Publications:

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Systematic analysis of the aberrances and functional implications of cuproptosis in cancer.

Iscience

Li, Jiangbing J; Li, Boyan B; Zhao, Rongrong R; Li, Gang G

Publication Date: 2023-04-21

Variant appearance in text: KRAS: S17A

PubMed Link: 36950125

Variant Present in the following documents:

• main.pdf

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A compendium of co-regulated mitoribosomal proteins in pan-cancer uncovers collateral defective events in tumor malignancy.

Iscience

Chang, Ching-Wen CW; Wei, Zhuang Z; Durell, Stewart R SR; Ma, Lichun L; Forgues, Marshonna M; Wang, Xin Wei XW

Publication Date: 2022-10-21

Variant appearance in text: KRAS: S17A

PubMed Link: 36274950

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• main.pdf

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Elucidating the mechanism behind and investigating the efficacy of Traditional Chinese Medicine and Traditional Tibetan Medicine in combination with standard therapeutics in hepatocellular carcinoma and cholangiocarcinoma in vitro.

Frontiers In Pharmacology

Suo, Huizhen H; Hochnadel, Inga I; Petriv, Nataliia N; Franke, Raimo R; Schmidt, Jennifer J; Limanska, Nataliia N; Tugai, Alisa A; Jedicke, Nils N; Broenstrup, Mark M; Manns, Michael P MP; Yevsa, Tetyana T

Publication Date: 2022

Variant appearance in text: KRAS: S17A

PubMed Link: 36172191

Variant Present in the following documents:

• Main text

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Targeting oncogenic KRAS with molecular brush-conjugated antisense oligonucleotides.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Wang, Dali D; Wang, Qiwei Q; Wang, Yuyan Y; Chen, Peiru P; Lu, Xueguang X; Jia, Fei F; Sun, Yehui Y; Sun, Tingyu T; Zhang, Lei L; Che, Fangyuan F; He, Jialu J; Lian, Liming L; Morano, Gemma G; Shen, Michael M; Ren, Mengqi M; Dong, Sijia S SS; Zhao, Jean J JJ; Zhang, Ke K

Publication Date: 2022-07-19

Variant appearance in text: KRAS: S17A

PubMed Link: 35858356

Variant Present in the following documents:

• pnas.202113180.pdf

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Loss of adipose TET proteins enhances β-adrenergic responses and protects against obesity by epigenetic regulation of β3-AR expression.

Proceedings Of The National Academy Of Sciences Of The United States Of America

Byun, Seongjun S; Lee, Chan Hyeong CH; Jeong, Hyeongmin H; Kim, Hyejin H; Kwon, Hyug Moo HM; Park, Sungho S; Myung, Kyungjae K; An, Jungeun J; Ko, Myunggon M

Publication Date: 2022-06-28

Variant appearance in text: KRAS: S17A

PubMed Link: 35737830

Variant Present in the following documents:

• pnas.2205626119.sapp.pdf

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Phasing analysis of lung cancer genomes using a long read sequencer.

Nature Communications

Sakamoto, Yoshitaka Y; Miyake, Shuhei S; Oka, Miho M; Kanai, Akinori A; Kawai, Yosuke Y; Nagasawa, Satoi S; Shiraishi, Yuichi Y; Tokunaga, Katsushi K; Kohno, Takashi T; Seki, Masahide M; Suzuki, Yutaka Y; Suzuki, Ayako A

Publication Date: 2022-06-16

Variant appearance in text: KRAS: S17a

PubMed Link: 35710642

Variant Present in the following documents:

• 41467_2022_31133_MOESM1_ESM.pdf

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Efficacy and safety of first-line checkpoint inhibitors-based treatments for non-oncogene-addicted non-small-cell lung cancer: a systematic review and meta-analysis.

Esmo Open

Siciliano, M A MA; Caridà, G G; Ciliberto, D D; d'Apolito, M M; Pelaia, C C; Caracciolo, D D; Riillo, C C; Correale, P P; Galvano, A A; Russo, A A; Barbieri, V V; Tassone, P P; Tagliaferri, P P

Publication Date: 2022-06

Variant appearance in text: KRAS: S17A

PubMed Link: 35427835

Variant Present in the following documents:

• main.pdf

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Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers.

Acs Central Science

Avital-Shmilovici, Michal M; Liu, Xiaohe X; Shaler, Thomas T; Lowenthal, Andrew A; Bourbon, Pauline P; Snider, Janey J; Tambo-Ong, Arlyn A; Repellin, Claire C; Yniguez, Kenya K; Sambucetti, Lidia L; Madrid, Peter B PB; Collins, Nathan N

Publication Date: 2022-01-26

Variant appearance in text: KRAS: S17a

PubMed Link: 35106376

Variant Present in the following documents:

• oc1c01041_si_001.pdf

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MicroRNA-16 Restores Sensitivity to Tyrosine Kinase Inhibitors and Outperforms MEK Inhibitors in KRAS-Mutated Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences

Fanini, Francesca F; Bandini, Erika E; Plousiou, Meropi M; Carloni, Silvia S; Wise, Petra P; Neviani, Paolo P; Murtadha, Mariam M; Foca, Flavia F; Fabbri, Francesco F; Vannini, Ivan I; Fabbri, Muller M

Publication Date: 2021-12-12

Variant appearance in text: KRAS: S17A

PubMed Link: 34948154

Variant Present in the following documents:

• Main text
• ijms-22-13357.pdf

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MicroRNA-16 Restores Sensitivity to Tyrosine Kinase Inhibitors and Outperforms MEK Inhibitors in KRAS-Mutated Non-Small Cell Lung Cancer.

International Journal Of Molecular Sciences

Fanini, Francesca F; Bandini, Erika E; Plousiou, Meropi M; Carloni, Silvia S; Wise, Petra P; Neviani, Paolo P; Murtadha, Mariam M; Foca, Flavia F; Fabbri, Francesco F; Vannini, Ivan I; Fabbri, Muller M

Publication Date: 2021-12-12

Variant appearance in text: KRAS: S17A

PubMed Link: 34948154

Variant Present in the following documents:

• Main text
• ijms-22-13357.pdf

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Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System.

Cancer Discovery

Yachida, Shinichi S; Totoki, Yasushi Y; Noë, Michaël M; Nakatani, Yoichiro Y; Horie, Masafumi M; Kawasaki, Kenta K; Nakamura, Hiromi H; Saito-Adachi, Mihoko M; Suzuki, Masami M; Takai, Erina E; Hama, Natsuko N; Higuchi, Ryota R; Hirono, Seiko S; Shiba, Satoshi S; Kato, Mamoru M; Furukawa, Eisaku E; Arai, Yasuhito Y; Rokutan, Hirofumi H; Hashimoto, Taiki T; Mitsunaga, Shuichi S; Kanda, Mitsuro M; Tanaka, Hidenori H; Takata, So S; Shimomura, Ayaka A; Oshima, Minoru M; Hackeng, Wenzel M WM; Okumura, Tomoyuki T; Okano, Keiichi K; Yamamoto, Masakazu M; Yamaue, Hiroki H; Morizane, Chigusa C; Arihiro, Koji K; Furukawa, Toru T; Sato, Toshiro T; Kiyono, Tohru T; Brosens, Lodewijk A A LAA; Wood, Laura D LD; Hruban, Ralph H RH; Shibata, Tatsuhiro T

Publication Date: 2022-03-01

Variant appearance in text: KRAS: S17A

PubMed Link: 34880079

Variant Present in the following documents:

• 692.pdf

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High Grade of Amplification of Six Regions on Chromosome 2p in a Neuroblastoma Patient with Very Poor Outcome: The Putative New Oncogene TSSC1.

Cancers

Ognibene, Marzia M; Amoroso, Loredana L; Melchionda, Fraia F; Cangelosi, Davide D; Zara, Federico F; Parodi, Stefano S; Pezzolo, Annalisa A

Publication Date: 2021-11-18

Variant appearance in text: KRAS: S17A

PubMed Link: 34830942

Variant Present in the following documents:

• Main text
• cancers-13-05792.pdf

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The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.

Nature Communications

Gebregiworgis, Teklab T; Kano, Yoshihito Y; St-Germain, Jonathan J; Radulovich, Nikolina N; Udaskin, Molly L ML; Mentes, Ahmet A; Huang, Richard R; Poon, Betty P K BPK; He, Wenguang W; Valencia-Sama, Ivette I; Robinson, Claire M CM; Huestis, Melissa M; Miao, Jinmin J; Yeh, Jen Jen JJ; Zhang, Zhong-Yin ZY; Irwin, Meredith S MS; Lee, Jeffrey E JE; Tsao, Ming-Sound MS; Raught, Brian B; Marshall, Christopher B CB; Ohh, Michael M; Ikura, Mitsuhiko M

Publication Date: 2021-11-01

Variant appearance in text: KRAS: S17a

PubMed Link: 34725361

Variant Present in the following documents:

• 41467_2021_26526_MOESM2_ESM.pdf

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Genomic and Transcriptomic Characteristics of Esophageal Adenocarcinoma.

Cancers

Hoppe, Sascha S; Jonas, Christoph C; Wenzel, Marten Christian MC; Velazquez Camacho, Oscar O; Arolt, Christoph C; Zhao, Yue Y; Büttner, Reinhard R; Quaas, Alexander A; Plum, Patrick Sven PS; Hillmer, Axel Maximilian AM

Publication Date: 2021-08-26

Variant appearance in text: KRAS: S17A

PubMed Link: 34503107

Variant Present in the following documents:

• Main text

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The expressed mutational landscape of microsatellite stable colorectal cancers.

Genome Medicine

Sveen, Anita A; Johannessen, Bjarne B; Eilertsen, Ina A IA; Røsok, Bård I BI; Gulla, Marie M; Eide, Peter W PW; Bruun, Jarle J; Kryeziu, Kushtrim K; Meza-Zepeda, Leonardo A LA; Myklebost, Ola O; Bjørnbeth, Bjørn A BA; Skotheim, Rolf I RI; Nesbakken, Arild A; Lothe, Ragnhild A RA

Publication Date: 2021-09-01

Variant appearance in text: KRAS: S17a

PubMed Link: 34470667

Variant Present in the following documents:

• Main text
• 13073_2021_Article_955.pdf

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An in vitro model of tumor heterogeneity resolves genetic, epigenetic, and stochastic sources of cell state variability.

Plos Biology

Hayford, Corey E CE; Tyson, Darren R DR; Robbins, C Jack CJ; Frick, Peter L PL; Quaranta, Vito V; Harris, Leonard A LA

Publication Date: 2021-06

Variant appearance in text: KRAS: S17A

PubMed Link: 34061819

Variant Present in the following documents:

• pbio.3000797.s017.pdf

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Systematic interrogation of mutation groupings reveals divergent downstream expression programs within key cancer genes.

Bmc Bioinformatics

Grzadkowski, Michal R MR; Holly, Hannah D HD; Somers, Julia J; Demir, Emek E

Publication Date: 2021-05-06

Variant appearance in text: KRAS: S17A

PubMed Link: 33957863

Variant Present in the following documents:

• Main text

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Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor.

Molecular Systems Biology

Jaiswal, Alok A; Gautam, Prson P; Pietilä, Elina A EA; Timonen, Sanna S; Nordström, Nora N; Akimov, Yevhen Y; Sipari, Nina N; Tanoli, Ziaurrehman Z; Fleischer, Thomas T; Lehti, Kaisa K; Wennerberg, Krister K; Aittokallio, Tero T

Publication Date: 2021-03

Variant appearance in text: KRAS: S17A

PubMed Link: 33750001

Variant Present in the following documents:

• Main text
• MSB-17-e9526.pdf

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Spontaneous and frequent conformational dynamics induced by A…A mismatch in d(CAA)·d(TAG) duplex.

Scientific Reports

Ajjugal, Yogeeshwar Y; Tomar, Kripi K; Rao, D Krishna DK; Rathinavelan, Thenmalarchelvi T

Publication Date: 2021-02-11

Variant appearance in text: KRAS: S17A

PubMed Link: 33574412

Variant Present in the following documents:

• 41598_2021_Article_82669.pdf

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Use of ratiometrically designed nanocarrier targeting CDK4/6 and autophagy pathways for effective pancreatic cancer treatment.

Nature Communications

Ji, Ying Y; Liu, Xiangsheng X; Li, Juan J; Xie, Xiaodong X; Huang, Max M; Jiang, Jinhong J; Liao, Yu-Pei YP; Donahue, Timothy T; Meng, Huan H

Publication Date: 2020-08-25

Variant appearance in text: KRAS: S17A

PubMed Link: 32843618

Variant Present in the following documents:

• 41467_2020_17996_MOESM2_ESM.pdf

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Two Distinct Structures of Membrane-Associated Homodimers of GTP- and GDP-Bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.

Angewandte Chemie (International Ed. In English)

Lee, Ki-Young KY; Fang, Zhenhao Z; Enomoto, Masahiro M; Gasmi-Seabrook, Genevieve G; Zheng, Le L; Koide, Shohei S; Ikura, Mitsuhiko M; Marshall, Christopher B CB

Publication Date: 2020-06-26

Variant appearance in text: KRAS: S17A

PubMed Link: 32227412

Variant Present in the following documents:

• Main text

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In situ formation of transcriptional modulators using non-canonical DNA i-motifs.

Chemical Science

Saha, Puja P; Panda, Deepanjan D; Müller, Diana D; Maity, Arunabha A; Schwalbe, Harald H; Dash, Jyotirmayee J

Publication Date: 2020-02-28

Variant appearance in text: KRAS: S17a

PubMed Link: 32180928

Variant Present in the following documents:

• SC-011-D0SC00514B.pdf

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Stromal Modulation and Treatment of Metastatic Pancreatic Cancer with Local Intraperitoneal Triple miRNA/siRNA Nanotherapy.

Acs Nano

Xie, Ying Y; Hang, Yu Y; Wang, Yazhe Y; Sleightholm, Richard R; Prajapati, Dipakkumar R DR; Bader, Johannes J; Yu, Ao A; Tang, Weimin W; Jaramillo, Lee L; Li, Jing J; Singh, Rakesh K RK; Oupický, David D

Publication Date: 2020-01-28

Variant appearance in text: KRAS: S17A

PubMed Link: 31927946

Variant Present in the following documents:

• Main text

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Targeting the Mevalonate Pathway to Overcome Acquired Anti-HER2 Treatment Resistance in Breast Cancer.

Molecular Cancer Research : Mcr

Sethunath, Vidyalakshmi V; Hu, Huizhong H; De Angelis, Carmine C; Veeraraghavan, Jamunarani J; Qin, Lanfang L; Wang, Nicholas N; Simon, Lukas M LM; Wang, Tao T; Fu, Xiaoyong X; Nardone, Agostina A; Pereira, Resel R; Nanda, Sarmistha S; Griffith, Obi L OL; Tsimelzon, Anna A; Shaw, Chad C; Chamness, Gary C GC; Reis-Filho, Jorge S JS; Weigelt, Britta B; Heiser, Laura M LM; Hilsenbeck, Susan G SG; Huang, Shixia S; Rimawi, Mothaffar F MF; Gray, Joe W JW; Osborne, C Kent CK; Schiff, Rachel R

Publication Date: 2019-11

Variant appearance in text: KRAS: S17A

PubMed Link: 31420371

Variant Present in the following documents:

• Main text

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Small Molecule KRAS Agonist for Mutant KRAS Cancer Therapy.

Molecular Cancer

Xu, Ke K; Park, Dongkyoo D; Magis, Andrew T AT; Zhang, Jun J; Zhou, Wei W; Sica, Gabriel L GL; Ramalingam, Suresh S SS; Curran, Walter J WJ; Deng, Xingming X

Publication Date: 2019-04-10

Variant appearance in text: KRAS: S17A

PubMed Link: 30971271

Variant Present in the following documents:

• Main text
• 12943_2019_Article_1012.pdf

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PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis.

Ebiomedicine

Rodriguez-Aguayo, Cristian C; Bayraktar, Emine E; Ivan, Cristina C; Aslan, Burcu B; Mai, Junhua J; He, Guangan G; Mangala, Lingegowda S LS; Jiang, Dahai D; Nagaraja, Archana S AS; Ozpolat, Bulent B; Chavez-Reyes, Arturo A; Ferrari, Mauro M; Mitra, Rahul R; Siddik, Zahid H ZH; Shen, Haifa H; Yang, Xianbin X; Sood, Anil K AK; Lopez-Berestein, Gabriel G

Publication Date: 2019-02

Variant appearance in text: KRAS: S17A

PubMed Link: 30655206

Variant Present in the following documents:

• Main text

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NMR solution structure of an asymmetric intermolecular leaped V-shape G-quadruplex: selective recognition of the d(G2NG3NG4) sequence motif by a short linear G-rich DNA probe.

Nucleic Acids Research

Wan, Chanjuan C; Fu, Wenqiang W; Jing, Haitao H; Zhang, Na N

Publication Date: 2019-02-20

Variant appearance in text: KRAS: S17A

PubMed Link: 30445650

Variant Present in the following documents:

• gky1167.pdf

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LZTR1 is a regulator of RAS ubiquitination and signaling.

Science (New York, N.Y.)

Bigenzahn, Johannes W JW; Collu, Giovanna M GM; Kartnig, Felix F; Pieraks, Melanie M; Vladimer, Gregory I GI; Heinz, Leonhard X LX; Sedlyarov, Vitaly V; Schischlik, Fiorella F; Fauster, Astrid A; Rebsamen, Manuele M; Parapatics, Katja K; Blomen, Vincent A VA; Müller, André C AC; Winter, Georg E GE; Kralovics, Robert R; Brummelkamp, Thijn R TR; Mlodzik, Marek M; Superti-Furga, Giulio G

Publication Date: 2018-12-07

Variant appearance in text: KRAS: S17A

PubMed Link: 30442766

Variant Present in the following documents:

• Main text

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Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.

Nature Communications

Li, Xiaodun X; Francies, Hayley E HE; Secrier, Maria M; Perner, Juliane J; Miremadi, Ahmad A; Galeano-Dalmau, Núria N; Barendt, William J WJ; Letchford, Laura L; Leyden, Genevieve M GM; Goffin, Emma K EK; Barthorpe, Andrew A; Lightfoot, Howard H; Chen, Elisabeth E; Gilbert, James J; Noorani, Ayesha A; Devonshire, Ginny G; Bower, Lawrence L; Grantham, Amber A; MacRae, Shona S; Grehan, Nicola N; Wedge, David C DC; Fitzgerald, Rebecca C RC; Garnett, Mathew J MJ

Publication Date: 2018-07-30

Variant appearance in text: KRAS: S17A

PubMed Link: 30061675

Variant Present in the following documents:

• Main text

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Osteoblasts remotely supply lung tumors with cancer-promoting SiglecFhigh neutrophils.

Science (New York, N.Y.)

Engblom, Camilla C; Pfirschke, Christina C; Zilionis, Rapolas R; Da Silva Martins, Janaina J; Bos, Stijn A SA; Courties, Gabriel G; Rickelt, Steffen S; Severe, Nicolas N; Baryawno, Ninib N; Faget, Julien J; Savova, Virginia V; Zemmour, David D; Kline, Jaclyn J; Siwicki, Marie M; Garris, Christopher C; Pucci, Ferdinando F; Liao, Hsin-Wei HW; Lin, Yi-Jang YJ; Newton, Andita A; Yaghi, Omar K OK; Iwamoto, Yoshiko Y; Tricot, Benoit B; Wojtkiewicz, Gregory R GR; Nahrendorf, Matthias M; Cortez-Retamozo, Virna V; Meylan, Etienne E; Hynes, Richard O RO; Demay, Marie M; Klein, Allon A; Bredella, Miriam A MA; Scadden, David T DT; Weissleder, Ralph R; Pittet, Mikael J MJ

Publication Date: 2017-12-01

Variant appearance in text: KRAS: S17A

PubMed Link: 29191879

Variant Present in the following documents:

• Main text

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The Evolving Genomic Landscape of Barrett's Esophagus and Esophageal Adenocarcinoma.

Gastroenterology

Contino, Gianmarco G; Vaughan, Thomas L TL; Whiteman, David D; Fitzgerald, Rebecca C RC

Publication Date: 2017-09

Variant appearance in text: KRAS: S17A

PubMed Link: 28716721

Variant Present in the following documents:

• Main text

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CoINcIDE: A framework for discovery of patient subtypes across multiple datasets.

Genome Medicine

Planey, Catherine R CR; Gevaert, Olivier O

Publication Date: 2016-03-09

Variant appearance in text: KRAS: S17A

PubMed Link: 26961683

Variant Present in the following documents:

• Main text

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Integrated Multiregional Analysis Proposing a New Model of Colorectal Cancer Evolution.

Plos Genetics

Uchi, Ryutaro R; Takahashi, Yusuke Y; Niida, Atsushi A; Shimamura, Teppei T; Hirata, Hidenari H; Sugimachi, Keishi K; Sawada, Genta G; Iwaya, Takeshi T; Kurashige, Junji J; Shinden, Yoshiaki Y; Iguchi, Tomohiro T; Eguchi, Hidetoshi H; Chiba, Kenichi K; Shiraishi, Yuichi Y; Nagae, Genta G; Yoshida, Kenichi K; Nagata, Yasunobu Y; Haeno, Hiroshi H; Yamamoto, Hirofumi H; Ishii, Hideshi H; Doki, Yuichiro Y; Iinuma, Hisae H; Sasaki, Shin S; Nagayama, Satoshi S; Yamada, Kazutaka K; Yachida, Shinichi S; Kato, Mamoru M; Shibata, Tatsuhiro T; Oki, Eiji E; Saeki, Hiroshi H; Shirabe, Ken K; Oda, Yoshinao Y; Maehara, Yoshihiko Y; Komune, Shizuo S; Mori, Masaki M; Suzuki, Yutaka Y; Yamamoto, Ken K; Aburatani, Hiroyuki H; Ogawa, Seishi S; Miyano, Satoru S; Mimori, Koshi K

Publication Date: 2016-02

Variant appearance in text: KRAS: S17A

PubMed Link: 26890883

Variant Present in the following documents:

• Main text
• pgen.1005778.pdf

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Genomic Characterization of Brain Metastases Reveals Branched Evolution and Potential Therapeutic Targets.

Cancer Discovery

Brastianos, Priscilla K PK; Carter, Scott L SL; Santagata, Sandro S; Cahill, Daniel P DP; Taylor-Weiner, Amaro A; Jones, Robert T RT; Van Allen, Eliezer M EM; Lawrence, Michael S MS; Horowitz, Peleg M PM; Cibulskis, Kristian K; Ligon, Keith L KL; Tabernero, Josep J; Seoane, Joan J; Martinez-Saez, Elena E; Curry, William T WT; Dunn, Ian F IF; Paek, Sun Ha SH; Park, Sung-Hye SH; McKenna, Aaron A; Chevalier, Aaron A; Rosenberg, Mara M; Barker, Frederick G FG; Gill, Corey M CM; Van Hummelen, Paul P; Thorner, Aaron R AR; Johnson, Bruce E BE; Hoang, Mai P MP; Choueiri, Toni K TK; Signoretti, Sabina S; Sougnez, Carrie C; Rabin, Michael S MS; Lin, Nancy U NU; Winer, Eric P EP; Stemmer-Rachamimov, Anat A; Meyerson, Matthew M; Garraway, Levi L; Gabriel, Stacey S; Lander, Eric S ES; Beroukhim, Rameen R; Batchelor, Tracy T TT; Baselga, Jose J; Louis, David N DN; Getz, Gad G; Hahn, William C WC

Publication Date: 2015-11

Variant appearance in text: KRAS: S17A

PubMed Link: 26410082

Variant Present in the following documents:

• Main text

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Genome-wide mutational landscape of mucinous carcinomatosis peritonei of appendiceal origin.

Genome Medicine

Alakus, Hakan H; Babicky, Michele L ML; Ghosh, Pradipta P; Yost, Shawn S; Jepsen, Kristen K; Dai, Yang Y; Arias, Angelo A; Samuels, Michael L ML; Mose, Evangeline S ES; Schwab, Richard B RB; Peterson, Michael R MR; Lowy, Andrew M AM; Frazer, Kelly A KA; Harismendy, Olivier O

Publication Date: 2014

Variant appearance in text: KRAS: S17a

PubMed Link: 24944587

Variant Present in the following documents:

• gm559-S3.xls, sheet 18

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Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.

Cancer Research

Hata, Aaron N AN; Yeo, Alan A; Faber, Anthony C AC; Lifshits, Eugene E; Chen, Zhao Z; Cheng, Katherine A KA; Walton, Zandra Z; Sarosiek, Kristopher A KA; Letai, Anthony A; Heist, Rebecca S RS; Mino-Kenudson, Mari M; Wong, Kwok-Kin KK; Engelman, Jeffrey A JA

Publication Date: 2014-06-01

Variant appearance in text: KRAS: S17A

PubMed Link: 24675361

Variant Present in the following documents:

• Main text

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Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets.

Science Signaling

Miller, Martin L ML; Molinelli, Evan J EJ; Nair, Jayasree S JS; Sheikh, Tahir T; Samy, Rita R; Jing, Xiaohong X; He, Qin Q; Korkut, Anil A; Crago, Aimee M AM; Singer, Samuel S; Schwartz, Gary K GK; Sander, Chris C

Publication Date: 2013-09-24

Variant appearance in text: KRAS: S17A

PubMed Link: 24065146

Variant Present in the following documents:

• Main text

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