Evolution of age-related mutation-driven clonal haematopoiesis over 20 years is associated with metabolic dysfunction in obesity.
Ebiomedicine
Andersson-Assarsson, Johanna C JC; van Deuren, Rosanne C RC; Kristensson, Felipe M FM; Steehouwer, Marloes M; Sjöholm, Kajsa K; Svensson, Per-Arne PA; Pieterse, Marc M; Gilissen, Christian C; Taube, Magdalena M; Jacobson, Peter P; Perkins, Rosie R; Brunner, Han G HG; Netea, Mihai G MG; Peltonen, Markku M; Carlsson, Björn B; Hoischen, Alexander A; Carlsson, Lena M S LMS
The efficacy of immune checkpoint inhibitors in biliary tract cancer with KRAS mutation.
Therapeutic Advances In Gastroenterology
Jeong, Sun Young SY; Hong, Jung Yong JY; Park, Joon Oh JO; Park, Young Suk YS; Lim, Ho Yeong HY; Jang, Jae Yeon JY; Jeon, Youngkyung Y; Kim, Seung Tae ST
Contribution of Somatic Ras/Raf/Mitogen-Activated Protein Kinase Variants in the Hippocampus in Drug-Resistant Mesial Temporal Lobe Epilepsy.
Jama Neurology
Khoshkhoo, Sattar S; Wang, Yilan Y; Chahine, Yasmine Y; Erson-Omay, E Zeynep EZ; Robert, Stephanie M SM; Kiziltug, Emre E; Damisah, Eyiyemisi C EC; Nelson-Williams, Carol C; Zhu, Guangya G; Kong, Wenna W; Huang, August Yue AY; Stronge, Edward E; Phillips, H Westley HW; Chhouk, Brian H BH; Bizzotto, Sara S; Chen, Ming Hui MH; Adikari, Thiuni N TN; Ye, Zimeng Z; Witkowski, Tom T; Lai, Dulcie D; Lee, Nadine N; Lokan, Julie J; Scheffer, Ingrid E IE; Berkovic, Samuel F SF; Haider, Shozeb S; Hildebrand, Michael S MS; Yang, Edward E; Gunel, Murat M; Lifton, Richard P RP; Richardson, R Mark RM; Blümcke, Ingmar I; Alexandrescu, Sanda S; Huttner, Anita A; Heinzen, Erin L EL; Zhu, Jidong J; Poduri, Annapurna A; DeLanerolle, Nihal N; Spencer, Dennis D DD; Lee, Eunjung Alice EA; Walsh, Christopher A CA; Kahle, Kristopher T KT
Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry.
Rsc Medicinal Chemistry
Thomas, Ross P RP; Grant, Emma K EK; Dickinson, Eleanor R ER; Zappacosta, Francesca F; Edwards, Lee J LJ; Hann, Michael M MM; House, David D; Tomkinson, Nicholas C O NCO; Bush, Jacob T JT
Genomic profiling of idiopathic peri-hilar cholangiocarcinoma reveals new targets and mutational pathways.
Scientific Reports
Quinn, Leonard M LM; Haldenby, Sam S; Antzcak, Philip P; Fowler, Anna A; Bullock, Katie K; Kenny, John J; Gilbert, Timothy T; Andrews, Timothy T; Diaz-Nieto, Rafael R; Fenwick, Stephen S; Jones, Robert R; Costello-Goldring, Eithne E; Poston, Graeme G; Greenhalf, William W; Palmer, Daniel D; Malik, Hassan H; Goldring, Chris C
Distinct Nrf2 Signaling Thresholds Mediate Lung Tumor Initiation and Progression.
Cancer Research
DeBlasi, Janine M JM; Falzone, Aimee A; Caldwell, Samantha S; Prieto-Farigua, Nicolas N; Prigge, Justin R JR; Schmidt, Edward E EE; Chio, Iok In Christine IIC; Karreth, Florian A FA; DeNicola, Gina M GM
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA.
Nature
Abbosh, Christopher C; Frankell, Alexander M AM; Harrison, Thomas T; Kisistok, Judit J; Garnett, Aaron A; Johnson, Laura L; Veeriah, Selvaraju S; Moreau, Mike M; Chesh, Adrian A; Chaunzwa, Tafadzwa L TL; Weiss, Jakob J; Schroeder, Morgan R MR; Ward, Sophia S; Grigoriadis, Kristiana K; Shahpurwalla, Aamir A; Litchfield, Kevin K; Puttick, Clare C; Biswas, Dhruva D; Karasaki, Takahiro T; Black, James R M JRM; Martínez-Ruiz, Carlos C; Bakir, Maise Al MA; Pich, Oriol O; Watkins, Thomas B K TBK; Lim, Emilia L EL; Huebner, Ariana A; Moore, David A DA; Godin-Heymann, Nadia N; L'Hernault, Anne A; Bye, Hannah H; Odell, Aaron A; Roberts, Paula P; Gomes, Fabio F; Patel, Akshay J AJ; Manzano, Elizabeth E; Hiley, Crispin T CT; Carey, Nicolas N; Riley, Joan J; Cook, Daniel E DE; Hodgson, Darren D; Stetson, Daniel D; Barrett, J Carl JC; Kortlever, Roderik M RM; Evan, Gerard I GI; Hackshaw, Allan A; Daber, Robert D RD; Shaw, Jacqui A JA; Aerts, Hugo J W L HJWL; Licon, Abel A; Stahl, Josh J; Jamal-Hanjani, Mariam M; , ; Birkbak, Nicolai J NJ; McGranahan, Nicholas N; Swanton, Charles C
Long non-coding RNA HIF1A-As2 and MYC form a double-positive feedback loop to promote cell proliferation and metastasis in KRAS-driven non-small cell lung cancer.
Cell Death And Differentiation
Yang, Kaixin K; Zhang, Wenyang W; Zhong, Linghui L; Xiao, Yinan Y; Sahoo, Sudhakar S; Fassan, Matteo M; Zeng, Kang K; Magee, Peter P; Garofalo, Michela M; Shi, Lei L
An ERK1/2-driven RNA-binding switch in nucleolin drives ribosome biogenesis and pancreatic tumorigenesis downstream of RAS oncogene.
The Embo Journal
Azman, Muhammad S MS; Alard, Emilie L EL; Dodel, Martin M; Capraro, Federica F; Faraway, Rupert R; Dermit, Maria M; Fan, Wanling W; Chakraborty, Alina A; Ule, Jernej J; Mardakheh, Faraz K FK
Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues.
Nature Communications
Abelin, Jennifer G JG; Bergstrom, Erik J EJ; Rivera, Keith D KD; Taylor, Hannah B HB; Klaeger, Susan S; Xu, Charles C; Verzani, Eva K EK; Jackson White, C C; Woldemichael, Hilina B HB; Virshup, Maya M; Olive, Meagan E ME; Maynard, Myranda M; Vartany, Stephanie A SA; Allen, Joseph D JD; Phulphagar, Kshiti K; Harry Kane, M M; Rachimi, Suzanna S; Mani, D R DR; Gillette, Michael A MA; Satpathy, Shankha S; Clauser, Karl R KR; Udeshi, Namrata D ND; Carr, Steven A SA