb publication page



The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy.

Oncotarget
Ahn, Sung-Min SM; Ansari, Adnan Ahmad AA; Kim, Jihun J; Kim, Deokhoon D; Chun, Sung-Min SM; Kim, Jiyun J; Kim, Tae Won TW; Park, Inja I; Yu, Chang-Sik CS; Jang, Se Jin SJ
Publication Date: 2016-10-18

Variant appearance in text: KRAS: E31K
PubMed Link: 27612425
Variant Present in the following documents:
  • oncotarget-07-68638-s008.xlsx, sheet 1
View BVdb publication page



Intratumoral KIT mutational heterogeneity and recurrent KIT/ PDGFRA mutations in KIT/PDGFRA wild-type gastrointestinal stromal tumors.

Oncotarget
Gao, Jing J; Li, Jian J; Li, Yanyan Y; Li, Zhongwu Z; Gong, Jifang J; Wu, Jian J; Liu, Na N; Dong, Bin B; Qi, Changsong C; Li, Jie J; Shen, Lin L
Publication Date: 2016-05-24

Variant appearance in text: KRAS: 91G>A; E31K
PubMed Link: 26848617
Variant Present in the following documents:
  • oncotarget-07-30241-s002.xlsx, sheet 1
View BVdb publication page



Compound EGFR mutation is frequently detected with co-mutations of actionable genes and associated with poor clinical outcome in lung adenocarcinoma.

Cancer Biology & Therapy
Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS
Publication Date: 2016

Variant appearance in text: KRAS: 91G>A
PubMed Link: 26785607
Variant Present in the following documents:
  • kcbt-17-03-1139235.pdf
View BVdb publication page



Genetic heterogeneity of actionable genes between primary and metastatic tumor in lung adenocarcinoma.

Bmc Cancer
Kim, Eun Young EY; Cho, Eun Na EN; Park, Heae Surng HS; Kim, Arum A; Hong, Ji Young JY; Lim, Seri S; Youn, Jong Pil JP; Hwang, Seung Yong SY; Chang, Yoon Soo YS
Publication Date: 2016-01-18

Variant appearance in text: KRAS: 91G>A
PubMed Link: 26782967
Variant Present in the following documents:
  • 12885_2016_2049_MOESM1_ESM.xlsx, sheet 1
View BVdb publication page



GTP-Dependent K-Ras Dimerization.

Structure (London, England : 1993)
Muratcioglu, Serena S; Chavan, Tanmay S TS; Freed, Benjamin C BC; Jang, Hyunbum H; Khavrutskii, Lyuba L; Freed, R Natasha RN; Dyba, Marzena A MA; Stefanisko, Karen K; Tarasov, Sergey G SG; Gursoy, Attila A; Keskin, Ozlem O; Tarasova, Nadya I NI; Gaponenko, Vadim V; Nussinov, Ruth R
Publication Date: 2015-07-07

Variant appearance in text: K-Ras4B: E31K
PubMed Link: 26051715
Variant Present in the following documents:
  • Main text
View BVdb publication page



Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin.

Genome Medicine
Alakus, Hakan H; Babicky, Michele L ML; Ghosh, Pradipta P; Yost, Shawn S; Jepsen, Kristen K; Dai, Yang Y; Arias, Angelo A; Samuels, Michael L ML; Mose, Evangeline S ES; Schwab, Richard B RB; Peterson, Michael R MR; Lowy, Andrew M AM; Frazer, Kelly A KA; Harismendy, Olivier O
Publication Date: 2014

Variant appearance in text: KRAS: E31K
PubMed Link: 24944587
Variant Present in the following documents:
  • gm559-S3.xls, sheet 12
View BVdb publication page



Genomic and biological characterization of exon 4 KRAS mutations in human cancer.

Cancer Research
Janakiraman, Manickam M; Vakiani, Efsevia E; Zeng, Zhaoshi Z; Pratilas, Christine A CA; Taylor, Barry S BS; Chitale, Dhananjay D; Halilovic, Ensar E; Wilson, Manda M; Huberman, Kety K; Ricarte Filho, Julio Cezar JC; Persaud, Yogindra Y; Levine, Douglas A DA; Fagin, James A JA; Jhanwar, Suresh C SC; Mariadason, John M JM; Lash, Alex A; Ladanyi, Marc M; Saltz, Leonard B LB; Heguy, Adriana A; Paty, Philip B PB; Solit, David B DB
Publication Date: 2010-07-15

Variant appearance in text: KRAS: E31K
PubMed Link: 20570890
Variant Present in the following documents:
  • Main text
View BVdb publication page