Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen.
Nature Communications
Poole, Andrew A; Karuppiah, Vijaykumar V; Hartt, Annabelle A; Haidar, Jaafar N JN; Moureau, Sylvie S; Dobrzycki, Tomasz T; Hayes, Conor C; Rowley, Christopher C; Dias, Jorge J; Harper, Stephen S; Barnbrook, Keir K; Hock, Miriam M; Coles, Charlotte C; Yang, Wei W; Aleksic, Milos M; Lin, Aimee Bence AB; Robinson, Ross R; Dukes, Joe D JD; Liddy, Nathaniel N; Van der Kamp, Marc M; Plowman, Gregory D GD; Vuidepot, Annelise A; Cole, David K DK; Whale, Andrew D AD; Chillakuri, Chandramouli C
Comparison of variant allele frequency and number of mutant molecules as units of measurement for circulating tumor DNA.
Molecular Oncology
Bos, Manouk K MK; Nasserinejad, Kazem K; Jansen, Maurice P H M MPHM; Angus, Lindsay L; Atmodimedjo, Peggy N PN; de Jonge, Evert E; Dinjens, Winand N M WNM; van Schaik, Ron H N RHN; Del Re, Marzia M; Dubbink, Hendrikus J HJ; Sleijfer, Stefan S; Martens, John W M JWM
Genomic and Epigenomic Landscaping Defines New Therapeutic Targets for Adenosquamous Carcinoma of the Pancreas.
Cancer Research
Lenkiewicz, Elizabeth E; Malasi, Smriti S; Hogenson, Tara L TL; Flores, Luis F LF; Barham, Whitney W; Phillips, William J WJ; Roesler, Alexander S AS; Chambers, Kendall R KR; Rajbhandari, Nirakar N; Hayashi, Akimasa A; Antal, Corina E CE; Downes, Michael M; Grandgenett, Paul M PM; Hollingsworth, Michael A MA; Cridebring, Derek D; Xiong, Yuning Y; Lee, Jeong-Heon JH; Ye, Zhenqing Z; Yan, Huihuang H; Hernandez, Matthew C MC; Leiting, Jennifer L JL; Evans, Ronald M RM; Ordog, Tamas T; Truty, Mark J MJ; Borad, Mitesh J MJ; Reya, Tannishtha T; Von Hoff, Daniel D DD; Fernandez-Zapico, Martin E ME; Barrett, Michael T MT
Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival.
Nature Communications
Zaidi, Syed H SH; Harrison, Tabitha A TA; Phipps, Amanda I AI; Steinfelder, Robert R; Trinh, Quang M QM; Qu, Conghui C; Banbury, Barbara L BL; Georgeson, Peter P; Grasso, Catherine S CS; Giannakis, Marios M; Adams, Jeremy B JB; Alwers, Elizabeth E; Amitay, Efrat L EL; Barfield, Richard T RT; Berndt, Sonja I SI; Borozan, Ivan I; Brenner, Hermann H; Brezina, Stefanie S; Buchanan, Daniel D DD; Cao, Yin Y; Chan, Andrew T AT; Chang-Claude, Jenny J; Connolly, Charles M CM; Drew, David A DA; Farris, Alton Brad AB; Figueiredo, Jane C JC; French, Amy J AJ; Fuchs, Charles S CS; Garraway, Levi A LA; Gruber, Steve S; Guinter, Mark A MA; Hamilton, Stanley R SR; Harlid, Sophia S; Heisler, Lawrence E LE; Hidaka, Akihisa A; Hopper, John L JL; Huang, Wen-Yi WY; Huyghe, Jeroen R JR; Jenkins, Mark A MA; Krzyzanowski, Paul M PM; Lemire, Mathieu M; Lin, Yi Y; Luo, Xuemei X; Mardis, Elaine R ER; McPherson, John D JD; Miller, Jessica K JK; Moreno, Victor V; Mu, Xinmeng Jasmine XJ; Nishihara, Reiko R; Papadopoulos, Nickolas N; Pasternack, Danielle D; Quist, Michael J MJ; Rafikova, Adilya A; Reid, Emma E G EEG; Shinbrot, Eve E; Shirts, Brian H BH; Stein, Lincoln D LD; Teney, Cherie D CD; Timms, Lee L; Um, Caroline Y CY; Van Guelpen, Bethany B; Van Tassel, Megan M; Wang, Xiaolong X; Wheeler, David A DA; Yung, Christina K CK; Hsu, Li L; Ogino, Shuji S; Gsur, Andrea A; Newcomb, Polly A PA; Gallinger, Steven S; Hoffmeister, Michael M; Campbell, Peter T PT; Thibodeau, Stephen N SN; Sun, Wei W; Hudson, Thomas J TJ; Peters, Ulrike U
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.
Nature Communications
Kennedy, Susan A SA; Jarboui, Mohamed-Ali MA; Srihari, Sriganesh S; Raso, Cinzia C; Bryan, Kenneth K; Dernayka, Layal L; Charitou, Theodosia T; Bernal-Llinares, Manuel M; Herrera-Montavez, Carlos C; Krstic, Aleksandar A; Matallanas, David D; Kotlyar, Max M; Jurisica, Igor I; Curak, Jasna J; Wong, Victoria V; Stagljar, Igor I; LeBihan, Thierry T; Imrie, Lisa L; Pillai, Priyanka P; Lynn, Miriam A MA; Fasterius, Erik E; Al-Khalili Szigyarto, Cristina C; Breen, James J; Kiel, Christina C; Serrano, Luis L; Rauch, Nora N; Rukhlenko, Oleksii O; Kholodenko, Boris N BN; Iglesias-Martinez, Luis F LF; Ryan, Colm J CJ; Pilkington, Ruth R; Cammareri, Patrizia P; Sansom, Owen O; Shave, Steven S; Auer, Manfred M; Horn, Nicola N; Klose, Franziska F; Ueffing, Marius M; Boldt, Karsten K; Lynn, David J DJ; Kolch, Walter W
Sharma, Yogita Y; Miladi, Milad M; Dukare, Sandeep S; Boulay, Karine K; Caudron-Herger, Maiwen M; Groß, Matthias M; Backofen, Rolf R; Diederichs, Sven S
An integrated genomic analysis of anaplastic meningioma identifies prognostic molecular signatures.
Scientific Reports
Collord, Grace G; Tarpey, Patrick P; Kurbatova, Natalja N; Martincorena, Inigo I; Moran, Sebastian S; Castro, Manuel M; Nagy, Tibor T; Bignell, Graham G; Maura, Francesco F; Young, Matthew D MD; Berna, Jorge J; Tubio, Jose M C JMC; McMurran, Chris E CE; Young, Adam M H AMH; Sanders, Mathijs M; Noorani, Imran I; Price, Stephen J SJ; Watts, Colin C; Leipnitz, Elke E; Kirsch, Matthias M; Schackert, Gabriele G; Pearson, Danita D; Devadass, Abel A; Ram, Zvi Z; Collins, V Peter VP; Allinson, Kieren K; Jenkinson, Michael D MD; Zakaria, Rasheed R; Syed, Khaja K; Hanemann, C Oliver CO; Dunn, Jemma J; McDermott, Michael W MW; Kirollos, Ramez W RW; Vassiliou, George S GS; Esteller, Manel M; Behjati, Sam S; Brazma, Alvis A; Santarius, Thomas T; McDermott, Ultan U
Formalin fixation increases deamination mutation signature but should not lead to false positive mutations in clinical practice.
Plos One
Prentice, Leah M LM; Miller, Ruth R RR; Knaggs, Jeff J; Mazloomian, Alborz A; Aguirre Hernandez, Rosalia R; Franchini, Patrick P; Parsa, Kourosh K; Tessier-Cloutier, Basile B; Lapuk, Anna A; Huntsman, David D; Schaeffer, David F DF; Sheffield, Brandon S BS
Selective identification of somatic mutations in pancreatic cancer cells through a combination of next-generation sequencing of plasma DNA using molecular barcodes and a bioinformatic variant filter.
Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.
Cell Reports
Giannakis, Marios M; Mu, Xinmeng Jasmine XJ; Shukla, Sachet A SA; Qian, Zhi Rong ZR; Cohen, Ofir O; Nishihara, Reiko R; Bahl, Samira S; Cao, Yin Y; Amin-Mansour, Ali A; Yamauchi, Mai M; Sukawa, Yasutaka Y; Stewart, Chip C; Rosenberg, Mara M; Mima, Kosuke K; Inamura, Kentaro K; Nosho, Katsuhiko K; Nowak, Jonathan A JA; Lawrence, Michael S MS; Giovannucci, Edward L EL; Chan, Andrew T AT; Ng, Kimmie K; Meyerhardt, Jeffrey A JA; Van Allen, Eliezer M EM; Getz, Gad G; Gabriel, Stacey B SB; Lander, Eric S ES; Wu, Catherine J CJ; Fuchs, Charles S CS; Ogino, Shuji S; Garraway, Levi A LA
Genetic alterations of triple negative breast cancer by targeted next-generation sequencing and correlation with tumor morphology.
Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc
Weisman, Paul S PS; Ng, Charlotte K Y CK; Brogi, Edi E; Eisenberg, Rachel E RE; Won, Helen H HH; Piscuoglio, Salvatore S; De Filippo, Maria R MR; Ioris, Rafael R; Akram, Muzaffar M; Norton, Larry L; Weigelt, Britta B; Berger, Michael F MF; Reis-Filho, Jorge S JS; Wen, Hannah Y HY
Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype.
Scientific Reports
Fu, Yong Y; Cruz-Monserrate, Zobeida Z; Helen Lin, H H; Chung, Yiyin Y; Ji, Baoan B; Lin, Szu-Min SM; Vonderfecht, Steven S; Logsdon, Craig D CD; Li, Chien-Feng CF; Ann, David K DK