Elucidating the mechanism behind and investigating the efficacy of Traditional Chinese Medicine and Traditional Tibetan Medicine in combination with standard therapeutics in hepatocellular carcinoma and cholangiocarcinoma in vitro.
Frontiers In Pharmacology
Suo, Huizhen H; Hochnadel, Inga I; Petriv, Nataliia N; Franke, Raimo R; Schmidt, Jennifer J; Limanska, Nataliia N; Tugai, Alisa A; Jedicke, Nils N; Broenstrup, Mark M; Manns, Michael P MP; Yevsa, Tetyana T
Efficacy and safety of first-line checkpoint inhibitors-based treatments for non-oncogene-addicted non-small-cell lung cancer: a systematic review and meta-analysis.
Esmo Open
Siciliano, M A MA; Caridà, G G; Ciliberto, D D; d'Apolito, M M; Pelaia, C C; Caracciolo, D D; Riillo, C C; Correale, P P; Galvano, A A; Russo, A A; Barbieri, V V; Tassone, P P; Tagliaferri, P P
Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers.
Acs Central Science
Avital-Shmilovici, Michal M; Liu, Xiaohe X; Shaler, Thomas T; Lowenthal, Andrew A; Bourbon, Pauline P; Snider, Janey J; Tambo-Ong, Arlyn A; Repellin, Claire C; Yniguez, Kenya K; Sambucetti, Lidia L; Madrid, Peter B PB; Collins, Nathan N
MicroRNA-16 Restores Sensitivity to Tyrosine Kinase Inhibitors and Outperforms MEK Inhibitors in KRAS-Mutated Non-Small Cell Lung Cancer.
International Journal Of Molecular Sciences
Fanini, Francesca F; Bandini, Erika E; Plousiou, Meropi M; Carloni, Silvia S; Wise, Petra P; Neviani, Paolo P; Murtadha, Mariam M; Foca, Flavia F; Fabbri, Francesco F; Vannini, Ivan I; Fabbri, Muller M
MicroRNA-16 Restores Sensitivity to Tyrosine Kinase Inhibitors and Outperforms MEK Inhibitors in KRAS-Mutated Non-Small Cell Lung Cancer.
International Journal Of Molecular Sciences
Fanini, Francesca F; Bandini, Erika E; Plousiou, Meropi M; Carloni, Silvia S; Wise, Petra P; Neviani, Paolo P; Murtadha, Mariam M; Foca, Flavia F; Fabbri, Francesco F; Vannini, Ivan I; Fabbri, Muller M
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
Nature Communications
Gebregiworgis, Teklab T; Kano, Yoshihito Y; St-Germain, Jonathan J; Radulovich, Nikolina N; Udaskin, Molly L ML; Mentes, Ahmet A; Huang, Richard R; Poon, Betty P K BPK; He, Wenguang W; Valencia-Sama, Ivette I; Robinson, Claire M CM; Huestis, Melissa M; Miao, Jinmin J; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Irwin, Meredith S MS; Lee, Jeffrey E JE; Tsao, Ming-Sound MS; Raught, Brian B; Marshall, Christopher B CB; Ohh, Michael M; Ikura, Mitsuhiko M
Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma.
Cancers
Hoppe, Sascha S; Jonas, Christoph C; Wenzel, Marten Christian MC; Velazquez Camacho, Oscar O; Arolt, Christoph C; Zhao, Yue Y; Büttner, Reinhard R; Quaas, Alexander A; Plum, Patrick Sven PS; Hillmer, Axel Maximilian AM
The expressed mutational landscape of microsatellite stable colorectal cancers.
Genome Medicine
Sveen, Anita A; Johannessen, Bjarne B; Eilertsen, Ina A IA; Røsok, Bård I BI; Gulla, Marie M; Eide, Peter W PW; Bruun, Jarle J; Kryeziu, Kushtrim K; Meza-Zepeda, Leonardo A LA; Myklebost, Ola O; Bjørnbeth, Bjørn A BA; Skotheim, Rolf I RI; Nesbakken, Arild A; Lothe, Ragnhild A RA
Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.
Angewandte Chemie (International Ed. In English)
Lee, Ki-Young KY; Fang, Zhenhao Z; Enomoto, Masahiro M; Gasmi-Seabrook, Genevieve G; Zheng, Le L; Koide, Shohei S; Ikura, Mitsuhiko M; Marshall, Christopher B CB
Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy.
Acs Nano
Xie, Ying Y; Hang, Yu Y; Wang, Yazhe Y; Sleightholm, Richard R; Prajapati, Dipakkumar R DR; Bader, Johannes J; Yu, Ao A; Tang, Weimin W; Jaramillo, Lee L; Li, Jing J; Singh, Rakesh K RK; Oupický, David D
Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer.
Molecular Cancer Research : Mcr
Sethunath, Vidyalakshmi V; Hu, Huizhong H; De Angelis, Carmine C; Veeraraghavan, Jamunarani J; Qin, Lanfang L; Wang, Nicholas N; Simon, Lukas M LM; Wang, Tao T; Fu, Xiaoyong X; Nardone, Agostina A; Pereira, Resel R; Nanda, Sarmistha S; Griffith, Obi L OL; Tsimelzon, Anna A; Shaw, Chad C; Chamness, Gary C GC; Reis-Filho, Jorge S JS; Weigelt, Britta B; Heiser, Laura M LM; Hilsenbeck, Susan G SG; Huang, Shixia S; Rimawi, Mothaffar F MF; Gray, Joe W JW; Osborne, C Kent CK; Schiff, Rachel R
Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy.
Molecular Cancer
Xu, Ke K; Park, Dongkyoo D; Magis, Andrew T AT; Zhang, Jun J; Zhou, Wei W; Sica, Gabriel L GL; Ramalingam, Suresh S SS; Curran, Walter J WJ; Deng, Xingming X
NMR solution structure of an asymmetric intermolecular leaped V-shape G-quadruplex: selective recognition of the d(G2NG3NG4) sequence motif by a short linear G-rich DNA probe.
Nucleic Acids Research
Wan, Chanjuan C; Fu, Wenqiang W; Jing, Haitao H; Zhang, Na N
LZTR1 is a regulator of RAS ubiquitination and signaling.
Science (New York, N.Y.)
Bigenzahn, Johannes W JW; Collu, Giovanna M GM; Kartnig, Felix F; Pieraks, Melanie M; Vladimer, Gregory I GI; Heinz, Leonhard X LX; Sedlyarov, Vitaly V; Schischlik, Fiorella F; Fauster, Astrid A; Rebsamen, Manuele M; Parapatics, Katja K; Blomen, Vincent A VA; Müller, André C AC; Winter, Georg E GE; Kralovics, Robert R; Brummelkamp, Thijn R TR; Mlodzik, Marek M; Superti-Furga, Giulio G
Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.
Nature Communications
Li, Xiaodun X; Francies, Hayley E HE; Secrier, Maria M; Perner, Juliane J; Miremadi, Ahmad A; Galeano-Dalmau, Núria N; Barendt, William J WJ; Letchford, Laura L; Leyden, Genevieve M GM; Goffin, Emma K EK; Barthorpe, Andrew A; Lightfoot, Howard H; Chen, Elisabeth E; Gilbert, James J; Noorani, Ayesha A; Devonshire, Ginny G; Bower, Lawrence L; Grantham, Amber A; MacRae, Shona S; Grehan, Nicola N; Wedge, David C DC; Fitzgerald, Rebecca C RC; Garnett, Mathew J MJ
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.
Science (New York, N.Y.)
Engblom, Camilla C; Pfirschke, Christina C; Zilionis, Rapolas R; Da Silva Martins, Janaina J; Bos, Stijn A SA; Courties, Gabriel G; Rickelt, Steffen S; Severe, Nicolas N; Baryawno, Ninib N; Faget, Julien J; Savova, Virginia V; Zemmour, David D; Kline, Jaclyn J; Siwicki, Marie M; Garris, Christopher C; Pucci, Ferdinando F; Liao, Hsin-Wei HW; Lin, Yi-Jang YJ; Newton, Andita A; Yaghi, Omar K OK; Iwamoto, Yoshiko Y; Tricot, Benoit B; Wojtkiewicz, Gregory R GR; Nahrendorf, Matthias M; Cortez-Retamozo, Virna V; Meylan, Etienne E; Hynes, Richard O RO; Demay, Marie M; Klein, Allon A; Bredella, Miriam A MA; Scadden, David T DT; Weissleder, Ralph R; Pittet, Mikael J MJ
Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.
Cancer Discovery
Brastianos, Priscilla K PK; Carter, Scott L SL; Santagata, Sandro S; Cahill, Daniel P DP; Taylor-Weiner, Amaro A; Jones, Robert T RT; Van Allen, Eliezer M EM; Lawrence, Michael S MS; Horowitz, Peleg M PM; Cibulskis, Kristian K; Ligon, Keith L KL; Tabernero, Josep J; Seoane, Joan J; Martinez-Saez, Elena E; Curry, William T WT; Dunn, Ian F IF; Paek, Sun Ha SH; Park, Sung-Hye SH; McKenna, Aaron A; Chevalier, Aaron A; Rosenberg, Mara M; Barker, Frederick G FG; Gill, Corey M CM; Van Hummelen, Paul P; Thorner, Aaron R AR; Johnson, Bruce E BE; Hoang, Mai P MP; Choueiri, Toni K TK; Signoretti, Sabina S; Sougnez, Carrie C; Rabin, Michael S MS; Lin, Nancy U NU; Winer, Eric P EP; Stemmer-Rachamimov, Anat A; Meyerson, Matthew M; Garraway, Levi L; Gabriel, Stacey S; Lander, Eric S ES; Beroukhim, Rameen R; Batchelor, Tracy T TT; Baselga, Jose J; Louis, David N DN; Getz, Gad G; Hahn, William C WC
Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin.
Genome Medicine
Alakus, Hakan H; Babicky, Michele L ML; Ghosh, Pradipta P; Yost, Shawn S; Jepsen, Kristen K; Dai, Yang Y; Arias, Angelo A; Samuels, Michael L ML; Mose, Evangeline S ES; Schwab, Richard B RB; Peterson, Michael R MR; Lowy, Andrew M AM; Frazer, Kelly A KA; Harismendy, Olivier O
Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
Cancer Research
Hata, Aaron N AN; Yeo, Alan A; Faber, Anthony C AC; Lifshits, Eugene E; Chen, Zhao Z; Cheng, Katherine A KA; Walton, Zandra Z; Sarosiek, Kristopher A KA; Letai, Anthony A; Heist, Rebecca S RS; Mino-Kenudson, Mari M; Wong, Kwok-Kin KK; Engelman, Jeffrey A JA
Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets.
Science Signaling
Miller, Martin L ML; Molinelli, Evan J EJ; Nair, Jayasree S JS; Sheikh, Tahir T; Samy, Rita R; Jing, Xiaohong X; He, Qin Q; Korkut, Anil A; Crago, Aimee M AM; Singer, Samuel S; Schwartz, Gary K GK; Sander, Chris C